Patents by Inventor Ilia Fishbein
Ilia Fishbein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9694103Abstract: A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.Type: GrantFiled: September 7, 2012Date of Patent: July 4, 2017Assignee: The Children's Hospital of PhiladelphiaInventors: Ivan Alferiev, Ilia Fishbein, Michael Chorny, Robert J. Levy, Benjamin Yellen, Darryl Williams
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Patent number: 9095610Abstract: Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.Type: GrantFiled: September 30, 2013Date of Patent: August 4, 2015Assignees: CHILDREN'S HOSPITAL OF PHILADELPHIA, DREXEL UNIVERSITYInventors: Robert J. Levy, Boris Polyak, Michael Chorny, Ilia Fishbein, Ivan Alferiev, Gennady Friedman, Darryl Williams
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Patent number: 9084877Abstract: A treatment system includes a magnetic targeting catheter and a plurality of MNP. The MNP may include one or more magnetic field-responsive agents and one or more therapeutic agents. The catheter may include an inner shaft having at least one lumen and a fluid delivery balloon adapted to administer a fluid from the inner shaft into a space surrounding the catheter. An expandable mesh formed of a magnetizable material may surround the fluid delivery balloon. The catheter may further include one or more occlusion balloons for controlling blood flow through a vessel in which the catheter is placed. A method of treating a medical condition may include advancing a magnetic targeting catheter to a site, deploying an expandable mesh connected to the catheter, applying a magnetic field to the mesh and depositing a plurality of MNP or cells loaded with MNP near the mesh.Type: GrantFiled: October 27, 2011Date of Patent: July 21, 2015Assignee: The Children's Hospital of PhiladelphiaInventors: Robert J. Levy, Michael Chorny, Ilia Fishbein
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Publication number: 20140170201Abstract: Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.Type: ApplicationFiled: September 30, 2013Publication date: June 19, 2014Applicants: Drexel University, The Children's Hospital of PhiladelphiaInventors: Robert J. Levy, Boris Polyak, Michael Chorny, Ilia Fishbein, Ivan Alferiev, Gennady Friedman, Darryl Williams
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Patent number: 8580545Abstract: A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided.Type: GrantFiled: November 29, 2011Date of Patent: November 12, 2013Assignee: The Children's Hospital of PhiladelphiaInventors: Ivan Alferiev, Robert J. Levy, Ilia Fishbein
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Patent number: 8562505Abstract: Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.Type: GrantFiled: May 1, 2008Date of Patent: October 22, 2013Assignees: The Children's Hospital of Philadelphia, Drexel UniversityInventors: Robert J. Levy, Boris Polyak, Michael Chorny, Ivan Alferiev, Gennady Friedman, Darryl Williams, Ilia Fishbein
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Publication number: 20130267762Abstract: A treatment system includes a magnetic targeting catheter and a plurality of MNP. The MNP may include one or more magnetic field-responsive agents and one or more therapeutic agents. The catheter may include an inner shaft having at least one lumen and a fluid delivery balloon adapted to administer a fluid from the inner shaft into a space surrounding the catheter. An expandable mesh formed of a magnetizable material may surround the fluid delivery balloon. The catheter may further include one or more occlusion balloons for controlling blood flow through a vessel in which the catheter is placed. A method of treating a medical condition may include advancing a magnetic targeting catheter to a site, deploying an expandable mesh connected to the catheter, applying a magnetic field to the mesh and depositing a plurality of MNP or cells loaded with MNP near the mesh.Type: ApplicationFiled: October 27, 2011Publication date: October 10, 2013Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIAInventors: Robert J. Levy, Michael Chorny, Ilia Fishbein
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Publication number: 20130243862Abstract: A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.Type: ApplicationFiled: September 7, 2012Publication date: September 19, 2013Applicant: The Children's Hospital of PhiladelphiaInventors: Ivan Alferiev, Ilia Fishbein, Michael Chorny, Robert J. Levy, Benjamin Yellen, Darryl Williams
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Publication number: 20130096361Abstract: Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.Type: ApplicationFiled: May 1, 2008Publication date: April 18, 2013Applicant: The Children's Hospital of PhiladelphiaInventors: Robert J. Levy, Boris Polyak, Michael Chorny, Ivan Alferiev, Gennady Friedman, Darryl Williams, Ilia Fishbein
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Publication number: 20130011370Abstract: Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.Type: ApplicationFiled: September 13, 2012Publication date: January 10, 2013Applicant: The Children's Hospital of PhiladelphiaInventors: Robert J. Levy, Boris Polyak, Michael Chorny, Ilia Fishbein, Ivan Alferiev, Gennady Friedman, Darryl Williams
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Patent number: 8263127Abstract: A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.Type: GrantFiled: December 8, 2009Date of Patent: September 11, 2012Assignee: The Children's Hospital of PhiladelphiaInventors: Ivan Alferiev, Ilia Fishbein, Michael Chorny, Robert J. Levy, Benjamin Yellen, Darryl Williams
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Publication number: 20120141419Abstract: A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided.Type: ApplicationFiled: November 29, 2011Publication date: June 7, 2012Applicant: The Children's Hospital of PhiladelphiaInventors: Ivan Alferiev, Robert J. Levy, Ilia Fishbein
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Patent number: 8084435Abstract: A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided.Type: GrantFiled: May 3, 2007Date of Patent: December 27, 2011Assignee: The Children's Hospital of PhiladelphiaInventors: Ivan Alferiev, Robert J. Levy, Ilia Fishbein
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Publication number: 20110076767Abstract: A particle including a matrix-forming agent and a polyelectrolyte-amphiphilic agent adduct wherein the polyelectrolyte-amphiphilic agent adduct is in physical communication with the matrix-forming agent. The particle further includes a coated magnetic field-responsive agent and a biomaterial. Methods of making the particle are provided. Also provided are methods of delivery of the biomaterial to a target cell or a target tissue including administering the particle having the matrix-forming agent, polyelectrolyte-amphiphilic agent adduct, the coated magnetic field-responsive agent and the biomaterial; providing a magnetic device associated with the target cell or the target tissue; applying a magnetic force to the particle; and guiding the particle toward the magnetic device by the magnetic force.Type: ApplicationFiled: December 6, 2010Publication date: March 31, 2011Applicant: The Children's Hospital of PhiladelphiaInventors: Michael Chrony, Boris Polyak, Ilia Fishbein, Ivan Alferiev, Robert J. Levy
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Patent number: 7846201Abstract: A particle including a matrix-forming agent and a polyelectrolyte-amphiphilic agent adduct wherein the polyelectrolyte-amphiphilic agent adduct is in physical communication with the matrix-forming agent. The particle further includes a coated magnetic field-responsive agent and a biomaterial. Methods of making the particle are provided. Also provided are methods of delivery of the biomaterial to a target cell or a target tissue including administering the particle having the matrix-forming agent, polyelectrolyte-amphiphilic agent adduct, the coated magnetic field-responsive agent and the biomaterial; providing a magnetic device associated with the target cell or the target tissue; applying a magnetic force to the particle; and guiding the particle toward the magnetic device by the magnetic force.Type: GrantFiled: October 14, 2005Date of Patent: December 7, 2010Assignee: The Children's Hospital of PhiladelphiaInventors: Michael Chorny, Boris Polyak, Ilia Fishbein, Ivan Alferiev, Robert J. Levy
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Publication number: 20100210015Abstract: A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.Type: ApplicationFiled: December 8, 2009Publication date: August 19, 2010Applicant: The Children's Hospital of PhiladelphiaInventors: Ivan Alferiev, Ilia Fishbein, Michael Chorny, Robert J. Levy, Benjamin Yellen, Darryl Williams
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Patent number: 7635734Abstract: A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.Type: GrantFiled: October 14, 2005Date of Patent: December 22, 2009Assignee: The Children's Hospital of PhiladelphiaInventors: Ivan Alferiev, Ilia Fishbein, Michael Chorny, Robert J. Levy, Benjamin Yellen, Darryl Williams
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Patent number: 7589070Abstract: A therapeutic delivery system efficiently introduces biologically active molecules to mammalian cells without the use of synthetic polymers or biopolymer coatings. Surface modification of a metal support, such as a medical device, results in a single molecular layer that can fasten various molecules, thereby minimizing any cellular inflammatory response while enhancing biocompatibility.Type: GrantFiled: June 14, 2002Date of Patent: September 15, 2009Assignee: The Children's Hospital of PhiladelphiaInventors: Robert J. Levy, Ivan Alferiev, Cunxian Song, Ilia Fishbein
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Publication number: 20090216320Abstract: A therapeutic system and a method that uses stents, and/or other implantable devices (104) for local delivery of a therapeutic agent is disclosed. A therapeutic formulation (102) may include particles of a biocompatible magnetic or magnetizable material that carry the therapeutic agent, or magnetically responsive cells. The therapeutic formulation (102) is intravenously administered to a mammalian subject. A portion of the formulation (102) is delivered to the proximity of a device (104) implanted in the vascular system of the subject by externally generating a magnetic field gradient (106) on the implantable device (104). The portion of the therapeutic formulation (102) not delivered to the proximity of the implantable device (104) is removed from the vascular system. The method allows for the repeated administration of the same or different therapeutic agent, and further, has the option of locally injecting, or alternatively, peripherally administering, the therapeutic agent.Type: ApplicationFiled: April 20, 2007Publication date: August 27, 2009Applicants: The Children's Hospital of Philadelphia, Drexel UniversityInventors: Robert J. Levy, Ivan Alferlev, Michael Chorny, Ilia Fishbein, Gennady Friedman, Boris Polyak, Darryl Williams
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Publication number: 20090082611Abstract: Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.Type: ApplicationFiled: May 1, 2008Publication date: March 26, 2009Applicant: The Children's Hospital of PhiladelphiaInventors: Robert J. Levy, Boris Polyak, Michael Chorny, Ivan Alferiev, Gennady Friedman, Darryl Williams, Ilia Fishbein