Patents by Inventor Irina Borodina

Irina Borodina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MICROBIAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID
    Publication number: 20160138056
    Abstract: A yeast cell having a reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.
    Type: Application
    Filed: June 12, 2014
    Publication date: May 19, 2016
    Applicant: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Niels Bjerg JENSEN, Irina BORODINA, Yun CHEN, Jerome MAURY, Kanchana Rueksomtawin KILDEGAARD, Jochen FÖRSTER, Jens NIELSEN
  • 3HP TOLERANCE
    Publication number: 20160130613
    Abstract: Cells and cell cultures are provided that have improved tolerance to 3-hydroxypropionic acid (3HP). Genetic modifications to provide a mutated or overexpressed SFA1 gene or other enhancement of 3HP detoxification via a glutathione-dependent dehydrogenase reaction, including medium supplementation with glutathione, may be combined with a 3HP producing metabolic pathway.
    Type: Application
    Filed: June 12, 2014
    Publication date: May 12, 2016
    Applicant: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Kanchana Rueksomtawin KILDEGAARD, Irina BORODINA, Jochen FÖRSTER, Jens NIELSEN
  • GENETICALLY ENGINEERED YEAST
    Publication number: 20150267228
    Abstract: A genetically modified Saccharomyces cerevisiae including an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA from Bacillus cereus AH1272 catalysing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.
    Type: Application
    Filed: October 10, 2013
    Publication date: September 24, 2015
    Applicant: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Irina Borodina, Kanchana Rueksomtawin Kildegaard, Jochen Förster, Fredrik Öberg