Patents by Inventor Ian McDonald

Ian McDonald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide, peptide analog and amino acid analog protease inhibitors
    Patent number: 5969100
    Abstract: Methods of use of compounds and compounds for the treatment of disorders characterized by the cerebral deposition of amyloid are provided. Among the compounds are those of formulae (I), (II) and (III): ##STR1## in which R.sub.1 is preferably 2-methyl propene, 2-butene, norleucine; R.sub.2, R.sub.4, and R.sub.8 are each independently methyl or ethyl; R.sub.3 is preferably iso-butyl or phenyl; R.sub.5 is preferably iso-butyl; R.sub.6 is H or methyl; R.sub.7 --(Q).sub.n is preferably benzyloxycarbonyl or acetyl; Q is preferably --C(O)--; R.sub.B is preferbly iso-butyl; R.sub.A =--(T).sub.m --(D).sub.m --R.sub.1, is which T is preferably oxygen or carbon, and D is preferably a mono-unsaturated C.sub.3-4 alkenyl being more preferred; and X is an alcohol, particularly a secondary alcohol.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: October 19, 1999
    Assignee: SIBIA Neurosciences, Inc.
    Inventors: Benito Munoz, Ian A. McDonald, Elisabeth Albrecht
  • Weight adjusting apparatus
    Patent number: 5890342
    Abstract: Apparatus for reducing the mean weight of articles of a soft material, for example cheese, in a flow (1), including a first weighing device (2) for weighing the articles; a flow splitter for splitting the flow (1) into a first flow (3) of articles with individual weights less than an acceptable minimum, a second flow (5) each with a weight greater than the acceptable minimum but less than a predetermined amount in excess, and a third flow (4) each with a weight above the acceptable minimum plus the predetermined amount in excess; a cutter (6) for removing the predetermined amount of material from each of the articles in the third flow (4); a second weighing device (8) for weighing individual articles in the second flow (5) and those in the flow (7) leaving the cutter (6); and a controller for controlling the splitting of the original flow leaving the first weighing device (2) into the respective first, second and third flows.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: April 6, 1999
    Assignee: Food Machinery Design Limited
    Inventors: Ian William McDonald, James Ian McDonald
  • Indole derivatives useful to treat estrogen-related neoplasms and disorders
    Patent number: 5877202
    Abstract: The present invention relates to novel indole derivatives useful in down-regulating estrogen receptor expression. Also included are methods for the treatment of neoplasms or of controlling the growth of a neoplasm in a patient afflicted with a neoplastic disease, especially estrogen-dependent neoplasms such as those associated with breast, ovarian and cervical tissue. Another embodiment of the present invention is a method of prophylactically treating a patient at risk of developing a neoplastic disease state. Also provided is a method for treating autoimmune diseases. Also included are pharmaceutical compositions of the novel indole derivatives.
    Type: Grant
    Filed: January 31, 1996
    Date of Patent: March 2, 1999
    Inventors: Alan J. Bitonti, Ian A. McDonald, Francesco G. Salituro, Jeffrey P. Whitten, Esa T. Jarvi, Paul S. Wright
  • Methods of treating neurodegenerative disorders using protease inhibitors
    Patent number: 5872101
    Abstract: Methods of use of compounds and compounds for the treatment of disorders characterized by the cerebral deposition of amyloid are provided. Among the compounds are those of formulae (I), (II) and (III): ##STR1## in which R.sub.1 is preferably 2-methyl propene, 2-butene, norleucine; R.sub.2, R.sub.4, and R.sub.8 are each independently methyl or ethyl; R.sub.3 is preferably iso-butyl or phenyl; R.sub.5 is preferably iso-butyl; R.sub.6 is H or methyl; R.sub.7 --(Q).sub.n is preferably benzyloxycarbonyl or acetyl; Q is preferably --C(O)--; R.sub.8 is preferbly iso-butyl; R.sub.A =--(T).sub.m --(D).sub.m --R.sub.1, is which T is preferably oxygen or carbon, and D is preferably a mono-unsaturated C.sub.3-4 alkenyl being more preferred; and X is an alcohol, particularly a secondary alcohol.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: February 16, 1999
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Benito Munoz, Ian A. McDonald, Elisabeth Albrecht
  • Methods of treating neurodegenerative disorders using protease inhibitors
    Patent number: 5863902
    Abstract: Methods of use of compounds and compounds for the treatment of disorders characterized by the cerebral deposition of amyloid are provided. Among the compounds are those of formulae (I), (II) and (III): ##STR1## in which R.sub.1 is preferably 2-methyl propene, 2-butene, norleucine; R.sub.2, R.sub.4, and R.sub.8 are each independently methyl or ethyl; R.sub.3 is preferably iso-butyl or phenyl; R.sub.5 is preferably iso-butyl; R.sub.6 is H or methyl; R.sub.7 -(Q).sub.n is preferably benzyloxycarbonyl or acetyl; Q is preferably --C(O)--; RB is preferbly iso-butyl; R.sub.A =--(T).sub.m --(D).sub.m --R.sub.1, is which T is preferably oxygen or carbon, and D is preferably a mono-unsaturated C.sub.3-4 alkenyl being more preferred; and X is an alcohol, particularly a secondary alcohol.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: January 26, 1999
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Benito Munoz, Ian A. McDonald, Elisabeth Albrecht
  • Modulators of acetylcholine receptors
    Patent number: 5723477
    Abstract: The present invention provides a class of pyridine compounds which are modulators of acetylcholine receptors, i.e., compounds which displace acetylcholine receptor ligands from their binding sites.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 3, 1998
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Ian A. McDonald, Jeffrey P. Whitten, Nicholas D. Cosford
  • Inhibitors of nitric oxide biosynthesis
    Patent number: 5710324
    Abstract: The present invention is directed to a new class of compound which are useful as inhibitors of the biosynthesis of nitric oxide.
    Type: Grant
    Filed: October 4, 1994
    Date of Patent: January 20, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Jeffrey P. Whitten, Ian A. McDonald, Laurie E. Lambert, Niall S. Doherty
  • Modulators of acetylcholine receptors
    Patent number: 5703100
    Abstract: In accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 30, 1997
    Assignee: SIBIA Neurosciences, Inc.
    Inventors: Ian A. McDonald, Jeffrey P. Whitten, Nicholas D. Cosford
  • NMDA antagonists
    Patent number: 5606063
    Abstract: The present invention is directed to a new class of 4-sulfanimide-quinoline derivatives and to their use as NMDA antagonists.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 25, 1997
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Boyd L. Harrison, Bruce M. Baron, David M. Stemerick, Ian A. McDonald
  • Modulators of acetylcholine receptors
    Patent number: 5594011
    Abstract: In accordance with the present invention, there is provided a class of pyridine compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: January 14, 1997
    Assignee: SIBIA Neurosciences, Inc.
    Inventors: Ian A. McDonald, Jeffrey P. Whitten, Nicholas D. Cosford
  • Polycyclic fused ring modulators of acetylcholine receptors
    Patent number: 5567710
    Abstract: In accordance with the present invention, there is provided a class of polycyclic fused ring compounds which are modulators of acetylcholine receptors. The compounds of the invention displace acetylcholine receptor ligands from their binding sites. Invention compounds may act as agonists, partial agonists, antagonists or allosteric modulators of acetylcholine receptors.
    Type: Grant
    Filed: October 13, 1994
    Date of Patent: October 22, 1996
    Assignee: SIBIA Neurosciences, Inc.
    Inventors: Jeffrey P. Whitten, Ian A. McDonald, Jean-Michel Vernier
  • Serotonin 5HT.sub.1A agonistic method
    Patent number: 5559143
    Abstract: The present invention is directed to a new class of serotonin 5HT.sub.1A agonists.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: September 24, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Ian A. McDonald, Ronald C. Bernotas, Mark W. Dudley, Jeffrey S. Sprouse
  • NMDA antagonism method
    Patent number: 5547991
    Abstract: The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: July 17, 1995
    Date of Patent: August 20, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Michael G. Palfreyman, Ian A. McDonald, Francesco G. Salituro, Robert Schwarcz
  • Potentation of NMDA antagonists
    Patent number: 5489579
    Abstract: The present invention is directed to a method for poteniating the therapeutic effects of selected NMDA antagonists.
    Type: Grant
    Filed: February 4, 1994
    Date of Patent: February 6, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Ian A. McDonald, Bruce M. Baron
  • NMDA antagonists
    Patent number: 5470870
    Abstract: The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: November 28, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Michael G. Palfreyman, Ian A. McDonald, Francesco G. Salituro, Robert Schwarcz, Bruce M. Baron
  • Potentiation of NMDA antagonists
    Patent number: 5441963
    Abstract: The present invention is directed to a composition and method for poteniating the therapeutic effects of a class of known NMDA antagonists.
    Type: Grant
    Filed: December 7, 1992
    Date of Patent: August 15, 1995
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Ian A. McDonald, Bruce M. Baron
  • 1,4 benzodioxin derivatives and their use as serotonin 5HT.sub.1A agonists
    Patent number: 5387604
    Abstract: The present invention is directed to a new class of serotonin 5HT.sub.1A agonists.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: February 7, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Ian A. McDonald, Ronald C. Bernotas, Mark W. Dudley, Jeffrey S. Sprouse
  • NMDA antagonists
    Patent number: 5360814
    Abstract: The present invention is directed to a class of 4,6-disubstituted tryptophan derivatives, 4,6-disubstituted kynurenines, their use as NMDA antagonists and to pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: January 25, 1994
    Date of Patent: November 1, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Michael G. Palfreyman, Ian A. McDonald, Francesco G. Salituro, Robert Schwarcz, Bruce M. Baron
  • Inhibitors of nitric oxide biosynthesis
    Patent number: 5318992
    Abstract: The present invention is a method of treating hypotension and shock using select ornithine or N.sup.G -arginine derivatives.
    Type: Grant
    Filed: July 13, 1993
    Date of Patent: June 7, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Jeffrey P. Whitten, Ian A. McDonald, Laurie E. Lambert, Niall S. Doherty
  • Potentiation of NMDA antagonists
    Patent number: 5318985
    Abstract: The present invention is directed to a method for poteniating the therapeutic effects of selected NMDA antagonists.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: June 7, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Ian A. McDonald, Bruce M. Baron