Abstract: Anti-CD73 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer.

Abstract: Anti-TIP-1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.

Abstract: Anti-CLDN18.2 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer and/or an inflammatory disease.

Abstract: Anti-apelin antibodies and antigen-binding fragments thereof are described.

Abstract: Anti-CD47 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, inflammatory disease, infectious disease, atherosclerosis, cardiovascular disease, metabolic disease, radiation-induced injury, and/or autoimmune disease.

Abstract: A clutch device (400) for an upright vacuum cleaner and an upright vacuum cleaner (1) having the same are provided, in which the clutch device (400) is disposed between an electric motor assembly (200) and a machine body assembly (300) of the upright vacuum cleaner (1), and the electric motor assembly (200) includes an electric motor housing (21) and an electric motor (22). The clutch device (400) includes: a sliding track (41d) driven (300) to move by the machine body assembly; a toggling tongue (42d) fixed to the electric motor (22) and rotatable with respect to the electric motor housing (21); and a lever member (43d) having a second end of the lever member (43d) slidably fitted to the sliding track (41d) and a first end fitted with an end of the toggling tongue (42d).

Abstract: A method for testing cutting performance of a diamond saw blade, relating to a technical field of diamond tool test, is provided, which solves problems of inaccuracy and non-uniformity existing in conventional methods for testing cutting performance of a diamond tool. The method includes steps of: (1) obtaining a set load parameter value, particularly including steps of: controlling a feed amount of the diamond saw blade; finding out a load value K corresponding to a maximum feed amount of the diamond saw blade on a cutting object; and setting M=0.70K-0.85K, wherein M is the set load parameter value; and (2) during cutting, controlling a cutting load value of the diamond saw blade to be 0.90M-1.1M through a servo system. Therefore, uniform three cutting elements of machine and tool, object, and feed thrust are realized, and the performance of the diamond tool is automatically and accurately measured.

Abstract: The present invention provides methods for detecting and/or treating a subject having an aneurysm or at risk for developing an aneurysm. It has been discovered that a key metabolite of the kynurenine (Kyn) pathway, a major route for the metabolism of essential amino acid tryptophan (Trp) into nicotinamide adenine dinucleotide (NAD+), plays a critical role in the formation of aneurysms, for example abdominal aortic aneurysms. In particular, it has been discovered that 3-Hydroxyanthranilic acid (3-HAA), a product of kynureninase (KYNU), plays a causative role in the formation of aneurysms by, for example exerting pro-inflammatory effects on vascular smooth muscle cells. It has further been discovered that elevated levels of 3-HAA are indicative of the presence and/or progression of an aneurysm, and 3-HAA levels correlate with the size (aortic diameter) of the aneurysm.

Abstract: An upright vacuum cleaner (1) includes: a brushroll assembly (100) including a brushroll casing (12) and a brushroll (11), the brushroll casing (12) defining a brushroll air-suction channel (122) therein; a motor assembly (200) including a motor housing (21) and a motor (22), the motor housing (21) having an air exhaust hole (213), a dirty air outlet (211) and a clean air inlet (212) and defining a motor air-suction channel (216) and a motor air-exhaust channel; and a body assembly (300) including a body (31) and a dirt cup (37) mounted to the body (31), the dirt cup (37) having a separating chamber (371) communicating with the dirty air outlet (211) and the clean air inlet (212) respectively.

Abstract: The present invention relates to a technical field of optical communications. It relates to a dual-rate DML device and module, and a calibration method, and in particular, to a dual-rate DML device and module having a built-in signal calibration circuit, and a calibration method. According to the present invention, the signal calibration circuit is added into the device; a PD is prepositioned by means of a novel light splitting structure; a control structure for a sequence-divided multi-channel serial signal is utilized to feed back a monitoring signal to an electric driver to adjust drive current; crosstalk between backlight monitoring is reduced; and high-quality signal output under dual modulation frequencies of 25 Gbps and 28 Gbps is realized.

Abstract: A cyclonic separating device for an upright vacuum cleaner and an upright vacuum cleaner with the same are disclosed. The cyclonic separating device includes a dirt cup, a filter and a cyclonic cone assembly. The filter is disposed in the dirt cup and includes a filter inlet and a filter outlet communicating between the filter inlet and an air outlet. The cyclonic cone assembly includes a cyclone cylinder and a cyclonic guide, in which a first end of the cyclone cylinder is communicated with an air inlet, and the cyclonic guide is fitted in a second end of the cyclone cylinder and is detachably fitted over the filter to spirally guide dirty air introduced into the cyclone cylinder from the air inlet to the filter inlet.

Abstract: An augmented reality gaming system uses a gameplay device to removably secure a mobile device. The gameplay device has at least one user interface and a wireless transceiver for communicating with the mobile device. An augmented reality gaming app stored in the memory of the mobile device utilizes an image sensor of the mobile device to display a live image on a screen of the mobile device, and causes graphics corresponding to one or more virtual targets to be overlaid on the live image. Using information from a location sensor and an orientation sensor of the mobile device, together with information about a virtual location of the virtual target, the mobile device determines whether a virtual shot triggered by the at least one user interface causes virtual damage to the virtual target.

Abstract: An upright vacuum cleaner (1) includes a brushroll assembly (100) having a brushroll casing (12) and a brushroll (11); a motor assembly (200) having a motor housing (21) and a motor (22); a body assembly (300) having a body (31) and a bridging member (32), in which the bridging member (32) is pivotally connected to the motor housing (21) to make the body (31) rotatable between an upright position and an oblique position; and an elastic assembly (4) provided between the brushroll casing (12) and the bridging member (32), and configured to be pressed downward against the brushroll casing (12) by the bridging member (32) when the body (31) rotates from the upright position to the oblique position.

Abstract: A floor brush assembly for an upright vacuum cleaner (1) and an upright vacuum cleaner (1) with the same are disclosed. The floor brush includes a brushroll (11); a motor (22) driving the brushroll (11) to roll via a drive belt (13) that is winded upon a motor shaft (221) of the motor (22) and a central part of the brushroll (11); and a brushroll casing (12) provided outside the brushroll (11), having a dust suction port and defining a brushroll air-suction channel (122) and a drive-belt mounting chamber (123) for mounting the drive belt, in which the brushroll air-suction channel (122) comprises a first air-suction channel (1221) and a second air-suction channel (1222) located at both sides of the drive-belt mounting chamber (123).

Abstract: A plurality of beacons that do not include any service set identifiers may be broadcast from an access point. A request concerning association with the access point may be sent wirelessly from a user device and received at the access point. A unique service set identifier (SSID) for the requesting user device may be generated, and information regarding the unique SSID may be transmitted to the requesting user device. A subsequent association request from the requesting user device may include the unique SSID.

Abstract: A clutch device for an upright vacuum cleaner and an upright vacuum cleaner having the same are provided. The clutch device is disposed between an electric motor assembly and a machine body assembly of the upright vacuum cleaner, the electric motor assembly includes an electric motor housing and an electric motor, the machine body assembly includes a machine body and a bridging member rotatably connected to the electric motor housing. The clutch device includes a slide chute; and a triggering member having a first end provided with a sliding column slidably fitted in the slide chute and a second end provided with a toggling rod configured to stir the electric motor to move. When the bridging member drives the slide chute to move, the sliding column slides along the slide chute to rotate the triggering member. When the triggering member rotates, the toggling rod stirs the electric motor to rotate.

Abstract: An augmented reality gaming system uses a gameplay device to removably secure a mobile device. The gameplay device has at least one user interface and a wireless transceiver for communicating with the mobile device. An augmented reality gaming app stored in the memory of the mobile device utilizes an image sensor of the mobile device to display a live image on a screen of the mobile device, and causes graphics corresponding to one or more virtual targets to be overlaid on the live image. Using information from a location sensor and an orientation sensor of the mobile device, together with information about a virtual location of the virtual target, the mobile device determines whether a virtual shot triggered by the at least one user interface causes virtual damage to the virtual target.

Abstract: An upright vacuum cleaner (1) is provided, including a brushroll assembly (100), a motor assembly (200) and a body assembly (300). The brushroll assembly (200) includes a brushroll casing (12) and a brushroll (11). The motor assembly (200) includes a motor housing (21) and a motor (22), and the motor (22) drives the brushroll (11) to roll via a drive belt (13). The body assembly (300) includes a body (31) and a bridging member (32) mounted to the body (31), and the bridging member (32) is pivotably connected with the motor housing (21) to allow the body (31) to be rotatable between an upright position and an oblique position. When the body (31) is rotated from the upright position to the oblique position, the bridging member (32) pushes the brushroll casing (12) to move in a direction running away from the motor housing (21) so as to tension the drive belt (13).

Abstract: An augmented reality gaming system uses a gameplay device to removably secure a mobile device. The gameplay device has at least one user interface and a wireless transceiver for communicating with the mobile device. An augmented reality gaming app stored in the memory of the mobile device utilizes an image sensor of the mobile device to display a live image on a screen of the mobile device, and causes graphics corresponding to one or more virtual targets to be overlaid on the live image. Using information from a location sensor and an orientation sensor of the mobile device, together with information about a virtual location of the virtual target, the mobile device determines whether a virtual shot triggered by the at least one user interface causes virtual damage to the virtual target.