Abstract: Engineered bispecific antibodies with charge pairs introduced at the interface of CHI and CL alone or in combination with other charge pairs at the interface of VH and VL are described. Also described are anti-CD47/anti-CLDN18.2 and anti-CD3/anti-DLL3 bispecific antibodies and antigen-binding fragments thereof. Also described are nucleic acids encoding the bispecific antibodies, compositions comprising the bispecific antibodies, and methods of producing the bispecific antibodies and using the bispecific antibodies for treating or preventing diseases, such as cancer and/or associated complications.

Abstract: The present invention provides an anti-human MSLN-specific antibody and an MSLN-targeting immune effector cell. Also provided is an MSLN-targeting chimeric antigen receptor modified T-cell prepared using the antibody and a use thereof.

Abstract: Described are an encoding method and system for ROAs. The encoding method includes the following steps: given a set of authorized IP prefixes an AS which are maintained with an IP address trie. By specifying a sequence of hanging levels on the IP address trie, it is divided into a set of non-overlapping sub-trees, each rooted at a hanging level. A node on a hanging level uniquely defines a sub-tree rooted at it, whose prefix can be encoded as the identifier of this sub-tree. All authorized prefixes covered by a sub-tree can be encoded into a bitmap of 2h bits, where h is the height of this sub-tree. Thus, the set of authorized IP prefixes of an AS is encoded into several tuples (identifier, bitmap).

Abstract: The knob screen device includes a glass touch cover plate, a display screen, a screen support frame, a semi-transparent turning structure, an annular light-leading friction shim, at least one battery, a mainboard and a magnetic attraction assembly. The knob screen device further comprises: at least one Hall sensor provided on the mainboard; at least one multicolor LED ambient light provided on the mainboard; and at least one annular multipolar flexible magnet provided in the semi-transparent turning structure. The semi-transparent turning structure is connected to external component by means of the magnetic attraction assembly. In this way, the knob screen device is simple in structure, low in cost, easy to process and install and more flexible in application circumferences.

Abstract: A production line device prepares a superconducting circuit layer on a substrate. The device prepares an under bump metallization (UBM) layer on an upper surface of the superconducting circuit layer. A superconducting connection is formed between the UBM layer and the superconducting circuit layer. The production device prepares a welding spot on an upper surface of the UBM layer to obtain a qubit assembly configured for a flip-chip superconducting quantum chip. A superconducting electrical connection is formed between the welding spot and the UBM layer.

Abstract: Anti-FOLR1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.

Abstract: The present invention relates to the technical field of optical communications, and particularly relates to a wavelength locking optical module, a device, and a wavelength locking method. The optical module comprises a DSP unit, a TOSA, and a ROSA. The DSP unit has a signal output terminal connected to the TOSA and a signal input terminal connected to the ROSA. A TEC is provided within the TOSA, and is used to adjust a temperature according to a control signal sent from the DSP unit and accordingly adjust a emission wavelength of the TOSA. An optical filter is provided within the ROSA and used to filter a wave, such that light having a pre-determined wavelength passes through the filter and is converted into an electrical signal and output to the DSP unit. The DSP unit calculates an optical power according to the received electrical signal, and determines wavelength control of the TOSA according to an optical power change.

Abstract: Anti-TAA antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer and/or an inflammatory disease.

Abstract: Disclosed are a calibration method and apparatus for a coherent light module, and a computer-readable storage medium. The method comprises: obtaining a first and second curve relationship respectively representing a relationship between a power-gain monitoring voltage and optical power of a receiver of the coherent optical module and a relationship between a target setting voltage and the optical power of the receiver in the optical power range of the receiver; determining first optical power based on the first and second curve relationship, which is used for dividing the optical power range of the receiver into two ranges; and determining a calibration mode of the coherent light module based on the first optical power, which comprises: calibrating the coherent light module by using the first curve relationship or the second curve relationship when the optical power of the receiver is in a first range or in a second range.

Abstract: The present invention provides methods for detecting and/or treating a subject having an aneurysm or at risk for developing an aneurysm. It has been discovered that a key metabolite of the kynurenine (Kyn) pathway, a major route for the metabolism of essential amino acid tryptophan (Trp) into nicotinamide adenine dinucleotide (NAD+), plays a critical role in the formation of aneurysms, for example abdominal aortic aneurysms. In particular, it has been discovered that 3-Hydroxyanthranilic acid (3-HAA), a product of kynureninase (KYNU), plays a causative role in the formation of aneurysms by, for example exerting pro-inflammatory effects on vascular smooth muscle cells. It has further been discovered that elevated levels of 3-HAA are indicative of the presence and/or progression of an aneurysm, and 3-HAA levels correlate with the size (aortic diameter) of the aneurysm.

Abstract: Monoclonal antibodies (mAbs) or bispecific antibodies (bsAbs) or multi-specific antibodies comprising a fatty acid (FA) molecule conjugated to or near the antigen-binding domain are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases, such as cancer and/or associated complications.

Abstract: Anti-CLDN18.2 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer and/or an inflammatory disease.

Abstract: Engineered bispecific antibodies with shifted interchain disulfide bond on one arm while maintaining the native interchain disulfide bond on the second arm are described. Also described are anti-CD47/FR? bispecific antibodies and antigen-binding fragments thereof. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases, such as cancer and/or associated complications.

Abstract: A steam cleaning apparatus may include a wand, a cleaning assembly coupled to the wand, the cleaning assembly including a steam generator, and a cleaning head pivotally coupled to the wand. The cleaning head may include a plurality of cleaning pads, a pad motor having a motor driveshaft, a drivetrain configured to transfer rotational motion of the motor driveshaft to each of the plurality of cleaning pads such that a rotation of the motor driveshaft causes a corresponding rotation in each of the plurality of cleaning pads, and a temperature sensor positioned proximate to the drivetrain, the temperature sensor being configured to measure a temperature of the drivetrain.