Abstract: A method of detecting a defect in a sheet of glass includes: (i) directing a converging beam from a source of illumination onto a surface of the sheet of glass to illuminate the defect; (ii) focussing an image capture device onto a first plane to image the defect in the sheet of glass; (iii) capturing a first image of the defect; (iv) carrying out an adjustment step; and (v) capturing a second image of the defect. Each of the first and second images has a respective first portion from the illuminated defect and a respective second portion due to reflection of a portion of the beam from the glass surface. In the first image of the defect the first portion is brighter than the second portion, and in the second image of the defect the first portion is darker than the second portion. An apparatus for carrying out the method is also provided.

Abstract: A directed energy system includes a gimbal assembly that includes a turret configured to rotate about a first axis, and a directed energy head coupled to the turret and configured to rotate about a second axis that is orthogonal to the first axis. The system further includes an optical fiber spooling ring comprised of a fiber cable at least partially threaded through the gimbal assembly and including a plurality of optical fibers configured to transmit optical energy. The optical fiber spooling ring includes a plurality of 360 degree rotations of the fiber cable.

Abstract: A thermal management system includes a closed-circuit refrigerant system to circulate a refrigerant fluid. The system includes a compressor to compress a flow of the refrigerant fluid. The system includes a condenser coupled to the compressor. The system includes a receiver to store at least a portion of the refrigerant fluid. The receiver is coupled to the condenser. The system includes a pump to circulate the refrigerant fluid through at least a portion of the system. The pump is coupled to the receiver. The system includes a flow control device to control the flow of the refrigerant fluid to an evaporator. The flow control device is coupled to the pump. The evaporator extracts heat from at least one heat load that is in thermal conductive or convective contact with the evaporator.

Abstract: A turbine wheel for use in a gas turbine engine having a plurality of blades attached to a rotor disk. Each blade is formed from a composite comprising ceramic matrix material. The blades each include a root that fits within dovetail slots of the rotor disk and cooperates with a blade retention assembly to couple the blades to the rotor disk.

Abstract: A turbine wheel for use in a gas turbine engine having a plurality of blades attached to a rotor disk. Each blade is formed from a composite comprising ceramic matrix material. The blades each include a root that fits within dovetail slots of the rotor disk and cooperates with a blade retention assembly to couple the blades to the rotor disk.

Abstract: A turbine wheel for use in a gas turbine engine having a plurality of blades attached to a rotor disk. Each blade is formed from a composite comprising ceramic matrix material. The blades each include a root that fits within dovetail slots of the rotor disk and cooperates with a blade retention assembly to couple the blades to the rotor disk.

Abstract: A turbine wheel for use in a gas turbine engine having a plurality of blades attached to a rotor disk. Each blade is formed from a composite comprising ceramic matrix material. The blades each include a root that fits within dovetail slots of the rotor disk and cooperates with a blade retention assembly to couple the blades to the rotor disk.

Abstract: A turbine wheel for use in a gas turbine engine having a plurality of blades attached to a rotor disk. Each blade is formed from a composite comprising ceramic matrix material. The blades each include a root that fits within dovetail slots of the rotor disk and cooperates with a blade retention assembly to couple the blades to the rotor disk.

Abstract: A controller equipped with a user interface having multiple-day programming capabilities, including methods of programming such devices, are disclosed. The user interface may include one or more menus or screens that can be used to program a schedule for one or more selected days during the week. An illustrative method of programming the controller may include the steps of entering a scheduling routine, selecting multiple days for schedule modification, changing the schedule parameters for one or more periods during the selected days, and then exiting the scheduling routine.

Abstract: Compounds of formula (I) and salts and solvates are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.

Abstract: A controller equipped with a user interface having multiple-day programming capabilities, including methods of programming such devices, are disclosed. The user interface may include one or more menus or screens that can be used to program a schedule for one or more selected days during the week. An illustrative method of programming the controller may include the steps of entering a scheduling routine, selecting multiple days for schedule modification, changing the schedule parameters for one or more periods during the selected days, and then exiting the scheduling routine.

Abstract: Compounds of formula (I) and salts thereof are provided: wherein R4, R5, R6, Q, A, and Y are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.

Abstract: Compounds of the general formula And their use in the treatment of psychotic disorders and cognitive impairment are disclosed.

Abstract: Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.

Abstract: Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.

Abstract: Compounds of formula (I) and salts are provided: wherein R6 is selected from hydrogen, halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano, and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: Compounds of formula (I) and salts are provided: wherein R5 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; R6 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: Compounds of formula (I) and salts are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.