Patents by Inventor Ichiro Sase
Ichiro Sase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11906431Abstract: A microscope apparatus including: an illumination optical system that radiates activation light to activate some of fluorescent materials included in a sample and excitation light to excite at least some of the activated fluorescent materials; an image forming optical system that: has an objective lens and an astigmatic optical system that generates astigmatism to at least part of fluorescence from the fluorescent materials; and forms an image of the fluorescence; an image-capturing unit that captures an image formed by the image forming optical system; a drive unit that moves an image-capturing position in the sample along an optical axis-direction of the objective lens; and a control unit, wherein the control unit causes the image-capturing unit to capture images in a plurality of numbers of frames respectively at a first image-capturing position and at a second image-capturing position different from the first image-capturing position.Type: GrantFiled: February 18, 2021Date of Patent: February 20, 2024Assignee: NIKON CORPORATIONInventors: Ichiro Sase, Yasutoshi Kaneko, Tatsuo Fukui
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Patent number: 11442262Abstract: An image processor includes an image generator configured to generate corresponding image data corresponding to first microscopic image data obtained under a first observation condition, based on second microscopic image data and third microscopic image data obtained under a second observation condition, and an image output unit configured to output the corresponding image data. The corresponding image data may be image data corresponding to a first focal plane from which the first microscopic image data are obtained, and wherein the second microscopic image data and the third microscopic image data may be image data on a second focal plane and a third focal plane, respectively, which are different from the first focal plane.Type: GrantFiled: January 16, 2017Date of Patent: September 13, 2022Assignee: NIKON CORPORATIONInventors: Ichiro Sase, Yutaka Sasaki, Takaaki Okamoto, Yuki Terui, Kohki Konishi, Masafumi Mimura, Martin Berger, Petr Gazak, Miroslav Svoboda
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Patent number: 11409093Abstract: An image processor includes an image generator configured to generate corresponding image data corresponding to first microscopic image data obtained under a first observation condition, based on second microscopic image data and third microscopic image data obtained under a second observation condition, and an image output unit configured to output the corresponding image data. The corresponding image data may be image data corresponding to a first focal plane from which the first microscopic image data are obtained, and wherein the second microscopic image data and the third microscopic image data may be image data on a second focal plane and a third focal plane, respectively, which are different from the first focal plane.Type: GrantFiled: January 16, 2017Date of Patent: August 9, 2022Assignee: NIKON CORPORATIONInventors: Ichiro Sase, Yutaka Sasaki, Takaaki Okamoto, Yuki Terui, Kohki Konishi, Masafumi Mimura, Martin Berger, Petr Gazak, Miroslav Svoboda
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Patent number: 11222400Abstract: An image processor including: an accepting unit that accepts designation of at least part of three dimensional image of a microscope, and an image generator that generates image data for displaying, on a display, a first magnified image which corresponds to the part of the three dimensional image designated and a second magnified image which corresponds to the part of the three dimensional image designated and which is different from the first magnified image.Type: GrantFiled: November 24, 2016Date of Patent: January 11, 2022Assignee: NIKON CORPORATIONInventors: Yutaka Sasaki, Toshiya Okabe, Ichiro Sase, Ryosuke Komatsu, Johana Trojanova, Miroslav Svoboda
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Publication number: 20210231541Abstract: A sample preparation method includes: irradiating a first region of a sample with light at a time t1; irradiating a second region different from the first region with the light at a time t2 after the time t1; and fixing the sample at a time t3 after the time t2. A sample preparing apparatus includes: a light radiating unit that irradiates a first region of a sample with light at time t1 and irradiates a second region different from the first region with the light at a time t2 after the time t1; and a fixing unit that fixes the sample at a time t3 after the time t2.Type: ApplicationFiled: April 15, 2021Publication date: July 29, 2021Applicant: NIKON CORPORATIONInventor: Ichiro SASE
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Publication number: 20210172877Abstract: A microscope apparatus including: an illumination optical system that radiates activation light to activate some of fluorescent materials included in a sample and excitation light to excite at least some of the activated fluorescent materials; an image forming optical system that: has an objective lens and an astigmatic optical system that generates astigmatism to at least part of fluorescence from the fluorescent materials; and forms an image of the fluorescence; an image-capturing unit that captures an image formed by the image forming optical system; a drive unit that moves an image-capturing position in the sample along an optical axis-direction of the objective lens; and a control unit, wherein the control unit causes the image-capturing unit to capture images in a plurality of numbers of frames respectively at a first image-capturing position and at a second image-capturing position different from the first image-capturing position.Type: ApplicationFiled: February 18, 2021Publication date: June 10, 2021Applicant: NIKON CORPORATIONInventors: Ichiro SASE, Yasutoshi KANEKO, Tatsuo FUKUI
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Patent number: 11010914Abstract: An image processor includes an accepting unit that accepts designation of at least part of a three dimensional microscope image data, and an image generator that generates three dimensional magnified image data based on the designation. In the image processor, the image generator may sequentially output a first magnified image based on at least part of data of the three dimensional magnified image data, and a second magnified image based on the at least part of data of the three dimensional magnified image data which has at least part of data different from the first magnified image.Type: GrantFiled: November 24, 2016Date of Patent: May 18, 2021Assignee: NIKON CORPORATIONInventors: Toshiya Okabe, Ichiro Sase, Ryosuke Komatsu, Yutaka Sasaki, Miroslav Svoboda, Martin Sajdl, Jiri Sonsky
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Patent number: 10996147Abstract: A sample preparation method includes: irradiating a first region of a sample with light at a time t1; irradiating a second region different from the first region with the tight at a time t2 after the time t1; and fixing the sample at a time t3 after the time t2. A sample preparing apparatus includes: a light radiating unit that irradiates a first region of a sample with light at time t1 and irradiates a second region different from the first region with the light at a time t2 after the time t1; and a fixing unit that fixes the sample at a time t3 after the time t2.Type: GrantFiled: August 20, 2018Date of Patent: May 4, 2021Assignee: NIKON CORPORATIONInventor: Ichiro Sase
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Patent number: 10725278Abstract: Provided is a microscope including: an illumination optical system that irradiates a specimen including a fluorescent substance with illumination light; an observation optical system including an objective lens; an imager that takes an image formed by the observation optical system; an image processor that performs image processing by using a result of the image taking; and a controller that moves at least one of a stage and the objective lens in the optical axis direction of the objective lens.Type: GrantFiled: May 29, 2018Date of Patent: July 28, 2020Assignee: NIKON CORPORATIONInventors: Ichiro Sase, Yasutoshi Kaneko, Tatsuo Fukui
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Publication number: 20200218054Abstract: An image processor includes an image generator configured to generate corresponding image data corresponding to first microscopic image data obtained under a first observation condition, based on second microscopic image data and third microscopic image data obtained under a second observation condition, and an image output unit configured to output the corresponding image data. The corresponding image data may be image data corresponding to a first focal plane from which the first microscopic image data are obtained, and wherein the second microscopic image data and the third microscopic image data may be image data on a second focal plane and a third focal plane, respectively, which are different from the first focal plane.Type: ApplicationFiled: January 16, 2017Publication date: July 9, 2020Applicant: NIKON CORPORATIONInventors: Ichiro SASE, Yutaka SASAKI, Takaaki OKAMOTO, Yuki TERUI, Kohki KONISHI, Masafumi MIMURA, Martin BERGER, Petr GAZAK, Miroslav SVOBODA
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Publication number: 20200074669Abstract: An image processor includes an accepting unit that accepts designation of at least part of a three dimensional microscope image data, and an image generator that generates three dimensional magnified image data based on the designation. In the image processor, the image generator may sequentially output a first magnified image based on at least part of data of the three dimensional magnified image data, and a second magnified image based on the at least part of data of the three dimensional magnified image data which has at least part of data different from the first magnified image.Type: ApplicationFiled: November 24, 2016Publication date: March 5, 2020Applicant: NIKON CORPORATIONInventors: Toshiya OKABE, Ichiro SASE, Ryosuke KOMATSU, Yutaka SASAKI, Miroslav SVOBODA, Martin SAJDL, Jiri SONSKY
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Patent number: 10527838Abstract: An analysis device for quantifying a state of a fluorescent image containing a plurality of bright spots comprises an area setting unit in which states of a plurality of bright spots contained in a plurality of areas set in the fluorescent image in accordance with positions of the plurality of bright spots are quantified as numerical values.Type: GrantFiled: January 4, 2019Date of Patent: January 7, 2020Assignee: NIKON CORPORATIONInventor: Ichiro Sase
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Publication number: 20190295219Abstract: An image processor having: an accepting unit that accepts designation of at least part of three dimensional microscope image data, and an image generator that generates three dimensional magnified image data based on the designation. In the image processor, the image generator may sequentially output a first magnified image based on at least a part of data of the three dimensional magnified image data and a second magnified image based on at least a part of data of the three dimensional magnified image data in which at least a part of data is different from the data of the first magnified image.Type: ApplicationFiled: November 24, 2016Publication date: September 26, 2019Applicant: NIKON CORPORATIONInventors: Yutaka SASAKI, Toshiya OKABE, Ichiro SASE, Ryosuke KOMATSU, Johana TROJANOVA, Miroslav SVOBODA
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Publication number: 20190137754Abstract: An analysis device for quantifying a state of a fluorescent image containing a plurality of bright spots comprises an area setting unit in which states of a plurality of bright spots contained in a plurality of areas set in the fluorescent image in accordance with positions of the plurality of bright spots are quantified as numerical values.Type: ApplicationFiled: January 4, 2019Publication date: May 9, 2019Applicant: NIKON CORPORATIONInventor: Ichiro SASE
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Patent number: 10268033Abstract: An analysis device for quantifying a state of a fluorescent image containing a plurality of bright spots comprises an area setting unit in which states of a plurality of bright spots contained in a plurality of areas set in the fluorescent image in accordance with positions of the plurality of bright spots are quantified as numerical values.Type: GrantFiled: March 24, 2016Date of Patent: April 23, 2019Assignee: NIKON CORPORATIONInventor: Ichiro Sase
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Publication number: 20180356321Abstract: A sample preparation method includes: irradiating a first region of a sample with light at a time t1; irradiating a second region different from the first region with the tight at a time t2 after the time t1; and fixing the sample at a time t3 after the time t2. A sample preparing apparatus includes: a light radiating unit that irradiates a first region of a sample with light at time t1 and irradiates a second region different from the first region with the light at a time t2 after the time t1; and a fixing unit that fixes the sample at a time t3 after the time t2.Type: ApplicationFiled: August 20, 2018Publication date: December 13, 2018Applicant: NIKON CORPORATIONInventor: Ichiro SASE
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Publication number: 20180299659Abstract: Provided is a microscope including: an illumination optical system that irradiates a specimen including a fluorescent substance with illumination light; an observation optical system including an objective lens; an imager that takes an image formed by the observation optical system; an image processor that performs image processing by using a result of the image taking; and a controller that moves at least one of a stage and the objective lens in the optical axis direction of the objective lens.Type: ApplicationFiled: May 29, 2018Publication date: October 18, 2018Applicant: NIKON CORPORATIONInventors: Ichiro SASE, Yasutoshi KANEKO, Tatsuo FUKUI
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Publication number: 20180275061Abstract: A microscope apparatus including: an illumination optical system that radiates activation light to activate some of fluorescent materials included in a sample and excitation light to excite at least some of the activated fluorescent materials; an image forming optical system that: has an objective lens and an astigmatic optical system that generates astigmatism to at least part of fluorescence from the fluorescent materials; and forms an image of the fluorescence; an image-capturing unit that captures an image formed by the image forming optical system; a drive unit that moves an image-capturing position in the sample along an optical axis-direction of the objective lens; and a control unit, wherein the control unit causes the image-capturing unit to capture images in a plurality of numbers of frames respectively at a first image-capturing position and at a second image-capturing position different from the first image-capturing position.Type: ApplicationFiled: May 29, 2018Publication date: September 27, 2018Applicant: NIKON CORPORATIONInventors: Ichiro SASE, Yasutoshi KANEKO, Tatsuo FUKUI
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Patent number: 9946058Abstract: A microscope apparatus comprises: a distribution measurement apparatus which—with respect to an observation region wherein a sample is arranged which comprises a fluorescent material that is activated when irradiated with an activating light of a prescribed wavelength, and that emits fluorescence when irradiated in an activated condition with an exciting light of a wavelength that differs from that of the activating light—obtains a fluorescent picture image by conducting irradiation with the exciting light, and measures a fluorescent intensity distribution of the observation region; an irradiation intensity setting apparatus which sets irradiation intensities of the activating light for respective portions of the observation region based on the fluorescent intensity distribution; and a picture image formation apparatus which obtains a plurality of the fluorescent picture images by multiply repeating operations comprising an operation wherein the observation region is irradiated with the activating light at thType: GrantFiled: June 10, 2011Date of Patent: April 17, 2018Assignee: NIKON CORPORATIONInventor: Ichiro Sase
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Publication number: 20160202465Abstract: An analysis device for quantifying a state of a fluorescent image containing a plurality of bright spots comprises an area setting unit in which states of a plurality of bright spots contained in a plurality of areas set in the fluorescent image in accordance with positions of the plurality of bright spots are quantified as numerical values.Type: ApplicationFiled: March 24, 2016Publication date: July 14, 2016Applicant: NIKON CORPORATIONInventor: Ichiro SASE