Abstract: Methods and compositions capable of modulating activity of TLX (NR2E1), a nuclear receptor essential for neural stem cell self-renewal are provided. The modulations may comprise downregulating TLX expression and/or modulating TET3. In addition, methods of delivering shRNAs using dendrimer nanoparticles into glioblastoma stem cells are provided. The methods and compositions are useful for treating and preventing the progression of brain cancer, e.g. glioblastoma.

Abstract: An apparatus/method for extracting multiple features from time series data collected from a plurality of sensors and for performing transfer learning on them. There is provided an apparatus including: a multi-feature extraction unit for extracting multiple features from a data stream for each sensor inputted from the plurality of sensors; a transfer-learning model generation unit for extracting useful multi-feature information from a learning model which has finished pre-learning, for the multiple features for forwarding the extracted multi-feature information to a multi-feature learning unit to generate a learning model that performs transfer learning on the multiple features; and the multi-feature learning unit for receiving learning variables from the learning model for each of the multiple features and for performing parallel learning for the multiple features, to calculate and output a loss. In addition, there is provided an apparatus for detecting leaks in plant pipelines.

Abstract: Systems and methods of an integrated fluid control valve and valve actuator assembly are provided. The assembly includes a pressure operated fluid control valve for controlling the flow of liquid from a liquid supply piping system into a sprinkler piping system of a fire protection system when transitioning the fire protection system from a stand-by state to an actuated state. The control valve defines a valve chamber for holding a pressurized fluid to prevent the flow of fluid through the control valve. A valve actuator is coupled to the fluid control valve housing for setting of the fluid control valve in an unactuated ready state and for operating the fluid control valve automatically and/or manually. The assembly has a common supply port to supply fluid to the control valve and the actuator and a common discharge port connected to multiple devices that can place the system in an actuated state.

Abstract: Systems and methods of an integrated fluid control valve and valve actuator assembly are provided. The assembly includes a pressure operated fluid control valve for controlling the flow of liquid from a liquid supply piping system into a sprinkler piping system of a fire protection system when transitioning the fire protection system from a stand-by state to an actuated state. The control valve defines a valve chamber for holding a pressurized fluid to prevent the flow of fluid through the control valve. A valve actuator is coupled to the fluid control valve housing for setting of the fluid control valve in an unactuated ready state and for operating the fluid control valve automatically and/or manually. The assembly has a common supply port to supply fluid to the control valve and the actuator and a common discharge port connected to multiple devices that can place the system in an actuated state.

Abstract: A multiuse, high efficiency and environment-friendly cleaning solution and preparation method therefor, the cleaning solution comprising the following components: sodium polyacrylate, surface active agent and deionized water. The surface active agent comprises a combination of any two or more of alkyl-polyoxyethylene ether acetate, plant polyenoid phenol polyoxyethylene ether or laurinol polyoxyethylene ether. The cleaning solution has a wide range of cleaning uses, and may exhibit a good cleaning effect when applied in multiple fields.

Abstract: The knee joint prosthesis includes a tibial component and a femoral component. The tibial component has a top surface, a bottom surface opposite to the top surface and a first slot passing through the top surface and the bottom surface for accommodating a cruciate ligament. The tibial component has at least one first protrusion disposed on the bottom surface, and the first protrusion has a plurality of first through holes. The femoral component is carried by the tibial component and has a second slot for accommodating the cruciate ligament. The femoral component has at least one second protrusion disposed on a surface thereof opposite to the tibial component, and the second protrusion has a plurality of second through holes. The first protrusion has a first rear and front portions, and a width of the first protrusion gradually becomes thicker from the first rear portion toward the first front portion.

Abstract: A stereotactic device for primate brains indicates a brain coordinate reference point of a primate using a simulator for indicating a brain coordinate reference point, thereby providing an initial setting to a zero point corresponding to the brain coordinate reference point. The brain coordinate reference point is conveniently and accurately indicated without relatively expensive equipment, such as a magnetic resonance imaging (MRI) scanner, to determine brain coordinates of the primate, so that a targeting procedure can be conducted on the brain.

Abstract: Application of inter-class and intra-class filtering, based on aggregate point-to-point distances, to vector data for purposes of filtering the vector data for purposes of pattern recognition. In some embodiments: (i) the inter-class filtering is based on Euclidean distance, in all dimensions, between vector data points in vector space; and/or (ii) the intra-class filtering is based on a distance, in all dimensions, between vector data points in vector space.

Abstract: An apparatus for detecting a leak sound in plant equipment using time-frequency transformation includes a first microphone measuring an acoustic signal generated in the plant equipment, a second microphone measuring an acoustic signal generated in the plant equipment, and a leak sound detection module detecting a leak sound in the plant equipment using time-frequency transformation of the acoustic signal measured by the first microphone and the acoustic signal measured by the second microphone, wherein a leak sound may be detected even when a transient dispersive noise signal, as well as a periodic noise signal, is large.

Abstract: Disclosed is a gene/carrier complex for preventing or treating inflammatory diseases, including tumor necrosis factor-? converting enzyme (TNF-? converting enzyme, TACE) shRNA and a nonviral gene carrier, wherein the nonviral gene carrier includes an acetate of disulfide-linked poly(oligo-arginine) or a TFA salt of poly(oligo-aspartic acid)poly(oligo-arginine).

Abstract: Methods and compositions capable of modulating activity of TLX (NR2E1), a nuclear receptor essential for neural stem cell self-renewal are provided. The modulations may comprise downregulating TLX expression and/or modulating TET3. In addition, methods of delivering shRNAs using dendrimer nanoparticles into glioblastoma stem cells are provided. The methods and compositions are useful for treating and preventing the progression of brain cancer, e.g. glioblastoma.

Abstract: This invention relates, e.g., to a method for inhibiting the growth and/or proliferation and/or infectivity of a virus in a cell, such as a mammalian cell (e.g. for inhibiting entry of the virus into the cell), comprising administering, or causing to be administered, to the cell, 25-hydroxycholesterol (25HC) in an amount sufficient to inhibit the growth and/or proliferation and/or infectivity of the vines in the cell. The method can be carried out in vivo or in vitro. Among the viruses that can be inhibited are, e.g., VSV, HSV, MHV68, HCV, HIV, EBOV, RVFV, RSSEV and Nipah virus. In one embodiment of the invention, the 25HC is administered topically, e.g. to a mucosal surface.

Abstract: Embodiments of the present disclosure provide a method and apparatus for dynamic storage tiering by calculating a density of data according to a temperature of the data, and making the density of data with a higher temperature smaller; obtaining density threshold of each of the tiers, wherein the density threshold of an upper tier is smaller than that of a lower tier; comparing the density of the data with the density threshold of each of the tiers to determine which tier the data should be moved to; and moving the data to the determined tier. Embodiments of the present invention may be used to provide a dynamic storage tiering scheme with higher flexibility and scalability.

Abstract: Disclosed is a probe bonding device and method. The probe bonding device includes, a second gripper configured to move the probe to a bonding position on the substrate, a laser unit configured to emit a laser beam, a fourth vision device configured to check whether the probe gripped by the second gripper; and a controller configured to control the second gripper and the fourth vision device, wherein the controller controls the fourth vision device to photograph one end of the probe a plurality of numbers of times while sequentially adjusting a height of at least one of the second gripper and the fourth vision device at a predetermined interval to acquire information on a height of the probe based on a plurality of captured images, thereby bonding the probe to an accurate position to enhance bonding quality of the probe and quality of a probe card.

Abstract: Disclosed is a gene/carrier complex for preventing or treating inflammatory diseases, including tumor necrosis factor-? converting enzyme (TNF-? converting enzyme, TACE) shRNA and a nonviral gene carrier, wherein the nonviral gene carrier includes an acetate of disulfide-linked poly(oligo-arginine) or a TFA salt of poly(oligo-aspartic acid)poly(oligo-arginine).

Abstract: The present invention relates to an repebody capable of binding specifically to interleukin-6 (IL-6) to inhibit the biological activity of IL-6, a polynucleotide encoding the repebody, a vector comprising the polynucleotide, a recombinant microorganism having introduced therein the polynucleotide or the vector, a method of producing the repebody using the recombinant microorganism, a composition for preventing or treating cancer, which comprises the repebody, and a method for preventing or treating cancer, which comprises administering the composition for preventing or treating cancer, which comprises the repebody. The repebody of the present invention significantly reduces the activity of signal transduction and activator of transciption3 (STAT3) and the concentration of interleukin-6, and thus can be widely used as an agent for preventing or treating IL-6-related diseases.

Abstract: A storage container includes a cover portion, a body portion disposed below the cover portion so as to form a storage space together with the cover portion for storing an end of an article therein, and a connecting portion connecting the cover portion and the body portion to each other and imparting a tensile force in an opening direction when the cover portion is moved in an opening direction with respect to the body portion and a tensile force in a closing direction when the cover portion is moved in a closing direction with respect to the body portion. The storage container can be provided in which a cover portion and a body portion are included, and a connecting portion is included inside the storage container to impart tensile force in connection with the cover portion. Thus, storing and withdrawing articles can be done conveniently.

Abstract: Systems and methods of an integrated fluid control valve and valve actuator assembly are provided. The assembly includes a pressure operated fluid control valve for controlling the flow of liquid from a liquid supply piping system into a sprinkler piping system of a fire protection system when transitioning the fire protection system from a stand-by state to an actuated state. The control valve defines a valve chamber for holding a pressurized fluid to prevent the flow of fluid through the control valve. A valve actuator is coupled to the fluid control valve housing for setting of the fluid control valve in an unactuated ready state and for operating the fluid control valve automatically and/or manually. The assembly has a common supply port to supply fluid to the control valve and the actuator and a common discharge port connected to multiple devices that can place the system in an actuated state.

Abstract: An LED tube lamp includes a lamp tube, an LED light bar disposed inside the lamp tube with a plurality of LED light sources provided on the LED light bar, a diffusion film layer disposed inside the lamp tube and configured to transmit the light emitted from the LED light sources, and a reflective film layer disposed on an inner circumferential surface of the lamp tube. The reflective film layer is configured to partially occupy the inner circumferential surface of the lamp tube along a longitudinal direction and a circumferential direction of the lamp tube, and the diffusion film layer is a sheet disposed to cover the LED light sources without making direct contact with the LED light sources.