Patents by Inventor J. Brent Ratz

J. Brent Ratz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220006850
    Abstract: A method for replacing a native heart valve includes advancing a delivery catheter having a valve prosthesis disposed along a distal end portion thereof, wherein the valve includes an inner frame having an hourglass shape and an outer sealing frame connected to and surrounding the inner frame. A valve body is mounted within the inner frame and includes a plurality of leaflets. The leaflets have longitudinal curvatures when in an open position, wherein the curvatures are shaped for conforming to the curved interior surface of the inner frame. This combination of features reduces the possibility of blood stagnating between the leaflets and inner frame, which reduces the possibility of thrombus formation.
    Type: Application
    Filed: July 28, 2021
    Publication date: January 6, 2022
    Applicant: Edwards Lifesciences Corporation
    Inventors: Alexander H. Cooper, Juliet Laura Schwartz, Wendy Vo Pham, Hieu Minh Luong, Julio Cesar Sanchez, Matthew A. Peterson, J. Brent Ratz, Lisong Ai
  • Publication number: 20210401575
    Abstract: Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement valve to a native valve location in a heart. Disclosed are a number of features that can improve steerability or release of the prosthesis into the body location. In one preferred delivery system, a proximal handle can be manipulated to apply tension to a pair of diametrically opposed axial runner wires extending through lumens in a wall of a flexible tubular shaft. By applying tension to a pair of axial runner wires, the tubular shaft can be stiffened along a plane extending substantially through the pair of axial runner wires, while the shaft is permitted to freely bend in a perpendicular plane. This feature advantageously provides the ability to adjust the steerability and flexibility of a tubular shaft to meet the requirements of a particular procedure.
    Type: Application
    Filed: September 8, 2021
    Publication date: December 30, 2021
    Applicant: Edwards Lifesciences Corporation
    Inventors: David Robert Landon, Alexander H. Cooper, Julio Cesar Sanchez, Glen T. Rabito, J. Brent Ratz, Tarannum Ishaq Gutierrez, Ramon Aguilar, JR.
  • Publication number: 20210386544
    Abstract: Guide wire apparatuses and methods. Guide wires may be utilized for guiding a delivery apparatus, for example a transcatheter mitral valve delivery apparatus to replace a native mitral valve. A guide wire may include a core body having a length, and an outer layer having a length and extending around the core body and along the length of the core body. A guide wire may include an intermediate layer positioned between the core body and the outer layer and configured to be retracted relative to the core body and the outer layer along the length of the core body and the length of the outer layer.
    Type: Application
    Filed: July 30, 2021
    Publication date: December 16, 2021
    Applicant: Edwards Lifesciences Corporation
    Inventors: Alexander H. Cooper, J. Brent Ratz, Kevin M. Stewart, David Robert Landon, Garrett Dallas Johnson, Harish Manickam Srinimukesh, Deena Walid Jamal
  • Publication number: 20210378822
    Abstract: This disclosure relates generally to prosthetic valves and methods and systems for deploying, positioning, and recapturing the same. A prosthetic valve includes one or more support structures. At least one of the one or more support structures defines an elongate central passageway of the prosthetic valve. The prosthetic valve can also include a plurality of leaflet elements attached to at least one of the one or more support structures and disposed within the elongate central passageway for control of fluid flow through the elongate central passageway. At least one of the one or more support structures is configured to biodynamically fix the prosthetic valve within a native valve such as, for example, a native tricuspid valve of a heart.
    Type: Application
    Filed: June 11, 2021
    Publication date: December 9, 2021
    Applicant: inQB8 Medical Technologies, LLC
    Inventors: J. Brent Ratz, Arshad Quadri
  • Publication number: 20210315692
    Abstract: A prosthesis for placement within a native heart valve preferably includes an expandable frame having locking tabs disposed along a proximal end. A plurality of distal anchors is disposed along a distal end of the frame. Each distal anchor is provided with a cushion cover. An outer fabric member surrounds the frame and may extend outwardly from the frame in an expanded condition for providing an improved seal in the region of a native annulus. A valve body is positioned within an interior of the expandable from for allowing blood flow in only one direction. In preferred embodiments, the cushions are positioned over enlarged head portions of the distal anchors for further reducing trauma on surrounding tissue.
    Type: Application
    Filed: June 24, 2021
    Publication date: October 14, 2021
    Applicant: Edwards Lifesciences CardiAQ LLC
    Inventors: J. Brent Ratz, Luca Pesce, Glen T. Rabito, Christine Thanh Nguyen
  • Publication number: 20210307894
    Abstract: A system for treating aortic dissection including an aortic dissection implant comprising an expandable anchoring structure and an elongate tubular structure. The expandable anchoring structure can be configured to apply radial force to the sinuses of the aortic root and/or the sinotubular junction when expanded. The elongate tubular structure can comprise an expandable support frame and one or more layers. The expandable support frame can be configured to extend from the descending aorta to the ascending aorta and curve along with a curvature of the aortic arch when expanded within the aorta. The one or more layers can comprise a first porous layer comprising an atraumatic outer surface positioned over the expandable support frame and a second non-porous layer positioned over a portion of the first porous layer. The second non-porous layer may be configured to be positioned on opposite sides of the aortic dissection and to be inflatable via blood flow to seal against the dissection.
    Type: Application
    Filed: January 8, 2021
    Publication date: October 7, 2021
    Inventors: Arshad QUADRI, J. Brent RATZ, Christopher William Stivers
  • Publication number: 20210298902
    Abstract: This disclosure relates generally to prosthetic valves and methods and systems for deploying, positioning, and recapturing the same. A prosthetic valve includes one or more support structures. At least one of the one or more support structures defines an elongate central passageway of the prosthetic valve. The prosthetic valve can also include a plurality of leaflet elements attached to at least one of the one or more support structures and disposed within the elongate central passageway for control of fluid flow through the elongate central passageway. At least one of the one or more support structures is configured to biodynamically fix the prosthetic valve within a native valve such as, for example, a native tricuspid valve of a heart.
    Type: Application
    Filed: June 14, 2021
    Publication date: September 30, 2021
    Applicant: inQB8 Medical Technologies, LLC
    Inventors: J. Brent Ratz, Arshad Quadri
  • Publication number: 20210299430
    Abstract: A system for treating atrial dysfunction, including heart failure and/or atrial fibrillation, that includes one or more pressurizing elements and control circuitry. The one or more pressurizing elements can comprise one or more balloons and can be configured to be positioned in the left atrium, and optionally the pulmonary artery, of a patient's heart. The one or more pressurizing elements can be coupled to one or more positioning structures that can be configured to position the one or more pressurizing elements in the left atrium, and optionally the pulmonary artery. The control circuitry can be configured to operate the one or more pressurizing elements to decrease or increase pressure and/or volume in the left atrium, and optionally the pulmonary artery, in accordance with different phases of the cardiac cycle.
    Type: Application
    Filed: January 8, 2021
    Publication date: September 30, 2021
    Inventors: J. Brent Ratz, Arshad Quadri
  • Publication number: 20210290378
    Abstract: Disclosed herein are embodiments of an expandable replacement heart valve prosthesis. The expandable replacement heart valve prosthesis can include a number of different features, such as an hourglass (or generally hourglass) shape in the fully expanded position, anchor stiffening features, and improved retraction/retention configurations. For example, certain struts on the prosthesis can have different thicknesses/widths than other struts to improve compressibility.
    Type: Application
    Filed: June 9, 2021
    Publication date: September 23, 2021
    Applicant: Edwards Lifesciences Corporation
    Inventors: Alexander H. Cooper, Juliet Laura Schwartz, Wendy Vo Pham, Hieu Minh Luong, Julio Cesar Sanchez, Matthew A. Peterson, J. Brent Ratz, Lisong Ai
  • Patent number: 11123186
    Abstract: Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. Disclosed are a number of features that can improve steerability or release of the prosthesis into the body location.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: September 21, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: David Robert Landon, Alexander H. Cooper, Julio Cesar Sanchez, Glen T. Rabito, Victoria Cheng-Tan Wu, Kevin M. Golemo, J. Brent Ratz, Tarannum Ishaq Gutierrez, Ramon Aguilar, Jr., Taylor Jacob Scheinblum, Kevin M. Stewart, Garrett Dallas Johnson, Jesse Robert Edwards, Hieu Minh Luong, Lindsay Lam
  • Publication number: 20210205083
    Abstract: Methods for delivering a replacement heart valve include advancing a delivery system through a femoral vein and into the atrium of a heart, wherein the delivery system includes an outer sheath assembly, a mid shaft assembly and an inner assembly. The outer sheath assembly and the mid shaft assembly are adapted to retain the replacement heart valve in a radially compacted state over the inner assembly. The outer sheath assembly is retracted to allow a plurality of distal anchors to self-expand while a portion of the replacement heart valve remains retained in a compacted state by the mid shaft assembly. The distal anchors are positioned to engage one or more native leaflets and the retained portion of the replacement heart valve is then released and allowed to fully expand for implanting the replacement heart valve within the native valve.
    Type: Application
    Filed: March 19, 2021
    Publication date: July 8, 2021
    Applicant: Edwards Lifesciences CardiAQ LLC
    Inventors: Glen T. Rabito, J. Brent Ratz, Arshad Quadri, Lindsay Lam, David Robert Landon, Garrett Dallas Johnson
  • Patent number: 11051934
    Abstract: A mitral valve prosthesis includes an hourglass shaped inner frame and a bulbous outer frame. A valve body having a plurality of leaflets is positioned within an interior region of the inner frame. The leaflets are shaped to substantially conform to an interior surface of the inner frame when the leaflets are in an open position. As a result, the gap between the leaflets and the inner frame is decreased, thereby reducing the likelihood of thrombus formation. Ventricular anchors are preferably provided along a distal end of the inner frame. The anchors extend proximally for placement behind native mitral valve leaflets. A fabric skirt may extend along an inner or outer surface of the outer frame. In preferred embodiments, the fabric skirt extends distally beyond a distal end of the outer frame and is adapted for forming a seal along the mitral valve annulus.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: July 6, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Alexander H. Cooper, Juliet Laura Schwartz, Wendy Vo Pham, Hieu Minh Luong, Julio Cesar Sanchez, Matthew A. Peterson, J. Brent Ratz, Lisong Ai
  • Patent number: 11045313
    Abstract: A prosthesis for placement within a native mitral valve includes an expandable frame having locking tabs disposed along a proximal end. A plurality of distal anchors are disposed along a distal end of the frame. Each distal anchor is provided with a cushion cover. An outer fabric member surrounds the frame and may extend outwardly from the frame in an expanded condition for providing an improved seal in the region of a mitral annulus. A valve body is positioned within an interior of the expandable from for allowing blood flow in only one direction. In preferred embodiments, the cushions are positioned over enlarged head portions of the distal anchors for further reducing trauma on surrounding tissue.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: June 29, 2021
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: J. Brent Ratz, Luca Pesce, Glen T. Rabito, Christine Thanh Nguyen
  • Publication number: 20210113331
    Abstract: A system for implanting a replacement heart valve at a native valve location between an atrium and a ventricle of a patient includes a replacement valve having an expandable frame and a plurality of prosthetic valve leaflets positioned within the expandable frame. A delivery device is provided for delivering the replacement heart valve to the native valve location. The delivery device includes an elongate inner tube having an inner retention ring for coupling to and end of the replacement heart valve and an outer support tube slidable over the inner retention ring for securing the replacement heart valve to the inner retention ring. The inner retention ring preferably includes slots for receiving struts of the expandable frame. The expandable frame preferably includes a plurality of anchors extending from the downstream portion in an upstream direction for extending between chordae and for placement outside of the native leaflets.
    Type: Application
    Filed: December 22, 2020
    Publication date: April 22, 2021
    Inventors: Arshad Quadri, J. Brent Ratz
  • Patent number: 10952849
    Abstract: Devices, systems and methods are described herein a prosthesis for implantation within a lumen or body cavity and delivery devices for delivering the prosthesis to a location for implantation. A delivery system can include a plurality of components which are moveable relative to each other. The delivery system can include a nose cone which can cover at least a first end of the prosthesis, an outer elongate member which can cover at least a second end of the prosthesis, and a tether which can at least partially restrain the prosthesis from deployment.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: March 23, 2021
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Glen T. Rabito, J. Brent Ratz, Arshad Quadri, Lindsay Lam, David Robert Landon, Garrett Dallas Johnson
  • Patent number: 10888414
    Abstract: A system for treating aortic dissection including an aortic dissection implant comprising an expandable anchoring structure and an elongate tubular structure. The expandable anchoring structure can be configured to apply radial force to the sinuses of the aortic root and/or the sinotubular junction when expanded. The elongate tubular structure can comprise an expandable support frame and one or more layers. The expandable support frame can be configured to extend from the descending aorta to the ascending aorta and curve along with a curvature of the aortic arch when expanded within the aorta. The one or more layers can comprise a first porous layer comprising an atraumatic outer surface positioned over the expandable support frame and a second non-porous layer positioned over a portion of the first porous layer. The second non-porous layer may be configured to be positioned on opposite sides of the aortic dissection and to be inflatable via blood flow to seal against the dissection.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: January 12, 2021
    Assignee: inQB8 Medical Technologies, LLC
    Inventors: Arshad Quadri, J. Brent Ratz, Christopher William Stivers
  • Patent number: 10888644
    Abstract: A system for treating atrial dysfunction, including heart failure and/or atrial fibrillation, that includes one or more pressurizing elements and control circuitry. The one or more pressurizing elements can comprise one or more balloons and can be configured to be positioned in the left atrium, and optionally the pulmonary artery, of a patient's heart. The one or more pressurizing elements can be coupled to one or more positioning structures that can be configured to position the one or more pressurizing elements in the left atrium, and optionally the pulmonary artery. The control circuitry can be configured to operate the one or more pressurizing elements to decrease or increase pressure and/or volume in the left atrium, and optionally the pulmonary artery, in accordance with different phases of the cardiac cycle.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: January 12, 2021
    Assignee: inQB8 Medical Technologies, LLC
    Inventors: J. Brent Ratz, Arshad Quadri
  • Patent number: 10881510
    Abstract: A replacement heart valve and method of treating valve insufficiency includes an expandable frame configured to engage a native valve annulus. A valve body is coupled to the frame. The valve body can include a leaflet portion and possibly a skirt portion. A portion of the frame has a foreshortening portion configured to longitudinally expand when urged to a radially compacted state and longitudinally contract when urged to a radially expanded state. In one embodiment the valve skirt is attached to the frame so that it can adapt to changes in the length of the frame. A delivery device in some embodiments can use one or more coverings, such as sheaths, to controllably release the replacement heart valve at a native heart valve.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: January 5, 2021
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Arshad Quadri, J. Brent Ratz
  • Publication number: 20200375731
    Abstract: A mitral valve prosthesis includes an expandable frame having a proximal end, a distal end, and a middle portion. A plurality of tips extends from the proximal end of the frame for attachment to a delivery catheter. A plurality of anchors is disposed along the distal end of the frame and extend toward the proximal end for engaging tissue. An outer circumferential portion extends around the middle portion of the frame and is positioned radially outwardly of the frame. The outer circumferential portion preferably increases in diameter along a distal direction. A distal end of the outer circumferential portion is located distal of free ends of the anchors when the expandable frame is deployed. A valve body is positioned within an interior of the expandable frame and includes leaflets adapted to allow flow in a first direction and prevent flow in a second direction.
    Type: Application
    Filed: August 21, 2020
    Publication date: December 3, 2020
    Inventors: J. Brent Ratz, Luca Pesce, Siddharth Vad, Garrett Dallas Johnson
  • Publication number: 20200368015
    Abstract: Methods are described herein for delivering a replacement valve to a native valve location. In one method, ventricular anchors of the replacement valve are released and allowed to reverse orientation while positioned in the atrium of a human heart. After reversing orientation, the ventricular anchors extend in a generally proximal direction. The ventricular anchors can then be advanced through the annulus into the ventricle and then moved back toward the atrium to capture native valve leaflets between the main body and the ventricular anchors of the replacement valve. In one modification, the ventricular anchors are allowed to reverse orientation at a level adjacent the annulus. The implantation methods described herein are preferably performed via a transseptal delivery approach or a transapical delivery approach.
    Type: Application
    Filed: August 14, 2020
    Publication date: November 26, 2020
    Inventors: J. Brent Ratz, Glen T. Rabito