Abstract: A method of controlling a pumping stage of a fracturing fleet at a wellsite with a set of diesel pumps and at least one electric pump to reduce the total operating cost by decreasing the flowrate to the pump units with the higher operating cost and increasing the flowrate to the pump units with the lower operating costs. An optimization process on a computer system communicatively connected to the plurality of pumping units can communicate a first interim setpoint to each pumping unit. The optimization process can calculate an operating cost for the diesel frac pumps based on sensor measurements of pressure, flowrate, and motor speed. The optimization process can calculate an operating cost for the electric frac pumps based on the measured power usage and cost of the power. The optimization process can lower the operating cost of fracturing fleet below a threshold operating cost value.

Abstract: A method of controlling a pumping stage of a fracturing fleet at a wellsite with a set of diesel pumps and at least one electric pump to smooth the flowrate transition to an operational setpoint with a higher flowrate. An optimization process communicatively connected to the plurality of pumping units can iterate an interim setpoint with a transfer function model to each pumping unit. The transfer function model can generate a smooth flowrate transition by decreasing the flowrate of at least one pump unit while increasing the flowrate to the remaining pump units.

Abstract: Provided herein are methods for production of coffee intended to use a humic and or fulvic mineral blend in a thermally activated state for the enhanced detoxification of mycotoxins, other toxic and biologically detrimental compounds via their inclusion in a coffee beverage prior to and during the brewing process that additionally remineralizes the body via consumption. The nutritional compositions include humic and/or fulvic mineral blends and derivatives thereof delivered via coffee beans, grounds, capsules, bags, ampules, syringes, or K-Cups. Upon brewing, the mineral blends are solubilized and delivered into the aqueous base of the coffee and are ready for consumption.

Abstract: The present invention relates to additives and, more specifically, the use of biochar, in concrete and other cementitious materials to provide for building materials that have a lower carbon footprint than their traditional counterparts. Traditional methods for production of cement produce large amount of carbon dioxide (CO2). When coupled with the massive demand for cement building materials around the world, this means that the cement production has a significant impact on the amount of CO2 produced globally. By including biochar and other additives along with, or instead of some traditional components of cement, one may be able to provide for cementitious building materials that sequester carbon, rather than release it.

Abstract: The present invention seeks to reduce the burden of producing high-resolution tomograms by using an initial scan on a predetermined grid 10 to obtain a minimal set of images, and then regions of interest 20 are identified for further scanning. The further scanning locations 40 are determined by image entropy or gradient found in the previous iteration; such regions are indicative of edges, cracks or complex structure within the region. After each iteration, the level of information (e.g. image entropy or gradient) will decrease relative to the pixel/voxel size. In this way, a more efficient way to scan is achieved.

Abstract: A production system and method of operating the production system. A fluid flows through a flow control device. The flow control device having an element that generates an acoustic signal indicative of a value of a parameter of the fluid in response to the fluid flowing through the flow control device. The processor receives the acoustic signal from the element, determines the value of the parameter of the fluid from the parameter of the acoustic signal, and changes an operation of the production system based on the value of the parameter of the fluid.

Abstract: Disclosed herein is a method of determining dopamine concentration at a target location in neural tissue. In several embodiments, the method comprises measuring current level in response to square wave voltammetry with a coated electrode of a neural probe implanted at the target location, wherein the coated electrode comprises a coating of poly 3,4 ethylene dioxythiophene (PEDOT) doped with negatively charged carbon nanotubes (CNT), and comparing the measured current level to a control current level to determine the dopamine concentration at the target location.

Abstract: Provided herein are compositions and methods for the treatment or prevention of viral infections via the use of chemical substances administered in a combinatory fashion for the suppression, inhibition, and elimination of viral loads. These compositions and methods use a glycolysis inhibitor (e.g., 2-deoxy-D-glucose (2-DG)) in combination with one or more compounds comprising one or more aromatic rings and at least one alkylamino(C?12) group or substituted alkylamino(C?12) group.

Abstract: In some embodiments, a system and/or method may include a chemical composition which functions to promote hair growth and/or inhibits hair loss. The chemical composition may include a lipofullerene. The chemical composition may include activator. The activator may include a physiologically acceptable carrier. The lipofullerene may be applied to a subject separately from the activator. The lipofullerene may be applied to the subject first and the activator may be applied to the subject after in the same general area of the subject.

Abstract: A production system and method of operating the production system. A fluid flows through a flow control device. The flow control device having an element that generates an acoustic signal indicative of a value of a parameter of the fluid in response to the fluid flowing through the flow control device. The processor receives the acoustic signal from the element, determines the value of the parameter of the fluid from the parameter of the acoustic signal, and changes an operation of the production system based on the value of the parameter of the fluid.

Abstract: A method of controlling flow in a tubular including developing a pressure in the tubular with an electric submersible pump (ESP), directing a flow of fluid through a flow control device arranged on the tubular downhole of the ESP in response to the pressure, sensing a parameter of the flow of fluid, and adjusting, in real time, a flow parameter of the flow control device with a coil tubing in response to the parameter of the fluid.

Abstract: Downhole fiber optic interrogation systems are described. The systems include a fiber optic control system, a first sensing system, a second sensing system, an optical fiber disposed within a well, and an optical switch arranged between the optical fiber and the first and second sensing systems, wherein the fiber optic control system performs time division multiplex control of the optical switch wherein the first sensing system is operably connected to the optical fiber and the second sensing system is not connected to the optical fiber, and further controls the optical switch such that the second sensing system is operably connected to the optical fiber and the first sensing system is not connected to the optical fiber.

Abstract: A system and method to determine temperature include an optical fiber and at least two pulse laser sources to transmit light pulses with at least two wavelengths into the optical fiber. The system also includes an optical path length modulator to modulate the optical path length of the optical fiber as the light pulses are transmitted into the optical fiber. At least two photodetectors detect backscatter reflected in the optical fiber, and a processor determines the temperature based on the backscatter.

Abstract: Disclosed herein is a method of determining dopamine concentration at a target location in neural tissue. In several embodiments, the method comprises measuring current level in response to square wave voltammetry with a coated electrode of a neural probe implanted at the target location, wherein the coated electrode comprises a coating of poly 3,4 ethylene dioxythiophene (PEDOT) doped with negatively charged carbon nanotubes (CNT), and comparing the measured current level to a control current level to determine the dopamine concentration at the target location.

Abstract: Downhole fiber optic interrogation systems are described. The systems include a fiber optic control system, a first sensing system, a second sensing system, an optical fiber disposed within a well, and an optical switch arranged between the optical fiber and the first and second sensing systems, wherein the fiber optic control system performs time division multiplex control of the optical switch wherein the first sensing system is operably connected to the optical fiber and the second sensing system is not connected to the optical fiber, and further controls the optical switch such that the second sensing system is operably connected to the optical fiber and the first sensing system is not connected to the optical fiber.

Abstract: Disclosed herein are methods and compositions to improve the solubility of therapeutic agents. In one embodiment, a method of improving solubility of a therapeutic agent includes mixing fullerene in a lipid solution to form a lipofullerene mixture, and mixing the therapeutic agent with the lipofullerene mixture.

Abstract: A method of controlling flow in a tubular including developing a pressure in the tubular with an electric submersible pump (ESP), directing a flow of fluid through a flow control device arranged on the tubular downhole of the ESP in response to the pressure, sensing a parameter of the flow of fluid, and adjusting, in real time, a flow parameter of the flow control device with a coil tubing in response to the parameter of the fluid.

Abstract: A system and method to determine temperature include an optical fiber and at least two pulse laser sources to transmit light pulses with at least two wavelengths into the optical fiber. The system also includes an optical path length modulator to modulate the optical path length of the optical fiber as the light pulses are transmitted into the optical fiber. At least two photodetectors detect backscatter reflected in the optical fiber, and a processor determines the temperature based on the backscatter.

Abstract: In some embodiments, a lipofullerene-saccharide compound and a method of inhibiting and/or ameliorating metastasis of neoplastic cells using said compound is disclosed herein. The lipofullerene-saccharide compound may be used in therapeutically effective doses to inhibit the metastasis of neoplasms in mammals. In some embodiments, the method may include administering to a subject an effective amount of a pharmaceutically acceptable formulation including a lipofullerene-saccharide compound. In some embodiments, the lipofullerene-saccharide compound may be formed by reacting (e.g., coupling) a lipid and a saccharide with a fullerene. In some embodiments, neoplastic cells may include pancreatic cancer cells, prostate cancer cells, lung cancer cells, breast cancer cells, colon cancer cells, and/or brain cancer cells.

Abstract: A distributed temperature sensor and a method of determining temperature are described. The distributed temperature sensor includes an optical fiber to filter or remove Stokes Raman scatter and prevent stimulated Raman scatter and a light source to inject light into the optical fiber. The distributed temperature sensor also includes a photodetector to detect light energy resulting from the light injected into the optical fiber, the light energy including anti-Stokes Raman scatter and Rayleigh scatter; and a processor to determine temperature based on a ratio of the anti-Stokes Raman scatter and the Rayleigh scatter.