Patents by Inventor Isabelle André

Isabelle André has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Esterases and uses thereof
    Patent number: 11072784
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved activity compared to the esterase of SEQ ID No 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: July 27, 2021
    Assignee: CARBIOS
    Inventors: Vincent Tournier, Hélène Texier, Marie-Laure Desrousseaux, Christopher Topham, Isabelle Andre, Sophie Barbe, Sophie Duquesne, Alain Marty
  • METHOD FOR GENERATING T CELLS PROGENITORS
    Publication number: 20210169934
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Application
    Filed: February 11, 2021
    Publication date: June 10, 2021
    Applicants: Assistance Publique - Hopitaux de Paris, Fondation Imagine - Institut des Maladies Génétiques, Université de Paris, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen
  • NOVEL ESTERASES AND USES THEREOF
    Publication number: 20210171921
    Abstract: The present invention relates to novel esterases, more particularly to esterase variants having improved activity and/or improved thermostability compared to the esterase of SEQ ID NO:1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Application
    Filed: July 26, 2019
    Publication date: June 10, 2021
    Inventors: ISABELLE ANDRE, VINCENT TOURNIER, ALEXANDRE GILLES, SOPHIE DUQUESNE
  • METHOD FOR GENERATING T CELLS PROGENITORS
    Publication number: 20210169935
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Application
    Filed: February 11, 2021
    Publication date: June 10, 2021
    Applicants: Assistance Publique - Hopitaux de Paris, Fondation Imagine - Institut des Maladies Génétiques, Université de Paris, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen
  • NOVEL ESTERASES AND USES THEREOF
    Publication number: 20210163906
    Abstract: The present invention relates to novel esterases, more particularly to esterase variants having improved activity and/or improved thermostability compared to the esterase of SEQ ID NO:1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Application
    Filed: July 26, 2019
    Publication date: June 3, 2021
    Inventors: BENOÎT DAVID, ISABELLE ANDRE, MAHER BEN KHALED, SOPHIE DUQUESNE, ALAIN MARTY
  • METHOD FOR GENERATING T CELLS PROGENITORS
    Publication number: 20200390817
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Application
    Filed: September 2, 2020
    Publication date: December 17, 2020
    Applicants: Assistance Publique - Hopitaux de Paris, Fondation Imagine - Institut des Maladies Génétiques, Université de Paris, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen
  • NOVEL PROTEASES AND USES THEREOF
    Publication number: 20200385698
    Abstract: The present invention relates to novel proteases, more particularly to protease variants having improved activity compared to the protease of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The proteases of the invention are particularly suited to degrade polylactic acid, and material containing polylactic acid.
    Type: Application
    Filed: December 21, 2018
    Publication date: December 10, 2020
    Inventors: ALAIN MARTY, SOPHIE DUQUESNE, MARIE GUICHERD, MARC GUEROULT, ISABELLE ANDRE
  • NOVEL ESTERASES AND USES THEREOF
    Publication number: 20200277585
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved activity compared to the esterase of SEQ ID No 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Application
    Filed: March 16, 2020
    Publication date: September 3, 2020
    Inventors: VINCENT TOURNIER, HÉLÈNE TEXIER, MARIE-LAURE DESROUSSEAUX, CHRISTOPHER TOPHAM, ISABELLE ANDRE, SOPHIE BARBE, SOPHIE DUQUESNE, ALAIN MARTY
  • NOVEL ESTERASES AND USES THEREOF
    Publication number: 20200270591
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved thermostability compared to the esterase of SEQ ID No 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Application
    Filed: March 9, 2020
    Publication date: August 27, 2020
    Inventors: CHRISTOPHER TOPHAM, HÉLÈNE TEXIER, VINCENT TOURNIER, MARIE-LAURE DESROUSSEAUX, SOPHIE DUQUESNE, ISABELLE ANDRE, SOPHIE BARBE, ALAIN MARTY
  • Enzymatic production of glycosylated synthons
    Patent number: 10696995
    Abstract: The present invention relates to a method for producing a glycosylated synthon or a monomer. Said method includes at least one step of placing at least one glycan-saccharase in the presence of at least one hydroxylated synthon and at least one saccharose. The invention also relates to a method for producing a glyco(co)polymer, including polymerizing at least two monomers separately obtained from the enzymatic glycosylation method according to the invention, and to a method for producing a glyco(co)polymer, preferably a block glyco(co)polymer, including coupling at least two monomers separately obtained from the enzymatic glycosylation method according to the invention.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: June 30, 2020
    Assignees: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, INSTITUT NATIONAL DES SCIENCES APPIQUEES DE TOULOUSE (INSAT), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX
    Inventors: Isabelle Andre, Stephane Grelier, David Guieysse, Alvaro Lafraya, Pierre Monsan, Claire Moulis, Frederic Peruch, Magali Remaud-Simeon, Marlene Vuillemin
  • PROTECTED TETRASACCHARIDES, THEIR PROCESS OF PREPARATION AND THEIR USE AS TRANSGLUCOSYLASE ACCEPTOR SUBSTRATES IN THE CHEMO-ENZYMATIC SYNTHESIS OF SHIGELLA FLEXNERI SPECIFIC OLIGOSACCHARIDES
    Publication number: 20200165285
    Abstract: The present invention provides protected tetrasaccharides, their process of preparation and their use in the synthesis of oligosaccharides, in particular fragments of O-antigens from Shigella flexneri, for example of serotype 1a, 1b, 2a, 2b, 3a, X, 4a, 4b, 5a, 5b, 7a or 7b.
    Type: Application
    Filed: July 3, 2018
    Publication date: May 28, 2020
    Inventors: Laurence MULARD, Guillaume LE HEIGET, Zhaohu HU, Louis-Antoine BAREL, Isabelle ANDRE, Claire MOULIS, Magali REMAUD-SIMEON, Sophie BARBE, Mounir BENKOULOUCHE, Akli BEN IMEDDOURENE
  • Flavonoids O-A-glucosylated on the B cycle, method for the production thereof and uses
    Patent number: 10647739
    Abstract: The invention relates to a method for producing derivatives of O-?-glucosylated flavonoid, comprising at least one step of incubating a glucansucrase with a flavonoid and at least one sucrose, the flavonoid being a flavonoid which is monohydroxylated or hydroxylated in a non-vicinal manner on the B cycle. The invention also relates to novel O-?-glucosylated flavonoid derivatives, and to the use thereof.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: May 12, 2020
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUTE NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Sandrine Morel, Isabelle Andre, Yoan Brison, Emmanuelle Cambon, Yannick Malbert, Denis Pompon, Magali Remaud-Simeon, Philippe Urban
  • Esterases and uses thereof
    Patent number: 10590401
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved activity compared to the esterase of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: March 17, 2020
    Assignee: CARBIOS
    Inventors: Vincent Tournier, Helene Texier, Marie-Laure Desrousseaux, Christopher Topham, Isabelle Andre, Sophie Barbe, Sophie Duquesne, Alain Marty
  • Esterases and uses thereof
    Patent number: 10584320
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved thermostability compared to the esterase of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: March 10, 2020
    Assignee: CARBIOS
    Inventors: Christopher Topham, Helene Texier, Vincent Tournier, Marie-Laure Desrousseaux, Sophie Duquesne, Isabelle Andre, Sophie Barbe, Alain Marty
  • METHOD FOR GENERATING T CELLS PROGENITORS
    Publication number: 20200046767
    Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydro-carbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.
    Type: Application
    Filed: February 12, 2018
    Publication date: February 13, 2020
    Applicants: Assistance Publique - Hopitaux de Paris, Fondation Imagine - Institut des Maladies Génétiques, Université Paris Descartes, Institut National de la Santé et de la Recherche Médicale (INSERM)
    Inventors: Isabelle André, Marina Cavazzana, Kuiying Ma, John Tchen
  • MUTANT YEAST STRAIN CAPABLE OF PRODUCING MEDIUM CHAIN FATTY ACIDS
    Publication number: 20200017892
    Abstract: Embodiments of the present disclosure relate to mutant yeast strains, in particular mutant Yarrowia strains, capable of producing medium chain fatty acids compared to the parent oleaginous yeast strain from which said mutant oleaginous yeast strain derives. Embodiments of the present disclosure also relate to means and methods for obtaining these mutant yeast strains.
    Type: Application
    Filed: January 8, 2018
    Publication date: January 16, 2020
    Applicants: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Florence Bordes, Coraline Rigouin, Alain Marty, Marc Gueroult, Isabelle Andre, Sophie Barbe, Benjamin Percheron, Christian Croux, Fayza Daboussi
  • NOVEL ESTERASES AND USES THEREOF
    Publication number: 20190233803
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved thermostability compared to the esterase of SEQ ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Application
    Filed: July 12, 2017
    Publication date: August 1, 2019
    Inventors: Christopher TOPHAM, Helene TEXIER, Vincent TOURNIER, Marie-Laure DESROUSSEAUX, Sophie DUQUESNE, Isabelle ANDRE, Sophie BARBE, Alain MARTY
  • NOVEL ESTERASES AND USES THEREOF
    Publication number: 20190225954
    Abstract: The present invention relates to novel esterase, more particularly to esterase variants having improved activity compared to the esterase of SECS ID NO: 1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
    Type: Application
    Filed: July 12, 2017
    Publication date: July 25, 2019
    Applicant: CARBIOS
    Inventors: VINCENT TOURNIER, HELENE TEXIER, MARIE-LAURE DESROUSSEAUX, CHRISTOPHER TOPHAM, ISABELLE ANDRE, SOPHIE BARBE, SOPHIE DUQUESNE, ALAIN MARTY
  • Method of production of 2,4-dihydroxybutyric acid
    Patent number: 10358663
    Abstract: A method of producing 2,4-dihydroxybutyric acid (2,4-DHB) by a synthetic pathway that includes transforming malate into 4-phospho-malate using a malate kinase, then transforming 4-phospho-malate into malate-4-semialdehyde using a malate semialdehyde dehydrogenase, and then transforming malate-4-semialdehyde into 2,4-DHB using a DHB dehydrogenase.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: July 23, 2019
    Assignee: ADISSEO FRANCE S.A.S.
    Inventors: Thomas Walther, Helene Cordier, Christopher Topham, Isabelle Andre, Magali Remaud-Simeon, Robert Huet, Jean-Marie Francois
  • Enzymatic Production of Glycosylated Synthons
    Publication number: 20180258456
    Abstract: The present invention relates to a method for producing a glycosylated synthon or a monomer. Said method includes at least one step of placing at least one glycan-saccharase in the presence of at least one hydroxylated synthon and at least one saccharose. The invention also relates to a method for producing a glyco(co)polymer, including polymerizing at least two monomers separately obtained from the enzymatic glycosylation method according to the invention, and to a method for producing a glyco(co)polymer, preferably a block glyco(co)polymer, including coupling at least two monomers separately obtained from the enzymatic glycosylation method according to the invention.
    Type: Application
    Filed: March 17, 2016
    Publication date: September 13, 2018
    Inventors: Isabelle Andre, Stephane Grelier, David Guieysse, Alvaro Lafraya, Pierre Monsan, Claire Moulis, Frederic Peruch, Magali Remaud-Simeon, Marlene Vuillemin