Patents by Inventor Igor Vorechovsky
Igor Vorechovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11891605Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.Type: GrantFiled: June 22, 2022Date of Patent: February 6, 2024Assignee: University of SouthamptonInventors: Igor Vorechovsky, Jana Kralovicova
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Publication number: 20230416756Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.Type: ApplicationFiled: April 12, 2023Publication date: December 28, 2023Inventors: Igor VORECHOVSKY, Jana KRALOVICOVA
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Patent number: 11702660Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.Type: GrantFiled: January 27, 2021Date of Patent: July 18, 2023Assignee: University of SouthamptonInventors: Igor Vorechovsky, Jana Kralovicova
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Publication number: 20230183693Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.Type: ApplicationFiled: June 22, 2022Publication date: June 15, 2023Inventors: Igor Vorechovsky, Jana Kralovicova
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Patent number: 11390869Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.Type: GrantFiled: November 26, 2019Date of Patent: July 19, 2022Assignee: University of SouthamptonInventors: Igor Vorechovsky, Jana Kralovicova
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Publication number: 20210155936Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.Type: ApplicationFiled: January 27, 2021Publication date: May 27, 2021Inventors: Igor VORECHOVSKY, Jana KRALOVICOVA
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Patent number: 10941405Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.Type: GrantFiled: December 7, 2018Date of Patent: March 9, 2021Assignee: University of SouthamptonInventors: Igor Vorechovsky, Jana Kralovicova
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Publication number: 20200231969Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.Type: ApplicationFiled: November 26, 2019Publication date: July 23, 2020Inventors: Igor Vorechovsky, Jana Kralovicova
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Patent number: 10538764Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.Type: GrantFiled: June 12, 2017Date of Patent: January 21, 2020Assignee: University of SouthamptonInventors: Igor Vorechovsky, Jana Kralovicova
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Publication number: 20190264211Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.Type: ApplicationFiled: December 7, 2018Publication date: August 29, 2019Inventors: Igor Vorechovsky, Jana Kralovicova
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Patent number: 10196639Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.Type: GrantFiled: October 7, 2016Date of Patent: February 5, 2019Assignee: University of SouthamptonInventors: Igor Vorechovsky, Jana Kralovicova
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Publication number: 20180002694Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.Type: ApplicationFiled: June 12, 2017Publication date: January 4, 2018Inventors: Igor Vorechovsky, Jana Kralovicova
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Patent number: 9745577Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.Type: GrantFiled: June 16, 2015Date of Patent: August 29, 2017Assignee: UNIVERSITY OF SOUTHAMPTONInventors: Igor Vorechovsky, Jana Kralovicova
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Patent number: 9714422Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.Type: GrantFiled: May 6, 2016Date of Patent: July 25, 2017Assignee: UNIVERSITY OF SOUTHAMPTONInventors: Igor Vorechovsky, Jana Kralovicova
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Publication number: 20170101641Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.Type: ApplicationFiled: October 7, 2016Publication date: April 13, 2017Inventors: Igor Vorechovsky, Jana Kralovicova
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Publication number: 20160244762Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.Type: ApplicationFiled: May 6, 2016Publication date: August 25, 2016Inventors: Igor Vorechovsky, Jana Kralovicova
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Publication number: 20160017322Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.Type: ApplicationFiled: June 16, 2015Publication date: January 21, 2016Inventors: Igor Vorechovsky, Jana Kralovicova
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Patent number: 7317086Abstract: This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the Drosophila patched (ptc) gene.Type: GrantFiled: November 22, 2002Date of Patent: January 8, 2008Assignee: United States of America as represented by the Department of Health and Human ServicesInventors: Michael C. Dean, Heidi Eve Hahn, Carol Wicking, Jeffrey Christiansen, Peter G. Zaphiropoulos, Mae R. Gailani, Susan M. Shanley, Abirami Chidambaram, Igor Vorechovsky, Erika Holmberg-Lindstrom, Anne B. Unden, Susan A. Gilles, Kylie Negus, Ian McLeod Smyth, Carol L. Pressman, David J. Leffell, Bernard Gerrard, Alisa M. Goldstein, Brandon Wainwright, Rune C. M. Toftgard, Georgia Chenevix-Trench, Allen E. Bale
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Publication number: 20030171566Abstract: This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the Drosophila patched (ptc) gene.Type: ApplicationFiled: November 22, 2002Publication date: September 11, 2003Inventors: Michael Carlton Dean, Heidi Eve Hahn, Carol Wicking, Jeffrey Christiansen, Peter G. Zaphiropoulos, Mae R. Gailani, Susan Mary Shanley, Abirami Chidambaram, Igor Vorechovsky, Erika Holmberg-Lindstrom, Anne Birgitte Unden, Susan Alana Gillies, Kylie Negus, Ian McLeod Smyth, Carol Leah Pressman, David J. Leffell, Bernard Gerrard, Alisa Miriam Goldstein, Brandon Wainwright, Rune Carl Magnus Toftgard, Georgia Chenevix-Trench, Allen E. Bale
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Patent number: 6552181Abstract: This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the Drosophila patched (ptc) gene.Type: GrantFiled: May 16, 1997Date of Patent: April 22, 2003Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Michael Carlton Dean, Heidi Eve Hahn, Carol Wicking, Jeffrey Christiansen, Peter G Zaphiropoulos, Mae R. Gailani, Susan Mary Shanley, Abirami Chidambaram, Igor Vorechovsky, Erika Holmberg-Lindstrom, Anne Birgitte Unden, Susan Alana Gillies, Kylie Negus, Ian Mcleod Smyth, Carol Leah Pressman, David J. Leffell, Bernard Gerrard, Alisa Miriam Goldstein, Brandon Wainwright, Rune Carl-Magnus Toftgard, Georgia Chenevix-Trench, Allen E. Bale
