Patents by Inventor Isao Sakata

Isao Sakata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4849207
    Abstract: A porphyrin compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each --CH.dbd.CH.sub.2, --CH.sub.2 CH.sub.3, --CH(O-lower alkanoyl)CH.sub.3, --CH(OR)CH.sub.3 or --CH(O-lower alkylene-OR)CH.sub.3 ; R.sub.3 is --H, --COOH, --COO-lower alkyl, --COO-lower alkylene-OR or --COO-lower alkylene-OOC-Z; R.sub.4 is --H, -lower alkyl or -lower alkylene-OR; R is --H, -lower alkyl or a residue of a polyfunctional carboxyl compound excluding a hydrogen atom therefrom; Z is a residue of the compound of the formula (I) excluding R.sub.3 therefrom; A is --CH.sub.2 -- or --CO--; and the dotted line from the gamma-position indicates no bonding or a single direct bond; and the dotted line between the 7- and 8-positions indicates the presence of a single bond or a double bond; and its complexes with a metal(s) in the porphine skeleton and/or at the residue of the polyfuntional carboxyl compound, at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.
    Type: Grant
    Filed: October 23, 1986
    Date of Patent: July 18, 1989
    Assignees: Nihon Medi-Physics Co., Ltd., Toyo Hakka Kogyo Co., Ltd.
    Inventors: Isao Sakata, Susumu Nakajima, Koichi Koshimizu, Natsuki Samejima, Kazumi Inohara, Hiroyuki Takata, Hirohiko Yamauchi, Nobuo Ueda, Masaaki Hazue
  • Patent number: 4709022
    Abstract: Pheophorbide derivatives and alkaline salts thereof having the general formula (A): ##STR1## wherein R.sub.1 represents --CH.dbd.CH.sub.2, --CH(OH)CH.sub.3, --CH(OCH.sub.2 CH.sub.2 OH)CH.sub.3 or --CH(OCOCH.sub.3)CH.sub.3R.sub.2 represents --CH.sub.3, --CHO or --CH.sub.2 OHR.sub.3 represents .dbd.O, --OH or --OCOCH.sub.3R.sub.4 represents --H, --COOCH.sub.3, --COOCH.sub.2 CH.sub.2 OH, --COOCH.sub.2 CH.sub.2 OCOCH.sub.3, or a --CONH-- containing residue of an amino acid andR.sub.5 represents --COOH, --COONa or --COOCH.sub.3 ; provided, however, said derivatives and alkaline salts exclude pheophorbide, 9-desoxo-9-hydroxy-pheophorbide and pyropheophorbide.Dimeric pheophorbide derivatives and alkaline salts thereof represented by the general formula (B): ##STR2## wherein R.sub.1 through R.sub.5 are the same as in general formula (A), are useful for treating cancer having a strong preferential affinity for cancer cells over normal cells and exerting upon irradiation a destructive effect on such cancer cells.
    Type: Grant
    Filed: June 19, 1985
    Date of Patent: November 24, 1987
    Inventors: Isao Sakata, Susumu Nakajima, Koichi Koshimuzi, Natsuki Samejima, Kazumi Inohara, Hiroyuki Takata
  • Patent number: 4604241
    Abstract: Nine-desoxo-hydroxy-pheophorbide derivatives and alkaline salts thereof represented by the general formula: ##STR1## wherein R.sub.1 represents CH.sub.3 or CH.sub.2 OH,R.sub.2 represents H or Ac, andR.sub.3 represents H or alkali metal,are useful for treating cancer having a strong preferential affinity for cancer cells over normal cells and exerting upon irradiation a destructive effect on such cancer cells.
    Type: Grant
    Filed: October 24, 1984
    Date of Patent: August 5, 1986
    Inventors: Isao Sakata, Susumu Nakajima, Koichi Koshimizu, Natsuki Samejima, Kazumi Inohara, Hiroyuki Takata
  • Patent number: 4307206
    Abstract: A urea-formaldehyde resin adhesive comprising a powder of a substance having the property of gradually reacting with an acid and thus consuming the acid.
    Type: Grant
    Filed: July 7, 1980
    Date of Patent: December 22, 1981
    Assignees: Oshika Shinko Co., Ltd., Mitsuo Higuchi, Isao Sakata
    Inventors: Mitsuo Higuchi, Isao Sakata
  • Patent number: 4212954
    Abstract: A polyurethane foam which absorbs impact effectively is prepared by cross-linking short chain polyol to high polymer polyol chains by using polyisocyanate.
    Type: Grant
    Filed: August 9, 1977
    Date of Patent: July 15, 1980
    Assignee: Toyota Jidosha Kogyo Kabushiki Kaisha
    Inventors: Takao Nomura, Kunihiko Terasaka, Isao Sakata
  • Patent number: 4209564
    Abstract: A flexible foamed product with skin, characterized in that on the surface of the foamed product there is formed a skin composed of the reaction product of a linear urethane polymer, a polyol or an urethane prepolymer with an OH-terminal group compatible with the linear urethane polymer, and a blocked isocyanate; and the process for manufacturing such a product.
    Type: Grant
    Filed: March 23, 1979
    Date of Patent: June 24, 1980
    Assignee: Toyota Jidosha Kogyo Kabushiki Kaisha
    Inventors: Takao Nomura, Yoshio Taguchi, Kazuo Kobayashi, Isao Sakata
  • Patent number: 4119582
    Abstract: A process for manufacturing high-resilient flexible urethan foams characterized by, reacting and foaming polyalkylene ether polyol and an organic polyisocyanate in the presence of a blowing agent, a surfactant and catalyst, (1) using as said polyalkylene ether polyol one which contains 2 to 10% by weight of a vinyl type polymer and in which its hydroxyl number ranges from 25 to 60 mg KOH/g, of its hydroxyl groups 20 to 70 mol% are primary hydroxyl groups and the remaining hydroxyl groups are secondary hydroxyl groups; (2) using as said organic polyisocyanate a mixture of tolylene diisocyanate with diphenylmethane diisocyanate or a crude diphenylmethane diisocyanate; and (3) using as said surfactant a mixture of a high-molecular-weight siloxane-oxyalkylene copolymer with a low-molecular-weight siloxane-oxyalkylene copolymer.
    Type: Grant
    Filed: February 10, 1976
    Date of Patent: October 10, 1978
    Assignees: Mitsui-Nisso Corporation, Nippon Unicar Company, Limited, Toyota Jidosha Kogyo Kabushiki Kaisha
    Inventors: Kiyoshi Matsubara, Yuichi Nomura, Tadashi Yatomi, Tadashi Hamamura, Isao Noda, Terumi Watanabe, Takao Nomura, Isao Sakata
  • Patent number: 4038270
    Abstract: Water-soluble menthol glycosides are prepared by condensing menthol with a mono- or oligosaccharide, preferably a mono- or di-saccharide, i.e., a sugar, or acyl derivative thereof, using a condensing agent or catalyst as needed. These glycosides are hydrolyzed by carbohydrase enzymes, as occur in the human mouth, or common acids, releasing menthol, and provide a more persistent flavor than menthol alone.
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: July 26, 1977
    Assignee: Toyo Hakka Kobyo Kabushiki Kaisha
    Inventors: Tatsuo Higashiyama, Isao Sakata
  • Patent number: 3988482
    Abstract: Water-soluble menthol glycosides are prepared by condensing menthol with a mono- or oligosaccharide, preferably a mono- or disaccharide, i.e., a sugar, or acyl derivative thereof, using a condensing agent or catalyst as needed. These glycosides are hydrolyzed by carbohydrase enzymes, as occur in the human mouth, or common acids, releasing menthol, and provide a more persistent flavor than menthol alone.
    Type: Grant
    Filed: September 20, 1974
    Date of Patent: October 26, 1976
    Assignee: Toyo Hakka Kogyo Kabushiki Kaisha
    Inventors: Tatsuo Higashiyama, Isao Sakata