Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of RIP2 kinase, including degrading RIP2 kinase, the treatment of diseases and conditions mediated by the RIP2 kinase, in particular for the treatment of inflammatory diseases or conditions.

Abstract: A conductor lifter adapted to be mounted to a tower for temporarily supporting an energized conductor comprises a support arm having a base end and an opposite cantilevered end and a crank arm pivotally mounted on the cantilevered end, the crank arm having lower and upper crank arms. A first actuator is coupled to the support arm, and an elongate member is mounted to, so as to extend between, the upper crank arm and a first driver of the first actuator so as to rotate the crank arm about the pivotal coupling when the first actuator is actuated. A lower end of the lower crank arm is selectively elevatable by a second actuator relative to the upper crank arm so as to elevate a conductor when held by a conductor retainer on an insulator mounted to the lower crank arm. A method for using the conductor lifter is also provided.

Abstract: A selective IAP binder together with a linker moiety.

Abstract: A miniature camera having an image sensor; an actuator which includes conductive components capable of conducting a pulse width modulation drive signal for driving the actuator; and a screening component located between the conductive components of the actuator and the image sensor, the screening component being electrically isolated from the actuator.

Abstract: An electrical isolator includes a flexible non-electrically conductive membrane and an inelastic flexible dielectric member journalled in the membrane and extending from the first end of the membrane to the second end of the membrane. First and second couplings are mounted to the ends of the dielectric member. The ends of the membrane are mated in sealed engagement with the couplings so as to fluidically seal the ends of the membrane and the dielectric member within the membrane. The membrane is filled with a dielectric fluid so as to displace any air in the membrane and the dielectric member. The couplings are adapted to couple to objects at opposite ends of the electrical isolator.

Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of RIP2 kinase, including degrading RIP2 kinase, the treatment of diseases and conditions mediated by the RIP2 kinase, in particular for the treatment of inflammatory diseases or conditions.

Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of RIP2 kinase, including degrading RIP2 kinase, the treatment of diseases and conditions mediated by the RIP2 kinase, in particular for the treatment of inflammatory diseases or conditions.

Abstract: A dense array of sensors positioned in a virtual environment is reduced to a sparse array of sensors in a physical environment, which provides sufficient information to a controller that responds to environmental conditions and parameters in the physical environment in substantially the same manner as it would to the same environmental conditions and parameters in the equivalent virtual environment. Data from a sparse array of virtual sensors is correlated with data from a dense array of virtual sensors and is used for generating control signals for hardware devices that influence a real or virtual interior environment. The correlated data and the control signals are used to train an artificial intelligence based controller that then controls the values of the parameters of the interior environment. A model of the interior environment is created using basic parameters in a computer-aided design application.

Abstract: An apparatus for providing an autonomous fire extinguishing system including a tank filled with an extinguishing agent with a targeting system with independently mounted targeting servos and targeting gimbal to position an emitter and an infra-red camera. A microcontroller provides control signals to the targeting servos and an actuation valve. One or more heat sensors, smoke detectors, humidity sensors, and/or carbon monoxide detectors are electrically connected to the microcontroller; and the microcontroller continuously reads in the sensor data till appropriate conditions indicating a potential fire are detected; these appropriate can be based on temperature, rate of temperate increase, smoke levels, humidity, and/or carbon monoxide levels. Once the appropriate conditions are detecting, the microcontroller commands the targeting gimbal to position the infra-red camera to a number of calculated positions, taking infra-red pictures covering the environment requiring protection.

Abstract: A mobile bridge module includes a reinforcement applied in a non-destructive manner. This might alternatively and/or additionally be defined as a non-destructively reinforced mobile bridge module.

Abstract: A mobile bridge apparatus includes one or more mobile bridge modules and a plurality of sensors for sensing a deformation of the one or more mobile bridge modules.

Abstract: Experiments are used to optimize web pages. The effectiveness of these optimizations depends heavily on the analytics provided by the experimental analysis system. This invention is a new type of experimental analysis system that provides the user with sequentially valid analytics focused on the key performance indicators of interest such as % improvement and avoids multiple comparison problems through multivariate testing procedures.

Abstract: New methodologies related to experimentation and optimization include using historical data from past experiments, important distributional parameters are estimated, allowing the display of vastly more accurate analytics. Scalability to big data systems is implemented via a limited information likelihood approximation. One example application includes performing online experiments including testing website preferences of visitors.

Abstract: A compound of formula (I): or a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions mediated by the estrogen receptor.

Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of RIP2 kinase, including degrading RIP2 kinase, the treatment of diseases and conditions mediated by the RIP2 kinase, in particular for the treatment of inflammatory diseases or conditions.

Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of RIP2 kinase, including degrading RIP2 kinase, the treatment of diseases and conditions mediated by the RIP2 kinase, in particular for the treatment of inflammatory diseases or conditions.

Abstract: The present invention relates to a skin radiation apparatus and method. The apparatus includes a photon radiation unit for generating a line-shaped radiation pattern that extends in a first direction; a movement facility for moving the line shaped radiation pattern in a second direction transverse to the first direction; a detection unit for detecting a skin condition profile; and a control unit for controlling the line-shaped radiation pattern, dependent on the detected skin condition profile.

Abstract: According to a first aspect of the invention, there is provided a mobile bridge apparatus, comprising: one or more mobile bridge modules; and a plurality of sensors for sensing a deformation of the one or more mobile bridge modules.