Patents by Inventor Ilan Ben-Oren
Ilan Ben-Oren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210100493Abstract: There is provided a method of evaluating a liver condition of a subject, the method includes computing a fluctuation parameter from a liver breath test based on at least one of a percentage dose recovery (PDR) curve and a delta over baseline (DOB) curve of an isotope labeled methacetin, or a salt or a derivative thereof, and evaluating at least one liver condition of the subject, based at least on the fluctuation parameter. There is provided herein a method of evaluating a liver condition of a subject, the method includes computing a hepatic impairment score based at least on a breath test related parameter and on a demographic parameter.Type: ApplicationFiled: October 1, 2020Publication date: April 8, 2021Inventors: Ilan BEN OREN, Gil GUGGENHEIM, Avraham HERSHKOWITZ, Yaron ILAN
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Patent number: 10925671Abstract: The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.Type: GrantFiled: September 20, 2018Date of Patent: February 23, 2021Assignee: DIGMA MEDICAL LTD.Inventors: Ilan Ben-Oren, Avia Herschkovitz, Tamir Wolf, Irit Yaniv
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Publication number: 20210030472Abstract: Systems for enabling delivery of very high peak power laser pulses through optical fibers for use in ablation procedures preferably in contact mode. Such lasers advantageously emit at 355 nm wavelength. Other systems enable selective removal of undesired tissue within a blood vessel, while minimizing the risk of damaging the blood vessel itself, based on the use of the ablative properties of short laser pulses of 320 to 400 nm laser wavelength, with selected parameters of the mechanical walls of the tubes constituting the catheter, of the laser fluence and of the force that is applied by the catheter on the tissues. Additionally, a novel method of calibrating such catheters is disclosed, which also enables real time monitoring of the ablation process. Additionally, novel methods of protecting the fibers exit facets are disclosed.Type: ApplicationFiled: October 21, 2020Publication date: February 4, 2021Inventors: Yoel ZABAR, Oren Meshulam STERN, Ilan BEN OREN
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Patent number: 10888377Abstract: The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.Type: GrantFiled: May 7, 2018Date of Patent: January 12, 2021Assignee: DIGMA MEDICAL LTD.Inventors: Ilan Ben-Oren, Avia Herschkovitz, Tamir Wolf, Irit Yaniv
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Publication number: 20200397312Abstract: The invention comprises a system and method for identification and/or characterization of lesions and/or the various type of tissues inside blood vessels, including utilizing a laser system configured to transmit laser radiation towards and/or onto a lesion within a blood vessel, monitoring ablation of the lesion utilizing at least one acoustic sensor; and, using a processor, comparing the signals obtained from the acoustic signal to previously obtained acoustic signals associated with specific lesion types and determine a type of the lesion and/or an efficiency of the ablation process based on the comparison.Type: ApplicationFiled: June 4, 2020Publication date: December 24, 2020Applicant: EXIMO MEDICAL LTDInventors: Ilan Ben Oren, Yoel Zabar, ZIV ALPEROVICH
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Patent number: 10827969Abstract: There is provided a method of evaluating a liver condition of a subject, the method includes computing a fluctuation parameter from a liver breath test based on at least one of a percentage dose recovery (PDR) curve and a delta over baseline (DOB) curve of an isotope labeled methacetin, or a salt or a derivative thereof, and evaluating at least one liver condition of the subject, based at least on the fluctuation parameter. There is provided herein a method of evaluating a liver condition of a subject, the method includes computing a hepatic impairment score based at least on a breath test related parameter and on a demographic parameter.Type: GrantFiled: July 16, 2013Date of Patent: November 10, 2020Assignee: EXALENZ BIOSCIENCE LTD.Inventors: Ilan Ben-Oren, Gil Guggenheim, Avraham Hershkowitz, Yaron Ilan
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Publication number: 20200337772Abstract: The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.Type: ApplicationFiled: July 13, 2020Publication date: October 29, 2020Inventors: Ilan BEN-OREN, Avia HERSCHKOVITZ, Tamir WOLF, Irit YANIV
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Patent number: 10792103Abstract: Systems for enabling delivery of very high peak power laser pulses through optical fibers for use in ablation procedures preferably in contact mode. Such lasers advantageously emit at 355 nm wavelength. Other systems enable selective removal of undesired tissue within a blood vessel, while minimizing the risk of damaging the blood vessel itself, based on the use of the ablative properties of short laser pulses of 320 to 400 nm laser wavelength, with selected parameters of the mechanical walls of the tubes constituting the catheter, of the laser fluence and of the force that is applied by the catheter on the tissues. Additionally, a novel method of calibrating such catheters is disclosed, which also enables real time monitoring of the ablation process. Additionally, novel methods of protecting the fibers exit facets are disclosed.Type: GrantFiled: October 17, 2019Date of Patent: October 6, 2020Assignee: EXIMO MEDICAL LTD.Inventors: Yoel Zabar, Oren Meshulam Stern, Ilan Ben Oren
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Patent number: 10772683Abstract: Systems for enabling delivery of very high peak power laser pulses through optical fibers for use in ablation procedures preferably in contact mode. Such lasers advantageously emit at 355 nm wavelength. Other systems enable selective removal of undesired tissue within a blood vessel, while minimizing the risk of damaging the blood vessel itself, based on the use of the ablative properties of short laser pulses of 320 to 400 nm laser wavelength, with selected parameters of the mechanical walls of the tubes constituting the catheter, of the laser fluence and of the force that is applied by the catheter on the tissues. Additionally, a novel method of calibrating such catheters is disclosed, which also enables real time monitoring of the ablation process. Additionally, novel methods of protecting the fibers exit facets are disclosed.Type: GrantFiled: October 3, 2019Date of Patent: September 15, 2020Assignee: EXIMO MEDICAL LTD.Inventors: Yoel Zabar, Oren Meshulam Stern, Ilan Ben Oren
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Publication number: 20200281483Abstract: A device for detection of internal bleeding in a patient's body is provided. An optical interface for transmitting IR light through an area of a skin of a patient and to collect IR light from the area of the skin, is provided. In some embodiments the optical interface includes one or more delivery components and one or more collection components. The delivery component includes a plurality of first optical channels configured to transmit the IR light through a plurality of respective first sub-areas on the area of the skin, into an internal layer of the body. The collection component includes a plurality of second optical channels, configured to collect IR light from a plurality of respective second sub-areas on the area of the skin.Type: ApplicationFiled: May 1, 2019Publication date: September 10, 2020Inventors: Dean NAHMAN, Yaron ILAN, Ilan BEN OREN, Yaron BAR-ILAN, Shmuel CHEN
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Publication number: 20200261013Abstract: There is provided herein systems and methods for managing a subject suffering from cognitive impairment, the method comprising: providing to a subject a cognitive training session; determining at least one aspect of the subject's cognitive performance based on and/or in response to said training session; monitoring one or more life style, physiological and/or medical parameters of the subject before, during and/or after said training session; identifying peaks in the subject's cognitive performance; wherein the identifying comprises comparing the determined cognitive performance to stored cognitive performance data; identifying changes in one or more life style, physiological and/or medical parameters positively or negatively associated with the peak in the cognitive performance; and providing the subject with a life style, physiological and/or medical recommendation based on the on identified association.Type: ApplicationFiled: September 20, 2018Publication date: August 20, 2020Inventor: Ilan BEN-OREN
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Publication number: 20200237440Abstract: New devices and methods for deflecting a catheter progressing within a lumen, into a preferred direction, typically in order to accomplish ablative removal of obstructive material within that lumen without the danger of uncontrolled catheter deflection risking perforation of the lumen. The catheter may ride on a guide wire, or it may be free riding down the lumen, limited by the passages available in the obstructive material, and generating its own passage by debulking the material within the lumen. The types of deflection required may be radial or lateral. A number of novel configurations are described, including improvements to the slotted wall catheter, by selection of the shape, spacing and location of the slots. Other implementations include a catheter with a novel spring configuration, which can release itself from a situation in which the catheter becomes stuck when widening an initial narrow bore in an obstructed vessel.Type: ApplicationFiled: April 3, 2020Publication date: July 30, 2020Applicant: EXIMO MEDICAL LTDInventors: Yoel ZABAR, Ilan BEN OREN, Oren Meshulam STERN, Shay GRANOT
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Patent number: 10575904Abstract: Device and method for selectively ablating a submucosal layer of a duodenal wall and/or of sensory neurons therein, including a laser transmitting element coupled with the catheter body and configured to transmit a laser beam having a spot diameter of less than 200 microns and to provide an ablative dose of 0.5-2.5 J/mm; wherein the laser beam is configured to selectively ablate an area of the submucosal layer that is at least twice the size of the spot diameter, while essentially preventing damage of the surrounding mucosal, muscularis and/or serosal layers of the duodenal wall; and an expandable member configured to stretch the duodenal wall and to generate a fixed distance between the catheter's laser transmitting element and the duodenal wall.Type: GrantFiled: August 14, 2017Date of Patent: March 3, 2020Assignee: DIGMA MEDICAL LTD.Inventors: Ilan Ben Oren, Boaz Behar
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Publication number: 20200046430Abstract: Systems for enabling delivery of very high peak power laser pulses through optical fibers for use in ablation procedures preferably in contact mode. Such lasers advantageously emit at 355 nm wavelength. Other systems enable selective removal of undesired tissue within a blood vessel, while minimizing the risk of damaging the blood vessel itself, based on the use of the ablative properties of short laser pulses of 320 to 400 nm laser wavelength, with selected parameters of the mechanical walls of the tubes constituting the catheter, of the laser fluence and of the force that is applied by the catheter on the tissues. Additionally, a novel method of calibrating such catheters is disclosed, which also enables real time monitoring of the ablation process. Additionally, novel methods of protecting the fibers exit facets are disclosed.Type: ApplicationFiled: October 17, 2019Publication date: February 13, 2020Inventors: Yoel ZABAR, Oren Meshulam STERN, Ilan BEN OREN
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Publication number: 20200038107Abstract: Systems for enabling delivery of very high peak power laser pulses through optical fibers for use in ablation procedures preferably in contact mode. Such lasers advantageously emit at 355 nm wavelength. Other systems enable selective removal of undesired tissue within a blood vessel, while minimizing the risk of damaging the blood vessel itself, based on the use of the ablative properties of short laser pulses of 320 to 400 nm laser wavelength, with selected parameters of the mechanical walls of the tubes constituting the catheter, of the laser fluence and of the force that is applied by the catheter on the tissues. Additionally, a novel method of calibrating such catheters is disclosed, which also enables real time monitoring of the ablation process. Additionally, novel methods of protecting the fibers exit facets are disclosed.Type: ApplicationFiled: October 3, 2019Publication date: February 6, 2020Inventors: Yoel ZABAR, Oren Meshulam STERN, Ilan BEN OREN
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Patent number: 10537387Abstract: The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation.Type: GrantFiled: April 16, 2015Date of Patent: January 21, 2020Assignee: DIGMA MEDICAL LTD.Inventors: Ilan Ben Oren, Irit Yaniv, Tamir Wolf, Avia Herschkovitz
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Publication number: 20190321103Abstract: A catheter for debulking of an undesired deposit from an inner surface of at least one of a blood vessel wall and a stent located in a blood vessel, the catheter having a tip section comprising: circumferentially-directed laser optics; and a circular-action cutter, wherein said circumferentially-directed laser optics is configured to transmit laser radiation for modifying an area of the undesired deposit thereby preparing said area for penetration of said cutter, wherein said cutter is configured to cut through said modified area and thereby debulk at least a part of the undesired deposit. In addition, a catheter for pacemaker and ICD (Implantable Cardioverter Defibrillator) lead extraction is disclosed.Type: ApplicationFiled: June 10, 2019Publication date: October 24, 2019Inventors: Ilan Ben-Oren, Yifat Ben-Oren Tamir
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Publication number: 20190254536Abstract: A device for detection of internal bleeding in a patient's body is provided. An optical interface for transmitting IR light through an area of a skin of a patient and to collect IR light from the area of the skin, is provided. In some embodiments the optical interface includes one or more delivery components and one or more collection components. The delivery component includes a plurality of first optical channels configured to transmit the IR light through a plurality of respective first sub-areas on the area of the skin, into an internal layer of the body. The collection component includes a plurality of second optical channels, configured to collect IR light from a plurality of respective second sub-areas on the area of the skin.Type: ApplicationFiled: May 1, 2019Publication date: August 22, 2019Inventors: Dean NAHMAN, Yaron ILAN, Ilan BEN OREN, Yaron BAR-ILAN, Shmuel CHEN
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Patent number: 10363099Abstract: A catheter for debulking an undesired deposit from an inner surface of at least one of a blood vessel wall and a stent located in a blood vessel, the catheter having a tip section comprising: circumferentially-directed laser optics; and a circular-action cutter, wherein the circumferentially-directed laser optics is configured to transmit laser radiation for modifying an area of the undesired deposit thereby preparing the area for penetration of the cutter, wherein the cutter is configured to cut through the modified area and thereby debulk at least a part of the undesired deposit. In addition, a catheter for pacemaker and ICD (Implantable Cardioverter Defibrillator) lead extraction is disclosed.Type: GrantFiled: July 13, 2017Date of Patent: July 30, 2019Assignee: Eximo Medical Ltd.Inventors: Ilan Ben Oren, Yifat Ben Oren Tamir
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Patent number: D879957Type: GrantFiled: October 2, 2017Date of Patent: March 31, 2020Assignee: AngioDynamics, Inc.Inventors: Yoel Zabar, Ilan Ben-Oren