Abstract: The present invention relates to a pyrazolopyrimidine derivative, a preparation method thereof and a pharmaceutical composition comprising the same as an active ingredient for the prevention or treatment of cancer, autoimmune disease and brain disease. The pyrazolopyrimidine derivative of the present invention exhibits excellent Bruton's tyrosine kinase inhibition activity, so that it can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer, autoimmune disease and Parkinson's disease.

Abstract: Provided is a method and apparatus for metal artifact reduction in industrial three-dimensional (3D) cone beam computed tomography (CBCT) that may align computer-aided design (CAD) data to correspond to CT data, generate registration data from the aligned CAD data, set a sinogram surgery region corresponding to a metal region based on the registration data, perform an average fill-in process on the CT data based on the registration data, update data of the sinogram surgery region based on the averaged filled-in information, and reconstruct a 3D CT image from the updated sinogram data with surgery region.

Abstract: The present invention relates to a tube-type cosmetic container for discharging liquid contents in a droplet form, the container having a sealing member, which is coupled to the inside of an overcap and has a sealing protrusion for closing a discharge hole of a contents discharge tube, and pulling a sealing cap downward by the tensioning of an elastic supporting body so as to maintain a state in which the sealing protrusion further comes in close contact with the inner wall of the content discharge tube, when the overcap rotates such that the sealing member is coupled to a discharge part, thereby enabling the leakage of contents to be efficiently prevented regardless of an injection deviation and an assembly deviation between components.

Abstract: The present invention relates to a powder dispensing container. When a button is pressed, a piston formed in close contact with the inner wall of an external housing is lowered so that air in the external housing is moved to an inner housing and discharges powder flowing into the internal housing, thus it is possible to always dispense the powder consistently regardless of the amount of the powder stored in a container body.

Abstract: Provided is a method and apparatus for metal artifact reduction in industrial three-dimensional (3D) cone beam computed tomography (CBCT) that may align computer-aided design (CAD) data to correspond to CT data, generate registration data from the aligned CAD data, set a sinogram surgery region corresponding to a metal region based on the registration data, perform an average fill-in process on the CT data based on the registration data, update data of the sinogram surgery region based on the averaged filled-in information, and reconstruct a 3D CT image from the updated sinogram data with surgery region.

Abstract: The present invention relates to a powder dispensing container. When a button is pressed, a piston formed in close contact with the inner wall of an external housing is lowered so that air in the external housing is moved to an inner housing and discharges powder flowing into the internal housing, thus it is possible to always dispense the powder consistently regardless of the amount of the powder stored in a container body.

Abstract: The present invention relates to a tube-type cosmetic container for discharging liquid contents in a droplet form, the container having a sealing member, which is coupled to the inside of an overcap and has a sealing protrusion for closing a discharge hole of a contents discharge tube, and pulling a sealing cap downward by the tensioning of an elastic supporting body so as to maintain a state in which the sealing protrusion further comes in close contact with the inner wall of the content discharge tube, when the overcap rotates such that the sealing member is coupled to a discharge part, thereby enabling the leakage of contents to be efficiently prevented regardless of an injection deviation and an assembly deviation between components.

Abstract: The present invention relates to a pyrazolopyrimidine derivative, a preparation method thereof and a pharmaceutical composition comprising the same as an active ingredient for the prevention or treatment of cancer, autoimmune disease and brain disease. The pyrazolopyrimidine derivative of the present invention exhibits excellent Bruton's tyrosine kinase inhibition activity, so that it can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer, autoimmune disease and Parkinson's disease.

Abstract: A controller for controlling an operation of a data storage device may include: a host interface configured to perform data communication with a host device; a memory configured to store firmware for controlling an operation of the host interface; and a processor configured to load the firmware to control the operation of the host interface. The firmware may generate transfer pattern information regarding previous data transfer operations by monitoring a data transfer status between the host interface and the host device, adjust an operation timing of the host interface based on the generated transfer pattern information, and control the host interface to perform a current data transfer operation according to the adjusted operation timing.

Abstract: The present disclosure relates to a novel piperidine-2,6-dione derivative and a use thereof and, more specifically, to a piperidine-2,6-dione derivative compound having a structure of a thalidomide analog. A compound of chemical formula 1 according to the present disclosure specifically binds with CRBN protein, and is involved in functions thereof. Therefore, the compound of the present disclosure can be favorably used in the prevention or treatment of leprosy, chronic graft versus host disease, an inflammatory disease, or cancer, which are caused by actions of CRBN protein.

Abstract: Provided is a compound activating ROR? gene, particularly a JC1 compound containing CGP52608 thiazolidinedione as a lead substance, and a pharmaceutically acceptable salt thereof. The compound is a lipid accumulation inhibitor and applicable to the treatment of metabolic diseases or inflammatory diseases.

Abstract: The present invention relates to a 4-(2-amino-tetrahydronaphthaleneyl)pyrimidine derivative, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of cancer comprising the same as an active ingredient. The 4-(2-amino-tetrahydronaphthaleneyl)pyrimidine derivative, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of the present invention is very effective in suppressing anaplastic lymphoma kinase (ALK) activity and as a result it can improve the effectiveness of treatment on cancer cells having anaplastic lymphoma kinase (ALK) fusion proteins such as EML4-ALK and NPM-ALK, so that it can be effectively used as a pharmaceutical composition for preventing or treating cancer.