Abstract: The present disclosure provides a catheter for treating lesions in a body lumen, such as calcified lesions and occlusions in vasculature. The catheter can include a dual-layer electrode assembly having a first conductive sheath and a second conductive sheath arranged circumferentially therearound. In some implementations, a first conductive sheath can be a flat coil. When a voltage is applied across the conductive sheaths, current flows across an arcing region, for example, from the distal side edge of the first sheath to the distal side edge of the second sheath to produce shock waves and/or cavitation bubbles. As a treatment continues, the sheaths slowly erode at the arcing region where current flows between the sheaths. To increase the lifespan of the electrode assembly, the distal side edges of the sheaths may be shaped to promote erosion of the sheaths in a predetermined or semi-controlled pattern.

Abstract: Systems and methods for delivering energy to passageways in a patient, such as airways in the lung of a patient for treating asthma. One embodiment of a method for delivering energy to a passageway comprises positioning an access device in a lung airway of a patient and advancing an elongated body of a treatment device along the access device until an energy delivery unit at a distal portion of the elongated body projects from the access device. The method can further include expanding the energy delivery unit such that energy delivery elements contact a sidewall of the airway and activating an energy supply coupled to the treatment device such that energy is delivered to the sidewall of the airway. A single person physically operates both the access device and the treatment device while expanding the energy delivery unit and activating the energy supply.

Abstract: Systems and methods for delivering energy to passageways in a patient, such as airways in the lung of a patient for treating asthma. One embodiment of a method for delivering energy to a passageway comprises positioning an access device in a lung airway of a patient and advancing an elongated body of a treatment device along the access device until an energy delivery unit at a distal portion of the elongated body projects from the access device. The method can further include expanding the energy delivery unit such that energy delivery elements contact a sidewall of the airway and activating an energy supply coupled to the treatment device such that energy is delivered to the sidewall of the airway. A single person physically operates both the access device and the treatment device while expanding the energy delivery unit and activating the energy supply.

Abstract: The present invention provides a catheter for treating occlusions in blood vessels. An exemplary catheter for treating occlusions in blood vessels comprises a tubular inner member including a base segment with a first lumen defining a fluid inlet port, and a second lumen defining a fluid outlet port. An extension segment is distal to the base segment. The extension segment has a reduced cross-section. An emitter assembly includes a first insulated wire extending through the second lumen and a second insulated wire, and a conductive sheath wrapped circumferentially around the first insulated wire, the second insulated wire, and the extension segment. A cap or balloon is sealably attached to the distal end of the catheter and surrounds the emitter assembly, said cap or balloon being fillable with conductive fluid.

Abstract: Provided herein are devices, systems, and methods for a three-dimensional registering, tracking, and/or guiding an object of interest, such a body part, a surgical tool, or an implant, during a surgical procedure. Such devices, systems, and methods may offer minimally invasive, high precision registering, tracking, and/or guiding of the object of interest using a patterned light beam and data processing using artificial intelligence. The methods, devices, and systems disclosed herein may be compatible with a simple marker or markers placed by a minimally invasive method on the object of interest.

Abstract: Methods and systems for aiding users in generating object pattern designs with increased speed. In particular, one or more embodiments train a sequence-based machine-learning model using training objects, each training object including a plurality of regions with a plurality of design elements. One or more embodiments identify a plurality regions of an object with a first region adjacent a second region. One or more embodiments receive a user selection of a design element for populating the first region with a first design element from a plurality of design elements. One or more embodiments identify a second design element from the plurality of design elements based on the first design element using the trained sequence-based machine-learning model. One or more embodiments also populate the second region with one or more instances of the second design element.

Abstract: Described herein are software and systems for analyzing videos and/or images. Software and systems described herein are configured in different embodiments to carry out different types of analyses. For example, in some embodiments, software and systems described herein are configured to locate an object of interest within a video and/or image.

Abstract: The present invention relates to variants of an alpha-amylase which have an increased exoamylase activity compared to the parent alpha-amylase. The present invention also relates to methods of making the variant alpha-amylase and the use of the variant alpha-amylase in baking, detergents, personal care products, in the processing of textiles, in pulp and paper processing, in the production of ethanol, lignocellulosic ethanol or syrups and as viscosity breaker in oilfield and mining industries.

Abstract: The present invention provides a system and method for treating tight, hard-to-cross calcified lesions in which an angioplasty balloon is used to dilate the lesions and provide shock waves to restore normal blood flow in a patient's artery. An exemplary device includes an elongated tube and a balloon wrapped circumferentially around the tube and sealed to a distal end of the tube. During treatment, the device is advanced into a patient's vasculature and the balloon is inflated with conductive fluid such that the balloon is fixed to walls of the vasculature proximal to the calcified lesion. The balloon includes at least one low-profile emitter positioned near the distal end of the balloon, which may be activated to generate shock waves to break loose calcifications in the lesion. After calcium in the tight lesion has been modified, the balloon can be deflated and advanced further into the lesion to continue treatment.

Abstract: The present invention provides a catheter for treating occlusions in blood vessels. The catheter includes at least one electrode pair positioned inside of a flexible angioplasty balloon at the distal end of the catheter. In some designs, the electrode pairs are arranged in a low-profile or coplanar configuration, reducing the diameter of the distal end of the device and permitting treatment of tight and hard-to-cross occlusions. The flexible angioplasty balloon has an extremely low profile and does need to be folded before insertion of the catheter into the cardiovascular system. During treatment, the balloon can be expanded a relatively small amount sufficient to immerse the electrode pairs in a conductive fluid before generating shock waves across the electrodes to treat the occlusion. The balloon can be made of material having elastomeric properties such that it returns to its original low profile configuration when it is deflated following treatment.

Abstract: Described herein are software and systems for analyzing videos and/or images. Software and systems described herein are configured in different embodiments to carry out different types of analyses. For example, in some embodiments, software and systems described herein are configured to locate an object of interest within a video and/or image.

Abstract: Described herein are software and systems for analyzing videos and/or images. Software and systems described herein are configured in different embodiments to carry out different types of analyses. For example, in some embodiments, software and systems described herein are configured to locate an object of interest within a video and/or image.

Abstract: Automatically generating a glossary of terms for a given document or group of documents is provided. A single document or a group of documents associated with a given project or event are parsed for one or more unique terms (e.g., words, acronyms, phrases, etc.). Identified terms are passed to a local or external definition source, and definitions for the one or more identified terms are retrieved. Retrieved definitions are presented to a user of the documents, and approved definitions are stored in a project store for subsequent use in association with the documents.

Abstract: In various embodiments, methods and systems for language scaling a natural language processing system (NLPS) are provided. A database schema of a database is accessed. The database schema includes entities that are defined in a query natural language different from an NLPS natural language upon which NLPS components are built. The entities are communicated to a machine translation service and top translations. A translated database schema model is generated based on the entities and translations. When a query associated with the query natural language and the database schema is received, a query translation is generated. The query translation comprises selectively translated portions of the query based on a selective translation mechanism that includes accessing the machine translation service to translate selected portions of the query. The selected portions are selected based on the translated database schema. The query translation is executed on the NLPS components to identify query results.

Abstract: Systems and methods for delivering energy to passageways in a patient, such as airways in the lung of a patient for treating asthma. One embodiment of a method for delivering energy to a passageway comprises positioning an access device in a lung airway of a patient and advancing an elongated body of a treatment device along the access device until an energy delivery unit at a distal portion of the elongated body projects from the access device. The method can further include expanding the energy delivery unit such that energy delivery elements contact a sidewall of the airway and activating an energy supply coupled to the treatment device such that energy is delivered to the sidewall of the airway. A single person physically operates both the access device and the treatment device while expanding the energy delivery unit and activating the energy supply.

Abstract: Systems and methods for delivering energy to passageways in a patient, such as airways in the lung of a patient for treating asthma. One embodiment of a method for delivering energy to a passageway comprises positioning an access device in a lung airway of a patient and advancing an elongated body of a treatment device along the access device until an energy delivery unit at a distal portion of the elongated body projects from the access device. The method can further include expanding the energy delivery unit such that energy delivery elements contact a sidewall of the airway and activating an energy supply coupled to the treatment device such that energy is delivered to the sidewall of the airway. A single person physically operates both the access device and the treatment device while expanding the energy delivery unit and activating the energy supply.

Abstract: A method for augmenting a threaded conversation between a first device and a second device. The method includes: receiving a selection of a selectable animation, via a selection of a selectable animation representation, at the first device, wherein the selectable animation is configured for augmenting the threaded conversation; and incorporating the selection of the selectable animation into the threaded conversation such that the selectable animation appears in a conversation view of the first device and the second device.

Abstract: Methods and systems for aiding users in generating object pattern designs with increased speed. In particular, one or more embodiments train a sequence-based machine-learning model using training objects, each training object including a plurality of regions with a plurality of design elements. One or more embodiments identify a plurality regions of an object with a first region adjacent a second region. One or more embodiments receive a user selection of a design element for populating the first region with a first design element from a plurality of design elements. One or more embodiments identify a second design element from the plurality of design elements based on the first design element using the trained sequence-based machine-learning model. One or more embodiments also populate the second region with one or more instances of the second design element.

Abstract: Tubing made of two or more polymers circumferentially arranged around the perimeter of the tubing in a single layer may be useful as medical tubing. Specifically, such tubing may be useful in catheters, sheaths, sheath introducers, implant delivery systems, and other medical devices having elongated tubular components. Selection of the two or more polymers based on the durometer and melting temperature permits optimization of axial strength and flexibility for particular applications. Such tubing may be extruded as a single layer tubing or a multi-layer tubing where the additional layers may be single material layers or more multi-polymer layers.

Abstract: In various embodiments, methods and systems for language scaling a natural language processing system (NLPS) are provided. A database schema of a database is accessed. The database schema includes entities that are defined in a query natural language different from an NLPS natural language upon which NLPS components are built. The entities are communicated to a machine translation service and top translations. A translated database schema model is generated based on the entities and translations. When a query associated with the query natural language and the database schema is received, a query translation is generated. The query translation comprises selectively translated portions of the query based on a selective translation mechanism that includes accessing the machine translation service to translate selected portions of the query. The selected portions are selected based on the translated database schema. The query translation is executed on the NLPS components to identify query results.