Abstract: A spinal disc replacement has at least one bellows disposed between two spaced-apart plates. The bellows are compressible anteriorly/posteriorly and left/right. Several embodiments have top plates and bottom plates which are torsionally rotatable. Methods of use are provided.

Abstract: A Cold Cathode Fluorescent Lamp (CCFL) is enclosed within a bulb normally used for incandescent fixtures. The CCFL is bent into a u-shape to fit within the bulb and the ballast can be installed in the lamp base. In an alternative embodiment, one or more CCFLs is enclosed within a fluorescent lamp tube or bulb with bi pin end caps. An insert in the end cap can support the CCFLs. Contact is made to the CCFLs through a connection with the pins of the end caps. In an alternative arrangement, the CCFLs are supported within the tube by electrode wires connecting to the pins.

Abstract: A failsafe arrangement comprising a first mounting member and a second mounting member which is angularly moveable relative to the first mounting member. The first and second mounting members define first and second surfaces respectively which define therebetween a channel, the first and second surfaces being shaped such that the channel is of non-uniform width. At least one wedge member is disposed within the channel, the or each wedge member being carried by a drive member and being arranged such that, in use, when the drive member and the second mounting member move at substantially the same angular speed, the wedge member does not impair movement of the second mounting member relative to the first mounting member, relative angular movement of the drive member and the second mounting member causing the wedge member to cooperate with the first and second surfaces to apply a braking force so as to impede relative angular movement of the first and second mounting members.

Abstract: CYP1B1 proteins and their role in metabolising or inactivating anti-cancer drugs is disclosed, together with compositions for treating cancer comprising a substance capable of inhibiting CYP1B1 protein and an anti-cancer drug (e.g. docetaxel, paclitaxel, flutamide, tamoxifen, mitoxantrone, doxorubicin or daunomycin).

Abstract: The discovery that CYP1B1 protein is detectable in a wide range of human cancers of different histogenetic types, but is not detectable in non-cancerous tissues, gives rise to diagnostic methods for detecting tumors based on this protein as a marker, and to the possibility of tumor therapies involving the protein. A diagnostic method may include the steps of (a) obtaining from a patient a tissue sample to be tested for the presence of cancer cells; (b) producing a prepared sample in a sample preparation process; (c) contacting the prepared sample with an antibody that reacts with human CYP1B1 protein; and (d) detecting binding of the antibody to CYP1B1 protein in the prepared sample.

Abstract: A prosthetic femoral implant for use in a hip joint, as a ball and socket type joint, is disclosed. The implant includes a modular neck having a variety of adjustable positions to adjust the lateral offset and version angle of the femoral implant in relation to the femur. The implant further includes a broad, full collar for providing a compression force increasing the interdigitation between the interface of the bone, implant and cement. The implant also includes a stem having a depression having a roughened porous surface for resisting the increased torsional loads placed on the implant due to the increased lateral offset and version angle. The stem further comprises three distinct zones, each zone having its own roughened surface creating a tripartite differential porosity.

Abstract: A method of reducing intra-ocular pressure (IOP) in a patient afflicted with elevated IOP is disclosed. The method comprises the step of administering (preferably topically to an afflicted eye) to the patient a therapeutically effective amount of a &bgr;-HSD-1 inhibitor.

Abstract: The discovery that CYP1B1 protein is detectable in a wide range of human cancers of different histogenetic types, but is not detectable in non-cancerous tissues, gives rise to diagnostic methods for detecting tumors based on this protein as a marker, and to the possibility of tumor therapies involving the protein. A diagnostic method may include the steps of: (a) obtaining from a patient a tissue sample to be tested for the presence of cancer cells; (b) producing a prepared sample in a sample preparation process; (c) contacting the prepared sample with an antibody that reacts with human CYP1B1 protein; and (d) detecting binding of the antibody to CYP1B1 protein in the prepared sample.

Abstract: The discovery that Cyp1B1 protein is detectable in a wide range of human cancers of different histogenetic types, but is not detectable in non-cancerous tissues, gives rise to diagnostic methods for detecting tumors based on this protein as a marker, and to the possibility of tumor therapies involving the protein. A diagnostic method may include the steps of: (a) obtaining from a patient a tissue sample to be tested for the presence of cancer cells; (b) producing a prepared sample in a sample preparation process; (c) contacting the prepared sample with an antibody that reacts with human Cyp1B1 protein; and (d) detecting binding of the antibody to CYP1B1 protein in the prepared sample.

Abstract: A composition of matter is provided in which a phosphonic acid or phosphonic acid ester group is linked through a thioether residue to a silicon atom which is further covalently bonded to a solid inorganic support. The compositions can be employed to selectively separate metal ions having high cationic charge from a solution containing lower-charged cations, and also to selectively separate highly charged cations having a relatively high charge density from cations having the same charge, but a lower charge density.

Abstract: A container apparatus and method of manufacture for same, in which the container includes an inner tube formed of plastic material, and an outer tube of one or more plies of material. The container is generally configured to lie flat, when in its unfilled condition. The container has a flat first end formed from flap members configured from one or more plies of the outer tube. The container is advantageously configured to enable opening of the first end of the outer tube to provide access to the inner tube.

Abstract: A container apparatus and method of manufacture for same, in which the container includes an inner tube formed of plastics material, and an outer tube of one or more plies of material. The container is generally configured to lie flat, when in its unfilled condition. The container has a flat first end formed from flap members configured from one or more plies of the outer tube. The container is advantageously configured to enable opening of the first end of the outer tube to provide access to the inner tube.

Abstract: A constrained prosthetic knee having as its component parts a femoral implant, a tibial implant, and a meniscal plate disposed between the implants. Knee flexion and extension is permitted by compoundly curved condyle surfaces of the femoral implant, which resemble corresponding surfaces of a natural knee, and correspondingly shaped convex bearing surfaces in the meniscal plate and tibial implant. This interface is defined by a continuous, concave, spherically shaped surface in the upwardly facing plateau of the tibial implant and a corresponding, continuous, convex spherical surface of the meniscal plate. A post projects from the tibial implant into a cavity defined by the femoral implant and the free end of the post and the cavity have opposing, cooperating and overlapping ledges which maintain the implants constrained to each other. The ledges permit unrestrained flexion, extension and torsional movement of the knee and limited lateral rocking (adduction-abduction).

Abstract: A prosthetic knee having as its component parts a femoral implant, a tibial implant, and a meniscal plate disposed between the implants. Knee flexion and extension is permitted by compoundly curved condyle surfaces of the femoral implant, which resemble corresponding surfaces of a natural knee, and correspondingly shaped convex bearing surfaces in the meniscal plate. All other motions of the prosthetic knee take place at the interface between the meniscal plate and tibial implant. This interface is defined by a continuous, concave, spherically shaped surface in the upwardly facing plateau of the tibial implant and a corresponding, continuous, convex spherical surface of the meniscal plate. The components are biased into mutual engagement along the cooperating concave and convex surfaces by the natural ligaments which surround the prosthetic knee. The continuous biased engagement of the cooperating convex and concave surfaces of the prosthetic knee assure its stability.

Abstract: A replacement spark plug for reciprocating internal combustion engines that functions as a fuel injector and as a spark plug to provide a "stratified-charge" effect. The conventional carburetor is retained to supply the main fuel-air mixture which may be very lean because of the stratified charge. The replacement plug includes a cylindrical piezoelectric ceramic which contracts to act as a pump whenever an ignition pulse is applied to a central rod through the ceramic. The rod is hollow at its upper end for receiving fuel, it is tapered along its lower length to act as a pump, and it is flattened at its lower end to act as a valve for fuel injection from the pump into the cylinder. The rod also acts as the center electrode of the plug, with the spark jumping from the plug base to the lower end of the rod to thereby provide spark ignition that has inherent proper timing with the fuel injection.