Patents by Inventor Ikunoshin Kato

Ikunoshin Kato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of using a gene conferring resistance to 4,5-dihydroxy-2-cyclopenten-1-one (DHCP) and identifying inhibitors of a polypeptide encoded by the gene
    Patent number: 7476526
    Abstract: The invention relates to a gene isolated from E. coli, dep, which confers resistance to the antibacterial activity of 4,5-dihydroxy-2-cyclopenten-1-one (DHCP). The invention further relates to the putative protein encoded by dep, which is a hydrophobic, transmembrane efflux protein specific for DHCP. The invention further relates to plasmids containing the dep gene, and to bacterial cells expressing dep. Furthermore, the invention provides applications for use in conferring resistance to antibacterial activity in organisms. The dep gene can be used to identify compounds which inhibit the efflux activity responsible for the resistance to DHCP or to compounds which are functionally equivalent to DHCP.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: January 13, 2009
    Assignee: Takara Bio Inc.
    Inventors: Sangita Phadtare, Kunitoshi Yamanaka, Ikunoshin Kato, Masayori Inouye
  • METHOD OF RETROVIRUS STORAGE
    Publication number: 20090011485
    Abstract: A method of retrovirus storage, characterized in that a retrovirus is sustained in the presence of a substance with retrovirus binding activity immobilized on a solid phase. Further, there is provided a retrovirus composition characterized in that a retrovirus in the form of binding to a substance with retrovirus binding activity is sealed in a container holding a solid phase having the substance with retrovirus binding activity immobilized thereon.
    Type: Application
    Filed: February 6, 2006
    Publication date: January 8, 2009
    Applicant: TAKARA BIO INC.
    Inventors: Hideto Chono, Yasushi Katayama, Hiromi Okuyama, Junichi Mineno, Kiyozo Asada, Ikunoshin Kato
  • METHOD FOR FUNGAL BED CULTIVATION OF MUSHROOM
    Publication number: 20080295399
    Abstract: Problem: To provide a method for fungal bed cultivation of a mushroom of a large size having an excellent shape and crunchy texture, a mushroom cutting useful for the fungal bed cultivation method, a culture medium for fungal bed cultivation into which the cutting is transplanted, and a culture medium suitable for fungal bed cultivation. Solution: A method for cultivating a mushroom in fungal bed comprising a step of transplanting an isolated cutting of the mushroom into a culture medium for fungal bed cultivation, an isolated cutting of a mushroom to be used in the method, and a culture medium for fungal bed cultivation of a mushroom into which the cutting is transplanted.
    Type: Application
    Filed: May 29, 2008
    Publication date: December 4, 2008
    Applicant: TAKARA BIO INC.
    Inventors: Takashi KAWAI, Hiroko OHTA, Katsuhiko KUSAKABE, Akihiko KITA, Ikunoshin KATO
  • Cell for Producing Retrovirus Vector
    Publication number: 20080293141
    Abstract: The N-acetylglucosaminyltransferase III activity is enhanced in a cell carrying retrovirus-origin gag-pol gene and env gene. By constructing a retrovirus vector with the use of the above cell, a retrovirus vector having a modified sugar chain structure can be obtained. The retrovirus vector constructed by this method shows a high infection efficiency particularly in the presence of a functional substance.
    Type: Application
    Filed: September 28, 2005
    Publication date: November 27, 2008
    Applicant: TAKARA BIO INC.
    Inventors: Hideto Chono, Hiromi Okuyama, Tomoe Egashira, Nobuto Koyama, Junichi Mineno, Ikunoshin Kato
  • Alga-origin promoter, intron and terminator
    Patent number: 7449568
    Abstract: A promoter, an intron and a terminator by which a useful foreign gene can be efficiently expressed in algae and which are thus useful in breeding algae using genetic engineering techniques.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: November 11, 2008
    Assignee: Takara Bio Inc.
    Inventors: Satoru Fukuda, Naotsune Saga, Toshiharu Ohba, Sawako Nagashima, Shuichi Takahashi, Kiyozo Asada, Ikunoshin Kato
  • Method for gene transfer into target cells with retrovirus
    Patent number: 7446170
    Abstract: A polypeptide represented by SEQ. ID No. 13, a polypeptide represented by SEQ. ID No. 30 or functional equivalents thereof and a polypeptide represented by SEQ. ID No. 17.
    Type: Grant
    Filed: July 14, 2005
    Date of Patent: November 4, 2008
    Assignee: Takara Bio Inc.
    Inventors: Kiyozo Asada, Takashi Uemori, Takashi Ueno, Nobuto Koyama, Kimikazu Hashino, Ikunoshin Kato
  • CERAMIDASE INHIBITOR
    Publication number: 20080268073
    Abstract: The present invention provides a ceramidase activity inhibitor which inhibits ceramidase activity, specifically neutral/alkaline ceramidase activity, characterized in that the inhibitor comprises, as an active ingredient, a processed product derived from at least one plant selected from the group consisting of plants belonging to Ginkgoaceae, plants belonging to Cucurbitaceae, plants belonging to Rutaceae, plants belonging to Laminariaceae, plants belonging to Myrtaceae and plants belonging to Compositae, and a medicament, a quasi-drug, cosmetics and a food, each comprising the inhibitor.
    Type: Application
    Filed: June 27, 2008
    Publication date: October 30, 2008
    Applicant: TAKARA BIO INC.
    Inventors: Mutsumi SANO, Hiroyuki Izu, Mitsuo Imamura, Motoko Okamoto, Toyohisa Kurita, Ikunoshin Kato
  • Cyclic peptide
    Patent number: 7442683
    Abstract: A novel cyclic peptide having an antifungal activity, its pharmacologically acceptable salts and antifungal medicinal compositions containing the same.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: October 28, 2008
    Assignee: Takara Bio Inc.
    Inventors: Toru Kurome, Naoyuki Awazu, Kazutoh Takesako, Ikunoshin Kato
  • PROCESS FOR PRODUCING CYTOTOXIC LYMPHOCYTE
    Publication number: 20080227204
    Abstract: The present invention relates to a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one of induction, maintenance and expansion of a cytotoxic lymphocyte in the presence of fibronectin, a fragment thereof or a mixture thereof.
    Type: Application
    Filed: July 31, 2007
    Publication date: September 18, 2008
    Applicant: TAKARA BIO INC.
    Inventors: Hiroaki Sagawa, Mitsuko Ideno, Ikunoshin Kato
  • Thermotolerant ribonuclease H
    Patent number: 7422888
    Abstract: Polypeptides having an RNase H activity highly useful in genetic engineering; genes encoding these polypeptides; and a process for genetic engineeringly producing these polypeptides.
    Type: Grant
    Filed: September 13, 2001
    Date of Patent: September 9, 2008
    Assignee: Takara Bio Inc.
    Inventors: Takashi Uemori, Yoshimi Sato, Nobuto Koyama, Ryo Hirano, Hikaru Takakura, Hiroshi Kobori, Yuji Hashimoto, Kiyozo Asada, Ikunoshin Kato
  • Food or beverage containing fucoidan and method of production thereof
    Patent number: 7422750
    Abstract: Food or beverage where fucoidan which is derived from a fucoidan-containing substance is contained therein, added thereto and/or diluted therein. Food or beverage where fucoidan which is derived from a fucoidan-containing substance and where algins are reduced or eliminated, is contained therein. Apoptosis-inducing food or beverage where an effective amount of fucoidan having an apoptosis-inducing ability is contained therein.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: September 9, 2008
    Assignee: Takara Bio Inc.
    Inventors: Yoshihisa Umeda, Hiroshi Kihara, Katsushige Ikai, Ikunoshin Kato
  • Process For Producing Polypeptide
    Publication number: 20080206811
    Abstract: A process for producing a target protein at low temperature, comprising inducing expression of not only a vector having introduced therein a gene coding for the target protein but also a vector having a chaperone gene introduced therein.
    Type: Application
    Filed: August 19, 2005
    Publication date: August 28, 2008
    Applicant: Takara Bio Inc.
    Inventors: Toshihiro Shodai, Hiroshi Kobori, Takehiro Sagara, Hiroshi Endo, Hikaru Takakura, Jun Tomono, Hiroaki Sagawa, Hiroyuki Mukai, Ikunoshin Kato
  • COMPLEX
    Publication number: 20080206873
    Abstract: A complex comprising a double-stranded DNA containing a terminal repeated sequence originating in a retrovirus and a DNA having a base sequence which does not occur in this retrovirus and a retrovirus-origin protein component.
    Type: Application
    Filed: May 14, 2007
    Publication date: August 28, 2008
    Applicant: TAKARA BIO INC.
    Inventors: Hideto Chono, Hajime Matsumura, Mitsuhiro Ueno, Ikunoshin Kato
  • Use of algae-derived physiologically active substances for treating a carcinomatous disease
    Patent number: 7417031
    Abstract: Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.
    Type: Grant
    Filed: January 13, 2005
    Date of Patent: August 26, 2008
    Assignee: Takara Bio Inc.
    Inventors: Tatsui Enoki, Hiroaki Sagawa, Takanari Tominaga, Eiji Nishiyama, Nobuto Koyama, Takeshi Sakai, Fu-Gong Yu, Katsushige Ikai, Ikunoshin Kato
  • Sulfated fucogalactan digesting enzyme gene
    Patent number: 7410786
    Abstract: A gene encoding a polypeptide having an activity of digesting sulfated fucogalactan which is useful in sugar chain engineering reagents, analyzing the structures of sulfated fucose-containing polysaccharides and preparing degraded products of the polysaccharides; a genetic engineering process for producing the polypeptide; and the polypeptide obtained by the process.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: August 12, 2008
    Assignee: Takara Bio. Inc.
    Inventors: Harumi Ueno, Jun Tomono, Hiroaki Sagawa, Takeshi Sakai, Ikunoshin Kato
  • NUCLEIC ACID ISOLATION METHOD BY HEATING ON MAGNETIC SUPPORT
    Publication number: 20080171337
    Abstract: A method for isolating a nucleic acid from a cell-containing sample by using a magnet with a removable cover attached thereto and a plurality of containers arranged on a table, the plurality of containers having (1) a first container for mixing a cell-containing sample and magnetic beads to which cells can be adhered, (2) a cleaning tank for cleaning the magnetic beads with cells adhering thereto, and (3) a second container for heating the cleaned magnetic beads, the method includes: mixing a liquid including cell-containing sample and magnetic beads in the cell-containing sample in the first container so as to adhere cells in the cell-containing sample to magnetic beads; taking out the magnetic beads from the first container and cleaning the magnetic beads; and suspending the magnetic beads in a re-suspension buffer in the second container and heating the second container at 80 to 120° C. for 20 to 30°.
    Type: Application
    Filed: January 11, 2008
    Publication date: July 17, 2008
    Applicant: KONICA MINOLTA MEDICAL & GRAPHIC, INC.
    Inventors: Koji MIYAZAKI, Akihisa Nakajima, Kanako Usui, Fumitsugu HINO, HIroyuki MUKAI, Ikunoshin KATO
  • Method of extensive culture of antigen-specific cytotoxic T cells
    Publication number: 20080166325
    Abstract: The present invention provides methods for inducing, maintaining and expanding CTL (cytotoxic T cell) having an antigen-specific cytotoxic activity at a high level, which is useful in the adoptive immunotherapy, by using as an effective ingredient at least one compound selected from the group consisting of acidic polysaccharides, acidic oligosaccharides, acidic monosaccharides, and salts thereof. The above-mentioned compounds include fucoidans, heparins, alginic acid, chondroitin sulfate A, chondroitin sulfate B, pectic acid, hyaluronic acid, degradation products of fucoidans, sulfated glucose, sulfated fucose and salts thereof.
    Type: Application
    Filed: April 23, 2007
    Publication date: July 10, 2008
    Inventors: Hiroaki Sagawa, Mitsuko Ideno, Ikunoshin Kato
  • alpha-AGARASE AND PROCESS FOR PRODUCING THE SAME
    Publication number: 20080160584
    Abstract: A polypeptide having an ?-agarase activity, a gene encoding the polypeptide, a method for producing the polypeptide by genetic engineering and a method for producing an agarooligosaccharide using the polypeptide.
    Type: Application
    Filed: February 7, 2008
    Publication date: July 3, 2008
    Applicant: TAKARA BIO INC.
    Inventors: Jun TOMONO, Yoshiko Nomura, Hiroaki Sagawa, Takeshi Sakai, Ikunoshin Kato
  • AGARASE AND GENE THEREOF
    Publication number: 20080096249
    Abstract: Production of efficiently producing agaro-oligosaccharide; a polypeptide having an agarase activity which is usable in, for example, efficiently extracting a substance such as a nucleic acid from an agarose gel; the amino acid sequence of the polypeptide; a gene encoding the polypeptide; a process for producing the polypeptide; a process for producing agaro-oligosaccharide; and a process for extracting a substance such as a nucleic acid from an agarose gel.
    Type: Application
    Filed: November 30, 2007
    Publication date: April 24, 2008
    Applicant: Takara Bio Inc.
    Inventors: Jun TOMONO, Hiroaki Sagawa, Ikunoshin Kato
  • Chalcone compound
    Patent number: 7361774
    Abstract: The present invention relates to a chalcone compound represented by the following general formula: wherein R1 and R2 are taken together with the carbon atom to which they are bound, respectively, to form a hydroxydimethyl hexane ring, or where R1 is a hydroxyl group, R2 is an isohexenyl group, a derivative thereof, or a salt thereof. Also, the present invention relates to a therapeutic agent or prophylactic agent for a disease requiring neuronal protection, suppression for nitrogen monoxide (NO) production, inhibition for aldose reductase or suppression for interleukin production, and a food, beverage or feed for treatment or prevention of the above-mentioned disease, characterized in that each comprises the above-mentioned compound as an effective ingredient.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: April 22, 2008
    Assignee: Takara Bio Inc.
    Inventors: Hiromu Ohnogi, Katsumi Sugiyama, Nobuko Muraki, Tatsuji Enoki, Hiroaki Sagawa, Ikunoshin Kato