Patents by Inventor Ian L. Scott

Ian L. Scott has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Propanoic acid derivatives that inhibit the binding of integrins to their receptors
    Publication number: 20030199692
    Abstract: A method for the inhibition of the binding of &agr;4&bgr;1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which &agr;4&bgr;1 is involved.
    Type: Application
    Filed: October 9, 2001
    Publication date: October 23, 2003
    Inventors: Ronald J. Biediger, Brian Dupre, Linda K. Hamaker, George W. Holland, Jamal M. Kassir, Wen Li, Robert V. Market, Noel Nguyen, Ian L. Scott, Chengde Wu, E. Radford Decker
  • Compounds that inhibit the binding of integrins to their receptors
    Patent number: 6262084
    Abstract: A method for the inhibition of the binding of &agr;4&bgr;1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions thereof; and the use of the compounds either as above, or in formulations for the control or prevention of diseases states in which &agr;4&bgr;1 is involved.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: July 17, 2001
    Assignee: Texas Biotechnology Corporation
    Inventors: Ronald J. Biediger, Vanessa O. Grabbe, George W. Holland, Jamal Kassir, Karin M. Keller, Timothy P. Kogan, Shuqun Lin, Robert V. Market, Bore G. Raju, Ian L. Scott, Chengde Wu
  • N, N-disubstituted amides that inhibit the binding of integrins to their receptors
    Patent number: 6194448
    Abstract: A method for the inhibition of the binding of &agr;4&bgr;1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which &agr;4&bgr;1 is involved.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: February 27, 2001
    Assignee: Texas Biotechnology Corporation
    Inventors: Ronald J. Biediger, Vanessa O. Grabbe, George W. Holland, Jamal M. Kassir, Timothy P. Kogan, Shuqun Lin, Robert V. Market, Bore G. Raju, Ian L. Scott, Chengde Wu
  • Compounds that inhibit the binding of integrins to their receptors
    Patent number: 6096773
    Abstract: A method for the inhibition of the binding of .alpha..sub.4 .beta..sub.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which .alpha..sub.4 .beta..sub.1 is involved.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: August 1, 2000
    Assignee: Texas Biotechnology Corporation, Inc.
    Inventors: Ian L. Scott, Bore G. Raju, Ronald J. Biediger, Vanessa O. Grabbe, Jamal Kassir, Karin M. Keller, Timothy P. Kogan, deceased, Shuqun Lin, Robert V. Market
  • Di- and trivalent small molecule selectin inhibitors
    Patent number: 5919768
    Abstract: The present invention provides compounds having structure (II), and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof.
    Type: Grant
    Filed: February 11, 1998
    Date of Patent: July 6, 1999
    Assignee: Texas Biotechnology Corporation
    Inventors: Timothy P. Kogan, Brian Dupre, Ian L. Scott, Huong Bui, Kathy L. Wheeler, Karin M. Keller, Jamal M. Kassir
  • High yield stereospecific mannosylation
    Patent number: 5712387
    Abstract: A process of preparing mannosylated alcohols or phenols in high chemical yield and purity using tetra-O-pivaloylmannosylfluoride and a Lewis acid catalyst.
    Type: Grant
    Filed: May 20, 1996
    Date of Patent: January 27, 1998
    Assignee: Texas Biotechnology Corporation
    Inventors: Ian L. Scott, Timothy P. Kogan, Harold Meckler
  • Binding of E-selectin or P-selectin to sialyl Lewis.sup.x or sialyl-Lewis.sup.a
    Patent number: 5444050
    Abstract: This invention relates to compounds that inhibit the binding of E-selectin and/or P-selectin to sialyl-Lewis.sup.x or sialyl-Lewis.sup.a presented on a cell surface having the general structure ##STR1## wherein X is selected from the group consisting of --(CH.sub.2).sub.n CO.sub.2 H, --O(CH.sub.2).sub.m CO.sub.2 H, --(CH.sub.2).sub.n O(CH.sub.2).sub.m CO.sub.2 H, --CONH(CH.sub.2).sub.m CO.sub.2 H, --CH(OZ)(CO.sub.2 H), --CH(Z)(CO.sub.2 H), --(CH.sub.2).sub.n SO.sub.3 H, --(CH.sub.2).sub.n PO.sub.3 D.sub.1 D.sub.2, --NH(CH.sub.2).sub.m CO.sub.2 H, --CONH(CHR.sub.6)CO.sub.2 H, (1-H-tetrazolyl-5-alkyl-), and --OH;R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, alkyl, halogen, --OZ, --NO.sub.2, --NH.sub.2 and --NHZ;R.sub.3 is selected from the group consisting of hydrogen, halogen, alkyl, --OZ and --NHZ;R.sub.4 is selected from the group consisting of hydrogen, halogen, alkyl, hydroxyl, hydroxyl-O-sulfate and --OZ;R.sub.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: August 22, 1995
    Assignee: Texas Biotechnology Corporation
    Inventors: Timothy P. Kogan, Brian Dupre, Ian L. Scott, Karin Keller, Huong Dao, Pamela J. Beck