Patents by Inventor Isao Ishida

Isao Ishida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200236915
    Abstract: The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody ? light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
    Type: Application
    Filed: September 12, 2019
    Publication date: July 30, 2020
    Inventors: Yoshimi KUROIWA, Kazuma TOMIZUKA, Hitoshi YOSHIDA, Isao ISHIDA
  • Publication number: 20200117035
    Abstract: According to one embodiment, a semiconductor device includes an insulating substrate, a first metal layer on the insulating substrate, a first insulating layer on the insulating substrate and the first metal layer, a semiconductor layer on the first insulating layer, a second insulating layer on the semiconductor layer and the first insulating layer, a second metal layer on the second insulating layer, and a first electrode and a second electrode which are electrically connected to the semiconductor layer. The first metal layer overlaps the second metal layer. A third metal layer contacts a top surface of the second metal layer and a top surface of the first metal layer.
    Type: Application
    Filed: December 12, 2019
    Publication date: April 16, 2020
    Applicant: Japan Display Inc.
    Inventors: Yohei YAMAGUCHI, Arichika Ishida, Hidekazu Miyake, Hiroto Miyake, Isao Suzumura
  • Patent number: 10539846
    Abstract: According to one embodiment, a display device includes an insulating substrate, a thin-film transistor including a semiconductor layer formed on a layer above the insulating substrate, a gate electrode which at least partly overlaps the semiconductor layer, and a first electrode and a second electrode which are electrically connected to the semiconductor layer, and a light shielding layer formed between the thin-film transistor and the insulating substrate to at least partly overlap the semiconductor layer, the light shielding layer electrically connected to the gate electrode.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: January 21, 2020
    Assignee: Japan Display Inc.
    Inventors: Yohei Yamaguchi, Arichika Ishida, Hidekazu Miyake, Hiroto Miyake, Isao Suzumura
  • Patent number: 10448622
    Abstract: The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody ? light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: October 22, 2019
    Assignees: E. R. Squibb & Sons, L.L.C., Kyowa Hakko Kirin Co., Ltd
    Inventors: Yoshimi Kuroiwa, Kazuma Tomizuka, Hitoshi Yoshida, Isao Ishida
  • Publication number: 20190316963
    Abstract: An automatic analysis apparatus comprises: a light source generating light having a center wavelength equal to or shorter than 340 nm; a fluorescent substance excited by the light source light, and generates light together with transmitted light from the light source, having a wavelength of 340 nm to 800 nm; a condenser lens; at least one slit; a reaction cell holding a reaction solution where a specimen and reagent are mixed, and that the light source light and the light from the fluorescent substance enter; and a detector that detects light transmitted through the reaction cell. The light source, fluorescent substance, condenser lens, and slit are provided along a straight light corresponding to the optical axis. The width of the slit's opening is equal to or narrower than the width of a ray forming an image of the light source at the position of the slit.
    Type: Application
    Filed: October 24, 2017
    Publication date: October 17, 2019
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Takeshi ISHIDA, Isao YAMAZAKI, Sakuichiro ADACHI, Shin IMAMURA
  • Publication number: 20190310275
    Abstract: An automatic analyzer is equipped with a sterilization mechanism removably attached to an opening of a container that holds a reagent and having an ultraviolet light generation section that radiates ultraviolet light; a suction nozzle removably attached, together with the sterilization mechanism, to the opening of the container; an analysis section adding the reagent drawn in by suction from the container via the suction nozzle to the reagent, and executing an analysis operation; and a control section exercising variable control over an irradiation light intensity of the ultraviolet light generated by the ultraviolet light generation section.
    Type: Application
    Filed: April 24, 2017
    Publication date: October 10, 2019
    Inventors: Takeshi ISHIDA, Sakuichiro ADACHI, Yoshihiro YAMASHITA, Shunichirou NOBUKI, Hisashi YABUTANI, Isao YAMAZAKI, Michaela WINDFUHR, Bernhard HAUPTMANN, Simon KUESTER
  • Publication number: 20190248659
    Abstract: Realized is a solid substance concentration managing method which allows quick detection of an abnormality in a chemical reactor. The present invention is an invention of a solid substance concentration managing method of managing a concentration of a solid substance which is contained in a residue that is discharged in a reaction product gas processing step included in a trichlorosilane producing method, the solid substance concentration managing method including a concentration measuring step of measuring the concentration of the solid substance which is contained in an after-crystallization residue that is obtained by crystallizing part of aluminum chloride.
    Type: Application
    Filed: October 6, 2017
    Publication date: August 15, 2019
    Inventors: Junichi ISHIDA, Masami ENOKUCHI, Isao YAMASHITA, Yoshikazu KODAMA, Hiroyuki NISHIMURA
  • Publication number: 20190193523
    Abstract: An electric vehicle includes an electric motor, a power storage device, a control device, and a refrigerant circuit. The refrigerant circuit includes a compressor, an outdoor heat exchanger, an expansion valve, a first indoor heat exchanger, and a heating decompression valve. The heating decompression valve changes a passage resistance between the compressor and the outdoor heat exchanger. The control device increases the passage resistance by the heating decompression valve when the remaining capacity of the power storage device is equal to or larger than a predetermined value.
    Type: Application
    Filed: December 13, 2018
    Publication date: June 27, 2019
    Inventors: Yoshiyuki Takeuchi, Isao Tsunoda, Osamu Ishida, Nobumasa Toyoshima, Ryoma Taguchi, Takahiro Ohmi
  • Publication number: 20190193520
    Abstract: A motor-driven vehicle includes an electric motor, a power storage device, a controller, and a refrigerant circuit. The refrigerant circuit includes a compressor, an outdoor heat exchanger, a first indoor heat exchanger, a first expansion valve, a second expansion valve, and a second indoor heat exchanger. The controller switches a ratio of an amount of pressure reduction of the second expansion valve to an amount of pressure reduction of the first expansion valve with a predetermined temperature as a boundary when a remaining capacity of the power storage device is equal to or greater than a predetermined value.
    Type: Application
    Filed: December 6, 2018
    Publication date: June 27, 2019
    Inventors: Isao Tsunoda, Osamu Ishida, Yoshiyuki Takeuchi, Ryoma Taguchi, Takahiro Ohmi
  • Publication number: 20190193521
    Abstract: A motor-driven vehicle includes an electric motor, a power storage device, a control device, and a refrigerant circuit. The refrigerant circuit has a compressor, an indoor heat exchanger, an expansion valve, and an outdoor heat exchanger. The indoor heat exchanger exchanges heat with the refrigerant compressed by the compressor. The refrigerant which passes through the indoor heat exchanger is decompressed by the expansion valve, and the outdoor heat exchanger exchanges heat with the decompressed refrigerant and allows the refrigerant to return to the compressor. When the remaining capacity of the power storage device is equal to or more than a predetermined value, the control device operates the compressor and decreases a passing-through air volume of a first air guide device that controls a passing-through air volume of the outdoor heat exchanger.
    Type: Application
    Filed: December 6, 2018
    Publication date: June 27, 2019
    Inventors: Osamu Ishida, Isao Tsunoda, Yoshiyuki Takeuchi
  • Patent number: 10330043
    Abstract: In a saddle-ride type vehicle in which a cylinder head of a single-cylinder engine main unit has a front wall and a rear wall, an exhaust system being connected to the front wall and an intake system being connected to the rear wall, a joining surface of the cylinder head to a head cover is formed on a plane crossing a cylinder axis, the plane being inclined downward toward a front. Rotation axes of camshafts are arranged on the plane. An axis of a valve stem of a throttle valve is arranged on the plane. A curve cover curved so as to cover driven sprockets fixed to the camshafts is formed on one side in a vehicle width direction of the head cover. A drum housing box housing a throttle drum fixed to one end of the valve stem is arranged close to the curve cover.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: June 25, 2019
    Assignee: HONDA MOTOR CO., LTD.
    Inventors: Nozomi Okada, Yusaburo Tani, Yosuke Hoi, Tatsuhiko Asano, Shuichi Ishida, Isao Azumagakito
  • Publication number: 20190169305
    Abstract: An object of the present invention is to effectively induce cancer cell apoptosis using the anti-TRAIL-R1 antibody(ies) and the anti-TRAIL-R2 antibody(ies) and to reduce the toxicity imposed on normal cells. The present invention relates to recombinant obligate anaerobic Gram-positive bacteria that include a nucleic acid encoding a fusion protein having 3 or more anti-TRAIL-R1 single-chain antibodies and/or 3 or more anti-TRAIL-R2 single-chain antibodies, in an expressible state.
    Type: Application
    Filed: February 19, 2019
    Publication date: June 6, 2019
    Applicant: TEIKYO HEISEI UNIVERSITY
    Inventors: Takeshi Nishikawa, Yuichiro Taira, Ikuko Taira, Isao Ishida
  • Patent number: 10266601
    Abstract: An object of the present invention is to effectively induce cancer cell apoptosis using the anti-TRAIL-R1 antibody(ies) and the anti-TRAIL-R2 antibody(ies) and to reduce the toxicity imposed on normal cells. The present invention relates to recombinant obligate anaerobic Gram-positive bacteria that include a nucleic acid encoding a fusion protein having 3 or more anti-TRAIL-R1 single-chain antibodies and/or 3 or more anti-TRAIL-R2 single-chain antibodies, in an expressible state.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: April 23, 2019
    Assignee: TEIKYO HEISEI UNIVERSITY
    Inventors: Takeshi Nishikawa, Yuichiro Taira, Ikuko Taira, Isao Ishida
  • Patent number: 10076103
    Abstract: The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: September 18, 2018
    Assignees: KYOWA HAKKO KIRIN CO., LTD., E.R. SQUIBB & SONS, L.L.C.
    Inventors: Kazuma Tomizuka, Isao Ishida, Nils Lonberg, Edward L. Halk
  • Publication number: 20170099814
    Abstract: The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody ? light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
    Type: Application
    Filed: October 19, 2016
    Publication date: April 13, 2017
    Applicants: E.R. Squibb & Sons, L.L.C., Kyowa Hakko Kirin Co. Ltd.
    Inventors: YOSHIMI KUROIWA, Kazuma Tomizuka, Hitoshi Yoshida, Isao Ishida
  • Patent number: 9499838
    Abstract: The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody ? light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: November 22, 2016
    Assignees: KYOWA HAKKO KIRIN CO., LTD., E. R. SQUIBB & SONS, L.L.C.
    Inventors: Yoshimi Kuroiwa, Kazuma Tomizuka, Hitoshi Yoshida, Isao Ishida
  • Publication number: 20160326256
    Abstract: An object of the present invention is to effectively induce cancer cell apoptosis using the anti-TRAIL-R1 antibody(ies) and the anti-TRAIL-R2 antibody(ies) and to reduce the toxicity imposed on normal cells. The present invention relates to recombinant obligate anaerobic Gram-positive bacteria that include a nucleic acid encoding a fusion protein having 3 or more anti-TRAIL-R1 single-chain antibodies and/or 3 or more anti-TRAIL-R2 single-chain antibodies, in an expressible state.
    Type: Application
    Filed: December 24, 2014
    Publication date: November 10, 2016
    Inventors: Takeshi NISHIKAWA, Yuichiro TAIRA, Ikuko TAIRA, Isao ISHIDA
  • Publication number: 20160324131
    Abstract: The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
    Type: Application
    Filed: July 25, 2016
    Publication date: November 10, 2016
    Inventors: Kazuma Tomizuka, Isao Ishida, Nils Lonberg, Edward L. Halk
  • Patent number: 9426970
    Abstract: The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: August 30, 2016
    Assignees: E. R. SQUIBB & SONS, L.L.C., KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Kazuma Tomizuka, Isao Ishida, Nils Lonberg, Edward L. Halk
  • Publication number: 20150191706
    Abstract: An object of the present invention is to provide an antitumor agent and/or a marker fur tumor detection with low invasiveness, few side effects, and high target specificity. Through the use of a recombinant obligate anaerobic gram-positive bacterium as an active ingredient containing a nucleic acid encoding a secretory fusion protein comprising a signal peptide, a low-molecular-weight single-chain antibody, and a functional peptide, an antitumor agent that enables delivery of a functional peptide to a target cell and/or a marker for tumor detection that enables monitoring of therapeutic effects over time are provided.
    Type: Application
    Filed: July 12, 2013
    Publication date: July 9, 2015
    Inventors: Yuichiro Taira, Isao Ishida