Abstract: An expression construct is disclosed which comprises: (i) a DNA sequence which encodes at least one guide RNA (gRNA) operatively linked to a transcriptional regulatory sequence so as to allow expression of the gRNA in a target cell; (ii) a barcode sequence for identification of the at least one gRNA operatively linked to a transcriptional regulatory sequence so as to allow expression of the barcode sequence in the target cell.

Abstract: A portable communications device includes a housing, a push button disposed along the housing, and an antenna radiating element disposed within the housing and spaced from the push button. The antenna radiating element is configured to be contacted and deflected by the push button to provide a tactile response when the push button is pressed.

Abstract: A portable communications device includes a housing, a push button disposed along the housing, and an antenna radiating element disposed within the housing and spaced from the push button. The antenna radiating element is configured to be contacted and deflected by the push button to provide a tactile response when the push button is pressed.

Abstract: A method and apparatus for carrying a battery of a portable communication device. The battery carrier includes a body, a carrier sealing surface, and a wiper. The carrier sealing surface engages a battery seal while the battery is positioned in the battery carrier. The wiper is positioned on a support surface of a battery receptacle in the body. The wiper is aligned with battery contacts of the battery. The wiper wipes the electrical contacts when the battery is inserted into the battery receptacle.

Abstract: The present invention relates to methods of decreasing inflammation by inhibiting polo-like kinase (Plk)

Abstract: A method of treating or preventing a disease associated with a secondary infection in a subject infected with a pathogen is provided. The method comprises administering to the subject a therapeutically effective amount of an anti-pathogenic agent directed towards the pathogen and a therapeutically effective amount of an agent which down-regulates at least one extracellular matrix-associated polypeptide.

Abstract: A method of upregulating an anti-inflammatory response in a central nervous system (CNS) of a subject in need thereof is disclosed. The method comprising locally administering to the CNS of the subject a therapeutically effective amount of IFN-beta, thereby upregulating the anti-inflammatory response in the CNS of the subject. Methods of treating an inflammation in a CNS or treating a disease, disorder, condition or injury of a CNS of a subject are also disclosed.

Abstract: Kits and methods for single cell or multiple cell transcriptome analysis are provided. An adapter polynucleotide is disclosed which comprises a double-stranded DNA portion of 15 base pairs and no more than 100 base pairs with a 3?single stranded overhang of at least 3 bases and no more than 10 bases, wherein said double stranded DNA portion is at the 5? end of the polynucleotide and wherein the sequence of said 3? single stranded overhang is selected from the group consisting of SEQ ID NOs: 1-8 and 9, wherein the 5? end of the strand of said double-stranded DNA which is devoid of said 3? single stranded overhang comprises a free phosphate.

Abstract: A method of analyzing DNA which, in a cell, is bound to a DNA binding moiety, the method comprising: (a) obtaining at least two samples of complexes of DNA bound to a DNA binding moiety; (b) isolating the complexes on a solid support; (c) labeling the DNA of the complexes, wherein the labeling distinguishes between the complexes of the first of the at least two samples and the complexes of the second of the at least two samples; (d) pooling the at least two samples of complexes; and (e) isolating the complexes using an agent which specifically binds to the DNA binding moiety; and (f) analyzing the DNA of the complexes.

Abstract: Kits and methods for single cell or multiple cell transcriptome analysis are provided. An adapter polynucleotide is disclosed which comprises a double-stranded DNA portion of 15 base pairs and no more than 100 base pairs with a 3? single stranded overhang of at least 3 bases and no more than 10 bases, wherein said double stranded DNA portion is at the 5? end of the polynucleotide and wherein the sequence of said 3? single stranded overhang is selected from the group consisting of SEQ ID NOs: 1-8 and 9, wherein the 5? end of the strand of said double-stranded DNA which is devoid of said 3? single stranded overhang comprises a free phosphate.

Abstract: The present invention relates to methods of decreasing inflammation by inhibiting polo-like kinase (PlK)

Abstract: An isolated polynucleotide is provided. The isolated polynucleotide encodes a polypeptide having a sequence of at least 10 and no more than 500 amino acids, wherein said sequence is derived from the amino acid sequences of SEQ ID NO: 2, 4 or 6. Also provided are compositions and methods using same for treating Tsg101 associated diseases.