Abstract: Provided are previously uncharacterized markers of cancers, for example colorectal cancers, and uses of these as diagnostic and prognostic markers of cancers, and in particular colorectal cancers. The markers are SEQ ID NO:1—hnRNP-K; SEQ ID NO:2—HMG-1; SEQ ID NO:3—proteasome subunit alpha type 1; SEQ ID NO:4—bifunctional purine biosynthesis protein; SEQ ID NO:5—STI1; SEQ ID NO:6—annex in IV; SEQ ID NO:7—60 kDa heat shock protein; SEQ ID NO:8—T complex protein 1 beta subunit; SEQ ID NO:9—T complex protein 1 epsilon subunit; SEQ ID NO:10—mortalin; and SEQ ID NO:11—TER-ATPase. The invention further provides related methods and materials for the use of the markers in therapeutic intervention in colorectal and other cancers e.g. to specifically target neoplastic cells without causing significant toxicity in healthy tissues, and to provide methods for the evaluation of the ability of candidate therapeutic compounds to modulate the biological activity of cancerous cells from the colon, rectum and other tissues.

Abstract: A system for testing visual fields comprising a display for presenting a visual stimulus and an eye tracker for tracking movement of at least one of a patient's eyes to determine its position in three dimensions without requiring the patient to wear any tracking equipment. A computer controls the position of the stimulus on the display and causes it to move by an amount that is a function of the tracked three-dimensional position of the patient's eye and a visual field position that is to be tested. Changes to the position of the stimulus and any corresponding tracked eye movement are used to assess the patient's visual field.

Abstract: Provided are previously uncharacterised markers of cancers, for example colorectal cancers, and uses of these as diagnostic and prognostic markers of cancers, and in particular colorectal cancers. The markers are SEQ ID NO: 1—hnRNP-K; SEQ ID NO:2—HMG-1; SEQ ID NO:3—proteasome subunit alpha type 1; SEQ ID NO:4—bifunctional purine biosynthesis protein; SEQ ID NO:5—ST11; SEQ ID NO:6—annex in IV; SEQ ID NO:7—60 kDa heat shock protein; SEQ ID NO:8—T complex protein 1 beta subunit; SEQ ID NO:9—T complex protein 1 epsilon subunit; SEQ ID NO: 10—mortalin; and SEQ ID NO: 11—TER-ATPase. The invention further provides related methods and materials for the use of the markers in therapeutic intervention in colorectal and other cancers e.g. to specifically target neoplastic cells without causing significant toxicity in healthy tissues, and to provide methods for the evaluation of the ability of candidate therapeutic compounds to modulate the biological activity of cancerous cells from the colon, rectum and other tissues.

Abstract: A fuel saving device comprising a support body (10) having at least one flow opening (15) therein and a periphery which adapts the support body (10) for positioning within a sealed environment of a fuel system of a combustion engine in a manner in which the longitudinal axis of the at least one flow opening (15) is coaxial with a fluid flow path, and a plurality of permanent magnets (11-14), the polar axes of all magnets oriented parallel to the flow path through the opening (15), the magnets (11-14) are provided in at least two stacks (16, 16?, each stack (16, 16? containing at least two magnets (11-14), the magnets (11-14) of each stack (16, 16?) each have a polar axis extending in the same direction with the magnets (11-14) of at least one stack (16) having polar axes extending in opposite direction to the other of the at least two stacks (16?).

Abstract: A particle damper is formed using a solid freeform manufacturing technique. A filler provides support for the closing wall of the cavity as it is formed. Apertures allow at least a portion of the filler to be removed. A particle fill of between 90 and 95% is achieved either by removing sufficient filler to reach this fill or removing excess filler and re-filling with damping particles.

Abstract: A lower cost combustor is formed from a series of sheets of metal that are secured by mechanical fasteners. An increase in diameter of the combustor is achieved through the provision of securing rings to which the sheets of metal are secured.

Abstract: It is necessary to support components while machining is performed. In such circumstances work supports are now provided, whilst previously there was a dedicated arrangement for each component to be supported. By achieving a modularity in terms of adjustment through creating mountings comprising rings, arcs or bars secured upon posts a rigidity of presentation of support ends is achieved. By providing spacers for location about the posts on the mountings variability with regard to the positioning of the support ends is achieved such that similar geometry but different sized components and articles can be supported by the support arrangements. Furthermore, the spacers may be readily removed if C shaped, and the rings, arcs or bars can be shifted.

Abstract: A wall element for a combustion space, the wall element comprising a ceramic body, a support within the body, and attachment means extending from the support and protruding from the body for securing the ceramic body to a combustion space wall.

Abstract: A tile for use as part of an inner wall of a gas turbine engine combustor, the tile being provided with deformable cooling pedestals extending into a space between the tile and the outer wall. The pedestals are deformed in contact with the outer wall of the combustor.

Abstract: Antibodies that can specially bind to cytochrome P450 CYP1B1 and methods of making them are disclosed, in particular antibodies that bind to amino acid sequence VNQWSVNHDPVKWPN or PExFDPARFLDKDGy, where x is D or N and y is L or F, or an antigenic fragment thereof. The antibodies can be used in the diagnosis or treatment of cancers linked to enhanced CYP1B1 expression, including breast cancer, prostate cancer, colorectal cancer, liver cancer and ovarian cancer.

Abstract: An actuator comprises a rack arranged to be driven for movement by a rotatable pinion the rack having at least a first region having a first pitch circle diameter and a second region having a second, different, pitch circle diameter, and movable support means for supporting the rack for movement.

Abstract: Antibodies that can specially bind to cytochrome P450 CYP1B1 and methods of making them are disclosed, in particular antibodies that bind to amino acid sequence VNQWSVNHDPVKWPN or PExFDPARFLDKDGy, where x is D or N and y is L or F, or an antigenic fragment thereof. The antibodies can be used in the diagnosis or treatment of cancers linked to enhanced CYP1B1 expression, including breast cancer, prostate cancer, colorectal cancer, liver cancer and ovarian cancer.

Abstract: It is necessary to support components while machining is performed. In such circumstances work supports are now provided, whilst previously there was a dedicated arrangement for each component to be supported. By achieving a modularity in terms of adjustment through creating mountings comprising rings, arcs or bars secured upon posts a rigidity of presentation of support ends is achieved. By providing spacers for location about the posts on the mountings variability with regard to the positioning of the support ends is achieved such that similar geometry but different sized components and articles can be supported by the support arrangements. Furthermore, the spacers may be readily removed if C shaped, and the rings, arcs or bars can be shifted.

Abstract: A prosthetic femoral implant for use in a hip joint, as a ball and socket type joint, is disclosed. The implant includes a modular neck having a variety of adjustable positions to adjust the lateral offset and version angle of the femoral implant in relation to the femur. The implant further includes a broad, full collar for providing a compression force increasing the interdigitation between the interface of the bone, implant and cement. The implant also includes a stem having a depression having a roughened porous surface for resisting the increased torsional loads placed on the implant due to the increased lateral offset and version angle. The stem further comprises three distinct zones, each zone having its own roughened surface creating a tripartite differential porosity.

Abstract: According to an aspect of the present invention, there is provided a measurement apparatus for measuring a property of an eye of a subject, having a target arranged to be viewed by the subject, the target including a first light and a second light arranged to undergo a modulation in anti-phase, the modulation decreasing from an initial modulation frequency at which an initial flicker of the first light and second light is not perceivable by the subject; and an indication device allowing the subject to indicate when a flicker is perceived, the modulation frequency at which the subject indicates that the flicker is perceived being defined as a threshold modulation frequency.

Abstract: A combustor assembly comprising a combustor liner having an opening and a combustor chute, which is formed of a sheet material which is bent to form the desired chute. The chute allows the passage of cooling and dilution air into the combustor.

Abstract: A prosthetic femoral implant for use in a hip joint, as a ball and socket type joint, is disclosed. The implant includes a modular neck having a variety of adjustable positions to adjust the lateral offset and version angle of the femoral implant in relation to the femur. The implant further includes a broad, full collar for providing a compression force increasing the interdigitation between the interface of the bone, implant and cement. The implant also includes a stem having a depression having a roughened porous surface for resisting the increased torsional loads placed on the implant due to the increased lateral offset and version angle. The stem further comprises three distinct zones, each zone having its own roughened surface creating a tripartite differential porosity.

Abstract: A prosthetic femoral implant for use in a hip joint, as a ball and socket type joint, is disclosed. The implant includes a modular neck having a variety of adjustable positions to adjust the lateral offset and version angle of the femoral implant in relation to the femur. The implant further includes a broad, full collar for providing a compression force increasing the interdigitation between the interface of the bone, implant and cement. The implant also includes a stem having a depression having a roughened porous surface for resisting the increased torsional loads placed on the implant due to the increased lateral offset and version angle. The stem further comprises three distinct zones, each zone having its own roughened surface creating a tripartite differential porosity.

Abstract: A prosthetic device and method of using the device is disclosed. The device may include a bushing insert, a femoral head component, a neck component that may be either integral or modular, and a stem component having a proximal body portion and a distal portion. The proximal body portion may include such features as a recess for receiving a portion of the modular neck, a proximal conical flare having a bottom surface with a rounded contour, an anterior metaphyseal tapering flare, as well as other features. The distal portion may include a coronal slot, a sagittal slot, a helical slot, or a combination thereof. The above features may be provided for increasing the intrinsic stability of the device and for resisting torsional loads placed on the device.

Abstract: According to an aspect of the present invention, there is provided a measurement apparatus for measuring a property of an eye of a subject, having a target arranged to be viewed by the subject, the target including a first light and a second light arranged to undergo a modulation in anti-phase, the modulation decreasing from an initial modulation frequency at which an initial flicker of the first light and second light is not perceivable by the subject; and an indication device allowing the subject to indicate when a flicker is perceived, the modulation frequency at which the subject indicates that the flicker is perceived being defined as a threshold modulation frequency.