Abstract: Provided are antibodies to TREM2 and Gpnmb. Also provided are compositions comprising the antibodies and methods of using same.

Abstract: Systems and methods for controlling a vehicle. The systems and methods receive image data from at least one camera of the vehicle, detect a 2D measurement location of a static object in an image plane of the camera using the image data, receive an input vector of measurements from a sensor system of the vehicle, predict a predicted 3D location of the static object using a Unscented Kalman Filter (UKF) that incorporates a motion model for the vehicle and further using the 2D measurement location of the static object, and the input vector, and control at least one vehicle feature based on the predicted 3D location of the static object.

Abstract: Novel systems methods and kits are disclosed for determining effects of Nucleic Acid (NA) editing procedures. The technique (methods systems and kits) of the present invention are adapted for receiving sequencing data indicative of pluralities of reads, RTx={riTx} and RMc={rjMc}, of the multiplexed amplifications of each of the edit and control NA collections, originating from a similar source of NAs whereby a certain NA editing procedure was applied to the edit NA collection; and processing the sequencing data, per each particular type of adverse effect of interest to determine a statistical model for classifying whether that type of adverse effect actually occurred due to the NA editing procedure. The technique is suitable for determining occurrences of INDEL types and/or TRANSLOCATION types/species of adverse effect.

Abstract: A method of prognosing a subject diagnosed with multiple myeloma (MM) is provided. Also provided a method of treating a subject diagnosed with MM selected expressing intracellular PPIA and/or RRM2 above a predetermined threshold, the method comprising administering to the subject a therapeutically effective amount of at least one agent which specifically down-regulates activity or expression of PPIA and/or RRM2, thereby treating the subject.

Abstract: A method of determining cell members of a cell cluster in a tissue of interest is disclosed. The cell members physically interact with one another in the cell cluster. Computer software products capable of carrying out the method are also disclosed.

Abstract: A method of reducing the immune suppressor activity of myeloid cells is disclosed. The method comprises contacting myeloid cells with an effective amount of an agent which specifically reduces the amount and/or activity of myeloid cells expressing both Triggering Receptor Expressed On Myeloid Cells 2 (Trem2) and Transmembrane glycoprotein NMB (Gpnmb). The method can be used for treating cancer. Antibodies and bi-specific antibodies are also disclosed.

Abstract: Methods of treating acute liver disease acute liver diseases are provided. Accordingly, there is provided a method of treating acute liver disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an agent capable of binding a component of a TLR-MYC signaling pathway selected from the group consisting of MYC, MYD88, TRIF and p38 and inhibiting expression and/or activity of the component.

Abstract: An expression construct is disclosed which comprises: (i) a DNA sequence which encodes at least one guide RNA (gRNA) operatively linked to a transcriptional regulatory sequence so as to allow expression of the gRNA in a target cell; (ii) a barcode sequence for identification of the at least one gRNA operatively linked to a transcriptional regulatory sequence so as to allow expression of the barcode sequence in the target cell.

Abstract: A method of permeabilizing a cell is disclosed. Kits for permeabilizing cells and analysing RNA contents are also disclosed.

Abstract: A method of treating or preventing a disease associated with a secondary infection in a subject infected with a pathogen is provided. The method comprises administering to the subject a therapeutically effective amount of an anti-pathogenic agent directed towards the pathogen and a therapeutically effective amount of an agent which down-regulates at least one extracellular matrix-associated polypeptide.

Abstract: Method of activating dysfunctional T cells, determining responsiveness of a subject having a tumor to an immune checkpoint inhibition are provided. Also provided is an agent capable of inhibiting a target gene or expression product thereof for use in treating a subject having a tumor. Additionally or alternatively provided is an immune checkpoint inhibitor and an agent capable of inhibiting a target gene or expression product thereof for use in treating a subject having a tumor.

Abstract: A method of treating a disease or disorder that can benefit from increasing an M2/M1 macrophage ratio in a subject in need thereof is provided. The method comprising: (a) culturing basophils in the presence of IL33 and/or GM-SCF; and (b) administering to the subject a therapeutically effective amount of the basophils following the culturing, thereby treating the disease or disorder that can benefit from increasing an M2/M1 macrophage ratio in the subject.

Abstract: A microphone packaging assembly (100) provides a printed circuit board (pcb) (106) for coupling to a microphone device (102) having a bottom acoustic port (104). The pcb provides an acoustic port opening (108) which aligns with the bottom acoustic port (104) of the microphone device (102). A solder pad pattern (110) is disposed on the pcb (106). The solder pad pattern (110) is configured to provide both electrical connection (114) and an incomplete solder seal (116) having purposeful acoustic leak to the microphone device (102). A conformable coating (126) provides a seal to the purposeful acoustic leak. A single acoustic test can be performed to detect proper environmental protection and acoustic sealing of the packaged assembly (100).

Abstract: A method of treating or preventing a disease associated with a secondary infection in a subject infected with a pathogen is provided. The method comprises administering to the subject a therapeutically effective amount of an anti-pathogenic agent directed towards the pathogen and a therapeutically effective amount of an agent which down-regulates at least one extracellular matrix-associated polypeptide.

Abstract: Kits and methods for single cell or multiple cell transcriptome analysis are provided. An adapter polynucleotide is disclosed which comprises a double-stranded DNA portion of 15 base pairs and no more than 100 base pairs with a 3?single stranded overhang of at least 3 bases and no more than 10 bases, wherein the double stranded DNA portion is at the 5? end of the polynucleotide and wherein the sequence of the 3?single stranded overhang is selected from the group consisting of SEQ ID NOs: 1-8 and 9, wherein the 5? end of the strand of the double-stranded DNA which is devoid of the 3?single stranded overhang comprises a free phosphate.

Abstract: A microphone packaging assembly (100) provides a printed circuit board (pcb) (106) for coupling to a microphone device (102) having a bottom acoustic port (104). The pcb provides an acoustic port opening (108) which aligns with the bottom acoustic port (104) of the microphone device (102). A solder pad pattern (110) is disposed on the pcb (106). The solder pad pattern (110) is configured to provide both electrical connection (114) and an incomplete solder seal (116) having purposeful acoustic leak to the microphone device (102). A conformable coating (126) provides a seal to the purposeful acoustic leak. A single acoustic test can be performed to detect proper environmental protection and acoustic sealing of the packaged assembly (100).

Abstract: A method of treating or preventing a disease associated with a secondary infection in a subject infected with a pathogen is provided. The method comprises administering to the subject a therapeutically effective amount of an anti-pathogenic agent directed towards the pathogen and a therapeutically effective amount of an agent which down-regulates at least one extracellular matrix-associated polypeptide.

Abstract: A method of analyzing DNA which, in a cell, is bound to a DNA binding moiety, the method comprising: (a) obtaining at least two samples of complexes of DNA bound to a DNA binding moiety; (b) isolating the complexes on a solid support; (c) labeling the DNA of the complexes, wherein the labeling distinguishes between the complexes of the first of the at least two samples and the complexes of the second of the at least two samples; (d) pooling the at least two samples of complexes; and (e) isolating the complexes using an agent which specifically binds to the DNA binding moiety; and (f) analyzing the DNA of the complexes.

Abstract: An active agent that causes an increase in the number of disease-associated microglia (DAM) for use in treating a neurodegenerative disease is provided.

Abstract: A method and apparatus for carrying a battery of a portable communication device. The battery carrier includes a body, a carrier sealing surface, and a wiper. The carrier sealing surface engages a battery seal while the battery is positioned in the battery carrier. The wiper is positioned on a support surface of a battery receptacle in the body. The wiper is aligned with battery contacts of the battery. The wiper wipes the electrical contacts when the battery is inserted into the battery receptacle.