Patents by Inventor Ichiro Sase

Ichiro Sase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210231541
    Abstract: A sample preparation method includes: irradiating a first region of a sample with light at a time t1; irradiating a second region different from the first region with the light at a time t2 after the time t1; and fixing the sample at a time t3 after the time t2. A sample preparing apparatus includes: a light radiating unit that irradiates a first region of a sample with light at time t1 and irradiates a second region different from the first region with the light at a time t2 after the time t1; and a fixing unit that fixes the sample at a time t3 after the time t2.
    Type: Application
    Filed: April 15, 2021
    Publication date: July 29, 2021
    Applicant: NIKON CORPORATION
    Inventor: Ichiro SASE
  • Publication number: 20210172877
    Abstract: A microscope apparatus including: an illumination optical system that radiates activation light to activate some of fluorescent materials included in a sample and excitation light to excite at least some of the activated fluorescent materials; an image forming optical system that: has an objective lens and an astigmatic optical system that generates astigmatism to at least part of fluorescence from the fluorescent materials; and forms an image of the fluorescence; an image-capturing unit that captures an image formed by the image forming optical system; a drive unit that moves an image-capturing position in the sample along an optical axis-direction of the objective lens; and a control unit, wherein the control unit causes the image-capturing unit to capture images in a plurality of numbers of frames respectively at a first image-capturing position and at a second image-capturing position different from the first image-capturing position.
    Type: Application
    Filed: February 18, 2021
    Publication date: June 10, 2021
    Applicant: NIKON CORPORATION
    Inventors: Ichiro SASE, Yasutoshi KANEKO, Tatsuo FUKUI
  • Patent number: 11010914
    Abstract: An image processor includes an accepting unit that accepts designation of at least part of a three dimensional microscope image data, and an image generator that generates three dimensional magnified image data based on the designation. In the image processor, the image generator may sequentially output a first magnified image based on at least part of data of the three dimensional magnified image data, and a second magnified image based on the at least part of data of the three dimensional magnified image data which has at least part of data different from the first magnified image.
    Type: Grant
    Filed: November 24, 2016
    Date of Patent: May 18, 2021
    Assignee: NIKON CORPORATION
    Inventors: Toshiya Okabe, Ichiro Sase, Ryosuke Komatsu, Yutaka Sasaki, Miroslav Svoboda, Martin Sajdl, Jiri Sonsky
  • Patent number: 10996147
    Abstract: A sample preparation method includes: irradiating a first region of a sample with light at a time t1; irradiating a second region different from the first region with the tight at a time t2 after the time t1; and fixing the sample at a time t3 after the time t2. A sample preparing apparatus includes: a light radiating unit that irradiates a first region of a sample with light at time t1 and irradiates a second region different from the first region with the light at a time t2 after the time t1; and a fixing unit that fixes the sample at a time t3 after the time t2.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: May 4, 2021
    Assignee: NIKON CORPORATION
    Inventor: Ichiro Sase
  • Patent number: 10725278
    Abstract: Provided is a microscope including: an illumination optical system that irradiates a specimen including a fluorescent substance with illumination light; an observation optical system including an objective lens; an imager that takes an image formed by the observation optical system; an image processor that performs image processing by using a result of the image taking; and a controller that moves at least one of a stage and the objective lens in the optical axis direction of the objective lens.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: July 28, 2020
    Assignee: NIKON CORPORATION
    Inventors: Ichiro Sase, Yasutoshi Kaneko, Tatsuo Fukui
  • Publication number: 20200218054
    Abstract: An image processor includes an image generator configured to generate corresponding image data corresponding to first microscopic image data obtained under a first observation condition, based on second microscopic image data and third microscopic image data obtained under a second observation condition, and an image output unit configured to output the corresponding image data. The corresponding image data may be image data corresponding to a first focal plane from which the first microscopic image data are obtained, and wherein the second microscopic image data and the third microscopic image data may be image data on a second focal plane and a third focal plane, respectively, which are different from the first focal plane.
    Type: Application
    Filed: January 16, 2017
    Publication date: July 9, 2020
    Applicant: NIKON CORPORATION
    Inventors: Ichiro SASE, Yutaka SASAKI, Takaaki OKAMOTO, Yuki TERUI, Kohki KONISHI, Masafumi MIMURA, Martin BERGER, Petr GAZAK, Miroslav SVOBODA
  • Publication number: 20200074669
    Abstract: An image processor includes an accepting unit that accepts designation of at least part of a three dimensional microscope image data, and an image generator that generates three dimensional magnified image data based on the designation. In the image processor, the image generator may sequentially output a first magnified image based on at least part of data of the three dimensional magnified image data, and a second magnified image based on the at least part of data of the three dimensional magnified image data which has at least part of data different from the first magnified image.
    Type: Application
    Filed: November 24, 2016
    Publication date: March 5, 2020
    Applicant: NIKON CORPORATION
    Inventors: Toshiya OKABE, Ichiro SASE, Ryosuke KOMATSU, Yutaka SASAKI, Miroslav SVOBODA, Martin SAJDL, Jiri SONSKY
  • Patent number: 10527838
    Abstract: An analysis device for quantifying a state of a fluorescent image containing a plurality of bright spots comprises an area setting unit in which states of a plurality of bright spots contained in a plurality of areas set in the fluorescent image in accordance with positions of the plurality of bright spots are quantified as numerical values.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: January 7, 2020
    Assignee: NIKON CORPORATION
    Inventor: Ichiro Sase
  • Publication number: 20190295219
    Abstract: An image processor having: an accepting unit that accepts designation of at least part of three dimensional microscope image data, and an image generator that generates three dimensional magnified image data based on the designation. In the image processor, the image generator may sequentially output a first magnified image based on at least a part of data of the three dimensional magnified image data and a second magnified image based on at least a part of data of the three dimensional magnified image data in which at least a part of data is different from the data of the first magnified image.
    Type: Application
    Filed: November 24, 2016
    Publication date: September 26, 2019
    Applicant: NIKON CORPORATION
    Inventors: Yutaka SASAKI, Toshiya OKABE, Ichiro SASE, Ryosuke KOMATSU, Johana TROJANOVA, Miroslav SVOBODA
  • Publication number: 20190137754
    Abstract: An analysis device for quantifying a state of a fluorescent image containing a plurality of bright spots comprises an area setting unit in which states of a plurality of bright spots contained in a plurality of areas set in the fluorescent image in accordance with positions of the plurality of bright spots are quantified as numerical values.
    Type: Application
    Filed: January 4, 2019
    Publication date: May 9, 2019
    Applicant: NIKON CORPORATION
    Inventor: Ichiro SASE
  • Patent number: 10268033
    Abstract: An analysis device for quantifying a state of a fluorescent image containing a plurality of bright spots comprises an area setting unit in which states of a plurality of bright spots contained in a plurality of areas set in the fluorescent image in accordance with positions of the plurality of bright spots are quantified as numerical values.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: April 23, 2019
    Assignee: NIKON CORPORATION
    Inventor: Ichiro Sase
  • Publication number: 20180356321
    Abstract: A sample preparation method includes: irradiating a first region of a sample with light at a time t1; irradiating a second region different from the first region with the tight at a time t2 after the time t1; and fixing the sample at a time t3 after the time t2. A sample preparing apparatus includes: a light radiating unit that irradiates a first region of a sample with light at time t1 and irradiates a second region different from the first region with the light at a time t2 after the time t1; and a fixing unit that fixes the sample at a time t3 after the time t2.
    Type: Application
    Filed: August 20, 2018
    Publication date: December 13, 2018
    Applicant: NIKON CORPORATION
    Inventor: Ichiro SASE
  • Publication number: 20180299659
    Abstract: Provided is a microscope including: an illumination optical system that irradiates a specimen including a fluorescent substance with illumination light; an observation optical system including an objective lens; an imager that takes an image formed by the observation optical system; an image processor that performs image processing by using a result of the image taking; and a controller that moves at least one of a stage and the objective lens in the optical axis direction of the objective lens.
    Type: Application
    Filed: May 29, 2018
    Publication date: October 18, 2018
    Applicant: NIKON CORPORATION
    Inventors: Ichiro SASE, Yasutoshi KANEKO, Tatsuo FUKUI
  • Publication number: 20180275061
    Abstract: A microscope apparatus including: an illumination optical system that radiates activation light to activate some of fluorescent materials included in a sample and excitation light to excite at least some of the activated fluorescent materials; an image forming optical system that: has an objective lens and an astigmatic optical system that generates astigmatism to at least part of fluorescence from the fluorescent materials; and forms an image of the fluorescence; an image-capturing unit that captures an image formed by the image forming optical system; a drive unit that moves an image-capturing position in the sample along an optical axis-direction of the objective lens; and a control unit, wherein the control unit causes the image-capturing unit to capture images in a plurality of numbers of frames respectively at a first image-capturing position and at a second image-capturing position different from the first image-capturing position.
    Type: Application
    Filed: May 29, 2018
    Publication date: September 27, 2018
    Applicant: NIKON CORPORATION
    Inventors: Ichiro SASE, Yasutoshi KANEKO, Tatsuo FUKUI
  • Patent number: 9946058
    Abstract: A microscope apparatus comprises: a distribution measurement apparatus which—with respect to an observation region wherein a sample is arranged which comprises a fluorescent material that is activated when irradiated with an activating light of a prescribed wavelength, and that emits fluorescence when irradiated in an activated condition with an exciting light of a wavelength that differs from that of the activating light—obtains a fluorescent picture image by conducting irradiation with the exciting light, and measures a fluorescent intensity distribution of the observation region; an irradiation intensity setting apparatus which sets irradiation intensities of the activating light for respective portions of the observation region based on the fluorescent intensity distribution; and a picture image formation apparatus which obtains a plurality of the fluorescent picture images by multiply repeating operations comprising an operation wherein the observation region is irradiated with the activating light at th
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: April 17, 2018
    Assignee: NIKON CORPORATION
    Inventor: Ichiro Sase
  • Publication number: 20160202465
    Abstract: An analysis device for quantifying a state of a fluorescent image containing a plurality of bright spots comprises an area setting unit in which states of a plurality of bright spots contained in a plurality of areas set in the fluorescent image in accordance with positions of the plurality of bright spots are quantified as numerical values.
    Type: Application
    Filed: March 24, 2016
    Publication date: July 14, 2016
    Applicant: NIKON CORPORATION
    Inventor: Ichiro SASE
  • Patent number: 8629382
    Abstract: An reference light emitted from an LED for auto focus enters a glass cover, on which a sample is adhered to, via a half mirror to an objective lens. The reference light that entered the glass cover is reflected by the boundary surface to be reflected light, and this reflected light enters a dichroic mirror via an objective lens. A part transmits the reflected light and allows the light to enter the camera via the dichroic mirror to the lens. A user rotates a motor-operated mirror while viewing the image of the reference light captured by a camera, so as to shift the reference light image position on the boundary surface.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: January 14, 2014
    Assignee: Nikon Corporation
    Inventor: Ichiro Sase
  • Patent number: 8507261
    Abstract: A laboratory dish comprises an incubation container, containing cultured cells, for observation through a microscope, in which a partitioning member partitions an interior of the incubation container into a plurality of incubation chambers by substantially perpendicular walls. The partitioning member tightly fits to a bottom portion of the incubation container, thereby capable of retaining in separation a liquid inputted in each of the incubation chambers from liquids in the other incubation chambers. A cover member covers an upper portion of each of the incubation chambers partitioned by the partitioning member and tightly fitted to the partitioning member. A whole or part of the cover member is formed of a transparent member, and the upper portion of each incubation chamber is formed with an opening via which to input the liquid.
    Type: Grant
    Filed: November 29, 2009
    Date of Patent: August 13, 2013
    Assignee: Nikon Corporation
    Inventors: Yasushi Ogihara, Ichiro Sase, Roman Zantl
  • Patent number: 8208202
    Abstract: A focus detection apparatus is provided with a light source 16 that emanates light with a given wavelength range; a reflection member 15 that reflects light emanated from the light source 16 to lead to an object 6a, reflects light from the light source 16 reflected from the object 6a, and transmits light from the object 6a with at least two different wavelength ranges except the light reflected from the object 6a; a photodetector 21 detecting the light from the light source 16 reflected from the object 6a; and a controller 22 detecting a focus shift between the objective lens 8 and the object 6a in the microscope 2 based on a signal detected by the photodetector 21, thereby providing a focus detection apparatus capable of limiting wavelength range of light for focus detection thereby able to use wider wavelength range for the microscope observation, and a microscope equipped therewith.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: June 26, 2012
    Assignee: Nikon Corporation
    Inventor: Ichiro Sase
  • Publication number: 20120062722
    Abstract: A microscope apparatus comprises: a distribution measurement apparatus with respect to an observation region that comprises a fluorescent material that is activated when irradiated with an activating light, and that emits fluorescence when irradiated with an exciting light of a wavelength different from the activating light, obtains a fluorescent picture image through irradiation with the exciting light, and measures a fluorescent intensity distribution; an irradiation intensity setting apparatus which sets irradiation intensities of the activating light for respective portions of the observation region based on the fluorescent intensity distribution; and a picture image formation apparatus which obtains a plurality of the fluorescent picture images by repeating an operation wherein the observation region is irradiated with the activating light at the set irradiation intensities, and repeating an operation wherein a fluorescent picture image is obtained by irradiating with the exciting light after the activat
    Type: Application
    Filed: June 10, 2011
    Publication date: March 15, 2012
    Applicant: NIKON CORPORATION
    Inventor: Ichiro SASE