Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: An example method of implementing a layered feature set management model by a service monitoring system includes: monitoring a feature set configuration associated with a specified application instance; setting, based on the feature set configuration, a feature set level transition marker associated with the specified application instance; identifying, based on a current feature set level associated with the specified application instance and the feature set level transition marker, a new feature set level associated with the specified application instance; identifying a new feature set corresponding to the new feature set level and one or more roles associated with a specified user; and configuring a graphical user interface (GUI) enabling the new feature set for the specified user of the specified application instance.

Abstract: Systems, methods, apparatuses and devices provide an integrated display module or apparatus including a Liquid crystal assembly with highly integrated components including display driver circuitry and backplane circuitry. These approaches provide for packaging of displays with small form-factor displays and microdisplays and, in aspects, for usage in virtual and augmented reality devices.

Abstract: A constant lead barrel tool that may be reground multiple times.

Abstract: A method of clamping a voltage includes providing a fin-based field effect transistor (FinFET) device. The FinFET device includes an array of FinFETs. Each FinFET includes a source contact electrically coupled to a fin and a gate contact. The method also includes applying the voltage to the source contact and applying a second voltage to the gate contact. The voltage is greater than the second voltage. The method further includes increasing the voltage to a threshold voltage and conducting current from the source contact to the gate contact in response to the voltage reaching the threshold voltage.

Abstract: A diagnostic device includes a probe, a motor configured to scan the probe over a test circuit, a superconducting quantum interference device (SQUID) attached to the probe and configured to be coupled to the test circuit such that an electronic noise present in the test circuit induces a first current that flows through the SQUID, and a current path configured to receive a second current that flows through the SQUID. The SQUID is configured to generate an output in a form of a first voltage in response to a sum of the first current and the second current being less than a threshold current, and a second voltage in response to the sum of the first current and the second current being greater than the threshold current.

Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Abstract: The present invention relates to the real-time simulation of sound in three-dimensional virtual environments. In particular, a geometric method based on the principles of acoustic radiosity determines the room impulse responses of a virtual environment with arbitrary polygonal surfaces. The complexity of the method is of the order of the square of the number of patches that define the virtual environment. The room impulse responses are convolved with an audio signal and output through a speaker to simulate reverberation within the virtual environment, which corresponds to a physical environment.

Abstract: The present disclosure provides protection to communications after establishing a secured connection to a secured website or application. An authentication service, after establishing a secured session, can calculate a trust score for a user. Based on the trust score, the security agent can encrypt access tokens used to authenticate a secure connection. The system can interrupt the secure connection based on the trust score of the user or the user device. The interruption takes place by ignoring requests to decrypt the access token. Without the decrypted access token, the browser is unable to authenticate the session, preventing further communications. After the user improves the security posture of the device or user, the security agent can recalculate the trust score. When the trust score is above a threshold, the security agent can being decrypting the access token, thereby authenticating communications from the browser.

Abstract: Disclosed is a method of synchronising an image sensor with a PWM driver operable to drive an arrangement associated with the image sensor, wherein at least one synchronisation signal produced by the image sensor is used to reset the PWM driver and the at least one synchronisation signal is delayed before being used to reset the PWM driver such that the switching on or off of the at least one synchronisation signal occurs at a defined time in relation to a sensitive period of the image sensor's operation.

Abstract: An example method of content pack management by a service monitoring system includes: receiving a plurality of object identifiers, each object identifier referencing a corresponding object installed in an instance of a service monitoring system; performing a partial backup of the instance of a service monitoring system, wherein the partial backup comprises a plurality of objects referenced by the plurality of object identifiers; converting the partial backup into a plurality of object definitions in a predefined format; and packaging the plurality of object definitions into a content pack.

Abstract: An example method of entity lifecycle management in a service monitoring system includes: receiving, by a software application of a service monitoring system, a policy definition specifying an entity lifecycle management policy, wherein the entity lifecycle management policy defines management rules for a plurality of entities in a network environment, wherein each entity of the plurality of entities is represented by one of: a device, an application, a service, or a user account; identifying, by applying the entity lifecycle management policy, one or more candidate entities for retirement; identifying, as retired entities, at least a subset of the one or more candidate entities; and excluding the retired entities from a plurality of active entities, thus preventing the retired entities from interacting with other components of the service monitoring system; and determining a value of a key performance indicator (KPI) reflecting an aspect of performance of the service, wherein the KPI is defined by a search q

Abstract: Devices and methods for generating an aerosol of a therapeutic agent and methods of using and preparing the same are disclosed. The device includes a heatable porous substrate (e.g., a porous metal or metal alloy) embedded with a composition containing a vaporizable carrier compound (e.g., a phospholipid) and at least one therapeutic agent. The device can be incorporated into a delivery device, such as a metered dose inhaler or an exposure chamber. When the heatable porous substrate is heated, such as by resistive heating, the carrier compound is vaporized and both it and the at least one therapeutic agent are carried out of the porous substrate and, upon cooling, form aerosol particles comprising the at least one therapeutic agent.

Abstract: Composite assemblies are described that include composite spars that are co-cured with one or more sacrificial members on their flanges, forming an integrated sacrificial surface for the composite spars. In one embodiment, the composite assembly includes a composite spar having a web and flanges that project from sides of the web. The composite assembly further includes a sacrificial member of composite materials co-cured with the composite spar on an outer surface of at least one of the flanges. In addition, the sacrificial member has an outer surface that has been machined into conformance with an inner surface of at least one skin panel for an aircraft structure to form a contact surface with the at least one skin panel.

Abstract: Visible light disinfection is a healthcare technology wherein violet light is used to inactivate pathogens such as bacteria, fungi, and viruses. The present invention overcomes the limitations of continuous irradiance in whole-room environments by pulse width modulation of the light sources and increasing the instantaneous irradiance while maintaining average irradiance and hence light power requirements. The invention further discloses the use of multispectral light sources wherein the pulse modulation frequencies are synchronized and the phase of the spectral components are offset in order to maximize synergistic or antagonistic responses to intracellular chromophore excitation.

Abstract: A slot milling sequence includes a plurality of material removal processes or operations. Each of the material removal operations includes utilization of an end mill tool. Some of the material removal operations utilize trochoidal tool paths, whereas other material removal processes utilize one or more profile cuts. Some material removal operations that utilize profile cuts remove material from both sides of the cut in a single pass, whereas other material removal operations remove material from one side of the cut via a first pass of the end mill tool and remove material from the opposing side of the cut via a second pass of the end mill tool.

Abstract: Visible light disinfection is a healthcare technology wherein violet light is used to inactivate pathogens such as bacteria, fungi, and viruses. The present invention overcomes the limitations of continuous irradiance in whole-room environments by pulse width modulation of the light sources and increasing the instantaneous irradiance while maintaining average irradiance and hence light power requirements. The invention further discloses the use of multispectral light sources wherein the pulse modulation frequencies are synchronized and the phase of the spectral components are offset in order to maximize synergistic or antagonistic responses to intracellular chromophore excitation.

Abstract: A method includes selecting, from content packs in a centralized content management system, a content pack to update in a data intake and query system. The content pack includes utility objects. For each utility object of at least a subset of the utility objects determining whether the utility object already exists in the data intake and query system, and loading the utility object to the data intake and query system when the utility object does not exist to obtain an updated utility object. The method further includes monitoring, by the data intake and query system, an endpoint of an endpoint type using the updated utility object.