Abstract: In one aspect, the present disclosure relates to a method including obtaining, by a heart rate sensor of a fitness tracking device, a heart rate measurement of a user of the fitness tracking device; obtaining, by at least one motion sensor, motion data of the user; analyzing, by the fitness tracking device, the motion data of the user to estimate a step rate of the user; estimating, by the fitness tracking device, a load associated with a physical activity of the user by comparing the heart rate measurement with the step rate of the user; and estimating, by the fitness tracking device, an energy expenditure rate of the user using the load and at least one of the heart rate measurement and the step rate.

Abstract: A system and method for collecting motion data using a fitness tracking device located on an arm of a user, detecting that the arm is constrained based on the motion data, estimating a stride length of the user based on the motion data and historical step cadence-to-stride length data, calculating fitness data using the estimated stride length, and outputting the fitness data to the user.

Abstract: Systems, methods, and computer-readable media for managing or classifying movement states of an electronic device are provided that may utilize communications circuitry data from one or more communications circuitries when determining a current or future movement state of an electronic device.

Abstract: The present invention provides a triple-mode antibody display system that simultaneously matures, displays and secretes an antibody to a target of interest. An antibody in vivo-matured and complexed with membrane anchored bait can be expressed on the surface of the host cell, while complexed with a soluble bait the antibody is secreted from the host cell. Methods of using the system for identifying binders that bind specifically to an antigen of interest are also provided.

Abstract: An electronic device that provides situationally-aware alerts determines to provide an alert output (such as haptic, audio, visual, and so on) via an output device, determines a movement pattern based on one or more signals from one or more sensors indicating information relating at least to movement of the electronic device, and adjusts the alert output to account for the movement pattern. In some implementations, the electronic device may adjust the alert output by delaying the alert output. In other implementations, the electronic device may adjust the alert output by altering the alert output to be discernible despite the movement pattern based on a cadence of the movement pattern. In still other implementations, the electronic device may determine to provide the alert output in response to receiving an incoming communication and may adjust the alert output differently based on a priority associated with the incoming communication.

Abstract: A fitness tracking device configured to be worn by a user obtains a plurality of physical characteristics of the user including a first age and a sex of the user. The fitness tracking device maps each physical characteristic of the user to a corresponding index, wherein the first age of the user is mapped to a first age index of a first age range of a plurality of age ranges, and wherein the sex of the user is mapped to a first sex index. The fitness tracking device selects, from a memory of the fitness tracking device, a first calorimetry model of a plurality of calorimetry models, wherein the first calorimetry model is associated with each corresponding index, including the first age index and the first sex index of the user. The fitness tracking device estimates an energy expenditure rate using the first calorimetry model.

Abstract: An electronic device may include a motion sensor for detecting movement of the electronic device and a pressure sensor for detecting changes in elevation of the electronic device. Applications that run on the electronic device such as health and fitness applications may use motion sensor and pressure sensor data to track a user's physical activity. For example, processing circuitry in the electronic device may use the motion sensor to track a user's steps and the pressure sensor to track changes in the user's elevation. The processing circuitry may determine whether the user is climbing stairs based on the user's step rate and the user's changes in elevation. When the processing circuitry determines that the user is climbing stairs, the processing circuitry may use the pressure sensor and motion sensor to track and store the number of flights of stairs climbed by the user.

Abstract: The invention provides methods for treating fibrosis, chronic inflammation, chronic pancreatitis, cancer or inflammatory myofibroblastic tumors (IMTs) in a subject in need thereof. The methods include providing a composition comprising a Lyn inhibitor and administering an effective amount of the composition to the subject to treat fibrosis, chronic inflammation, chronic pancreatitis, cancer or inflammatory myofibroblastic tumors (IMTs). fibrosis, chronic inflammation, chronic pancreatitis, cancer or inflammatory myofibroblastic tumors (IMTs).

Abstract: The invention features oligofluorinated cross-linked polymers and their use in the manufacture of articles and coating surfaces.

Abstract: An electronic device that provides situationally-aware alerts determines to provide an alert output (such as haptic, audio, visual, and so on) via an output device, determines a movement pattern based on one or more signals from one or more sensors indicating information relating at least to movement of the electronic device, and adjusts the alert output to account for the movement pattern. In some implementations, the electronic device may adjust the alert output by delaying the alert output. In other implementations, the electronic device may adjust the alert output by altering the alert output to be discernible despite the movement pattern based on a cadence of the movement pattern. In still other implementations, the electronic device may determine to provide the alert output in response to receiving an incoming communication and may adjust the alert output differently based on a priority associated with the incoming communication.

Abstract: A calibration track to use for pedometer calibration can be automatically selected based on detecting sustained locomotion activity and an ability to obtain and maintain a reliable location fix over a calibration period. Calibration tracks can be generated, rated for quality, and used to compute calibration parameters to convert accelerometer data to stride length and/or distance traveled. Quality of a calibration can be assessed, and old and new calibration parameter sets can be combined based on quality weights assigned to each. Calibration parameters can be separately maintained for different locomotion activities and/or different on-body locations of the pedometers. Pedometer devices can also cooperatively calibrate each other.

Abstract: The invention provides an injectable composition and method for the minimally invasive, in-situ repair and regeneration of an injured ligament or tendon in a mammalian subject. The composition is also useful for the delivery of growth factors, therapeutic agents and cells into the area of tendon or ligament injury.

Abstract: Described herein are methods and compositions for treatment of diabetes and/or obesity. Bitter oligopeptide molecules formulated for enteric delivery modulate signals involving receptors facing the lumen of the gastrointestinal tract, said signaling related hormones such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) that involve inhibition of gastric emptying and appetite.

Abstract: A crankcase heating control system for a heat pump system includes a data receiving module and a power control module. The data receiving module is configured to receive: data indicative of a temperature of a compressor of the heat pump system; and data indicative of an ambient temperature. The power control module is configured to: selectively apply power to a heater of a crankcase of the compressor; and disable the heater when all of: a period since the compressor was last turned is greater than a predetermined period; the ambient temperature is less than a predetermined temperature; and the temperature of the compressor is less than the predetermined temperature.

Abstract: The invention provides an injectable composition and method for the minimally invasive, in-situ repair and regeneration of an injured ligament or tendon in a mammalian subject. The composition is also useful for the delivery of growth factors, therapeutic agents and cells into the area of tendon or ligament injury.

Abstract: Techniques for transmitting a response in a messaging application via a notification can include receiving, at a computing device having one or more processors, an electronic message via a messaging application. The technique can also include outputting, at the computing device, a notification of the electronic message via a system level notification function when the messaging application is executing in a background of the computing device. The notification can include an identifier of a sender of the electronic message, at least a portion of the electronic message, and one or more suggested responses to the electronic message. The technique can further include receiving a selection of a particular response of the one or more suggested responses via the notification, and transmitting, via the messaging application, the particular response for sending to the sender of the electronic message while the messaging application is executing in the background of the computing device.

Abstract: Implementations relate to automatic suggested responses based on message stickers provided in a messaging application. In some implementations, a computer-implemented method to provide message suggestions in a messaging application includes detecting a first message sent by a first user device to a second user device over a communication network, programmatically analyzing the first message to determine a semantic concept associated with the first message, identifying one or more message stickers based at least in part on the semantic concept, and transmitting instructions to cause the one or more message stickers to be displayed in a user interface displayed on the second user device.

Abstract: In one aspect, the present disclosure relates to a method including obtaining a plurality of heart rate measurements of the user over a period of time; obtaining motion data of the user over the period of time; analyzing the motion data of the user to determine for each of the plurality of heart rate measurements, a corresponding work rate measurement; determining, for each of the plurality of heart rate measurements, a first confidence level; determining, for each corresponding work rate measurement, a second confidence level; and estimating a first energy expenditure rate using the plurality of heart rate measurements; estimating a second energy expenditure rate using the plurality of work rate measurements; and estimating a weighted energy expenditure rate of the user by combining the first energy expenditure rate weighted by the first confidence level and the second energy expenditure rate weighted by the second confidence level.

Abstract: Provided are methods for treating a musculoskeletal tissue interface injury using decellularized, allogeneic or xenogeneic composite tissue bioscaffolds.

Abstract: Ear buds may have optical proximity sensors and accelerometers. Control circuitry may analyze output from the optical proximity sensors and the accelerometers to identify a current operational state for the ear buds. The control circuitry may also analyze the accelerometer output to identify tap input such as double taps made by a user on ear bud housings. Samples in the accelerometer output may be analyzed to determine whether the samples associated with a tap have been clipped. If the samples have been clipped, a curve may be fit to the samples. Optical sensor data may be analyzed in conjunction with potential tap input data from the accelerometer. If the optical sensor data is ordered, a tap input may be confirmed. If the optical sensor data is disordered, the control circuitry can conclude that accelerometer data corresponds to false tap input associated with unintentional contact with the housing.