Patents by Inventor Irina Borodina

Irina Borodina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200102582
    Abstract: The present invention relates to the production of compounds comprised in pheromones, in particular moth pheromones, such as desaturated fatty alcohols and desaturated fatty acyl acetates and derivatives thereof, from a yeast cell.
    Type: Application
    Filed: December 15, 2017
    Publication date: April 2, 2020
    Applicant: Danmarks Tekniske Universitet
    Inventors: Irina Borodina, Carina Holkenbrink, Marie Inger Dam, Christer Löfstedt, Baojian Ding, Hong-Lei Wang
  • Publication number: 20190330646
    Abstract: The present invention relates to oleaginous yeast cells for the production of fatty alcohols and derivatives thereof, in particular desaturated fatty alcohols, desaturated fatty acyl acetates and desaturated fatty aldehydes. Also provided are methods for obtaining such compounds, which are useful in pheromone compositions.
    Type: Application
    Filed: December 15, 2017
    Publication date: October 31, 2019
    Inventors: Irina Borodina, Carina Holkenbrink, Marie Inger Dam, Christer Löfstedt
  • Patent number: 10077455
    Abstract: Cells and cell cultures are provided that have improved tolerance to 3-hydroxypropionic acid (3HP). Genetic modifications to provide a mutated or overexpressed SFA1 gene or other enhancement of 3HP detoxification via a glutathione-dependent dehydrogenase reaction, including medium supplementation with glutathione, may be combined with a 3HP producing metabolic pathway.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: September 18, 2018
    Assignee: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Kanchana Rueksomtawin Kildegaard, Irina Borodina, Jochen Förster, Jens Nielsen
  • Patent number: 10066245
    Abstract: A yeast cell having a reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: September 4, 2018
    Assignee: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Niels Bjerg Jensen, Irina Borodina, Yun Chen, Jerome Maury, Kanchana Rueksomtawin Kildegaard, Jochen Förster, Jens Nielsen
  • Publication number: 20180162916
    Abstract: The present disclosure relates to methods for production of (Z)-11-hexadecen-1-ol in a yeast cell using desaturases and fatty acyl-CoA reductase. Also disclosed are methods for production of (Z)-11-hexadecenal in a yeast cell. Also disclosed are methods for production of (Z)-11-hexadecen-1-yl acetate in a yeast cell. The disclosure also provides for nucleic acid constructs and yeast cells useful for performing the present methods, as well as to pheromone compositions.
    Type: Application
    Filed: June 24, 2016
    Publication date: June 14, 2018
    Inventors: Irina Borodina, Carina Holkenbrink, Marie Inger Dam, Christer Löfstedt, Baojian Ding, Hong-Lei Wang
  • Patent number: 9868966
    Abstract: A genetically modified Saccharomyces cerevisiae including an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA from Bacillus cereus AH1272 catalyzing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: January 16, 2018
    Assignee: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Irina Borodina, Kanchana Rueksomtawin Kildegaard, Jochen Förster, Fredrik Öberg
  • Publication number: 20160230200
    Abstract: Recombinant microbial cells and methods for producing 5HTP, melatonin and related compounds using such cells are described. More specifically, the recombinant microbial cell may comprise exogenous genes encoding one or more of an L-tryptophan hydroxylase, a 5-hydroxy-L-tryptophan decarboxylyase, a serotonin acetyltransferase, an acetylserotonin O-methyltransferase; and means for providing tetrahydrobiopterin (THB), and can be further genetically modified to enrich one or more of tryptophan, S-adenosyl-L-methinonine and acetyl coenzyme A. Related sequences and vectors for use in preparing such recombinant microbial cells are also described.
    Type: Application
    Filed: September 5, 2014
    Publication date: August 11, 2016
    Inventors: JIANGFENG ZHU, NIELS BJERG JENSEN, XIAO CHEN, JOCHEN FÖRSTER, IRINA BORODINA
  • Publication number: 20160138056
    Abstract: A yeast cell having a reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.
    Type: Application
    Filed: June 12, 2014
    Publication date: May 19, 2016
    Applicant: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Niels Bjerg JENSEN, Irina BORODINA, Yun CHEN, Jerome MAURY, Kanchana Rueksomtawin KILDEGAARD, Jochen FÖRSTER, Jens NIELSEN
  • Publication number: 20160130613
    Abstract: Cells and cell cultures are provided that have improved tolerance to 3-hydroxypropionic acid (3HP). Genetic modifications to provide a mutated or overexpressed SFA1 gene or other enhancement of 3HP detoxification via a glutathione-dependent dehydrogenase reaction, including medium supplementation with glutathione, may be combined with a 3HP producing metabolic pathway.
    Type: Application
    Filed: June 12, 2014
    Publication date: May 12, 2016
    Applicant: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Kanchana Rueksomtawin KILDEGAARD, Irina BORODINA, Jochen FÖRSTER, Jens NIELSEN
  • Publication number: 20150267228
    Abstract: A genetically modified Saccharomyces cerevisiae including an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA from Bacillus cereus AH1272 catalysing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.
    Type: Application
    Filed: October 10, 2013
    Publication date: September 24, 2015
    Applicant: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Irina Borodina, Kanchana Rueksomtawin Kildegaard, Jochen Förster, Fredrik Öberg