Abstract: The present invention relates to improved processes for purifying polypeptides of interest by increasing the amount of a polypeptide of interest bound to an ion-exchange matrix relative to the amount of one or more impurities bound to the ion-exchange matrix. This effect is achieved by adding a chemical compound in the process which by also binding to the ion-exchange matrix due to a change that is opposite to the change of the ion-exchange matrix, reduces the binding of impurities more than the binding of the polypeptide of interest.

Abstract: A secondary internal topsheet and leg wrap structure is provided in a disposable absorbent garment such as a diaper or training pants. The leg wrap structure has a base layer, a top layer, and an elastic construction disposed inbetween. The elastic construction includes a plurality of spaced apart elastic elements that are aligned in a generally in generally parallel relation. The leg wrap structure and secondary topsheet provides for the efficient formation of a reservoir and a plurality of fluid dams each capable of capturing a quantity of fluid to minimize the occurrence of fluid leaks from the absorbent article. Methods of forming such absorbent articles are disclosed.

Abstract: Energy systems and energy supply methods are described. In one aspect, an energy system includes a bus system configured to conduct electrical energy, a plurality of input adapters electrically coupled with the bus system and configured to electrically couple with a plurality of respective source entities which are individually configured to provide electrical energy, a plurality of output adapters electrically coupled with the bus system and configured to electrically couple with a plurality of respective consuming entities which are individually configured to consume electrical energy, and control circuitry configured to control individual ones of the input adapters to provide electrical energy from respective ones of the source entities to the bus system and to control individual ones of the output adapters to provide electrical energy from the bus system to respective ones of the consuming entities.

Abstract: Energy systems and energy supply methods are described. In one aspect, an energy system includes a bus system configured to conduct electrical energy, a plurality of input adapters electrically coupled with the bus system and configured to electrically couple with a plurality of respective source entities which are individually configured to provide electrical energy, a plurality of output adapters electrically coupled with the bus system and configured to electrically couple with a plurality of respective consuming entities which are individually configured to consume electrical energy, and control circuitry configured to control individual ones of the input adapters to provide electrical energy from respective ones of the source entities to the bus system and to control individual ones of the output adapters to provide electrical energy from the bus system to respective ones of the consuming entities.

Abstract: A formulation for topical administration, comprises bethanechol and a penetration enhancer. The formulation is preferably used by being maintained in the buccal cavity for a period of time prior to being swallowed.

Abstract: The present invention relates to improved processes for purifying polypeptides of interest by increasing the amount of a polypeptide of interest bound to an ion-exchange matrix relative to the amount of one or more impurities bound to the ion-exchange matrix. This effect is achieved by adding a chemical compound in the process which by also binding to the ion-exchange matrix due to a charge that is opposite to the charge of the ion-exchange matrix, reduces the binding of impurities more than the binding of the polypeptide of interest.

Abstract: The present invention relates generally to a method of purifying Factor VII and/or Factor VIIa from a solution containing either or both proteins, the method comprising: diluting the solution containing Factor VII and/or Factor VIIa in a loading buffer; adding the diluted solution from step (i) to a multi-modal anion exchange resinunder conditions selected such that Factor VII and/or Factor VIIa is bound to the resin; optionally washing the resin with a wash buffer; adding an elution buffer to the resin under conditions selected such that Factor VII and/or Factor VIIa is eluted from the resin; and recovering the eluted recombinant Factor VII and/or Factor VIIa; wherein the loading buffer, the optional wash buffer and the elution buffer each comprise about 35 mM or less of calcium ions.

Abstract: A secondary internal topsheet and leg wrap structure is provided in a disposable absorbent garment such as a diaper or training pants. The leg wrap structure has a base layer, a top layer, and an elastic construction disposed inbetween. The elastic construction includes a plurality of spaced apart elastic elements that are aligned in a generally in generally parallel relation. The leg wrap structure and secondary topsheet provides for the efficient formation of a reservoir and a plurality of fluid dams each capable of capturing a quantity of fluid to minimize the occurrence of fluid leaks from the absorbent article. Methods of forming such absorbent articles are disclosed.

Abstract: A leg wrap structure is provided in a disposable absorbent garment such as a diaper or training pants. The leg wrap structure has a base layer, a top layer, and an elastic construction disposed therebetween. The elastic construction includes a plurality of spaced apart (e.g. generally equally spaced apart) elastic elements (e.g. strands or threads) that are aligned in a generally in generally parallel relation. Further, the top and base layers define a region of inelasticity. The leg wrap structure provides for the efficient formation of a reservoir and a plurality of fluid dams each capable of capturing a quantity of fluid to minimize the occurrence of fluid leaks from the absorbent article. Methods of forming such absorbent articles are disclosed.

Abstract: A formulation for topical administration, comprises bethanechol and a penetration enhancer. The formulation is preferably used by being maintained in the buccal cavity for a period of time prior to being swallowed.

Abstract: The present invention relates to improved processes for purifying polypeptides of interest by increasing the amount of a polypeptide of interest bound to an ion-exchange matrix relative to the amount of one or more impurities bound to the ion-exchange matrix. This effect is achieved by adding a chemical compound in the process which by also binding to the ion-exchange matrix due to a change that is opposite to the change of the ion-exchange matrix, reduces the binding of impurities more than the binding of the polypeptide of interest.

Abstract: A method for using an intelligent milestone for a collaboration system includes, with a physical computing system, determining event sources for a set of events associated with a milestone object for a project, subscribing the milestone object to the event sources, receiving event notifications from the event sources for the milestone object, and applying a set of predefined logical conditions using the event notifications to determine if an objective of the milestone object is complete.

Abstract: Energy systems and energy supply methods are described. In one aspect, an energy system includes a bus system configured to conduct electrical energy, a plurality of input adapters electrically coupled with the bus system and configured to electrically couple with a plurality of respective source entities which are individually configured to provide electrical energy, a plurality of output adapters electrically coupled with the bus system and configured to electrically couple with a plurality of respective consuming entities which are individually configured to consume electrical energy, and control circuitry configured to control individual ones of the input adapters to provide electrical energy from respective ones of the source entities to the bus system and to control individual ones of the output adapters to provide electrical energy from the bus system to respective ones of the consuming entities.

Abstract: Energy systems and energy storage system charging methods are described. In one aspect, an energy storage system charging method includes applying an excitation signal to a stator of an induction machine, outputting electrical energy from the stator of the induction machine during the applying, and charging an energy storage system using the electrical energy outputted from the stator.

Abstract: A leg wrap structure is provided in a disposable absorbent garment such as a diaper or training pants. The leg wrap structure has a base layer, a top layer, and an elastic construction disposed therebetween. The elastic construction includes a plurality of spaced apart (e.g. generally equally spaced apart) elastic elements (e.g. strands or threads) that are aligned in a generally in generally parallel relation. Further, the top and base layers define a region of inelasticity. The leg wrap structure provides for the efficient formation of a reservoir and a plurality of fluid dams each capable of capturing a quantity of fluid to minimize the occurrence of fluid leaks from the absorbent article. Methods of forming such absorbent articles are disclosed.

Abstract: A leg wrap structure is provided in a disposable absorbent garment such as a diaper or training pants. The leg wrap structure has a base layer, a top layer, and an elastic construction disposed therebetween. The elastic construction includes a plurality of spaced apart (e.g. generally equally spaced apart) elastic elements (e.g. strands or threads) that are aligned in a generally in generally parallel relation. Further, the top and base layers define a region of inelasticity. The leg wrap structure provides for the efficient formation of a reservoir and a plurality of fluid dams each capable of capturing a quantity of fluid to minimize the occurrence of fluid leaks from the absorbent article. Methods of forming such absorbent articles are disclosed.

Abstract: A secondary internal topsheet and leg wrap structure is provided in a disposable absorbent garment such as a diaper or training pants. The leg wrap structure has a base layer, a top layer, and an elastic construction disposed inbetween. The elastic construction includes a plurality of spaced apart elastic elements that are aligned in a generally in generally parallel relation. The leg wrap structure and secondary topsheet provides for the efficient formation of a reservoir and a plurality of fluid dams each capable of capturing a quantity of fluid to minimize the occurrence of fluid leaks from the absorbent article. Methods of forming such absorbent articles are disclosed.

Abstract: A leg wrap structure is provided in a disposable absorbent garment such as a diaper or training pants. The leg wrap structure has a base layer, a top layer, and an elastic construction disposed therebetween. The elastic construction includes a plurality of spaced apart (e.g. generally equally spaced apart) elastic elements (e.g. strands or threads) that are aligned in a generally in generally parallel relation. Further, the top and base layers define a region of inelasticity. The leg wrap structure provides for the efficient formation of a reservoir and a plurality of fluid dams each capable of capturing a quantity of fluid to minimize the occurrence of fluid leaks from the absorbent article. Methods of forming such absorbent articles are disclosed.

Abstract: The invention relates to a molecular sieve catalyst composition, to a method of making or forming the molecular sieve catalyst composition, and to a conversion process using the catalyst composition. In particular, the invention is directed to a catalyst composition comprising a molecular sieve having a framework including at least [AlO4] and [PO4] tetrahedral units, at least one of a binder and a matrix material and at least one phosphorus compound separate from said molecular sieve wherein, after calcination at 760° C. for 3 hours, said catalyst composition has a microporous surface area in excess of 20% of the microporous surface area of said molecular sieve after calcination at 650° C. in nitrogen for 2 hours. The catalyst composition is particularly useful in a conversion process for producing olefin(s), preferably ethylene and/or propylene, from a feedstock, preferably an oxygenate containing feedstock.