Abstract: The instant disclosure relates to nucleic acid-lipid particles having 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), which preferentially localize and deliver associated cargoes to the lung and various lung tissues, as well as to tissues to which such particles are directly injected. The instant disclosure provides compositions comprising such lipid particles, optionally in association with a therapeutic agent (e.g., a therapeutic mRNA and/or nucleic acid controller system), as well as methods and kits for delivering a lipid particle-associated therapeutic agent and/or treating a disease or disorder, e.g., a lung disease or disorder, in a subject, using the lipid particle compositions provided herein.

Abstract: Example methods, apparatus, systems and articles of manufacture (e.g., physical storage media) to implement contextual key management for data encryption are disclosed. Example apparatus disclosed are to determine whether a key mapping is associated with a combination of two or more context rules defined for a set of context values associated with input data to be encrypted. Disclosed example apparatus are also to, in response to a determination that no key mapping is associated with the combination of two or more context rules, map a key identifier to the combination of two or more context rules and generate a key corresponding to the key identifier. Disclosed example apparatus are further to encrypt the input data based on the key to obtain encrypted data.

Abstract: A chainsaw chain includes a plurality of drive links, a plurality of cutters, and a plurality of rivets. Each drive link includes a drive link body, a rivet hole extending through the drive link body, and a tang configured to engage a drive element of a chainsaw. Each cutter includes a cutter body having a rivet hole extending therethrough, a cutting tooth coupled to an upper portion of the cutter body, a carbide cutting tip coupled to the cutting tooth, a feed limiter coupled to the upper portion of the cutter body and spaced from the cutting tooth, and a gullet defined between the cutting tooth and the feed limiter. The plurality of rivets is received within corresponding rivet holes of the plurality of drive links and the plurality of cutters, to couple the plurality of drive links and the plurality of cutters together.

Abstract: A chainsaw chain includes a plurality of drive links, a plurality of cutters, and a plurality of rivets. Each drive link includes a drive link body, a pair of rivet holes extending through the drive link body, and a tang extending from the drive link body and configured to engage a drive element of a chainsaw. Each cutter includes a cutter body having a pair of rivet holes extending therethrough, a cutting tooth coupled to an upper portion of the cutter body, a feed limiter, and a gullet. The cutter body defines a longitudinal axis extending through the pair of rivet holes and a vertical axis oriented perpendicular to the longitudinal axis. The cutting tooth is set relative to the vertical axis. The plurality of rivets couples the plurality of drive links and the plurality of cutters together.

Abstract: One aspect of the invention provides a method of separating long polynucleotides from a composition. The method includes: introducing a composition including one or more long polynucleotides into a container including at least one boundary defined by a filter comprising a plurality of pores, wherein the pores have a smaller cross-sectional dimension than specified for the long polynucleotide's molecular weight; and applying elevated hydraulic pressure to the composition, thereby causing at least some of the one or more long polynucleotides to pass through the pores.

Abstract: The present invention relates to methods for the detection of an analyte, such as coronavirus (e.g. SARS-CoV-2) or other virus particles and proteins, in a test sample. The invention also provides a flow device for use in such methods. Additionally, there is provided a coronavirus-binding reagent having the structure [sialic acid]-[linker]-[polymer]-[gold nanoparticle] for use in the devices and methods of the invention.

Abstract: A method of making a contact lens comprising the steps of reacting in a mold a polymerizable formulation comprising at least one fluorine-containing silicone monomer at least one non-fluorine-containing silicone monomer and at least one hydrophilic monomer to form a contact lens, subjecting the contact lens to one or more solvent extraction steps to remove impurities, oligomers and unreacted monomers and hydrate the contact lens, wherein all of the solvent extraction steps are undertaken using an aqueous solvent.

Abstract: A method of making a contact lens comprising the steps of reacting in a mould a polymerisable formulation comprising at least one fluorine-containing silicone monomer at least one non-fluorine-containing silicone monomer and at least one hydrophilic monomer to form a contact lens, subjecting the contact lens to one or more solvent extraction steps to remove impurities, oligomers and unreacted monomers and hydrate the contact lens, wherein all of the solvent extraction steps are undertaken using an aqueous solvent.

Abstract: A method of making a contact lens comprising the steps of reacting in a mold a polymerizable formulation comprising at least one fluorine-containing silicone monomer at least one non-fluorine-containing silicone monomer and at least one hydrophilic monomer to form a contact lens, subjecting the contact lens to one or more solvent extraction steps to remove impurities, oligomers and unreacted monomers and hydrate the contact lens, wherein all of the solvent extraction steps are undertaken using an aqueous solvent.

Abstract: The invention provides a method of preventing or reducing the growth of crystals in a substance which is susceptible to crystal growth in which colloidal particles having an amphiphilic structure, e.g. Janus particles, are contacted with the substance. Colloidal particles suitable for use in the invention include cross-linked, colloidal materials formed from hydrophobic monomers such as acrylates or methacrylates and hydrophilic monomers such as those derived from acrylic and/or methacrylic acid. The colloidal particles find particular use in methods of cryopreservation of biological samples (e.g. cells, tissues or organs), as a texture modifier in frozen food products, in the inhibition of gas hydrate formation, and as scale inhibitors.

Abstract: A method of making a contact lens comprising the steps of reacting in a mould a polymerisable formulation comprising at least one fluorine-containing silicone monomer at least one non-fluorine-containing silicone monomer and at least one hydrophilic monomer to form a contact lens, subjecting the contact lens to one or more solvent extraction steps to remove impurities, oligomers and unreacted monomers and hydrate the contact lens, wherein all of the solvent extraction steps are undertaken using an aqueous solvent.

Abstract: A vehicle has a vehicle body and a vehicle bonnet assembly. The vehicle bonnet assembly includes a bonnet 14 hinged at its front to the vehicle body 10 and latched at its rear by two latch devices. Each latch device comprises a latch assembly 17 mounted to the vehicle body 10 and a striker 21 mounted to the bonnet 14. Impact sensors are configured to detect a front collision with a pedestrian and two lift actuators 18 are arranged to raise the rear edge of the bonnet 14 into a deployed position in response to a pedestrian impact. Each latch assembly 17 includes a latch claw 26 moveable between a latch position in which the striker 21 is held by the latch claw 26 and a release position in which the striker 21 is releasable from the latch claw 26. Each latch assembly 17 also includes a release member 27 which is operable by a driver of the vehicle to allow the latch claw 26 to be moved towards its release position and allow the bonnet 14 to be lifted.

Abstract: A vehicle has a vehicle body and a vehicle bonnet assembly. The vehicle bonnet assembly includes a bonnet 14 hinged at its front to the vehicle body 10 and latched at its rear by two latch devices. Each latch device comprises a latch assembly 17 mounted to the vehicle body 10 and a striker 21 mounted to the bonnet 14. Impact sensors are configured to detect a front collision with a pedestrian and two lift actuators 18 are arranged to raise the rear edge of the bonnet 14 into a deployed position in response to a pedestrian impact. Each latch assembly 17 includes a latch claw 26 moveable between a latch position in which the striker 21 is held by the latch claw 26 and a release position in which the striker 21 is releasable from the latch claw 26. Each latch assembly 17 also includes a release member 27 which is operable by a driver of the vehicle to allow the latch claw 26 to be moved towards its release position and allow the bonnet 14 to be lifted.

Abstract: The prosthesis device can have a pair of articular members adapted to be mounted onto adjoining bones, respectively, to replace a joint. The first and second articular members can have first and second bearing elements, respectively. The bearing elements can be formed to be capable of replacing at least a portion of the bone ends of the adjoining bones, respectively, and providing an articulation close to that of a natural joint. The bearing elements can be fixed to the respective bones through an initial implant fixation achieved by press-fit anchoring immediately after surgery and/or a secondary implant fixation established from bone-ingrowth.

Abstract: A method (500) of generating a matching key (599) for an image (501) is disclosed. The matching key (599) is substantially invariant to rotation, scale and translation. The method (500) starts by forming a spatial domain representation of the image (501) that is substantially invariant to translation of the image (501). Rotation and/or scaling in the spatial domain representation is next transformed (580) into translation to form a transformed image. A representation of the transformed image is then formed that is substantially invariant to translation of the transformed image. The representation of the transformed image is the matching key (599) for the image (501).

Abstract: The prosthesis device can have a pair of articular members adapted to be mounted onto adjoining bones, respectively, to replace a joint. The first and second articular members can have first and second bearing elements, respectively. The bearing elements can be formed to be capable of replacing at least a portion of the bone ends of the adjoining bones, respectively, and providing an articulation close to that of a natural joint. The bearing elements can be fixed to the respective bones through an initial implant fixation achieved by press-fit anchoring immediately after surgery and/or a secondary implant fixation established from bone-ingrowth.

Abstract: A graphics processor performs graphical operations on graphical objects represented in an external data format. The graphics processor includes a setup unit, first and second mapping units, and a calculator. The setup unit sets up one or more registers reflecting a current instruction. The first mapping unit maps, responsive to the current instruction, the external data format to at least one corresponding internal data format selected from a set of internal data formats. The calculator performs graphical operations on the graphical objects when in one of the selected internal data formats. The second mapping unit maps, responsive to the current instruction, each internal data format in the set of internal data formats to the external data format after the graphical operations have been performed.

Abstract: The present invention discloses apparatus for, and a method of, rendering image data prior to outputting of the resulting image. A graphics co-processor (224) is utilized together with a host CPU (202), the former having a plurality of data calculation streams (241, 242, 243) arranged in parallel fashion. Only one of the data calculation streams (241, 242, 243) is operated at any one time. Preferably at least one (242) of the data calculation streams is able to be reconfigured.

Abstract: Apparatus for supplying multiple, separately addressed data items from a data table in external memory. The apparatus comprises a cache memory (230) having n separately addressable memories banks organised as m cache-lines and n programmable address generators (1881) each coupled to a corresponding one of said n memory banks. The generators (1881) using an index to generate multiple addresses to simultaneously retrieve multiple data items from the memory banks. A data organizer (1892) positions the retrieved data in an output packet.

Abstract: A graphics processor includes a plurality of interrelated functional modules and at least one register associated with each of the functional modules. The plurality of interrelated functional modules are interconnected by a data pipeline for conveying data, and each register is configured to control a function of its associated functional module. The graphics processor also includes a control bus interconnecting each of the registers for conveying instructions, and an instruction controller for decoding instructions for use with the graphics processor. The control bus and the data pipeline are physically separate, and the instruction controller includes a register setting unit adapted to set the registers via the control bus in accordance with a decoded instruction. This enables the function of each of the functional modules to be configured in response to each instruction.