Abstract: A pump intake device comprising a main body which includes a side wall section having an inner side and an outer side, an intake section extending from the outer side of the side wall section and an intake passage extending through the intake section, the intake passage having an inner surface and an entry end and an exit end with a central axis extending between the entry and exit ends, a first portion of the inner surface having one or more first guides thereon for directing fluid passing through the intake passage so that in use said fluid leaves the exit end at the first portion with an exit angle which is inclined relative to the central axis.

Abstract: Energy systems and energy supply methods are described. In one aspect, an energy system includes a bus system configured to conduct electrical energy, a plurality of input adapters electrically coupled with the bus system and configured to electrically couple with a plurality of respective source entities which are individually configured to provide electrical energy, a plurality of output adapters electrically coupled with the bus system and configured to electrically couple with a plurality of respective consuming entities which are individually configured to consume electrical energy, and control circuitry configured to control individual ones of the input adapters to provide electrical energy from respective ones of the source entities to the bus system and to control individual ones of the output adapters to provide electrical energy from the bus system to respective ones of the consuming entities.

Abstract: A pressure probe includes a non-deflecting airfoil, a sensing feature, and an interior passage. The non-deflecting airfoil is made of a metal and configured for use in a gas turbine engine. The airfoil extends from a base to a tapered portion, and thence to a linear portion, along a primary axis. The sensing feature is formed monolithically with the airfoil, as by additive manufacturing. The interior passage is operatively connected to the sensing feature and passes through both the airfoil and the base.

Abstract: A formulation for topical administration, comprises bethanechol and a penetration enhancer. The formulation is preferably used by being maintained in the buccal cavity for a period of time prior to being swallowed.

Abstract: A pump intake device comprises a main body which includes a side wall section having an inner side and an outer side, an intake section extending from the outer side of the side wall section and an intake passage extending through the intake section, the intake passage having an inner surface and an entry end and an exit end with a central axis extending between the entry and exit ends, where a first portion of the inner surface has one or more first guides thereon for directing fluid passing through the intake passage so that, in use, the fluid leaves the exit end at the first portion with an exit angle which is inclined relative to the central axis.

Abstract: The present invention relates to improved processes for purifying polypeptides of interest by increasing the amount of a polypeptide of interest bound to an ion-exchange matrix relative to the amount of one or more impurities bound to the ion-exchange matrix. This effect is achieved by adding a chemical compound in the process which by also binding to the ion-exchange matrix due to a charge that is opposite to the charge of the ion-exchange matrix, reduces the binding of impurities more than the binding of the polypeptide of interest.

Abstract: A pump impeller which includes: a back shroud having an inner main face with an outer peripheral edge and a central axis, the impeller in use being rotatable about the central axis in a direction of rotation, a plurality of pumping vanes extending from the inner main face of the back shroud, the pumping vanes being disposed in spaced apart relation, and each pumping vane including: opposed first and second side faces, a leading edge in the region of the central axis and a trailing edge in the region of the outer peripheral edge of the back shroud, and with a passageway between adjacent pumping vanes, wherein the first side face at the leading edge is in a plane which is at an acute angle with respect to a plane of the inner main face of the back shroud, and the first side face at the trailing edge is in a plane which is at an obtuse angle with respect to the plane of the inner main face of the back shroud.

Abstract: The present invention relates generally to a method of purifying Factor VII and/or Factor VIIa from a solution containing either or both proteins, the method comprising: diluting the solution containing Factor VII and/or Factor VIIa in a loading buffer; adding the diluted solution from step (i) to a multi-modal anion exchange resinunder conditions selected such that Factor VII and/or Factor VIIa is bound to the resin; optionally washing the resin with a wash buffer; adding an elution buffer to the resin under conditions selected such that Factor VII and/or Factor VIIa is eluted from the resin; and recovering the eluted recombinant Factor VII and/or Factor VIIa; wherein the loading buffer, the optional wash buffer and the elution buffer each comprise about 35 mM or less of calcium ions.

Abstract: A manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack comprises a body defining a chimney having a chimney inlet and a chimney exit, and defining a chamber having a chamber inlet and a chamber exit, wherein the chimney exit and said chamber inlet lie side-by-side such that when the open blister pocket is positioned adjacent thereto airflow is directed from the chimney exit to the chamber inlet via the open blister pocket, and wherein one or more bleed holes are provided between the chimney and the chamber such that bleed airflow is able to be directed into the chamber to disruptively impact the airflow that transports the entrained medicament powder.

Abstract: A secondary internal topsheet and leg wrap structure is provided in a disposable absorbent garment such as a diaper or training pants. The leg wrap structure has a base layer, a top layer, and an elastic construction disposed inbetween. The elastic construction includes a plurality of spaced apart elastic elements that are aligned in a generally in generally parallel relation. The leg wrap structure and secondary topsheet provides for the efficient formation of a reservoir and a plurality of fluid dams each capable of capturing a quantity of fluid to minimize the occurrence of fluid leaks from the absorbent article. Methods of forming such absorbent articles are disclosed.

Abstract: A leg wrap structure is provided in a disposable absorbent garment such as a diaper or training pants. The leg wrap structure has a base layer, a top layer, and an elastic construction disposed therebetween. The elastic construction includes a plurality of spaced apart (e.g. generally equally spaced apart) elastic elements (e.g. strands or threads) that are aligned in a generally in generally parallel relation. Further, the top and base layers define a region of inelasticity. The leg wrap structure provides for the efficient formation of a reservoir and a plurality of fluid dams each capable of capturing a quantity of fluid to minimize the occurrence of fluid leaks from the absorbent article. Methods of forming such absorbent articles are disclosed.

Abstract: A formulation for topical administration, comprises bethanechol and a penetration enhancer. The formulation is preferably used by being maintained in the buccal cavity for a period of time prior to being swallowed.

Abstract: The present invention relates to improved processes for purifying polypeptides of interest by increasing the amount of a polypeptide of interest bound to an ion-exchange matrix relative to the amount of one or more impurities bound to the ion-exchange matrix. This effect is achieved by adding a chemical compound in the process which by also binding to the ion-exchange matrix due to a change that is opposite to the change of the ion-exchange matrix, reduces the binding of impurities more than the binding of the polypeptide of interest.

Abstract: A manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack comprises a body defining a chimney having a chimney inlet and a chimney exit, and defining a chamber having a chamber inlet and a chamber exit, wherein the chimney exit and said chamber inlet lie side-by-side such that when the open blister pocket is positioned adjacent thereto airflow is directed from the chimney exit to the chamber inlet via the open blister pocket, and wherein one or more bleed holes are provided between the chimney and the chamber such that bleed airflow is able to be directed into the chamber to disruptively impact the airflow that transports the entrained medicament powder.

Abstract: A manifold for a medicament dispenser, where a manifold body defines a chimney with an inlet and an exit for directing airflow from the inlet to the exit, and a chamber with a chamber inlet and chamber exit. The chimney exit and the chamber inlet lie side-by-side each other such that when the open blister pocket of the blister pack is positioned adjacent thereto, the airflow may be directed from the chimney exit to the chamber inlet via the open blister pocket to entrain the medicament powder, enabling transport of powder in the airflow from chamber inlet to chamber outlet. The chimney creates turbulence in the airflow at the open blister pocket. The manifold comprises plural chimney exits, located at an angle relative to each other of from 150° to 30° such that, in use, plural airflow jets are directed at different and conflicting angles towards the open blister pocket.

Abstract: The invention provides methods and compositions for the treatment of primary, metastatic, and residual cancer in mammals, and more particularly, the use of materials such as whole cells and derivatives and portions thereof to stimulate the immune system to attack cancer.

Abstract: A manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack comprises a body, the body defining a chimney having a chimney inlet and a chimney exit for directing airflow from said chimney inlet to the chimney exit; the body further defining a chamber having a chamber inlet and a chamber exit, wherein the chimney exit and the chamber inlet lie side-by-side each other such that when the open blister pocket of the blister pack is positioned adjacent thereto the airflow is directed from the chimney exit to the chamber inlet via the open blister pocket to entrain the medicament powder and enable transport thereof in the airflow from the chamber inlet to the chamber exit, and wherein one or more bleed holes are provided between the chimney and the chamber such that bleed airflow is able to be directed into the chamber to disruptively impact the airflow that transports the entrained medicament powder.

Abstract: A pump intake device comprising a main body which includes a side wall section having an inner side and an outer side, an intake section extending from the outer side of the side wall section and an intake passage extending through the intake section, the intake passage having an inner surface and an entry end and an exit end with a central axis extending between the entry and exit ends, a first portion of the inner surface having one or more first guides thereon for directing fluid passing through the intake passage so that in use said fluid leaves the exit end at the first portion with an exit angle which is inclined relative to the central axis.

Abstract: A method for using an intelligent milestone for a collaboration system includes, with a physical computing system, determining event sources for a set of events associated with a milestone object for a project, subscribing the milestone object to the event sources, receiving event notifications from the event sources for the milestone object, and applying a set of predefined logical conditions using the event notifications to determine if an objective of the milestone object is complete.

Abstract: An improved inflatable, tapered tip nasopharyngeal airway allows for comfortable self insertion and provides a clear airway for patient breathing in those with obstructive sleep apnea (OSA).