Patents by Inventor Ira Spool
Ira Spool has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9220851Abstract: A dual-chambered drug delivery device (301) includes a first chamber (342) in which medicament is stored and a second chamber (331) in fluid communication with the first chamber (342). A medicament dose is transferred to the second chamber (331) from the first chamber (342) prior to injecting the medicament dose. A needle (363) communicates with the second chamber (331) for injecting the medicament dose into an injection site.Type: GrantFiled: December 8, 2009Date of Patent: December 29, 2015Assignee: Becton, Dickinson and CompanyInventors: Melissa Rosen, Michel Bruehwiler, Ryan Schoonmaker, Ira Spool
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Publication number: 20150366651Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: ApplicationFiled: February 6, 2015Publication date: December 24, 2015Applicants: THE CHARLES STARK DRAPER LABORATORY, THE GENERAL HOSPITAL CORPORATIONInventors: David M. Hoganson, Howard I. Pryor, Ira Spool, Joseph P. Vacanti, Jeffrey T. Borenstein
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Patent number: 9216253Abstract: A flip-open multi-pack assembly is provided which can contain a plurality of new pen needles, such as through the provision of a rectangular or tube-shaped shaped, hinged shell housing, wherein new pen needles can be stored in a plurality of user accessible openings each having a sterility barrier formed, for example, by covers that cover the non-patient end of the openings in which the new pen needles are contained. Used pen needles can be returned and stored in openings accessible by rotatably opening the shell housing. One or more of the openings within first and second opposite ends of the housing shell can be provided with a slidable internal holder within the device and are configured to releasably secure the inner shield of the new pen needle, and to then be pulled forward when the new pen needle is removed and lock at a forward position, and thereby create an interior space, accessible from an opposite end when the hinged housing is opened, for a used pen needle to be inserted and stored.Type: GrantFiled: August 5, 2011Date of Patent: December 22, 2015Assignee: Becton, Dickinson and CompanyInventors: Ira Spool, Cole Constantineau, Ryan Schoonmaker, Sean P. Sullivan, Abhijitsinh Raj, Michel Bruehwiler
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Patent number: 8951302Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: GrantFiled: October 9, 2009Date of Patent: February 10, 2015Assignees: The General Hospital Corporation, The Charles Stark Draper LaboratoryInventors: Howard I. Pryor, Ira Spool, David M. Hoganson, Joseph P. Vacanti, Jeffrey T. Borenstein
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Publication number: 20130204340Abstract: A tissue stimulation assembly, including an elongate electrode assembly having a longitudinal axis and including a contact electrode, the contact electrode including a contact surface, wherein at least a portion of the contact surface has a width that gradually increases as the contact surface progresses in a lateral direction.Type: ApplicationFiled: January 24, 2013Publication date: August 8, 2013Inventors: Brian M. CONN, James R. EASTER, Farid Moumane, Michael BRUHWILER, Ira SPOOL, Melissa ROSEN
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Publication number: 20120041390Abstract: A flip-open multi-pack assembly is provided which can contain a plurality of new pen needles, such as through the provision of a rectangular or tube-shaped shaped, hinged shell housing, wherein new pen needles can be stored in a plurality of user accessible openings each having a sterility barrier formed, for example, by covers that cover the non-patient end of the openings in which the new pen needles are contained. Used pen needles can be returned and stored in openings accessible by rotatably opening the shell housing. One or more of the openings within first and second opposite ends of the housing shell can be provided with a slidable internal holder within the device and are configured to releasably secure the inner shield of the new pen needle, and to then be pulled forward when the new pen needle is removed and lock at a forward position, and thereby create an interior space, accessible from an opposite end when the hinged housing is opened, for a used pen needle to be inserted and stored.Type: ApplicationFiled: August 5, 2011Publication date: February 16, 2012Inventors: Ira Spool, Cole Constantineau, Ryan Schoonmaker, Sean P. Sullivan, Abhijitsinh Raj, Michel Bruehwiler
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Publication number: 20120004640Abstract: A dual-chambered drug delivery device (301) includes a first chamber (342) in which medicament is stored and a second chamber (331) in fluid communication with the first chamber (342). A medicament dose is transferred to the second chamber (331) from the first chamber (342) prior to injecting the medicament dose. A needle (363) communicates with the second chamber (331) for injecting the medicament dose into an injection site.Type: ApplicationFiled: December 8, 2009Publication date: January 5, 2012Inventors: Melissa Rosen, Bruehwiler Michel, Ryan Schoonmaker, Ira Spool
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Publication number: 20120004620Abstract: A drug delivery device includes a cartridge (211) for storing a medicament and a needle (203) communicating with the cartridge (211) for injecting a medicament dose. A rack (241) is movably disposed in the cartridge (211) and is engageable with a stopper (213) for expelling the medicament dose from the cartridge (211). A lever assembly (231) has a lever arm (233) connected to a lever gear (230). The lever gear (232) is engaged with the rack (241) such that rotation of the lever arm (233) rotates the lever gear (232) during injection of the medicament dose, thereby moving the rack (241) and stopper (213) through the cartridge (211) to deliver the medicament dose.Type: ApplicationFiled: December 8, 2009Publication date: January 5, 2012Inventors: Ira Spool, Michel Bruehwiler, Ryan Schoonmaker, Melissa Rosen
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Publication number: 20110091930Abstract: A well-based flow system for cell culture is described which provides for flow of culture containing compounds for drug screening to be exposed to cells seeded on a membrane. The flow of medium may be planar or radial and means are provided for the removal of waste media through fluid outlets in fluid communication with the assay well plates through conduits. Methods of using the system for cell culture and drug toxicity screening are also provided including coculturing cells such as hepatocytes, stem cells, fibroblasts and smooth muscle cells and selectively exposing cells to test compounds.Type: ApplicationFiled: February 13, 2009Publication date: April 21, 2011Applicant: The General Hospital CorporationInventors: Joseph P. Vacanti, Howard I. Pryor, Craig M. Neville, Ira Spool
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Publication number: 20100318167Abstract: An implantable neurostimulation electrode array may include a flexible, electrically non-conductive carrier, and a plurality of electrodes supportably interconnected to and spaced along a length of a carrier. In various embodiments, different ones of at least some of the plurality of electrodes may comprise corresponding contact surfaces having different areas. The different surface areas may be achieved by defining a different area per unit length of the carrier and/or by defining a different total length (e.g. as measured along a length of the carrier). In some embodiments, insulator portions having different corresponding lengths may be disposed between different adjacent ones of the electrodes. The insulated portions may be integrally defined with the carrier. Electrical connection lines may be embedded within the carrier. In a manufacturing method, a plurality of electrodes may be supportably interconnected to a first side of a sacrificial substrate and a carrier may be interconnected to the electrodes.Type: ApplicationFiled: April 19, 2010Publication date: December 16, 2010Applicant: Otologics, LLCInventors: Brian M. Conn, James R. Easter, Farid Moumane, Michel Bruhwiler, Ira Spool, Melissa Rosen
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Publication number: 20100234678Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).Type: ApplicationFiled: October 9, 2009Publication date: September 16, 2010Applicants: The General Hospital Corporation, The Charles Stark Draper LaboratoryInventors: Howard I. Pryor, Ira Spool, David M. Hoganson, Joseph P. Vacanti, Jeffrey T. Borenstein
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Patent number: 7651458Abstract: The invention is a novel adaptive CT-friendly brachytherapy applicator with remotely-controlled radial and longitudinal motion radioactive source lumen shields that can be manipulated by the radiation oncologist to optimize the dose distribution to the target and normal tissue structures for brachytherapy procedures.Type: GrantFiled: July 28, 2006Date of Patent: January 26, 2010Assignee: Board of Regents The University of Texas SystemInventors: Firas Mourtada, John Horton, Patricia Eifel, Anuja Jhingran, Ira Spool
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Patent number: 7556596Abstract: The invention is a novel adaptive CT-compatible brachytherapy applicator with remotely-controlled radial and longitudinal motion radioactive source lumen shields that can be manipulated by the radiation oncologist to optimize the dose distribution to the target and normal tissue structures for brachytherapy procedures.Type: GrantFiled: July 20, 2005Date of Patent: July 7, 2009Assignee: Board of Regents The University of Texas SystemInventors: Firas Mourtada, John Horton, Patricia Eifel, Anuja Jhingran, Ira Spool
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Publication number: 20070027352Abstract: The invention is a novel adaptive CT-friendly brachytherapy applicator with remotely-controlled radial and longitudinal motion radioactive source lumen shields that can be manipulated by the radiation oncologist to optimize the dose distribution to the target and normal tissue structures for brachytherapy procedures.Type: ApplicationFiled: July 28, 2006Publication date: February 1, 2007Applicant: Board of Regents, The University of Texas SystemInventors: Firas Mourtada, John Horton, Patricia Eifel, Anuja Jhingran, Ira Spool
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Publication number: 20060235260Abstract: The invention is a novel adaptive CT-compatible brachytherapy applicator with remotely-controlled radial and longitudinal motion radioactive source lumen shields that can be manipulated by the radiation oncologist to optimize the dose distribution to the target and normal tissue structures for brachytherapy procedures.Type: ApplicationFiled: July 20, 2005Publication date: October 19, 2006Applicant: Board of Regents, The University of Texas SystemInventors: Firas Mourtada, John Horton, Patricia Eifel, Anuja Jhingran, Ira Spool
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Patent number: 6453560Abstract: A cutting device especially designed for cutting up salad greens includes two blades, a rib and handles. The two blades are inter-secured to rotate together about a common axis, but are spaced apart from each other along the common axis. The rib is pivotably secured to the two blades so as to rotate about the common axis, and is curved in a direction of rotation so as to have a concave surface. The handles are integrated with the two blades and the rib to control the two blades and the rib to rotate simultaneously between open and closed positions. The concave surface of the rib is the lead surface when moving from the open position to the closed position, and the cutting edges of the two blades cross edges of the concave surface when moving from the open position to the closed position, so as to perform a cutting action.Type: GrantFiled: April 4, 2001Date of Patent: September 24, 2002Assignee: Wenco LLCInventors: Michael I. Silver, Wendy L. Silver, Eric Chan, Rama Chorpash, Ira Spool
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Publication number: 20020020067Abstract: A cutting device especially designed for cutting up salad greens includes two blades, a rib and handles. The two blades are inter-secured to rotate together about a common axis, but are spaced apart from each other along the common axis. The rib is pivotably secured to the two blades so as to rotate about the common axis, and is curved in a direction of rotation so as to have a concave surface. The handles are integrated with the two blades and the rib to control the two blades and the rib to rotate simultaneously between open and closed positions. The concave surface of the rib is the lead surface when moving from the open position to the closed position, and the cutting edges of the two blades cross edges of the concave surface when moving from the open position to the closed position, so as to perform a cutting action.Type: ApplicationFiled: April 4, 2001Publication date: February 21, 2002Inventors: Michael I. Silver, Wendy L. Silver, Eric Chan, Rama Chorpash, Ira Spool
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Patent number: 6110151Abstract: An inflation device according to the present invention includes a barrel, a piston at least partially disposed within the barrel, and a collar surrounding at least a portion of the barrel. The piston includes a threaded portion. The collar and the barrel are axially movable with respect to one another, with the barrel being biased towards an equilibrium position within the collar by a collar spring. A nut is disposed at least partially within the barrel, the nut including an interior threaded surface and an exterior camming surface. The nut is movable along an axis substantially transverse to the barrel axis, and is biased towards a collar camming surface by a nut spring. When the barrel is in the equilibrium position, the nut is in a locking position in which the interior threaded surface engages the threaded portion of the piston. This prevents free movement of the piston within the barrel.Type: GrantFiled: August 13, 1998Date of Patent: August 29, 2000Assignee: Namic USA CorporationInventors: Ira Spool, Karl Dallas Kirk, III, Paul J. Mulhauser, Colin Hart, Glenn H. Wadleigh
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Patent number: RE39286Abstract: A cutting device especially designed for cutting up salad greens includes two blades, a rib and handles. The two blades are inter-secured to rotate together about a common axis, but are spaced apart from each other along the common axis. The rib is pivotably secured to the two blades so as to rotate about the common axis, and is curved in a direction of rotation so as to have a concave surface. The handles are integrated with the two blades and the rib to control the two blades and the rib to rotate simultaneously between open and closed positions. The concave surface of the rib is the lead surface when moving from the open position to the closed position, and the cutting edges of the two blades cross edges of the concave surface when moving from the open position to the closed position, so as to perform a cutting action.Type: GrantFiled: April 8, 2003Date of Patent: September 19, 2006Assignee: Wenco, L.L.C.Inventors: Michael I. Silver, Wendy L. Silver, Eric Chan, Rama Chorpash, Ira Spool