Patents by Inventor Isidro Hotzel

Isidro Hotzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10329344
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: June 25, 2019
    Assignees: Genentech, Inc., AC Immune SA
    Inventors: Oskar Adolfsson, Gai Ayalon, Isidro Hotzel, Danielle Marie Di Cara
  • Patent number: 10323094
    Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: June 18, 2019
    Assignee: Genentech, Inc.
    Inventors: Isidro Hotzel, Teemu T. Junttila, Ji Li, Justin Scheer, Danielle DiCara, Diego Ellerman, Christoph Spiess, Paul J. Carter
  • Patent number: 10308944
    Abstract: The present invention relates to polypeptide expression systems and methods of using the same.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: June 4, 2019
    Assignee: Genentech, Inc.
    Inventors: Isidro Hotzel, Yonglei Shang
  • Publication number: 20190112361
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Application
    Filed: September 24, 2018
    Publication date: April 18, 2019
    Applicants: GENENTECH, INC., AC IMMUNE SA
    Inventors: Oskar Adolfsson, Gai Ayalon, Isidro Hotzel, Danielle Marie Di Cara
  • Publication number: 20190112362
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Application
    Filed: September 24, 2018
    Publication date: April 18, 2019
    Applicants: GENENTECH, INC., AC IMMUNE SA
    Inventors: Oskar Adolfsson, Gai Ayalon, Isidro Hotzel, Danielle Marie Di Cara
  • Patent number: 10112990
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: October 30, 2018
    Assignees: Genentech, Inc., AC Immune SA
    Inventors: Oskar Adolfsson, Gai Ayalon, Isidro Hotzel, Danielle Marie Di Cara
  • Publication number: 20180125995
    Abstract: The invention provides rF1 antibody antibiotic conjugates and methods of using same.
    Type: Application
    Filed: June 2, 2017
    Publication date: May 10, 2018
    Applicant: Genentech, Inc.
    Inventors: Eric Brown, Wouter Hazenbos, Isidro Hotzel, Kimberly Kajihara, Sophie M. Lehar, Sanjeev Mariathasan, Thomas Pillow, Leanna Staben, Vishal Verma, Binqing Wei, Yi Xia, Min Xu
  • Publication number: 20180021450
    Abstract: The invention provides anti-Staphylococcus aureus antibody rifamycin antibiotic conjugates and methods of using same.
    Type: Application
    Filed: June 2, 2017
    Publication date: January 25, 2018
    Applicant: Genentech, Inc.
    Inventors: Eric Brown, Wouter Hazenbos, Isidro Hotzel, Kimberly Kajihara, Sophie M. Lehar, Sanjeev Mariathasan, Thomas Pillow, Leanna Staben, Vishal Verma, Binqing Wei, Min Xu
  • Publication number: 20170369869
    Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.
    Type: Application
    Filed: August 30, 2017
    Publication date: December 28, 2017
    Inventors: Devin TESAR, Xiaocheng CHEN, Mark DENNIS, Isidro HOTZEL
  • Patent number: 9803191
    Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: October 31, 2017
    Assignee: Genentech, Inc.
    Inventors: Devin Tesar, Xiaocheng Chen, Mark Dennis, Isidro Hotzel
  • Patent number: 9598485
    Abstract: The present invention relates to anti-Tau antibodies, such as antibodies that bind to a phosphorylated epitope on human Tau protein with high specificity and/or affinity, and methods of using the same.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: March 21, 2017
    Assignees: AC IMMUNE S.A., GENENTECH, INC.
    Inventors: Gai Ayalon, Danielle Marie Di Cara, Isidro Hotzel, Andrea Pfeifer, Andreas Muhs, Maria Pihlgren, Oskar Adolfsson
  • Patent number: 9580514
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. In certain aspects, the isolated nucleic acid molecule comprises a nucleotide sequence having at least about 80% nucleic acid sequence identity, alternatively at least about 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% nucleic acid sequence identity, to (a) a DNA molecule encoding a full-length TAT polypeptide having an amino acid sequence as disclosed herein, a TAT polypeptide amino acid sequence lacking the signal peptide as disclosed herein, an extracellular domain of a transmembrane TAT polypeptide, with or without the signal peptide, as disclosed herein.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: February 28, 2017
    Assignee: Genentech, Inc.
    Inventors: Sunil Bhakta, Meredith Hazen, Jo-Anne S Hongo, Jagath R Junutula, Isidro Hotzel, Yonglei Shang, Shang-Fan Yu
  • Publication number: 20160376351
    Abstract: The invention provides anti-Tau antibodies and methods of using the same.
    Type: Application
    Filed: June 2, 2016
    Publication date: December 29, 2016
    Applicants: GENENTECH, INC., AC IMMUNE SA
    Inventors: Oskar Adolfsson, Gai Ayalon, Isidro Hotzel, Danielle Marie Di Cara
  • Publication number: 20160368985
    Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
    Type: Application
    Filed: June 16, 2016
    Publication date: December 22, 2016
    Inventors: Isidro HOTZEL, Teemu T. JUNTTILA, Ji LI, Justin SCHEER, Danielle DICARA, Diego ELLERMAN, Christoph SPIESS, Paul J. CARTER
  • Publication number: 20160090422
    Abstract: The invention provides anti-CRTh2 antibodies and methods of using the same.
    Type: Application
    Filed: September 14, 2015
    Publication date: March 31, 2016
    Inventors: Karin REIF, Isidro HOTZEL, Jo-Anne S. HONGO, Tao HUANG, Yonglei SHANG, Meredith HAZEN
  • Publication number: 20160024193
    Abstract: The present invention relates to anti-Tau antibodies, such as antibodies that bind to a phosphorylated epitope on human Tau protein with high specificity and/or affinity, and methods of using the same.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 28, 2016
    Inventors: Gai Ayalon, Danielle Marie Di Cara, Isidro Hotzel, Andrea Pfeifer, Andreas Muhs, Maria Pihlgren, Oskar Adolfsson
  • Publication number: 20160002642
    Abstract: The present invention relates to polypeptide expression systems and methods of using the same.
    Type: Application
    Filed: July 2, 2015
    Publication date: January 7, 2016
    Inventors: Isidro HOTZEL, Yonglei SHANG
  • Publication number: 20150376265
    Abstract: The invention provides compositions comprising anti-gH antibodies and anti-Complex I antibodies as well as methods of using the same.
    Type: Application
    Filed: December 19, 2014
    Publication date: December 31, 2015
    Applicant: GENENTECH, INC.
    Inventors: Xiaocheng Chen, Mark Dennis, Becket L. Feierbach, Ashley Fouts, Isidro Hotzel, Bing Li, Jo-Anne S. Hongo, Rajesh Vij
  • Publication number: 20150175682
    Abstract: The present invention provides, methods end composites for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the Invention relates to humanized antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers to methods and compositions involving antibodies for the therapeutic and diagnostic use In the treatment of tauopathies including Alzheimer's Disease (AD).
    Type: Application
    Filed: March 15, 2013
    Publication date: June 25, 2015
    Inventors: Andrea Pfeifer, Andreas Muhs, Maria Pihlgren, Oskar Adolfsson, Fred Van Leuven, Gai Ayalon, Danielle Marie Di Cara, Isidro Hotzel
  • Publication number: 20150098946
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. In certain aspects, the isolated nucleic acid molecule comprises a nucleotide sequence having at least about 80% nucleic acid sequence identity, alternatively at least about 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% nucleic acid sequence identity, to (a) a DNA molecule encoding a full-length TAT polypeptide having an amino acid sequence as disclosed herein, a TAT polypeptide amino acid sequence lacking the signal peptide as disclosed herein, an extracellular domain of a transmembrane TAT polypeptide, with or without the signal peptide, as disclosed herein.
    Type: Application
    Filed: March 14, 2013
    Publication date: April 9, 2015
    Applicant: Genentech, Inc.
    Inventors: Sunil Bhakta, Meredith Hazen, Jo-Anne S Hongo, Jagath R Junutula, Isidro Hotzel, Yonglei Shang, Shang-Fan Yu