Patents by Inventor Ilan Ben-Oren
Ilan Ben-Oren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240058059Abstract: Systems for enabling delivery of very high peak power laser pulses through optical fibers for use in ablation procedures preferably in contact mode. Such lasers advantageously emit at 355 nm wavelength. Other systems enable selective removal of undesired tissue within a blood vessel, while minimizing the risk of damaging the blood vessel itself, based on the use of the ablative properties of short laser pulses of 320 to 400 nm laser wavelength, with selected parameters of the mechanical walls of the tubes constituting the catheter, of the laser fluence and of the force that is applied by the catheter on the tissues. Additionally, a novel method of calibrating such catheters is disclosed, which also enables real time monitoring of the ablation process. Additionally, novel methods of protecting the fibers exit facets are disclosed.Type: ApplicationFiled: August 30, 2023Publication date: February 22, 2024Applicant: Eximo Medical Ltd .Inventors: Yoel ZABAR, Oren Meshulam STERN, Ilan BEN OREN
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Publication number: 20230414284Abstract: The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.Type: ApplicationFiled: September 5, 2023Publication date: December 28, 2023Inventors: Ilan BEN-OREN, Avia HERSCHKOVITZ, Tamir WOLF, Irit YANIV
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Publication number: 20230408329Abstract: A system for testing an ablation system comprising an optical box and a catheter connector is disclosed. The system comprises a qualitative beam assessment device, a quantitative beam assessment device, and a processor. The qualitative beam assessment device has a camera configured to record signals related to a beam profile of a beam emitted by the optical box. The quantitative beam assessment device has an energy sensor configured to measure a beam energy of the beam. The processor is configured to receive the signals from the beam assessment devices, determine a qualitative condition of the beam based on the beam profile signals, and determine a quantitative condition of the beam based on the beam energy signals.Type: ApplicationFiled: June 21, 2023Publication date: December 21, 2023Applicant: Eximo Medical Ltd.Inventors: Yoel Zabar, Ilan Ben Oren, Oren Meshulam Stern, Yonatan Romm
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Publication number: 20230363819Abstract: There is provided herein a catheter for resecting an undesired tissue from a body of a subject, the catheter comprising a tip section in a shape of a cylinder or a cylinder's sector having a central longitudinal axis, the tip section comprising: a central longitudinal lumen; a first set of optical fibers configured to transmit laser radiation outside a distal extremity of the tip section, in a direction parallel to the central longitudinal axis; a second set of optical fibers configured to transmit laser radiation, transversely to the central longitudinal axis; wherein the first set of optical fibers and the second set of optical fibers are selectively operable to resect and/or ablate the undesired tissue.Type: ApplicationFiled: May 16, 2023Publication date: November 16, 2023Applicant: Eximo Medical Ltd.Inventors: Ilan BEN OREN, Yoel ZABAR, Oren Meshulam STERN
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Publication number: 20230282357Abstract: A method for predicting transplant-free survival of a patient suffering from acute liver failure (ALF) or acute liver injury (ALI), the method including: performing a 13C-methacetin breath test which includes administering 13C labelled methacetin to the patient; measuring exhaled breath to evaluate changes in a 13CO2 to 12CO2 ratio for a predetermined time after the administering; calculating a PDR-peak value of the patient; and predicting the patient as having high chances of transplant-free survival if the calculated PDR-peak value is above a threshold value or as having low chances of transplant-free survival if the PDR-peak value is below threshold value.Type: ApplicationFiled: May 27, 2021Publication date: September 7, 2023Inventors: Gil GUGGENHEIM, Ofer SCHLESINGER, Avraham HERSHKOWITZ, Ilan BEN OREN, Raphael WERNER
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Patent number: 11684420Abstract: There is provided herein a catheter for resecting an undesired tissue from a body of a subject, the catheter comprising a tip section in a shape of a cylinder or a cylinder's sector having a central longitudinal axis, the tip section comprising: a central longitudinal lumen; a first set of optical fibers configured to transmit laser radiation outside a distal extremity of the tip section, in a direction parallel to the central longitudinal axis; a second set of optical fibers configured to transmit laser radiation, transversely to the central longitudinal axis; wherein the first set of optical fibers and the second set of optical fibers are selectively operable to resect and/or ablate the undesired tissue.Type: GrantFiled: May 5, 2017Date of Patent: June 27, 2023Assignee: EXIMO MEDICAL LTD.Inventors: Ilan Ben Oren, Yoel Zabar, Oren Meshulam Stern
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Publication number: 20230149033Abstract: Systems and methods for dynamically modulating aspiration in response to sensed conditions. An aspiration system can include a catheter configured to be inserted within a vasculature of the subject, a canister coupled to the catheter, a pressure source that generates a vacuum pressure through the catheter for aspirating the fluid, a sensor configured to sense a parameter associated with at least one of the catheter, the canister, or the pressure source, and a computer system coupled to the sensor. The computer can cause the pressure source to initiate the vacuum pressure throughout the catheter, receive a measurement of the parameter from the sensor, determine whether the measurement violates a threshold associated with the parameter, and modulate the vacuum pressure at the catheter tip in response to a determination that the measurement violates the threshold.Type: ApplicationFiled: November 16, 2022Publication date: May 18, 2023Applicant: Eximo Medical Ltd.Inventors: Yoel ZABAR, Ilan BEN OREN, Oren Meshulam STERN, Eitan Yaacov POLLACK
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Patent number: 11576724Abstract: A catheter for debulking of an undesired deposit from an inner surface of at least one of a blood vessel wall and a stent located in a blood vessel, the catheter having a tip section comprising: circumferentially-directed laser optics; and a circular-action cutter, wherein said circumferentially-directed laser optics is configured to transmit laser radiation for modifying an area of the undesired deposit thereby preparing said area for penetration of said cutter, wherein said cutter is configured to cut through said modified area and thereby debulk at least a part of the undesired deposit. In addition, a catheter for pacemaker and ICD (Implantable Cardioverter Defibrillator) lead extraction is disclosed.Type: GrantFiled: June 10, 2019Date of Patent: February 14, 2023Assignee: Eximo Medical Ltd.Inventors: Ilan Ben-Oren, Yifat Ben-Oren Tamir
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Patent number: 11564743Abstract: Device and method for selectively ablating a submucosal layer of a duodenal wall and/or of sensory neurons therein, including a laser transmitting element coupled with the catheter body and configured to transmit a laser beam having a spot diameter of less than 200 microns and to provide an ablative dose of 0.5-2.5 J/mm; wherein the laser beam is configured to selectively ablate an area of the submucosal layer that is at least twice the size of the spot diameter, while essentially preventing damage of the surrounding mucosal, muscularis and/or serosal layers of the duodenal wall; and an expandable member configured to stretch the duodenal wall and to generate a fixed distance between the catheter's laser transmitting element and the duodenal wall.Type: GrantFiled: December 31, 2019Date of Patent: January 31, 2023Assignee: DIGMA MEDICAL LTD.Inventors: Ilan Ben Oren, Boaz Behar
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Publication number: 20230000555Abstract: A catheter for debulking of an undesired deposit from an inner surface of at least one of a blood vessel wall and a stent located in a blood vessel, the catheter having a tip section comprising: circumferentially-directed laser optics; and a circular-action cutter, wherein said circumferentially-directed laser optics is configured to transmit laser radiation for modifying an area of the undesired deposit thereby preparing said area for penetration of said cutter, wherein said cutter is configured to cut through said modified area and thereby debulk at least a part of the undesired deposit. In addition, a catheter for pacemaker and ICD (Implantable Cardioverter Defibrillator) lead extraction is disclosed.Type: ApplicationFiled: September 8, 2022Publication date: January 5, 2023Applicant: EXIMO MEDICAL LTD.Inventors: Ilan BEN-OREN, Yifat BEN-OREN TAMIR
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Publication number: 20220401038Abstract: Disclosed is a method for predicting a decompensation event in a patient suffering from NASH, including performing a 13C methacetin breath test on a patient; calculating a PDR-peak value of the patient, based on the 13C methacetin breath test; and identifying the patient as having high-risk of developing a decompensation event within 1 year from the performing of the breath test, if the PDR-peak value is at or below a predetermined threshold value; wherein the predetermined threshold value is 15%/h.Type: ApplicationFiled: November 16, 2020Publication date: December 22, 2022Inventors: Gil GUGGENHEIM, Ofer SCHLESINGER, Avraham HERSHKOWITZ, Ilan BEN-OREN, Raphael WERNER
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Publication number: 20220211437Abstract: The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.Type: ApplicationFiled: March 24, 2022Publication date: July 7, 2022Inventors: Ilan BEN-OREN, Avia HERSCHKOVITZ, Tamir WOLF, Irit YANIV
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Patent number: 11311337Abstract: The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.Type: GrantFiled: July 13, 2020Date of Patent: April 26, 2022Assignee: DIGMA MEDICAL LTD.Inventors: Ilan Ben-Oren, Avia Herschkovitz, Tamir Wolf, Irit Yaniv
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Publication number: 20210361355Abstract: Systems for enabling delivery of very high peak power laser pulses through optical fibers for use in ablation procedures preferably in contact mode. Such lasers advantageously emit at 355 nm wavelength. Other systems enable selective removal of undesired tissue within a blood vessel, while minimizing the risk of damaging the blood vessel itself, based on the use of the ablative properties of short laser pulses of 320 to 400 nm laser wavelength, with selected parameters of the mechanical walls of the tubes constituting the catheter, of the laser fluence and of the force that is applied by the catheter on the tissues. Additionally, a novel method of calibrating such catheters is disclosed, which also enables real time monitoring of the ablation process. Additionally, novel methods of protecting the fibers exit facets are disclosed.Type: ApplicationFiled: August 6, 2021Publication date: November 25, 2021Inventors: Yoel ZABAR, Oren Meshulam STERN, Ilan BEN OREN
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Publication number: 20210361354Abstract: Catheter for real-time evaluation of duodenal ablation, the catheter including an expandable member configured to stretch the duodenal wall and to generate a fixed distance between a center of the catheter and the duodenal wall; a laser transmitting element coupled with the catheter body and configured to transmit a first laser beam and a second laser beam; wherein the first laser beam is configured to cause ablative damage in a region of the duodenal wall as a result of its impingement thereon, and wherein the second laser beam is configured to detect modifications in the region of the duodenal wall resulting from the impingement of the first laser beam thereon.Type: ApplicationFiled: August 4, 2021Publication date: November 25, 2021Inventor: Ilan BEN OREN
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Patent number: 11116409Abstract: A device for detection of internal bleeding in a patient's body is provided. An optical interface for transmitting IR light through an area of a skin of a patient and to collect IR light from the area of the skin, is provided. In some embodiments the optical interface includes one or more delivery components and one or more collection components. The delivery component includes a plurality of first optical channels configured to transmit the IR light through a plurality of respective first sub-areas on the area of the skin, into an internal layer of the body. The collection component includes a plurality of second optical channels, configured to collect IR light from a plurality of respective second sub-areas on the area of the skin.Type: GrantFiled: May 1, 2019Date of Patent: September 14, 2021Inventors: Dean Nahman, Yaron Ilan, Ilan Ben Oren, Yaron Bar-Ilan, Shmuel Chen
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Patent number: 11116573Abstract: Systems for enabling delivery of very high peak power laser pulses through optical fibers for use in ablation procedures preferably in contact mode. Such lasers advantageously emit at 355 nm wavelength. Other systems enable selective removal of undesired tissue within a blood vessel, while minimizing the risk of damaging the blood vessel itself, based on the use of the ablative properties of short laser pulses of 320 to 400 nm laser wavelength, with selected parameters of the mechanical walls of the tubes constituting the catheter, of the laser fluence and of the force that is applied by the catheter on the tissues. Additionally, a novel method of calibrating such catheters is disclosed, which also enables real time monitoring of the ablation process. Additionally, novel methods of protecting the fibers exit facets are disclosed.Type: GrantFiled: October 21, 2020Date of Patent: September 14, 2021Inventors: Yoel Zabar, Oren Meshulam Stern, Ilan Ben Oren
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Patent number: 11109913Abstract: Catheter for real-time evaluation of duodenal ablation, the catheter including an expandable member configured to stretch the duodenal wall and to generate a fixed distance between a center of the catheter and the duodenal wall; a laser transmitting element coupled with the catheter body and configured to transmit a first laser beam and a second laser beam; wherein the first laser beam is configured to cause ablative damage in a region of the duodenal wall as a result of its impingement thereon, and wherein the second laser beam is configured to detect modifications in the region of the duodenal wall resulting from the impingement of the first laser beam thereon.Type: GrantFiled: August 14, 2017Date of Patent: September 7, 2021Assignee: DIGMA MEDICAL LTD.Inventors: Yonatan Shamay, Boaz Behar, Ilan Ben Oren
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Patent number: 11090117Abstract: Systems for enabling delivery of very high peak power laser pulses through optical fibers for use in ablation procedures preferably in contact mode. Such lasers advantageously emit at 355 nm wavelength. Other systems enable selective removal of undesired tissue within a blood vessel, while minimizing the risk of damaging the blood vessel itself, based on the use of the ablative properties of short laser pulses of 320 to 400 nm laser wavelength, with selected parameters of the mechanical walls of the tubes constituting the catheter, of the laser fluence and of the force that is applied by the catheter on the tissues. Additionally, a novel method of calibrating such catheters is disclosed, which also enables real time monitoring of the ablation process. Additionally, novel methods of protecting the fibers exit facets are disclosed.Type: GrantFiled: December 16, 2020Date of Patent: August 17, 2021Inventors: Yoel Zabar, Oren Meshulam Stern, Ilan Ben Oren
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Publication number: 20210128242Abstract: Systems for enabling delivery of very high peak power laser pulses through optical fibers for use in ablation procedures preferably in contact mode. Such lasers advantageously emit at 355 nm wavelength. Other systems enable selective removal of undesired tissue within a blood vessel, while minimizing the risk of damaging the blood vessel itself, based on the use of the ablative properties of short laser pulses of 320 to 400 nm laser wavelength, with selected parameters of the mechanical walls of the tubes constituting the catheter, of the laser fluence and of the force that is applied by the catheter on the tissues. Additionally, a novel method of calibrating such catheters is disclosed, which also enables real time monitoring of the ablation process. Additionally, novel methods of protecting the fibers exit facets are disclosed.Type: ApplicationFiled: December 16, 2020Publication date: May 6, 2021Inventors: Yoel ZABAR, Oren Meshulam STERN, Ilan BEN OREN