Abstract: Described herein are methods and compositions for treatment of diabetes and/or obesity. Bitter oligopeptide molecules formulated for enteric delivery modulate signals involving receptors facing the lumen of the gastrointestinal tract, said signaling related hormones such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) that involve inhibition of gastric emptying and appetite. As a novel way to treat diabetes with limited adverse effects the described invention uses body's own endocrine system to treat diabetes, which is an advantage over current therapies that may simply provide disease management without cure or require more radical approaches such as surgical intervention.

Abstract: Embodiments described herein relate to methods of forming fibrous food products. In some aspects, a method can include mixing a composition with a solvent to form a first solution, the first solution including between about 5 wt % and about 20 wt % of the composition, the composition including a plant protein and a polysaccharide. The method further includes rotating the first solution to cause ejection of a second solution in a jet, collecting the jet of the second solution in a precipitation bath, such that a collection of fibers forms, drying the collection of fibers, and forming the collection of fibers into a fillet shape. In some embodiments, the method can further include heating or refrigerating the second solution to a temperature between about 0° C. and about 100° C. during the mixing and/or the rotating.

Abstract: Described herein are methods and compositions for treatment of diabetes and/or obesity. Bitter oligopeptide molecules formulated for enteric delivery modulate signals involving receptors facing the lumen of the gastrointestinal tract, said signaling related hormones such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) that involve inhibition of gastric emptying and appetite. As a novel way to treat diabetes with limited adverse effects the described invention uses body's own endocrine system to treat diabetes, which is an advantage over current therapies that may simply provide disease management without cure or require more radical approaches such as surgical intervention.

Abstract: A method of making a meat structured protein product includes combining a denatured plant protein and a polysaccharide in the presence of an aqueous solvent to provide a phase-separated mixture including a dispersed phase rich in polysaccharide and a continuous phase rich in the denatured plant protein. The method further includes forming fibrous structures of the polysaccharide in a protein matrix of the plant protein at a temperature of less than 100° C. The protein matrix can be crosslinked to provide the meat structured protein product. Meat structured protein products made by the method are also disclosed.

Abstract: A method of making a meat structured protein product includes combining a denatured plant protein and a polysaccharide in the presence of an aqueous solvent to provide a phase-separated mixture including a dispersed phase rich in polysaccharide and a continuous phase rich in the denatured plant protein. The method further includes forming fibrous structures of the polysaccharide in a protein matrix of the plant protein at a temperature of less than 100° C. The protein matrix can be crosslinked to provide the meat structured protein product. Meat structured protein products made by the method are also disclosed.

Abstract: Example embodiments of the present disclosure relate to a solution for ph-AFQMC with direct product multi-Slater determinants trial. Multiple active spaces of a molecular system may be obtained and multiple coefficient tensors may be determined respectively. A composite coefficient tensor may be determined based on a tensor product of the multiple coefficient tensors of the multiple active spaces, and a trial wave function may be further determined based on the composite coefficient tensor and a cutoff value. As such, the multiple coefficient tensors for the multiple active spaces may be determined, thus the computation can be reduced. Additionally, since a cutoff value is used, the composite coefficient tensor is a sparse tensor and the number of Slater determinants may be reduced. Further, the determined trial wave function may be further used in a ph-AFQMC algorithm, and a balance between accuracy and efficiency may be achieved.

Abstract: Embodiments described herein relate to methods of forming fibrous food products. In some aspects, a method can include mixing a composition with a solvent to form a first solution, the first solution including between about 15 wt % and about 40 wt % of the composition, the composition including a plant protein and a polysaccharide. The method further includes causing ejection of a second solution in a jet, collecting the jet of the second solution in a precipitation bath, such that a collection of fibers forms, drying the collection of fibers, and pulling apart the collection of fibers, and adding a fat and a flavoring to the collection of fibers to form the fibrous food product. In some embodiments, the method can further include heating the second solution to a temperature between about 40° C. and about 90° C. during the mixing and/or causing the ejection.

Abstract: A refrigerant control system includes: a charge module configured to determine an amount of refrigerant that is present within a first portion of a refrigeration system within a building; and an isolation module configured to selectively open and close an isolation valve of the refrigeration system and to, via the isolation valve, maintain the amount of refrigerant within the first portion within the building below a predetermined amount of the refrigerant.

Abstract: A refrigerant control system includes: a charge module configured to determine an amount of refrigerant that is present within a refrigeration system of a building; a leak module configured to diagnose that a leak is present in the refrigeration system based on the amount of refrigerant; and at least one module configured to take at least one remedial action in response to the diagnosis that the leak is present in the refrigeration system.

Abstract: A method of making a meat structured protein product includes combining a denatured plant protein and a polysaccharide in the presence of an aqueous solvent to provide a phase-separated mixture including a dispersed phase rich in polysaccharide and a continuous phase rich in the denatured plant protein. The method further includes forming fibrous structures of the polysaccharide in a protein matrix of the plant protein at a temperature of less than 100° C. The protein matrix can be crosslinked to provide the meat structured protein product. Meat structured protein products made by the method are also disclosed.

Abstract: An indoor air quality (IAQ) system for a building includes an IAQ sensor that is located within the building and that is configured to measure an IAQ parameter. The IAQ parameter is one of: an amount of particulate of at least a predetermined size present in air; an amount of volatile organic compounds (VOCs) present in air; and an amount of carbon dioxide present in air. A mitigation module is configured to: selectively turn on a mitigation device based on a comparison of the IAQ parameter with a first ON threshold and a second ON threshold; and selectively turn off the mitigation device based on a comparison of the IAQ parameter with an OFF threshold. A clean module is configured to determine a clean value for the IAQ parameter. A thresholds module is configured to, based on the clean value, determine the first ON threshold and the OFF threshold.

Abstract: An indoor air quality (IAQ) system for a building includes an IAQ sensor that is located within the building and that is configured to measure an IAQ parameter. The IAQ parameter is one of: an amount of particulate of at least a predetermined size present in air; an amount of volatile organic compounds (VOCs) present in air; and an amount of carbon dioxide present in air. A mitigation module is configured to: selectively turn on a mitigation device based on a comparison of the IAQ parameter with a first ON threshold and a second ON threshold; and selectively turn off the mitigation device based on a comparison of the IAQ parameter with an OFF threshold. A clean module is configured to determine a clean value for the IAQ parameter. A thresholds module is configured to, based on the clean value, determine the first ON threshold and the OFF threshold.

Abstract: The present invention relates generally to a method of reducing the level of at least one protein selected from the group consisting of plasminogen, tissue plasminogen activator and other protease(s) in a solution comprising at least one protein selected from the group consisting of fibrinogen, Factor VIII and von Willebrand factor (VWF), the method comprising: (i) passing a feedstock comprising at least one protein selected from the group consisting of fibrinogen, Factor VIII and VWF through a hydrophobic charge-induction chromatographic resin under conditions selected such that at least one protein selected from the group consisting of plasminogen, tissue plasminogen activator and other protease(s) present in the feedstock is bound to the resin; and (ii) recovering a solution comprising the at least one protein selected from the group consisting of fibrinogen, Factor VIII and VWF which passes through the resin, wherein the concentration of the at least one protein selected from the group consisting of pl

Abstract: Techniques for transmitting a response in a messaging application via a notification can include receiving, at a computing device having one or more processors, an electronic message via a messaging application. The technique can also include outputting, at the computing device, a notification of the electronic message via a system level notification function when the messaging application is executing in a background of the computing device. The notification can include an identifier of a sender of the electronic message, at least a portion of the electronic message, and one or more suggested responses to the electronic message. The technique can further include receiving a selection of a particular response of the one or more suggested responses via the notification, and transmitting, via the messaging application, the particular response for sending to the sender of the electronic message while the messaging application is executing in the background of the computing device.

Abstract: Implementations relate to automatic suggested responses based on message stickers provided in a messaging application. In some implementations, a computer-implemented method to provide message suggestions in a messaging application includes detecting a first message sent by a first user device to a second user device over a communication network, programmatically analyzing the first message to determine a semantic concept associated with the first message, identifying one or more message stickers based at least in part on the semantic concept, and transmitting instructions to cause the one or more message stickers to be displayed in a user interface displayed on the second user device.

Abstract: A refrigerant control system includes: a charge module configured to determine an amount of refrigerant that is present within a refrigeration system of a building; a leak module configured to diagnose that a leak is present in the refrigeration system based on the amount of refrigerant; and at least one module configured to take at least one remedial action in response to the diagnosis that the leak is present in the refrigeration system.

Abstract: A refrigerant control system includes: a charge module configured to determine an amount of refrigerant that is present within a first portion of a refrigeration system within a building; and an isolation module configured to selectively open and close an isolation valve of the refrigeration system and to, via the isolation valve, maintain the amount of refrigerant within the first portion within the building below a predetermined amount of the refrigerant.

Abstract: A refrigerant control system includes: a charge module configured to determine an amount of refrigerant that is present within a refrigeration system of a building; a leak module configured to diagnose that a leak is present in the refrigeration system based on the amount of refrigerant; and at least one module configured to take at least one remedial action in response to the diagnosis that the leak is present in the refrigeration system.

Abstract: The present invention relates generally to a method of reducing the level of at least one protein selected from the group consisting of plasminogen, tissue plasminogen activator and other protease(s) in a solution comprising at least one protein selected from the group consisting of fibrinogen, Factor VIII and von Willebrand factor (VWF), the method comprising: (i) passing a feedstock comprising at least one protein selected from the group consisting of fibrinogen, Factor VIII and VWF through a hydrophobic charge-induction chromatographic resin under conditions selected such that at least one protein selected from the group consisting of plasminogen, tissue plasminogen activator and other protease(s) present in the feedstock is bound to the resin; and (ii) recovering a solution comprising the at least one protein selected from the group consisting of fibrinogen, Factor VIII and VWF which passes through the resin, wherein the concentration of the at least one protein selected from the group consisting of pl

Abstract: Implementations relate to automatic suggested responses based on message stickers provided in a messaging application. In some implementations, a computer-implemented method to provide message suggestions in a messaging application includes detecting a first message sent by a first user device to a second user device over a communication network, programmatically analyzing the first message to determine a semantic concept associated with the first message, identifying one or more message stickers based at least in part on the semantic concept, and transmitting instructions to cause the one or more message stickers to be displayed in a user interface displayed on the second user device.