Abstract: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.

Abstract: An alert device for a vehicle including a communications receiver for receiving file fragments for the device, a positioning data receiver for providing vehicle location data, a microcontroller system including a microcontroller and a programmable non-volatile memory system, for building and storing application and data files from the fragments, and executing an alert application of the device by processing at least one application file and associated data identified by configuration instructions included in at least one of the fragments to provide alert data for the vehicle corresponding to the location of the vehicle determined by the application on the basis of the vehicle location data.

Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.

Abstract: A process for producing an electrode which comprises forming an electrode precursor comprising a layer comprising an intercalation material, and then applying stabilised lithium metal particles to the surface of the electrode precursor.

Abstract: The present invention provides methods and apparatus for expanding a first, smaller diameter tubular into frictional contact with a second, larger diameter tubular or wellbore. In an embodiment, annular formations formed on an inner surface of a split ring engage an outer surface of the smaller tubular. In one aspect, the smaller diameter tubular is provided with an annular recess there around, the annular recess including recessed grooves formed there around. Therefore, the split ring is disposable within the annular recess and the annular formations formed on the split ring are constructed and arranged to fit within the recessed grooves of the annular recess of the tubular. An outer surface of the split ring is provided with teeth or some other grip-enhancing material or formation. The split ring also includes a split portion permitting the ring to expand in diameter as that portion of the tubular is expanded in diameter.

Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.

Abstract: In accordance with the present invention, there are provided methods of modulating the activity of excitatory amino acid receptors using a specifically defined class of heterocyclic compounds. In one embodiment, there are provided methods of modulating metabotropic glutamate receptors. The present invention also discloses methods of treating disease using heterocyclic compounds.

Abstract: The present invention provides compound libraries that can be rapidly and efficiently synthesized for use in lead discovery and design, and can be easily expanded for further drug discovery. The present invention also provides methods of using such compound libraries to design and identify novel drug leads.

Abstract: In accordance with the present invention, there is provided a novel class of heterocyclic compounds. Compounds of the invention contain a substituted, unsaturated five, six or seven membered heterocyclic ring that includes at least one nitrogen atom and at least one carbon atom. The ring additionally includes three, four or five atoms independently selected from carbon, nitrogen, sulfur and oxygen atoms. The heterocyclic ring has at least one substituent located at a ring position adjacent to a ring nitrogen atom. This mandatory substituent of the ring includes a moiety (B), linked to the heterocyclic ring via a carbon-carbon double bond, a carbon-carbon triple bond or an azo group. The mandatory substituent is positioned adjacent to the ring nitrogen atom. Invention compounds are capable of a wide variety of uses. For example heterocyclic compounds can act to modulate physiological processes by functioning as agonists and antagonists of receptors in the nervous system.

Abstract: A method for remotely monitoring and managing the operation of fare charging passenger carrying vehicles forming elements of a transportation system. The method is carried out as each vehicle travels a route to pick up and deliver passengers having previously established passenger accounts. The method comprises the steps of maintaining a wireless two-way data link between each vehicle and a system control center having stored passenger account data and maintaining a two-way data link between the system control center and a system management center to allow the system management center to exchange data with the system control center and with each vehicle. A fare charge schedule defining fare charges based on designated criteria is transferred from the system management center to the system control center. The identity of each passenger boarding each vehicle is transmitted to the system control center where the passenger identity is matched with the related passenger account within the system control center.

Abstract: A card-based system electronically transfers funds in real time. A customer card stores digital data representing a unique customer account number associated with a unique, remotely located customer account having at least one vendor-associated subaccount. A merchant terminal having a merchant IP address designating a unique merchant is affiliated with at least one unique vendor for transmitting to a system control center customer transaction data including the merchant IP address, the customer account number read from the customer card and account adjustment data designating either the value of a credit to be added to the vendor-associated subaccount reflecting a customer pre-payment or the value to be subtracted from the vendor-associated customer subaccount reflecting a customer purchase. The system control center maintains a vendor account database and a customer account database.

Abstract: The present invention provides methods and apparatus for expanding a first, smaller diameter tubular into frictional contact with a second, larger diameter tubular or wellbore. In an embodiment, annular formations formed on an inner surface of a split ring engage an outer surface of the smaller tubular. In one aspect, the smaller diameter tubular is provided with an annular recess there around, the annular recess including recessed grooves formed there around. Therefore, the split ring is disposable within the annular recess and the annular formations formed on the split ring are constructed and arranged to fit within the recessed grooves of the annular recess of the tubular. An outer surface of the split ring is provided with teeth or some other grip-enhancing material or formation. The split ring also includes a split portion permitting the ring to expand in diameter as that portion of the tubular is expanded in diameter.

Abstract: In accordance with the present invention, a novel class of substituted pyridine compounds (optionally containing ether, ester, amide, ketone or thioether substitutions) that promote the release of ligands involved in neurotransmission have been discovered. In a particular aspect compounds of the present invention are capable of modulating acetylcholine receptors. The compounds of the present invention are capable of modulating acetylcholine receptors. Invention compounds may act as agonists, partial agonists, antagonists or allosteric modulators of acetylcholine receptors.

Abstract: A card-based system electronically transfers funds in real time. A customer card stores digital data representing a unique customer account number associated with a unique, remotely located customer account having at least one vendor-associated subaccount. A merchant terminal having a merchant IP address designating a unique merchant is affiliated with at least one unique vendor for transmitting to a system control center customer transaction data including the merchant IP address, the customer account number read from the customer card and account adjustment data designating either the value of a credit to be added to the vendor-associated subaccount reflecting a customer pre-payment or the value to be subtracted from the vendor-associated customer subaccount reflecting a customer purchase. The system control center maintains a vendor account database and a customer account database.

Abstract: In accordance with the present invention, there is provided a novel class of heterocyclic compounds. Compounds of the invention contain a substituted, unsaturated five, six or seven membered heterocyclic ring that includes at least one nitrogen atom and at least one carbon atom. The ring additionally includes three, four or five atoms independently selected from carbon, nitrogen, sulfur and oxygen atoms. The heterocyclic ring has at least one substituent located at a ring position adjacent to a ring nitrogen atom. This mandatory substituent of the ring includes a moiety (B), linked to the heterocyclic ring via a carbon-carbon double bond, a carbon-carbon triple bond or an azo group. The mandatory substituent is positioned adjacent to the ring nitrogen atom. Invention compounds are capable of a wide variety of uses. For example heterocyclic compounds can act to modulate physiological processes by functioning as agonists and antagonists of receptors in the nervous system.

Abstract: An apparatus for displaying an image in space and for providing a background image behind the projected image having an image generator and optical system for projecting an image of an object in an image plane suspended in space. A partially light-transmissive screen is located between the image generator and optical system and the projected image. The screen contains a pattern of juxtaposed light-transmissive regions, through which the image is projected, and regions which are not light-transmissive (ie, substantially opaque areas or reflective surfaces). The background image is printed, or painted, on the opaque areas on the side of the screen remote from the image generator optical system. The screen may be made by printing the background image on opaque areas on a translucent or transparent film, or by printing the background image on a foraminated or perforated opaque sheet.

Abstract: In accordance with the present invention, a novel class of substituted aryl compounds (containing ether, ester, amide, ketone or thioether substitution) that promote the release of ligands involved in neurotransmission have been discovered. In a particular aspect, compounds of the present invention are capable of modulating acetylcholine receptors. The compounds of the present invention are capable of displacing one or more acetylcholine receptor ligands, e.g., 3H-nicotine, from mammalian neuronal membrane binding sites. Invention compounds may act as agonists, partial agonists, antagonists or allosteric modulators of acetylcholine receptors.

Abstract: Methods of use of compounds and compounds for the treatment of disorders characterized by the cerebral deposition of amyloid are provided. Among the compounds are those of formulae (I), (II) and (III): ##STR1## in which R.sub.1 is preferably 2-methyl propene, 2-butene, norleucine; R.sub.2, R.sub.4, and R.sub.8 are each independently methyl or ethyl; R.sub.3 is preferably iso-butyl or phenyl; R.sub.5 is preferably iso-butyl; R.sub.6 is H or methyl; R.sub.7 --(Q).sub.n is preferably benzyloxycarbonyl or acetyl; Q is preferably --C(O)--; R.sub.B is preferbly iso-butyl; R.sub.A =--(T).sub.m --(D).sub.m --R.sub.1, is which T is preferably oxygen or carbon, and D is preferably a mono-unsaturated C.sub.3-4 alkenyl being more preferred; and X is an alcohol, particularly a secondary alcohol.