Abstract: Compounds of formula (I) and salts and solvates are provided: wherein Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.

Abstract: Compounds of formula (I), salts and solvates are provided, Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.

Abstract: A controller equipped with a user interface having multiple-day programming capabilities, including methods of programming such devices, are disclosed. The user interface may include one or more menus or screens that can be used to program a schedule for one or more selected days during the week. An illustrative method of programming the controller may include the steps of entering a scheduling routine, selecting multiple days for schedule modification, changing the schedule parameters for one or more periods during the selected days, and then exiting the scheduling routine.

Abstract: A controller equipped with a user interface having multiple-day programming capabilities, including methods of programming such devices, are disclosed. The user interface may include one or more menus or screens that can be used to program a schedule for one or more selected days during the week. An illustrative method of programming the controller may include the steps of entering a scheduling routine, selecting multiple days for schedule modification, changing the schedule parameters for one or more periods during the selected days, and then exiting the scheduling routine.

Abstract: Compounds of formula (I), salts and solvates are provided: Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.

Abstract: A bedside cabinet comprises a body (10) carrying two drawers (12) and (14) all made from synthetic plastics material by rotational moulding. The body (10) comprises a proximal wall (16) and a distal wall (18) each extending upward from a generally horizontal platform (20), and a horizontal top (22) extending between the proximal wall (16) and the distal wall (18). An upstand (28) carries a horizontal shelf (30) extending partly over the top (22) and both the top (22) and the shelf (30) are directed towards the proximal side of the cabinet, having raised lips (32) and (34) respectively around their distal edges and their ends. The cabinet lacks dirt traps and is easily cleaned. In addition the drawers (12) and (14) are reversible so as to open forwards whether the cabinet is on the right-hand side or the left-hand side of a bed.

Abstract: Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.

Abstract: Compounds of formula (I) and salts and solvates are provided: wherein Uses of the compounds for the treatment of psychotic disorders and cognitive mpairment, are also disclosed.

Abstract: A controller equipped with a user interface having multiple-day programming capabilities, including methods of programming such devices, are disclosed. The user interface may include one or more menus or screens that can be used to program a schedule for one or more selected days during the week. An illustrative method of programming the controller may include the steps of entering a scheduling routine, selecting multiple days for schedule modification, changing the schedule parameters for one or more periods during the selected days, and then exiting the scheduling routine.

Abstract: A method of optically analysing a sample, which method comprises directing one or more frequencies of electromagnetic radiation (EMR) through a sample and onto a partially reflective surface (9) that allows EMR (6) directed thereon to be both reflected and transmitted, which reflected EMR (12) is directed back through the sample such that the pathlength through the sample is different for the transmitted EMR (10) and reflected EMR (12), which transmitted EMR and reflected EMR are both detected by one or more detectors (11,15), characterised in that the optical absorbance of the sample at the one or more wavelengths of EMR is calculated from the difference between the transmitted EMR (10) and reflected EMR (12).

Abstract: A controller equipped with a user interface having multiple-day programming capabilities, including methods of programming such devices, are disclosed. The user interface may include one or more menus or screens that can be used to program a schedule for one or more selected days during the week. An illustrative method of programming the controller may include the steps of entering a scheduling routine, selecting multiple days for schedule modification, changing the schedule parameters for one or more periods during the selected days, and then exiting the scheduling routine.

Abstract: A touch region for a controller having a touch screen that, when touched, makes a setting change to the controller. In one illustrative embodiment, the controller displays a display image on the touch screen, wherein the touch screen has a defined touch region that when touched makes a setting change to the controller. The display image has a portion that coincides with the touch region, wherein when the touch region is touched, at least part of the portion of the display image that coincides with the touch region changes from a first display image to a second display image to indicate a setting change of the controller. A subsequent touch to the touch region may cause at least part of the portion of the display image that coincides with the touch region to change from the second display image to a third display image to indicate a subsequent setting change of the controller.

Abstract: A controller equipped with a user interface having multiple-day programming capabilities, including methods of programming such devices, are disclosed. The user interface may include one or more menus or screens that can be used to program a schedule for one or more selected days during the week. An illustrative method of programming the controller may include the steps of entering a scheduling routine, selecting multiple days for schedule modification, changing the schedule parameters for one or more periods during the selected days, and then exiting the scheduling routine.

Abstract: The invention provides compounds of the formula or a pharmaceutically acceptable salts thereof. The compounds are useful in therapy, in particular as antipsychotic agents.

Abstract: Compounds of formula (I) and salts are provided: wherein R6 is selected from hydrogen, halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano, and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: Compounds of formula (I) and salts are provided: wherein R5 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; R6 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m— and —(CH2)n— respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxy C1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR5R6, —SO2NR5R6, —(CH2)pNR5R6, —(CH2)pNR5COR6, optionally substituted aryl ring, optionally substituted heteroaryl ring or optionally substituted heterocyclyl ring; R3 represents optionally substituted aryl ring or optionally substituted heteroaryl ring; R4 represents hydrogen, hydroxy, C1-6alkyl, C1-6alkoxy, trifluoromethyl, trifluoromethoxy, halogen, —OSO2CF3, —(CH2)pC3-6cycloalkyl, —(CH2)qOC1-6alkyl or —(CH2)pOC3-6cycloalkyl; R5 and R6 each independently represent hydrogen, C1-6alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalky

Abstract: Compounds of formula (I) and salts are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: Barriers for flood defence and other purposes are often constructed using sand bags. The strength of these barriers is limited and the invention seeks to address this problem. The invention provides a tie formed as a single injection moulded item placed between layers of sandbags to help to hold them together. The tie has two rigid triangular end plates (4) and (5) linked by a flexible arm (11). The end plates are formed with protruding spikes (6) shaped with a barb so that they will easily penetrate the fabric of a sandbag but are difficult to pull out. In use, each tie is placed between layers of sandbags so that spikes of respective plates (4) and (5) become anchored to adjoining bags. The bags of the barrier are thus held together and any irregularities in it are accommodated by the flexibility of the arm (11). Slots (14) and lugs (15) allow a plurality of ties to be linked together as may be required when oversize sandbags are employed.

Abstract: A system for inspecting rail tracks for loose connections (4, 7) employs moulded plastic caps (8). The caps carry arrows (9) or other indicators aligned with a datum direction such as the direction of the rails. Any loosening of the connectors (4, 7) is immediately apparent from the fact that the arrows are no longer aligned. The invention avoids the need for individual manual torquing of each connector during routine safety inspections.