Abstract: The invention relates to the use of one or more fructokinase (ketohexokinase) (KHK) inhibitors to both prevent and treat a wide variety of diseases including, but not limited to, alcohol craving, alcohol addiction, alcohol induced liver disease including a fatty liver and cirrhosis.

Abstract: In one implementation, a method of playing audio is performed by a device located in a physical environment, coupled to two or more speakers, and including one or more processors and non-transitory memory. The method includes executing an operating system and an application. The method includes receiving, by the operating system from the application via an application programming interface, audio session parameters including a spatial experience value providing instructions for the spatial playback of audio associated with the application. The method includes receiving, by the operating system from the application, instructions to play audio data. The method includes adjusting, by the operating system, the audio data based on the spatial experience value. The method includes sending, by the operating system to the two or more speakers, the adjusted audio data.

Abstract: The present disclosure relates to methods of forming adhesive films having at least one pressure-sensitive adhesive polymer, related films, and related methods of using such films in lapping processes.

Abstract: A system and control method of managing activities and organizations is provided herein.

Abstract: Methods and systems are provided to facilitate network egress fairness between applications. At an egress port of a network, an arbitrator can provide fairness-based traffic shaping to data associated with applications. The desired fairness-based traffic shaping can be provided based on bandwidth, traffic classes, or other parameters. Consequently, the egress link's bandwidth can be allocated with fairness among the applications.

Abstract: A network interface controller (NIC) capable of efficient memory access is provided. The NIC can be equipped with an operation logic block, a signaling logic block, and a tracking logic block. The operation logic block can maintain an operation group associated with packets requesting an operation on a memory segment of a host device of the NIC. The signaling logic block can determine whether a packet associated with the operation group has arrived at or departed from the NIC. Furthermore, the tracking logic block can determine that a request for releasing the memory segment has been issued. The tracking logic block can then determine whether at least one packet associated with the operation group is under processing in the NIC. If no packet associated with the operation group is under processing in the NIC, tracking logic block can notify the host device that the memory segment can be released.

Abstract: Presented herein are systems and methods for developing classifiers useful for predicting response to particular treatments. For example, in some embodiments, the present disclosure provides a method of treating subjects suffering from an autoimmune disorder, the method comprising administering an alternative to anti-TNF therapy to subjects who have been determined to be non-responsive via a classifier established to distinguish between responsive and non-responsive prior subjects in a cohort who have received the anti-TNF therapy.

Abstract: A first hypervisor running on a first processor cluster is provided. During operation, the first hypervisor can determine a first set of processing nodes and a first memory unit of the first processor cluster in response to the booting up of a first Basic Input/Output System (BIOS) of the first processor cluster. The first hypervisor can discover a second hypervisor running on a second processor cluster comprising a second set of processing nodes and a second memory unit. The first hypervisor can operate, with the second hypervisor, a distributed system comprising the first and second sets of processing nodes and the first and second memory units. The first hypervisor can then operate, with the second hypervisor, a global virtual machine on the distributed system. The virtual memory space of the global virtual machine can be mapped to respective memory spaces of the first and second processor clusters.

Abstract: The present disclosure includes an optical fiber cassette bidirectional mounting system having at least one bidirectional mounting ear configured to attach an optical fiber cassette to a structure. The bidirectional mounting ear can be configured to removably secure the optical fiber cassette to the structure in a forward or backward orientation without requiring additional tools or hardware. Certain implementations can include a fiber cassette extension arm system for safe storage of optical fiber cable and/or loose optical fiber. The system can include one or more of a rail clip configured to attach an optical fiber cassette to a structure, a radius limiter arm configured to removably attach to the rail clip, and an adjustable length radius limiter configured to removably attach to the radius limiter arm.

Abstract: Devices used to pressurize, depressurize, or otherwise displace fluid are disclosed. The devices may be configured to displace fluid in order to inflate or deflate a medical device, such as a balloon. The devices include a trigger configured to convert the devices from a pressurization state to a priming state. The devices further include a locking or toggle member configured to toggle and/or maintain the devices in a priming state.

Abstract: A fluid filtration system is provided. The system includes a filter head and a filter cartridge removably coupled to the filter head. The filter cartridge includes a shell housing defining a first housing end, a second housing end, and a housing sidewall extending between the first housing end and the second housing end. The filter cartridge further includes a filter element received within the shell housing and removably coupled to the shell housing. The filter element includes a media pack and an endplate. The media pack is configured to filter matter from a fluid flowing therethrough. The endplate is coupled to an end of the media pack. The endplate includes an expansible scaling member extending axially away from the endplate in a direction opposite to the media pack and having a compliant portion. The expansible sealing member is configured to expand in diameter when the expansible sealing member engages the shell housing.

Abstract: A data-driven intelligent networking system that can facilitate tracing of data flow packets is provided. The system add tracer packets to data flow packets arriving at an ingress point of the network. As the tracer packets progress through network in-band with the data flow packets, the system can copy, at each switch, trace data into pre-defined fields in the tracer packets. When the data flow packets arrive at an egress point of the network the system can separate the trace data from the data flow packet for analysis. Based on the analysis of the trace data, the system can adopt one or more policies to mitigate the impact of congestion on time-sensitive applications.

Abstract: Systems, methods, and other embodiments described herein relate to controlling a trailer without the presence of a physical connection. In one embodiment, a method includes in response to receiving a signal to initiate hitchless maneuvering of a trailer separately from a controlling vehicle, acquiring control inputs to maneuver the trailer from an input device within the controlling vehicle. The method includes communicating, from the controlling vehicle to the trailer, the control inputs to maneuver the trailer. The method includes in response to receiving feedback from the trailer indicating the trailer is within a requested position, sending a control signal to stop the trailer.

Abstract: A robotic wire termination system for efficiently and accurately connecting a plurality of wires to an electrical connector having a plurality of connector pins with corresponding wire receptacles. The system generally includes a housing, a removable alignment plate, a robotic positioner, a heating device, a touch responsive display, and a control unit. The alignment plate removably holds a selected electrical connector in a specific position and orientation with the connector pins exposed in the housing and the wire receptacles exposed outside. The display provides a visual representation of the connector pins and selections of the connector pins. The control unit receives inputs indicating the pin selections and controls the robotic positioner to sequentially move the heating device along three orthogonal longitudinal axes to a series of heating positions relative to the selected connector pins to provide heat for melting solder to connect wires to the wire receptacles.

Abstract: Described herein are methods for treating and preventing graft versus host disease using ACK inhibitors. The methods include administering to an individual in need thereof an ACK inhibitor such as ibrutinib for treating and preventing graft versus host disease.

Abstract: A communication system and method provide for automatic arrestee grouping and action recommendation during a mass incident arrest. A portable radio sends a notification to a server indicating a mass incident event with grouping request for grouping arrestees. The server returns an electronic form including a mass arrest ID based on type of mass event. The electronic form facilitates collecting individual arrestee information based on the type of mass event. Current offense type and personal attribute information are collected and further electronically tagged to each arrestee. The server automatically assigns each arrestee to an offense group based on current offense type, and then refines the offense group into sub-groups based on prior arrest records. The server generates arrest processing procedure recommendations customized for each sub-group and transmits the recommendations to the PS radio associated with the grouping request.

Abstract: Presented herein are systems and methods for developing classifiers useful for predicting response to particular treatments. For example, in some embodiments, the present disclosure provides a method of treating subjects suffering from an autoimmune disorder, the method comprising administering an alternative to anti-TNF therapy to subjects who have been determined to be non-responsive via a classifier established to distinguish between responsive and non-responsive prior subjects in a cohort who have received the anti-TNF therapy.

Abstract: A magnetic latching connector for making electrical connections between cables, electrical power and signal sources, equipment and the like in a variety of medical and other applications in which it is desired to have the connection maintained with a predetermined amount of magnetic attractive force. The magnetic latching connector generally includes male and female connector components. The male and female connector components comprise male and female couplings and male and female coupling housings. The male and female coupling housings enclose electrical connections between the male and female couplings and electrical cables. Recessed within the male and female couplings are electrically conductive pins and sockets and male and female magnetic latching elements. When the male and female connector components are coupled, the pins and sockets provide electrical connections and the recessed magnetic latching elements provide a predetermined magnetic attraction force to maintain the connections.

Abstract: Fraud detection and response associated with various access points is disclosed. Characteristics associated with events or activity on an access point can be compared to thresholds to detect risky behavior and measures implemented in response to the risky behavior. In one instance, operations can include monitoring one or more events associated with at least one account at a financial institution, analyzing characteristics associated with a first event of the one or more events, determining whether to designate the first event or the access point as risky, and implementing one or more measures in response to a risky designation.