Abstract: Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Abstract: The present disclosure may use reverse forwarded socket connections and rules to manage program code that is being developed. Each developer responsible for developing program code may be provided unique login information that they may use to access data associated with a development environment. Validations of a user/developer and/or computer identity may be performed before a user is allowed to access and update sets of program code. Reverse forwarded socket connections may be associated with endpoints at a remote computer. Once a particular connection is established and a validation performed, identifiers may be used to direct communications to processes, sub-processes, virtual machines, or specific computing resources that are associated with the development environment. By using reverse forwarded socket connections, computers that run different types of operating system software may be used to develop program code without having to install specialized software on those computers.

Abstract: Examples of a system and method for transacting media at a self-service terminal (SST), are generally described. A method may include receiving a PIN on a user interface component of a media interface aperture cover. The method may include causing the media interface aperture cover to retract to dispense or receive media through a media interface aperture.

Abstract: Examples of a system and method for transacting media at a self-service terminal (SST), are generally described. A method may include receiving a PIN on a user interface component of a media interface aperture cover. The method may include causing the media interface aperture cover to retract to dispense or receive media through a media interface aperture.

Abstract: Computer-implemented methods and structures deploy a heating ventilation and air conditioning (HVAC) energy optimization program. A standard operating control platform (OCP) is deployed in an energy optimization control engine (EOCE) computing system communicatively coupled to a plurality of HVAC components via a building automation system (BAS). An energy optimization portal (EOP), which receives from the EOCE computing system a first data set identifying the plurality of HVAC components, a second data set including operational control parameters for each of the plurality of HVAC components, and a third data set including measured operations data associated with each of the plurality of HVAC components. The EOP generates an energy optimized operating control platform based on the first, second, and third data sets, which is automatically communicated from the EOP to the EOCE computing system.

Abstract: Systems and methods for providing a communications and relative positioning capability using frequency-modulated continuous-wave radar installed on multiple mobile and/or stationary objects, providing secure/reliable determination of signal origin from a select one of a plurality of geographically mobile machines, equipment, devices, or systems and subsequent selective establishment/facilitation of direct/deterministic/reliable communication therewith.

Abstract: A food station includes a base configured to support a food product, a frame coupled to the base and including a longitudinal member having a length extending in a longitudinal direction, and a heat strip module coupled to the longitudinal member. The heat strip module includes a housing, a heating element coupled to the housing, and a reflector coupled to the housing. The heat strip module is at least one of (a) selectively rotatable relative to the longitudinal member between a first orientation and a second orientation and configured to emit the energy in both the first orientation and the second orientation or (b) selectively repositionable along the length of the longitudinal member between a first position and a second position and configured to emit the energy in both the first position and the second position.

Abstract: Systems and methods for composing a virtual environment are provided. The virtual environment may represent a room or other space having specified parameters. The system may facilitate placement of 3D models of objects in the virtual environment, where the 3D models correspond to one or more objects depicted in a 2D image, and the placement of the 3D models is algorithmically determined based on placement rules to generate an arrangement of the 3D models based on a layout of the one or more objects in the 2D image. The system can execute the placement rules to algorithmically determine placement locations of the 3D models corresponding to objects depicted in the 2D image.

Abstract: Disclosed herein an anti-pT217 Tau antibody or a pT217 Tau-binding fragment thereof.

Abstract: Methods and systems are described for precisely adjusting characteristics of microfabricated devices after device fabrication. The adjustments can be carried out in parallel on a plurality of the microfabricated devices. By carrying out the adjustment process, uniformity of feature sizes to a few picometers (one standard deviation) and corresponding uniformity of operating characteristics for a plurality of microfabricated devices are possible.

Abstract: Various aspects of the subject technology relate to systems, methods, and machine-readable media for connecting to an independent software vendor (ISV). The method includes receiving, at an integrated platform, a request to initiate a data connection with the ISV. The request may include a web address of the ISV. The method also includes associating, through the integrated platform, the data connection with a unique identifier. The method also includes issuing an authorization code based on authentication of an authorization request for the data connection. The method also includes exchanging, with a connector service, the authorization code for tokens utilized for establishing the data connection with the ISV. The method also includes receiving access to the ISV through the integrated platform.

Abstract: A horizontal can necking machine assembly includes a plural of main turrets and a plural of transfer starwheels. Each main turret includes a main turret shaft, a main gear mounted on the main turret shaft, a pusher assembly, and a die capable of necking a can body upon actuation of the turret shaft. Each transfer starwheel includes a transfer shaft and a transfer gear mounted on the transfer shaft. The main gears are engaged with the transfer gears such that lines through the main gear center and the centers of opposing transfer gears form an included angle of less than 170 degrees, thereby increasing the angular range available for necking the can body. The main turrets and transfer starwheels may operate to neck and move at least 2800 cans per minute, and each pusher assembly may have a stroke length relative to the die that is at least 1.5 inches.

Abstract: Techniques for allowing a user to invoke lifecycle operations on a data store configured in accordance with a data management scheme, without knowledge of the data management scheme. Techniques include receiving user input from a user interface; identifying, in the received user input, an indication of a first lifecycle operation corresponding to a first entry in a template; based on information in the first entry, identifying in the received user input a first configuration value associated with the first lifecycle operation; formatting the first configuration value as at least a portion of at least one argument to a first command; and invoking, via the first command with the at least one argument, a first computer program configured to perform the first lifecycle operation on the data store.

Abstract: A lottery ticket dispensing unit includes at least one ticket compartment and a separation module that has a drive roller and an opposed idler roller. A motor is geared to the drive roller and is switchable between a convey mode wherein the drive roller engages and conveys a leading ticket to a separation position and a brake mode wherein the motor provides a reverse retarding force to the drive roller to brake the drive roller against an attempted reeling of the lottery tickets. from the dispensing unit. A controller switches the motor between the convey and brakes modes such that in the brake mode, power to the motor is interrupted and windings in the motor are short-circuited.

Abstract: An internal multi-function rearview device for use with a vehicle includes a rearview element comprising at least one of a reflective element, a camera, or a display element; a housing configured to be attached to the vehicle and configured to be moveable relative to the vehicle; a bezel configured to be affixed to an opening defined by the housing and configured to surround the rearview element; and a foot configured to be fixed to the vehicle and relative to which the housing and bezel is moveable. The bezel is coated and a coating of the bezel is at least one of a decorative coating, an advanced surface technology, or a spectrally controlling system, and the rearview element is coupled to at least one of the bezel or the housing.

Abstract: In a method and system for managing a social group, the method includes determining a group member behavior from a member position relative to the social group, and inferring a member state from the member behavior. Spatial, spatio-temporal, and biometric data may be used. A social group management system includes an inference engine that infers a member state from the behavior of a monitored member. Another social group management method includes characterizing a first monitored member of the social group as a first discrete element; characterizing at least a second monitored member of the social group as at least a second discrete element; and determining a characteristic displacement between the first monitored member and at least the second monitored member in accordance with a discrete element method.

Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.

Abstract: The present disclosure relates to a telecommunications jack including a housing having a port for receiving a plug. The jack also includes a plurality of contact springs adapted to make electrical contact with the plug when the plug is inserted into the port of the housing, and a plurality of wire termination contacts for terminating wires to the jack. The jack further includes a circuit board that electrically connects the contact springs to the wire termination contacts. The circuit board includes a multi-zone crosstalk compensation arrangement for reducing crosstalk at the jack.

Abstract: A multi-function rearview device for use with a vehicle includes a housing configured to be attached to the vehicle and to be moveable relative to the vehicle, a rearview element including at least one of a reflective element, a camera and a display element, a bezel formed at an outer portion of the multi-function rearview device surrounding the rearview element, with the rearview element being attached to at least one of the bezel and the housing, one or more light assemblies providing at least one or more light function indications, including a Human Machine Interface (HMI), and at least one sensor, the sensor controlling the one or more light assemblies or the display element.

Abstract: Devices that include a low sensitivity bulk acoustic wave (BAW) resonator sensor including a surface to which a low recognition component is immobilized, the low recognition component being configured to selectively bind the analyte, an analyte molecule to which a tag is linked, or a tag, or any one of these molecules to which an amplification element-linked second recognition component is bound; a high sensitivity BAW resonator sensor including a surface to which a high recognition component is immobilized, the high recognition component being configured to selectively bind the analyte, an analyte molecule to which a tag is linked, or a tag, or any one of these molecules to which an amplification element-linked second recognition component is bound; one or more containers housing an amplification molecule, the amplification element-linked second recognition component, and optionally one or both of the tag and the analyte molecule.