Abstract: A process and system are disclosed for the biofiltration of volatile organic compounds. The process involved recirculating contaminated effluent gas through a biofilter (1), the biofilter (1) having an inlet (20), outlet (15) and micro-organism laden filter media bed (3). The filter media bed additionally having moisture retaining properties. This process has been effective in removing high levels of VOCs from effluent gas streams and also in removing VOCs from an effluent gas stream where the VOC levels and/or volumes of effluent gas vary over time.

Abstract: The subject invention pertains to pharmaceutical compositions, articles of manufacture, and methods useful for treatment of neurological conditions related to, or which can be affected by, modulation of glutamate receptor (GluR) activity. The treatment can be either prophylactic in nature or to alleviate symptoms of such neurological conditions. The pharmaceutical compositions of the subject invention include an aromatic amino acid (AAA), an analog or isomer of an AAA, or combinations thereof, and a pharmaceutically acceptable carrier or diluent. Methods of the subject invention involve parenterally administering to a patient at least one AAA, an analog or isomer of an AAA, or combinations thereof.

Abstract: An apparatus and method of installing a casing string in a borehole, the apparatus comprising a propulsion system movable through the borehole; the propulsion system having an attachment member; and the attachment member being engagable with the casing string causing the casing string to move with the propulsion system through the borehole. The apparatus further including a conduit for circulating fluids through the propulsion system to provide the power to move the propulsion system. The propulsion system may also be disposable.

Abstract: Antisense oligonucleotides sequences that inhibit expression of anthrax toxin receptor (ATR) mRNA and human tumor endothelial marker 8 have been designed and constructed. The antisense oligonucleotides may be used to inhibit anthrax infection of host cells as well as for treating cancerous tumors. Introducing such antisense oligonucleotides into a cell decreases ATR expression and decreases tumor cell viability in vitro. Methods for discovering other oligonucleotides with the same activity are taught, as are uses of the antisense molecules for treatment of diseases.

Abstract: The subject invention pertains to pharmaceutical compositions, articles of manufacture, and methods useful for treatment of neurological conditions related to, or which can be affected by, modulation of glutamate receptor (GluR) activity. The treatment can be either prophylactic in nature or to alleviate symptoms of such neurological conditions. The pharmaceutical compositions of the subject invention include an aromatic amino acid (AAA), an analog or isomer of an AAA, or combinations thereof, and a pharmaceutically acceptable carrier or diluent. Methods of the subject invention involve parenterally administering to a patient at least one AAA, an analog or isomer of an AAA, or combinations thereof.

Abstract: A vehicle electro-hydraulic braking system of the type which can operate in a brake-by-wire mode wherein hydraulic pressure is applied to brake actuators (16a, 16b) at the vehicle wheels in proportion to the driver's braking demand (DD) as sensed electronically at a brake pedal (12), wherein the pressure demand (RBD) for the rear brake actuators (16b) is arranged to be delayed until at least one or two conditions has been fulfilled, namely (a) the pressure of at least one front brake actuator (16a) has reached a predetermined pressure (Pmin), and/or (b) a delay threshold (Tmax) of a predetermined level has been exceeded and/or wherein delivery to the fluid to the rearbrake actuators (16b) is limited to a predetermined value that is relatively low with respect to that for the front brakes.

Abstract: A method of detection and identification of pressure sensor faults in an electro-hydraulic braking system of the type comprising a brake pedal, respective braking devices connected to the vehicle wheels and which communicate with electronically controlled proportional control valves in order to apply hydraulic fluid under pressure to the braking devices, respective pressure sensors for measuring the hydraulic pressures at the individual braking devices, a hydraulic pump driven by an electric motor, a high pressure hydraulic pressure accumulator fed by the pump for the provision of hydraulic fluid under pressure which can be passed to the braking devices via the proportional control valves in order to apply hydraulic fluid under pressure to the braking devices in proportion to the driver's braking demand as sensed at the brake pedal, and a supply pressure sensor for monitoring the hydraulic pressure supplied to the electronically controlled proportional control valves.

Abstract: Disclosed are antisense oligonucleotide, polynucleotide, and peptide nucleic acid compounds that specifically bind to mammalian mRNA encoding a &bgr;1-adrenoceptor polypeptide and that are useful in the control and/or treatment of cardiac dysfunction, hypertension, hypertrophy, myocardial ischemia, and other cardiovascular diseases in an affected mammal, and preferably, in a human subject. The antisense compounds disclosed herein, and pharmaceutical formulations thereof, provide sustained control of &bgr;1-adrenoceptor expression over prolonged periods, and achieve therapeutic effects from as little as a single dose. Administration of these antisense compositions to approved animal models resulted in a decrease in blood pressure, but no significant change in heart rate.

Abstract: A separator for separating solids and other objects (debris) from a liquid, and having a separator body (2) through which the liquid, having debris entrained therein (16, 19, 20), flows from an inlet (6) to an outlet (13), and a port (5) for diverting flow from the outlet during moderate flows whereby the debris entrained in the liquid is removed. A floor (11) wherein the separator is raised to form a hump (43) adjacent to or in which the opening (5) is located.

Abstract: Disclosed are antisense oligonucleotide, polynucleotide, and peptide nucleic acid compounds that specifically bind to mammalian mRNA encoding a &bgr;1-adrenoceptor polypeptide and that are useful in the control and/or treatment of cardiac dysfunction, hypertension, hypertrophy, myocardial ischemia, and other cardiovascular diseases in an affected mammal, and preferably, in a human subject. The antisense compounds disclosed herein, and pharmaceutical formulations thereof, provide sustained control of &bgr;1-adrenoceptor expression over prolonged periods, and achieve therapeutic effects from as little as a single dose. Administration of these antisense compositions to approved animal models resulted in a decrease in blood pressure, but no significant change in heart rate.

Abstract: A method of detection and identification of pressure sensor faults in an electro-hydraulic braking system of the type comprising a brake pedal, respective braking devices connected to the vehicle wheels and which communicate with electronically controlled proportional control valves in order to apply hydraulic fluid under pressure to the braking devices, respective pressure sensors for measuring the hydraulic pressures at the individual braking devices, a hydraulic pump driven by an electric motor, a high pressure hydraulic pressure accumulator fed by the pump for the provision of hydraulic fluid under pressure which can be passed to the braking devices via the proportional control valves in order to apply hydraulic fluid under pressure to the braking devices in proportion to the driver's braking demand as sensed at the brake pedal, and a supply pressure sensor for monitoring the hydraulic pressure supplied to the electronically controlled proportional control valves.

Abstract: A method of detection and identification of pressure sensor faults in an electro-hydraulic braking system of the type comprising a brake pedal, respective braking devices connected to the vehicle wheels and which communicate with electronically controlled proportional control valves in order to apply hydraulic fluid under pressure to the braking devices, respective pressure sensors for measuring the hydraulic pressures at the individual braking devices, a hydraulic pump driven by an electric motor, a high pressure hydraulic pressure accumulator fed by the pump for the provision of hydraulic fluid under pressure which can be passed to the braking devices via the proportional control valves in order to apply hydraulic fluid under pressure to the braking devices in proportion to the driver's braking demand as sensed at the brake pedal, and a supply pressure sensor for monitoring the hydraulic pressure supplied to the electronically controlled proportional control valves.

Abstract: Antisense oligonucleotides specific for mammalian ACE mRNA have been identified. Administration of these oligonucleotides to animals resulted in a decrease in blood pressure, but no significant change in heart rate. Methods for discovering other oligonucleotides with the same activity are taught, as are uses of the antisense molecules for treatment of human and animal diseases.

Abstract: A separator for separating material from a fluid which includes an inlet, a separating chamber in fluid communication with the inlet, a holding chamber, a deflector for deflecting material entrained in or moving with fluid entering the separating chamber from the inlet towards the holding chamber, and an outlet for permitting flow of fluid from which the material has been removed from the separating chamber.

Abstract: A vehicle hydraulic braking system of the brake-by-wire type is disclosed in which proportional solenoid-operated valves (12, 13) are adapted to control the pressure in wheel brake actuators of the brakes (8, 9) on a single axle of a vehicle, and a balance valve (20) is provided to enable individual hydraulic brake circuits to be hydraulically connected so that the pressure applied to each brake is guaranteed to be substantially the same, a first one (13) of the proportional valves (12, 13) is adapted to be isolated so that the hydraulic circuit is fed by a second, single, proportional valve (12). Applying both brakes under the control of a single proportional valve ensures that any fluid leakages are balanced since substantially equal brake-applying pressures are generated.

Abstract: An anti-skid braking system for wheeled vehicles having fluid actuated brakes associated with the vehicle wheels, has speed sensors associated with the vehicle wheels, a control device responsive to speed signals from the speed sensors to actuate a pressure dump device to periodically release the fluid pressure applied to the brake of any wheel which is determined to be about to lock and to later re-apply the actuating pressure to that brake when the tendency of that wheel to lock has reduced, pulsing of the pressure dump device at intervals during the pressure re-apply phase to cause a repeated interruption to the re-application of pressure to that brake. The pulse timing of the pulsing of the pressure dump device is controlled by the occurrence of wheel angular deceleration being determined to be equal to or in excess of a predetermined threshold value, the magnitude of which is dependent upon events from the previous anti-lock braking cycle.

Abstract: An anti-skid braking system for wheeled vehicles having fluid actuated brakes associated with the vehicle wheels. The anti-skid braking system includes speed sensors associated with the vehicle wheels, a scanning control device response to speed signals from the speed sensors to actuate a pressure dump device to periodically release the fluid pressure applied to the brake of any wheel which is determined, by detection of a predetermined level of relative slip between that wheel and the road surface to be about to lock. Later, the system, by detection, can re-apply the actuating pressure to that brake when the tendency of that wheel to lock has been reduced.

Abstract: In a control system, for instance forming part of a vehicle anti-lock brake system, a plurality of control processors provides similar or identical control signals of the system in response to a shared transducer input. An independent data correlation processor compares data generated in the control processors for correlation and, in the absence of proper correlation, provides an indication which may be used to disable anti-lock operation of the brake system. In preferred embodiments, a four wheel vehicle with an anti-lock brake system is monitored by dual microprocessors. Each wheel has a speed sensor which supplies an input to each microprocessor. The data correlation processor compares the outputs of the microprocessors for each wheel and sends and alarm or disables the anti-lock brake system if the difference in the microprocessors output is beyond a limit amount.

Abstract: A loudspeaking telephone instrument comprises a transmit path comprising a microphone (1) and comb filter (2); a receive path comprising a comb filter (3), a frequency shifter (4) and a loudspeaker (5); and a hybrid circuit (6). The frequency shifter (4) shifts the frequency of a signal applied to its input by a fixed amount and the comb filters (2,3) are arranged so that the frequency shifted signal falls in their stop bands. This increases the available gain in the loudspeaking telephone instrument before instability occurs. The spacings of the pass and stop bands of the comb filters (2,3) are at a multiple of the frequency by which the frequency shifter shifts that of its input signal.

Abstract: A telephone set comprising an input unit, a signal generating unit and an information processing unit, which may comprise a read-only memory, a microprocessor or a special LSI circuit for converting information supplied by the input unit into information to be transmitted. In order to obtain a greater reliability as a telephone set, a supervisory circuit, a switching unit and a d.c. isolated signal path have been provided between the switching unit and the information processing unit for coupling the input unit to the signal processing unit via the d.c. isolated signal path and for, possibly, coupling the signal processing unit to the signal generating unit when the supervisory circuit detects proper operation of the information processing unit and for connecting the input unit to the signal processing unit when the supervisory circuit detects a faulty operation of the said information processing unit.