Abstract: The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.

Abstract: A chimeric, non-human animal can be produced by a method that entails providing a microcell that contains one or more foreign chromosomes or fragment(s) thereof and then fusing the microcell with a pluripotent cell, thereby introducing the foreign chromosome(s) or fragment(s) into the latter. The pluripotent cell thus obtained can be used to generate a chimeric, non-human animal, the cells, tissues, and/or progeny of which can be the source of a product, such as an antibody, that is associated with one or more genes on the foreign chromosome(s) or fragment(s).

Abstract: The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.

Abstract: The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.

Abstract: This invention relates to a method for producing a plant with enhanced resistance to a pathogenic fungus, comprising transforming a plant with an expression vector comprising a DNA encoding a glucan elicitor receptor operably linked to a heterologous promoter, selecting a plant which has said DNA incorporated into a chromosome of said plant and which expresses said DNA, and recovering the selected plant. This invention also relates to a method for producing a progeny plant with resistance to a pathogenic fungus from said plant.

Abstract: The present invention relates to a method for creating a plant having resistance to RNA viruses, comprising incorporating a DNA sequence encoding an animal cell-derived (2′-5′)oligoadenylate synthetase and a DNA sequence encoding an animal cell-derived ribonuclease L into a chromosome(s) of the plant and expressing the DNA sequences, as well as plants created by the above method. The present invention is widely applicable to the breeding of virus resistant plant varieties.

Abstract: A glucan elicitor receptor having an amino acid sequence as substantially shown in SEQ ID NO:1; DNA molecules containing nucleotide sequences coding for a glucan elicitor receptor having an amino acid sequence as substantially shown in SEQ ID NO:1, or fragments thereof; DNA molecules containing nucleotide sequences coding for a glucan elicitor receptor, which are incorporated in plasmid pER23-1, or fragments thereof; vectors containing the DNA molecules or fragments thereof; plant cells transformed with the DNA molecules or fragments thereof; a method for creating a plant having resistance to pathogenic fungi comprising incorporating the DNA sequence coding for a glucan elicitor receptor, or fragment thereof into a chromosome of a plant and expressing the gene in the plant; a plant having resistance to pathogenic fungi, the plant having the DNA molecule containing a nucleotide sequence coding for a glucan elicitor receptor, or its fragment transferred thereinto and expressing the gene; and methods for using t

Abstract: This invention relates to a method for producing a plant having resistance against RNA viruses by integrating a DNA sequence, which encodes a protein having an enzyme activity specifically breaking down a double-strand RNA, into a chromosome of a plant and making the DNA sequence express in the plant cells; and a plant having resistance against RNA viruses obtained according to the above method.A plant according to the present invention has resistance against plural RNA viruses.

Abstract: The present invention is concerned with a thrust support system supporting on a stand the thrust of a rotator of a vertical shaft rotary machine. Said support system comprises a ring-like member for receiving thrust of the rotator, legs disposed at a given distance from and obliquely upwardly of said member, and slanted connecting members for connecting said ring-like member with the leg, and said legs being provided with a movement-preventing member for preventing the legs from moving in the diametral direction.With this arrangement, stresses acting on said respective members are distributed in simple and uniform manner.