Abstract: A lower cost combustor is formed from a series of sheets of metal that are secured by mechanical fasteners. An increase in diameter of the combustor is achieved through the provision of securing rings to which the sheets of metal are secured.

Abstract: It is necessary to support components while machining is performed. In such circumstances work supports are now provided, whilst previously there was a dedicated arrangement for each component to be supported. By achieving a modularity in terms of adjustment through creating mountings comprising rings, arcs or bars secured upon posts a rigidity of presentation of support ends is achieved. By providing spacers for location about the posts on the mountings variability with regard to the positioning of the support ends is achieved such that similar geometry but different sized components and articles can be supported by the support arrangements. Furthermore, the spacers may be readily removed if C shaped, and the rings, arcs or bars can be shifted.

Abstract: A wall element for a combustion space, the wall element comprising a ceramic body, a support within the body, and attachment means extending from the support and protruding from the body for securing the ceramic body to a combustion space wall.

Abstract: A tile for use as part of an inner wall of a gas turbine engine combustor, the tile being provided with deformable cooling pedestals extending into a space between the tile and the outer wall. The pedestals are deformed in contact with the outer wall of the combustor.

Abstract: Antibodies that can specially bind to cytochrome P450 CYP1B1 and methods of making them are disclosed, in particular antibodies that bind to amino acid sequence VNQWSVNHDPVKWPN or PExFDPARFLDKDGy, where x is D or N and y is L or F, or an antigenic fragment thereof. The antibodies can be used in the diagnosis or treatment of cancers linked to enhanced CYP1B1 expression, including breast cancer, prostate cancer, colorectal cancer, liver cancer and ovarian cancer.

Abstract: An actuator comprises a rack arranged to be driven for movement by a rotatable pinion the rack having at least a first region having a first pitch circle diameter and a second region having a second, different, pitch circle diameter, and movable support means for supporting the rack for movement.

Abstract: Antibodies that can specially bind to cytochrome P450 CYP1B1 and methods of making them are disclosed, in particular antibodies that bind to amino acid sequence VNQWSVNHDPVKWPN or PExFDPARFLDKDGy, where x is D or N and y is L or F, or an antigenic fragment thereof. The antibodies can be used in the diagnosis or treatment of cancers linked to enhanced CYP1B1 expression, including breast cancer, prostate cancer, colorectal cancer, liver cancer and ovarian cancer.

Abstract: According to an aspect of the present invention, there is provided a measurement apparatus for measuring a property of an eye of a subject, having a target arranged to be viewed by the subject, the target including a first light and a second light arranged to undergo a modulation in anti-phase, the modulation decreasing from an initial modulation frequency at which an initial flicker of the first light and second light is not perceivable by the subject; and an indication device allowing the subject to indicate when a flicker is perceived, the modulation frequency at which the subject indicates that the flicker is perceived being defined as a threshold modulation frequency.

Abstract: A prosthetic femoral implant for use in a hip joint, as a ball and socket type joint, is disclosed. The implant includes a modular neck having a variety of adjustable positions to adjust the lateral offset and version angle of the femoral implant in relation to the femur. The implant further includes a broad, full collar for providing a compression force increasing the interdigitation between the interface of the bone, implant and cement. The implant also includes a stem having a depression having a roughened porous surface for resisting the increased torsional loads placed on the implant due to the increased lateral offset and version angle. The stem further comprises three distinct zones, each zone having its own roughened surface creating a tripartite differential porosity.

Abstract: A prosthetic device and method of using the device is disclosed. The device may include a bushing insert, a femoral head component, a neck component that may be either integral or modular, and a stem component having a proximal body portion and a distal portion. The proximal body portion may include such features as a recess for receiving a portion of the modular neck, a proximal conical flare having a bottom surface with a rounded contour, an anterior metaphyseal tapering flare, as well as other features. The distal portion may include a coronal slot, a sagittal slot, a helical slot, or a combination thereof. The above features may be provided for increasing the intrinsic stability of the device and for resisting torsional loads placed on the device.

Abstract: A prosthetic femoral implant for use in a hip joint, as a ball and socket type joint, is disclosed. The implant includes a modular neck having a variety of adjustable positions to adjust the lateral offset and version angle of the femoral implant in relation to the femur. The implant further includes a broad, full collar for providing a compression force increasing the interdigitation between the interface of the bone, implant and cement. The implant also includes a stem having a depression having a roughened porous surface for resisting the increased torsional loads placed on the implant due to the increased lateral offset and version angle. The stem further comprises three distinct zones, each zone having its own roughened surface creating a tripartite differential porosity.

Abstract: According to an aspect of the present invention, there is provided a measurement apparatus for measuring a property of an eye of a subject, having a target arranged to be viewed by the subject, the target including a first light and a second light arranged to undergo a modulation in anti-phase, the modulation decreasing from an initial modulation frequency at which an initial flicker of the first light and second light is not perceivable by the subject; and an indication device allowing the subject to indicate when a flicker is perceived, the modulation frequency at which the subject indicates that the flicker is perceived being defined as a threshold modulation frequency.

Abstract: A spinal disc replacement has at least one bellows disposed between two spaced-apart plates. The bellows are compressible anteriorly/posteriorly and left/right. Several embodiments have top plates and bottom plates which are torsionally rotatable. Methods of use are provided.

Abstract: A Cold Cathode Fluorescent Lamp (CCFL) is enclosed within a bulb normally used for incandescent fixtures. The CCFL is bent into a u-shape to fit within the bulb and the ballast can be installed in the lamp base. In an alternative embodiment, one or more CCFLs is enclosed within a fluorescent lamp tube or bulb with bi pin end caps. An insert in the end cap can support the CCFLs. Contact is made to the CCFLs through a connection with the pins of the end caps. In an alternative arrangement, the CCFLs are supported within the tube by electrode wires connecting to the pins.

Abstract: A failsafe arrangement comprising a first mounting member and a second mounting member which is angularly moveable relative to the first mounting member. The first and second mounting members define first and second surfaces respectively which define therebetween a channel, the first and second surfaces being shaped such that the channel is of non-uniform width. At least one wedge member is disposed within the channel, the or each wedge member being carried by a drive member and being arranged such that, in use, when the drive member and the second mounting member move at substantially the same angular speed, the wedge member does not impair movement of the second mounting member relative to the first mounting member, relative angular movement of the drive member and the second mounting member causing the wedge member to cooperate with the first and second surfaces to apply a braking force so as to impede relative angular movement of the first and second mounting members.

Abstract: CYP1B1 proteins and their role in metabolising or inactivating anti-cancer drugs is disclosed, together with compositions for treating cancer comprising a substance capable of inhibiting CYP1B1 protein and an anti-cancer drug (e.g. docetaxel, paclitaxel, flutamide, tamoxifen, mitoxantrone, doxorubicin or daunomycin).

Abstract: The discovery that CYP1B1 protein is detectable in a wide range of human cancers of different histogenetic types, but is not detectable in non-cancerous tissues, gives rise to diagnostic methods for detecting tumors based on this protein as a marker, and to the possibility of tumor therapies involving the protein. A diagnostic method may include the steps of (a) obtaining from a patient a tissue sample to be tested for the presence of cancer cells; (b) producing a prepared sample in a sample preparation process; (c) contacting the prepared sample with an antibody that reacts with human CYP1B1 protein; and (d) detecting binding of the antibody to CYP1B1 protein in the prepared sample.

Abstract: A prosthetic femoral implant for use in a hip joint, as a ball and socket type joint, is disclosed. The implant includes a modular neck having a variety of adjustable positions to adjust the lateral offset and version angle of the femoral implant in relation to the femur. The implant further includes a broad, full collar for providing a compression force increasing the interdigitation between the interface of the bone, implant and cement. The implant also includes a stem having a depression having a roughened porous surface for resisting the increased torsional loads placed on the implant due to the increased lateral offset and version angle. The stem further comprises three distinct zones, each zone having its own roughened surface creating a tripartite differential porosity.

Abstract: A method of reducing intra-ocular pressure (IOP) in a patient afflicted with elevated IOP is disclosed. The method comprises the step of administering (preferably topically to an afflicted eye) to the patient a therapeutically effective amount of a &bgr;-HSD-1 inhibitor.

Abstract: The discovery that CYP1B1 protein is detectable in a wide range of human cancers of different histogenetic types, but is not detectable in non-cancerous tissues, gives rise to diagnostic methods for detecting tumors based on this protein as a marker, and to the possibility of tumor therapies involving the protein. A diagnostic method may include the steps of: (a) obtaining from a patient a tissue sample to be tested for the presence of cancer cells; (b) producing a prepared sample in a sample preparation process; (c) contacting the prepared sample with an antibody that reacts with human CYP1B1 protein; and (d) detecting binding of the antibody to CYP1B1 protein in the prepared sample.