Patents by Inventor Ikuo Nishimoto

Ikuo Nishimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8173771
    Abstract: One aspect of the present invention is directed to search receptors based on the information of HN signaling pathways in order to find Humanin receptor or Humanin-like polypeptide receptor (HNR), and to reveal a mechanism of promoting or suppressing the intracellular signal transduction for neuroprotecting activity of HN and identify a compound involved in the mechanism. The aspect of the invention is directed to a method for screening of HNR agonist and HNR antagonist, to utilize the screened compound in development of a drug for the treatment of neurodegenerative disease, and to provide an assay system of AD neuronal cell death, and to provide methods for the compulsory expression of HNR gene or knocking-out of intracellular genes.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: May 8, 2012
    Assignee: Keio Univeristy
    Inventors: Masaaki Matsuoka, Ikuo Nishimoto, Tomo Nishimoto, legal representative, Sadakazu Aiso
  • Patent number: 8076449
    Abstract: The present invention relates to a pharmaceutical composition for the treatment and/or prevention of a neurodegenerative disease, comprising the following polypeptide shown in any of (a) to (c): (a) a polypeptide comprising the amino acid sequence represented by Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro (SEQ ID NO: 1); (b) a polypeptide comprising an amino acid sequence having a deletion, substitution, insertion, and/or addition of one or several amino acids in the amino acid sequence consisting of Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro (SEQ ID NO: 1), and having an activity that inhibits neuronal cell death associated with neurodegenerative disease; and (c) a modified polypeptide from the polypeptide (a) or (b), or a pharmaceutically acceptable salt thereof, as an effective ingredient.
    Type: Grant
    Filed: April 8, 2005
    Date of Patent: December 13, 2011
    Assignees: Tomohiro Chiba, Massaaki Matsuoka, Kenzo Terashita, Sadakazu Also, Tomo Nishimoto
    Inventors: Tomohiro Chiba, Yoshiko Kita, Masaaki Matsuoka, Kenzo Terashita, Sadakazu Aiso, Ikuo Nishimoto, Tomo Nishimoto, legal representative
  • Publication number: 20100279942
    Abstract: An object of the present invention is to provide an agent effective for the treatment and/or prevention of motor neuron disease such as amyotrophic lateral sclerosis (ALS). The present invention provides a therapeutic and/or preventive agent for motor neuron disease comprising the following oligopeptide shown in any of (a) to (c) or a pharmaceutically acceptable salt thereof as an active ingredient: (a) an oligopeptide consisting of the amino acid sequence represented by Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala (SEQ ID NO: 1); (b) an oligopeptide consisting of an amino acid sequence having a deletion, substitution, insertion, or addition of one or several amino acids in Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala (SEQ ID NO: 1), and having an activity that inhibits neuronal cell death caused by a mutant superoxide dismutase-1 gene; and (c) a modified oligopeptide from the oligopeptide (a) or (b).
    Type: Application
    Filed: April 7, 2010
    Publication date: November 4, 2010
    Inventors: TOMOHIRO CHIBA, YOSHIKO KITA, MASAAKI MATSUOKA, KENZO TERASHITA, SADAKAZU AISO, IKUO NISHIMOTO, TOMO NISHIMOTO
  • Publication number: 20100223684
    Abstract: One aspect of the present invention is directed to search receptors based on the information of HN signaling pathways in order to find Humanin receptor or Humanin-like polypeptide receptor (HNR), and to reveal a mechanism of promoting or suppressing the intracellular signal transduction for neuroprotecting activity of HN and identify a compound involved in the mechanism. The aspect of the invention is directed to a method for screening of HNR agonist and HNR antagonist, to utilize the screened compound in development of a drug for the treatment of neurodegenerative disease, and to provide an assay system of AD neuronal cell death, and to provide methods for the compulsory expression of HNR gene or knocking-out of intracellular genes.
    Type: Application
    Filed: April 10, 2006
    Publication date: September 2, 2010
    Applicants: Japan Science and Technology Agency, KEIO University
    Inventors: Masaaki Matsuoka, Ikuo Nishimoto, Sadakazu Aiso
  • Publication number: 20080227699
    Abstract: The present invention relates to a pharmaceutical composition for the treatment and/or prevention of a neurodegenerative disease, comprising the following polypeptide shown in any of (a) to (c): (a) a polypeptide comprising the amino acid sequence represented by Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro (SEQ ID NO: 1); (b) a polypeptide comprising an amino acid sequence having a deletion, substitution, insertion, and/or addition of one or several amino acids in the amino acid sequence consisting of Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro (SEQ ID NO: 1), and having an activity that inhibits neuronal cell death associated with neurodegenerative disease; and (c) a modified polypeptide from the polypeptide (a) or (b), or a pharmaceutically acceptable salt thereof, as an effective ingredient.
    Type: Application
    Filed: April 8, 2005
    Publication date: September 18, 2008
    Inventors: Tomohiro Chiba, Yoshiko Kita, Masaaki Matsuoka, Kenzo Terashita, Sadakazu Aiso, Ikuo Nishimoto, Tomo Nishimoto
  • Patent number: 7410757
    Abstract: The present invention provides methods for screening and testing disorder suppressor genes and disorder suppressor polypeptides. By screening the cDNA expression library incorporated with nucleic acids derived from an organism suffering from a disorder that accompanies cell death, genes having suppressive effects on the disorder symptoms were successfully cloned. Furthermore, suppressive effects of the nucleic acid and polypeptide encoded by the nucleic acid on the disorder have been also examined. Screening of nucleic acids or polypeptides derived from an organism suffering from a disorder that accompanies cell death enables the efficient isolation and selection of suppressor genes of the disorder.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: August 12, 2008
    Assignee: Keio University
    Inventor: Ikuo Nishimoto
  • Patent number: 7314864
    Abstract: The present invention provides polypeptides that suppresses neuronal death associated with Alzheimer's disease. Using a neuronal cell system, wherein the expression of familial Alzheimer's disease mutant APP can be induced by ecdysone treatment, a gene that protects the neurons from cell death was successfully isolated. The gene encodes a secretory polypeptide consisting of 24 amino acids, and this polypeptide suppresses neuronal death caused by the expression of APP mutants and presenilin mutants. The polypeptide also suppressed cell death of primary neuronal culture caused by A?. Furthermore, by mutating the amino acids of the polypeptide, the neuronal death suppression activity of the polypwptide was successfully and significantly enhanced. These polypeptides and derivatives thereof are useful as pharmaceuticals to prevent neuronal death associated with Alzheimer's disease, and as seed compounds for developing novel pharmaceuticals for Alzheimer's disease.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: January 1, 2008
    Assignee: Keio University
    Inventor: Ikuo Nishimoto
  • Patent number: 7145633
    Abstract: A semiconductor manufacturing station (50) exposes light on a surface area of a spherical semiconductor device or ball (52). A mask pattern generator (56) provides a pattern of light, which undergoes temporal changes to collectively represent an image. The mask pattern generator has an active exposure contour (80) that provides a portion of the overall image. The pattern of light is directed though a lens (62) to the surface area of the semiconductor device. The semiconductor device rotates in relation to the temporal changes in the pattern of light to expose the pattern of light over a portion of a surface area of the semiconductor device. The exposure contour has a narrower center and becomes wider moving away from the center. The exposure contour may have a curvature.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: December 5, 2006
    Assignee: Yamatake Corporation
    Inventors: Ikuo Nishimoto, Nobuo Takeda, Ichitaroh Satoh
  • Publication number: 20060050343
    Abstract: A semiconductor manufacturing station (50) exposes light on a surface area of a spherical semiconductor device or ball (52). A mask pattern generator (56) provides a pattern of light, which undergoes temporal changes to collectively represent an image. The mask pattern generator has an active exposure contour (80) that provides a portion of the overall image. The pattern of light is directed though a lens (62) to the surface area of the semiconductor device. The semiconductor device rotates in relation to the temporal changes in the pattern of light to expose the pattern of light over a portion of a surface area of the semiconductor device. The exposure contour has a narrower center and becomes wider moving away from the center. The exposure contour may have a curvature.
    Type: Application
    Filed: January 9, 2003
    Publication date: March 9, 2006
    Inventors: Ikuo Nishimoto, Nobuo Takeda, Ichitaroh Satoh
  • Publication number: 20050233413
    Abstract: Humanin (HN), which has the sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala, is a polypeptide that was identified by screening for molecules that suppress neuronal cell death induced by a gene mutant associated with an familial Alzheimer's disease. The present application provides polypeptides derived from Humanin, which contain one or more D-amino acids or phosphorylated amino acids, or amino acids that form a multimer. The HN derivatives are useful in protecting neuronal cells from cytotoxicity related to neurodegenerative diseases. With higher potency and resulting lower effective amounts, HN derivatives represent better therapeutic agents than the naturally occurring form of RN.
    Type: Application
    Filed: May 16, 2003
    Publication date: October 20, 2005
    Inventors: Ikuo Nishimoto, Tomo Nishimoto
  • Patent number: 6841401
    Abstract: An integrated circuit device has a device main body 1 having a predetermined circuit function of providing an output corresponding to an input thereto, and is provided with a power supply section 4 for receiving through a coil 3 electromagnetic wave energy applied from outside to generate predetermined internal electric power required to operate the integrated circuit device. The integrated circuit device further includes a calibration data acquisition circuit (operation control section 5) for detecting the output of the device main body 1 operated in a predetermined operating environment to obtain calibration data on the device main body, and a nonvolatile memory 6 for storing the calibration data.
    Type: Grant
    Filed: November 10, 2000
    Date of Patent: January 11, 2005
    Assignee: Yamatake Corporation
    Inventors: Ikuo Nishimoto, Shiro Kano, Shigeo Miyagawa
  • Patent number: 6750560
    Abstract: A device includes a coil (11) coupled to a magnetic field having power energy by electromagnetic induction, a rectifier (12) for subjecting the power energy fetched by the coil to full-wave rectification, a smoothing circuit (13) for smoothing a rectified output from the rectifier and forming a fixed internal power source, an MOS transistor (14) having a source and a drain connected in parallel across the coil, and a constant-voltage control circuit (15) adapted to be actuated to control the gate voltage of the MOS transistor in response to the output of the smoothing circuit, thereby limiting voltage (power) applied to the rectifier.
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: June 15, 2004
    Assignee: Yamatake Corporation
    Inventors: Ikuo Nishimoto, Tatsuya Ueno
  • Patent number: 6649985
    Abstract: An insulated-gate semiconductor device comprises a source region (S) formed on a predetermined semiconductor substrate such as a ball semiconductor, a drain region (D) formed on the semiconductor substrate at a distance from the source region; and a gate electrode (G) formed on the semiconductor substrate with an insulating layer interposed therebetween to create a channel region between the source and drain regions. The insulated-gate semiconductor device is characterized in that the drain region and the source region are formed asymmetrically with respect to the channel region suited to be incorporated in a rectifier circuit for full-wave rectification of power supplied through inductive coupling of coils. In particular, the channel region is formed to surround the source region while the drain region is formed outside the channel region so that the effective channel width adjoining the source region may be different from that adjoining the drain region.
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: November 18, 2003
    Assignee: Yamatake Corporation
    Inventors: Ikuo Nishimoto, Tatsuya Ueno
  • Patent number: 6650213
    Abstract: An electromagnetic-induction coupling apparatus adapted for use as a feeder system for supplying electric power to a spherical semiconductor (10) having a coil (11) on the surface thereof by electromagnetic-induction coupling by means of the coil and/or a data communication system for transferring information signals to and from the spherical semiconductor through the coil. The apparatus comprises a coil array (22) including a plurality of coil elements (21) symmetrically two-dimensionally arranged in the longitudinal and transverse directions, for example, on a given plane, and a magnetic field control element (24) for controlling the respective polarities and phases of magnetic fields generated by means of the individual coil elements of the coil array, thereby changing the respective directions of magnetic fields in a region near the coil array to which the spherical semiconductor is guided.
    Type: Grant
    Filed: November 29, 2002
    Date of Patent: November 18, 2003
    Assignee: Yamatake Corporation
    Inventors: Yuji Sakurai, Ikuo Nishimoto
  • Patent number: 6534778
    Abstract: A ball detecting apparatus having a simple structure and being capable of surely detecting balls carried in a tube using transparent liquid as a carrier without being affected by bubbles produced in the tube. The ball detecting apparatus has a surface light source 12 for projecting diffused light having a predetermined beam cross section and a predetermined beam spread angle, from a side of a tube 11 in which balls 10 are carried, into the tube 11. A photo detector 13 is arranged opposite to the surface light source 12 with the tube between. The photo detector receives a component of the diffused light that travels directly toward a light receiving area and/or a component of the diffused light that has been deflected by a bubble produced in the transparent liquid to travel toward the receiving area. The light receiving area is adapted to be able to be completely shielded from the diffused light by the balls.
    Type: Grant
    Filed: July 17, 2000
    Date of Patent: March 18, 2003
    Assignee: Yamatake Corporation
    Inventor: Ikuo Nishimoto
  • Publication number: 20020125545
    Abstract: A spherical semiconductor device 1a comprises three spherical semiconductors 10, 20 and 30, which are connected together. An electronic circuit is formed on the surface of the central spherical semiconductor 10, among the three spherical semiconductors, while a coil 21 and a capacitor 31 are formed on the respective surfaces of the other spherical semiconductors 20 and 30, respectively. Since the spherical semiconductors 20 and 30 at the opposite ends are independent of the central spherical semiconductor 10, an insulating film on the coil 21 never influences the properties of the electronic circuit of the central spherical semiconductor 10, and the capacitor 31 can secure a capacity large enough to maintain satisfactory operating power for the spherical semiconductor device 1a. Since the three spherical semiconductors 10, 20 and 30 are manufactured in different processes, moreover, the productivity of the spherical semiconductors cannot be lowered by differences between manufacturing processes.
    Type: Application
    Filed: November 29, 2001
    Publication date: September 12, 2002
    Applicant: Yamatake Corporation
    Inventors: Shiro Kano, Ikuo Nishimoto, Shigeo Miyagawa
  • Patent number: 5578451
    Abstract: A method of identifying a therapeutic useful for treating or preventing Alzheimer's disease, which method includes the steps of contacting (a) a first molecule containing the couplone portion of APP (SEQ ID NO: 1) with (b) a second molecule containing the amino acid sequence of G.sub.o (SEQ ID NO: 2) or an APP-associating region of G.sub.o (SEQ ID NOs: 3, 4, or 5), in the presence of a candidate compound; and determining whether the candidate compound interferes with the association of the first and second molecules, such interference being an indication that the candidate compound is a potential Alzheimer's disease therapeutic.
    Type: Grant
    Filed: January 12, 1995
    Date of Patent: November 26, 1996
    Assignee: The General Hospital Corporation
    Inventor: Ikuo Nishimoto
  • Patent number: 5559209
    Abstract: A molecule having a peptide sequence of 80 or fewer amino acid residues containing the amino acid sequence of an anticouplone of any of the G proteins, which molecule is useful for inhibiting activation of the G protein by its G-coupled receptor.
    Type: Grant
    Filed: February 18, 1993
    Date of Patent: September 24, 1996
    Assignee: The General Hospital Corporation
    Inventor: Ikuo Nishimoto
  • Patent number: 5500728
    Abstract: The photoelectric distance sensor for sensing a distance to a sense object by irradiating light to the sense object, the photoelectric distance sensor comprises a light-irradiating section 3 for irradiating light to a sense object 6, a light-receiving section for receiving the reflected light from the sense object 6, an operating section for outputting the distance to the sense object 6 and the target value of received light amount fitted to the distance on the signal of the light-receiving section 4, and a light-irradiation-controlling section 17 for controlling a light irradiation amount on the target value of received light amount, and the photoelectric sensor is for controlling the light irradiation amount in order that the received light amount becomes the most fitted value according to the distance, and further the photoelectric sensor can enlarge the light irradiation amount according to the distance in near distances and can make measurement precision be improved.
    Type: Grant
    Filed: December 22, 1993
    Date of Patent: March 19, 1996
    Assignee: Yamatake-Honeywell Co., Ltd.
    Inventor: Ikuo Nishimoto
  • Patent number: 5471050
    Abstract: In the photoelectric conversion method and apparatus applicable to displacement sensors irradiating light to objects and sensing the distances to the objects, distance-determining type photoelectric sensors etc., the method and apparatus arrange n (n>2) light-receiving elements in a predetermined direction, and divide each photoelectric current I1, I2, . . . , In of each light-receiving element in predetermined ratios k1 to 1-k1, k2 to 1-k2, . . . , kn to 1-kn; and lead the divided photoelectric currents to the first and the second photoelectric current output terminal, and control the predetermined ratios k1, k2, . . . , kn in keeping such relationships as k1>0.5>kn and km.ltoreq.kp (p=m-1; m=2 to n), therefore the arbitrary positions on the light-receiving surface can be set in high sensibility, and high speed responsibility can be attained.
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: November 28, 1995
    Assignee: Yamatake-Honeywell Co., Ltd.
    Inventors: Ikuo Nishimoto, Minoru Tanaka