Abstract: In one embodiment, a method includes storing, by a tracking system server, information identifying each of multiple first computing devices and a location of each computing device. The method includes receiving a request including an identifier for a second computing device and configuration instructions executable by the second computing device. The method includes determining a most recent location associated with the second computing device. The method includes identifying a computing device from the first computing devices based at least in part on the stored location of the computing device and the most recent location associated with the second computing device. The method includes sending, to the identified computing device, a forwarding request including the identifier for the second computing device and the configuration instructions. The identified computing device is configured to send the configuration instructions to the second computing device.

Abstract: Apparatuses and methods for tapping serial communications and transforming the serial data into a format appropriate for routable networks are significant for purposes of security and troubleshooting, especially in critical infrastructure networks. Communication taps should be completely passive such that any failure would not interrupt the serial communications. Furthermore, automatic determination of unspecified serial protocol frames allow general implementation across various networks, or across devices within a single network, without the need to customize for each implementation.

Abstract: Adjustable mattress assemblies are described in which a mattress incorporates regions where additional pressure reduction is adjustable via pliable fluid bladders filled with a gas or fluid. Such areas of the mattress where additional pressure reduction is desired may include regions of the mattress which support areas of the body which may be particularly susceptible to pressure ulcers such as the heels, sacral regions, etc.

Abstract: An electronic device can be commissioned with an identifier for use in a centralized tracking system. The electronic device is assigned an interim unique identifier and authentication key, for instance by a manufacturer of the electronic device. The electronic device and the centralized tracking system each separately generate a permanent unique identifier and a permanent authentication key based on the interim unique identifier and interim authentication key, without requiring the permanent unique identifier and permanent authentication key from being transmitted between the electronic device and the central tracking server. Upon generating the permanent unique identifier and permanent authentication key, tracking device functionality can be enabled within the electronic device, enabling the electronic device to function as a tracking device within the centralized tracking system.

Abstract: Provided herein are synthetic peptides developed from slug and insect neuropeptides. Peptides described can be used to repel, control or deter slugs, including the gray garden slug (Deroceras reticulatum), from feeding on agricultural and horticultural plants. The peptides can be combined with bait materials, or applied directly to plants or areas, or produced by genetically modified plants.

Abstract: Stable and bioavailable extended-release formulations and dosage forms comprising a dispersion (e.g., spray-dried dispersion) of solid amorphous 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyrid azine-3-carboxamide (Formula (I); BMS-986165) in a solid polymer matrix are provided for the treatment of auto-immune and auto-inflammatory diseases such as an inflammatory bowel disease (IBD) and psoriasis.

Abstract: Provided herein are synthetic peptides developed from slug and insect neuropeptides. Peptides described can be used to repel, control or deter slugs, including the gray garden slug (Deroceras reticulatum), from feeding on agricultural and horticultural plants. The peptides can be combined with bait materials, or applied directly to plants or areas, or produced by genetically modified plants.

Abstract: Adjustable mattress assemblies are described in which a mattress incorporates regions where additional pressure reduction is adjustable via pliable fluid bladders filled with a gas or fluid. Such areas of the mattress where additional pressure reduction is desired may include regions of the mattress which support areas of the body which may be particularly susceptible to pressure ulcers such as the heels, sacral regions, etc.

Abstract: The present disclosure provides compounds that are inhibitors of PIKfyve and/or PI3 kinases, and are therefore useful for the treatment of neurological diseases treatable by inhibition of PIKfyve and/or PI3 kinases. Also provided are pharmaceutical compositions containing such compounds, and methods of treatment of neurological diseases using such compounds.

Abstract: The present disclosure provides compounds that are inhibitors of PIKfyve kinases useful for the treatment of neurological diseases treatable by inhibition of PIKfyve. Also provided are pharmaceutical compositions containing such compounds, and methods of treatment using such compounds.

Abstract: Apparatus and methods for adjusting a support to a body are described in which a portable support assembly may be worn or used by a bed-stricken or wheel-chair restricted individual around particular regions of the body where pressure ulcers tend to form. The portable support assembly may generally include adjustable supports which conform the assembly to the patient's body and which also help to distribute one or more fluid pad assemblies relative to the body. The support assembly may be incorporated into a design for a wheelchair or a bed.

Abstract: Method and systems for adaptively allocating assets in an investment portfolio are provided. The method includes: receiving first information relating to an investment portfolio of an investor; receiving second information relating to several financial goals of the investor; determining, based on the second information, respective estimated costs for achieving each corresponding financial goal; determining, based on the first information and the second information, a current status and proposed adjustments, including to asset allocation among asset classes, that relate to achieving the financial goals; and outputting third information that relates to the determined costs, the current status, and the proposed adjustments, including to asset allocation among asset classes.

Abstract: The present disclosure provides compounds that are inhibitors of PIKfyve and/or PI3 kinases, and are therefore useful for the treatment of neurological diseases that are treatable by inhibition of PIKfyve. Also provided are pharmaceutical compositions containing such compounds, and methods of treatment using such compounds.

Abstract: A back-end application computer server may access a location data store containing information about a set of locations to be visited, including location identifiers and location coordinates. The computer server may then prioritize the locations to be visited. A mobile unit data store may contain information about a set of mobile units, including mobile unit identifiers, mobile unit location coordinates, and mobile unit communication addresses. The computer server may then automatically assign each location to a mobile unit based on the location coordinates, the mobile unit location coordinates, at least one geo-fence, and said prioritization. Indications of assigned locations may be transmitted to each mobile unit via the associated mobile unit communication address, and electronic messages may be exchanged to support an interactive user interface display associated with assignments of locations to mobile units.

Abstract: A mobile phone connected to a tracking system detects the presence of a nearby tracking device. If the tracking device is detected for more than a threshold amount of time, the tracking system can instruct the mobile phone to generate a user notification prompting a user to claim ownership of the tracking device. After the user claims ownership of the tracking device, the mobile device provides the ownership claim to the tracking system which can associate the tracking device with that user's account in the tracking system, enabling the user to access features of the tracking device and tracking system reserved for owners of that tracking device.

Abstract: A back-end application computer server may access a location data store containing information about a set of locations to be visited, including location identifiers and location coordinates. The computer server may then prioritize the locations to be visited. A mobile unit data store may contain information about a set of mobile units, including mobile unit identifiers, mobile unit location coordinates, and mobile unit communication addresses. The computer server may then automatically assign each location to a mobile unit based on the location coordinates, the mobile unit location coordinates, at least one geo-fence, and said prioritization. Indications of assigned locations may be transmitted to each mobile unit via the associated mobile unit communication address, and electronic messages may be exchanged to support an interactive user interface display associated with assignments of locations to mobile units.

Abstract: Stable and bioavailable formulations and dosage forms comprising a dispersion (e.g., spray-dried dispersion) of solid amorphous 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide (Formula (I); BMS-986165) in a solid polymer matrix are provided for the treatment of auto-immune and auto-inflammatory diseases such as an inflammatory bowel disease (IBD) and psoriasis.

Abstract: Adjustable mattress assemblies are described in which a mattress incorporates regions where additional pressure reduction is adjustable via pliable fluid bladders filled with a gas or fluid. Such areas of the mattress where additional pressure reduction is desired may include regions of the mattress which support areas of the body which may be particularly susceptible to pressure ulcers such as the heels, sacral regions, etc.

Abstract: Apparatus and methods for adjusting a support to a body are described in which a portable support assembly may be worn or used by a bed-stricken or wheel-chair restricted individual around particular regions of the body where pressure ulcers tend to form. The portable support assembly may generally include adjustable supports which conform the assembly to the patient's body and which also help to distribute one or more fluid pad assemblies relative to the body. The support assembly may be incorporated into a design for a wheelchair or a bed.

Abstract: In one embodiment, a method includes storing, by a tracking system server, information identifying each of multiple first computing devices and a location of each computing device. The method includes receiving a request including an identifier for a second computing device and configuration instructions executable by the second computing device. The method includes determining a most recent location associated with the second computing device. The method includes identifying a computing device from the first computing devices based at least in part on the stored location of the computing device and the most recent location associated with the second computing device. The method includes sending, to the identified computing device, a forwarding request including the identifier for the second computing device and the configuration instructions. The identified computing device is configured to send the configuration instructions to the second computing device.