Patents by Inventor Isidro Hotzel

Isidro Hotzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Humanized and affinity matured antibodies to FcRH5 and methods of use
    Patent number: 12030947
    Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
    Type: Grant
    Filed: October 29, 2021
    Date of Patent: July 9, 2024
    Assignee: Genentech, Inc.
    Inventors: Isidro Hotzel, Teemu T. Junttila, Ji Li, Justin Scheer, Danielle Dicara, Diego Ellerman, Christoph Spiess, Paul J. Carter
  • ANTI-TAU ANTIBODIES AND METHODS OF USE
    Publication number: 20240067707
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Application
    Filed: December 13, 2022
    Publication date: February 29, 2024
    Applicants: Genentech, Inc., AC Immune SA
    Inventors: Oskar Adolfsson, Gai Ayalon, Isidro Hotzel, Danielle Marie Di Cara
  • EXPRESSION AND SECRETION SYSTEM
    Publication number: 20240043831
    Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.
    Type: Application
    Filed: March 10, 2023
    Publication date: February 8, 2024
    Inventors: Devin TESAR, Xiaocheng CHEN, Mark DENNIS, Isidro HOTZEL
  • Polypeptide expression systems
    Patent number: 11851661
    Abstract: The present invention relates to polypeptide expression systems and methods of using the same.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: December 26, 2023
    Assignee: Genentech, Inc.
    Inventors: Isidro Hotzel, Yonglei Shang
  • ANTI-TAU ANTIBODIES AND METHODS OF USE
    Publication number: 20230043289
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Application
    Filed: June 22, 2022
    Publication date: February 9, 2023
    Applicants: AC Immune SA, Genentech, Inc.
    Inventors: Oskar Adolfsson, Isidro Hotzel, Danielle DiCara
  • Anti-Tau antibodies and methods of use
    Patent number: 11555065
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: January 17, 2023
    Assignees: AC Immune SA, Genentech, Inc.
    Inventors: Oskar Adolfsson, Gai Ayalon, Isidro Hotzel, Danielle Marie Di Cara
  • Agonists of TREM2
    Publication number: 20220389097
    Abstract: This application discloses, inter alia, certain antibodies that specifically bind to human TREM2 (triggering receptor expressed on myeloid cells 2). In some embodiments, the antibodies act as TREM2 agonists. In some embodiments, antibodies herein specifically bind to the stalk region of intact, human TREM2, without binding to soluble TREM2, which is the product of TREM2 cleavage between residues H157 and S158. In some embodiments, the antibodies act as TREM2 agonists, specifically bind to the stalk region of TREM2 with dissociation constants ranging from 10 nM to as low as 100-500 pM, 10-50pM, or 1-10 pM, specifically bind to a TREM2 epitope spanning the H157-S158 cleavage site, and do not bind to soluble TREM2.
    Type: Application
    Filed: May 12, 2022
    Publication date: December 8, 2022
    Applicant: Genentech Inc.
    Inventors: Ainhoa Echeverria Larraza, David Verne Hansen, Isidro Hotzel, Yi-Chun Hsiao, Zhonghua Lin, Dhaya Seshasayee, Benny Chih
  • Anti-Tau antibodies and methods of use
    Patent number: 11427629
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: August 30, 2022
    Assignees: AC Immune SA, Genentech, Inc.
    Inventors: Oskar Adolfsson, Isidro Hotzel, Danielle DiCara
  • HUMANIZED AND AFFINITY MATURED ANTIBODIES TO FcRH5 AND METHODS OF USE
    Publication number: 20220048993
    Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
    Type: Application
    Filed: October 29, 2021
    Publication date: February 17, 2022
    Inventors: Isidro HOTZEL, Teemu T. JUNTTILA, Ji LI, Justin SCHEER, Danielle DICARA, Diego ELLERMAN, Christoph SPIESS, Paul J. CARTER
  • Humanized and affinity matured antibodies to FcRH5 and methods of use
    Patent number: 11192950
    Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: December 7, 2021
    Assignee: Genentech, Inc.
    Inventors: Isidro Hotzel, Teemu T. Junttila, Ji Li, Justin Scheer, Danielle Dicara, Diego Ellerman, Christoph Spiess, Paul J. Carter
  • ANTI-TAU ANTIBODIES AND METHODS OF USE
    Publication number: 20210332114
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Application
    Filed: December 3, 2020
    Publication date: October 28, 2021
    Applicants: Genentech, Inc., AC Immune SA
    Inventors: Oskar Adolfsson, Gai Ayalon, Isidro Hotzel, Danielle Marie Di Cara
  • ANTI-TAU ANTIBODIES AND METHODS OF USE
    Publication number: 20210122811
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Application
    Filed: June 5, 2020
    Publication date: April 29, 2021
    Applicants: AC Immune SA, Genentech, Inc.
    Inventors: Oskar Adolfsson, Isidro Hotzel, Danielle DiCara
  • EXPRESSION AND SECRETION SYSTEM
    Publication number: 20200385704
    Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.
    Type: Application
    Filed: March 17, 2020
    Publication date: December 10, 2020
    Inventors: Devin TESAR, Xiaocheng CHEN, Mark DENNIS, Isidro HOTZEL
  • Anti-Tau antibodies and methods of use
    Patent number: 10711058
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: July 14, 2020
    Assignees: AC Immune SA, Genentech, Inc.
    Inventors: Oskar Adolfsson, Isidro Hotzel, Danielle DiCara
  • Expression and secretion system
    Patent number: 10633650
    Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: April 28, 2020
    Assignee: Genentech, Inc.
    Inventors: Devin Tesar, Xiaocheng Chen, Mark Dennis, Isidro Hotzel
  • Anti-tau antibodies and methods of use
    Patent number: 10633436
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: April 28, 2020
    Assignees: Genentech, Inc., AC Immune SA
    Inventors: Oskar Adolfsson, Gai Ayalon, Isidro Hotzel, Danielle Marie Di Cara
  • ANTI-TAU ANTIBODIES AND METHODS OF USE
    Publication number: 20200017579
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Application
    Filed: May 23, 2019
    Publication date: January 16, 2020
    Applicants: AC Immune SA, Genentech, Inc.
    Inventors: Oskar Adolfsson, Isidro Hotzel, Danielle DiCara
  • ANTI-TAU ANTIBODIES AND METHODS OF USE
    Publication number: 20190367591
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Application
    Filed: May 7, 2019
    Publication date: December 5, 2019
    Applicants: Genentech, Inc., AC Immune SA
    Inventors: Oskar Adolfsson, Gai Ayalon, Isidro Hotzel, Danielle Marie Di Cara
  • HUMANIZED AND AFFINITY MATURED ANTIBODIES TO FcRH5 AND METHODS OF USE
    Publication number: 20190315860
    Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
    Type: Application
    Filed: April 25, 2019
    Publication date: October 17, 2019
    Inventors: Isidro HOTZEL, Teemu T. JUNTTILA, Ji LI, Justin SCHEER, Danielle DICARA, Diego ELLERMAN, Christoph SPIESS, Paul J. CARTER
  • POLYPEPTIDE EXPRESSION SYSTEMS
    Publication number: 20190256859
    Abstract: The present invention relates to polypeptide expression systems and methods of using the same.
    Type: Application
    Filed: April 17, 2019
    Publication date: August 22, 2019
    Inventors: Isidro HOTZEL, Yonglei SHANG