Patents by Inventor J. Leighton Read

J. Leighton Read has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleotides and analogs having photoremovable protecting groups
    Patent number: 7087732
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Grant
    Filed: December 28, 2001
    Date of Patent: August 8, 2006
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Lubert Stryer, J. Leighton Read, Michael C. Pirrung
  • Apparatus comprising polymers
    Patent number: 6955915
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: October 18, 2005
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Lubert Stryer, Michael C. Pirrung, J. Leighton Read, Paul D. Hoeprich, Jr.
  • Polypeptide arrays
    Patent number: 6919211
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: July 19, 2005
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, J. Leighton Read, Lubert Stryer, Michael C. Pirrung
  • Methods for polymer synthesis
    Patent number: 6747143
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: June 8, 2004
    Assignee: Affymetrix, Inc.
    Inventors: Lubert Stryer, Stephen P. A. Fodor, J. Leighton Read, Michael C. Pirrung
  • Support bound probes and methods of analysis using the same
    Publication number: 20040038268
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Application
    Filed: June 4, 2003
    Publication date: February 26, 2004
    Applicant: Affymetrix, Inc.
    Inventors: Michael C. Pirrung, Lubert Stryer, Stephen P.A. Fodor, J. Leighton Read
  • Very large scale immobilized polymer synthesis
    Publication number: 20030235853
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Application
    Filed: May 2, 2003
    Publication date: December 25, 2003
    Applicant: Affymetrix, INC.
    Inventors: Lubert Stryer, Stephen P.A. Fodor, J. Leighton Read, Michael C. Pirrung
  • Apparatus for polymer synthesis
    Patent number: 6660234
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: December 9, 2003
    Assignee: Affymetrix, Inc.
    Inventors: Luburt Stryer, Stephen P. A. Fodor, J. Leighton Read, Michael C. Pirrung
  • Nucleic acid reading and analysis system
    Patent number: 6646243
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: November 11, 2003
    Assignee: Affymetrix, Inc.
    Inventors: Michael C. Pirrung, J. Leighton Read, Stephen P. A. Fodor, Lubert Stryer
  • Methods of synthesizing a plurality of different polymers on a surface of a substrate
    Patent number: 6630308
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: October 7, 2003
    Assignee: Affymetrix, Inc.
    Inventors: Lubert Stryer, Michael C. Pirrung, J. Leighton Read, Stephen P. A. Fodor
  • Support bound probes and methods of analysis using the same
    Patent number: 6610482
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Grant
    Filed: April 24, 2000
    Date of Patent: August 26, 2003
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Michael C. Pirrung, Lubert Stryer, J. Leighton Read
  • Methods of making nucleic acid or oligonucleotide arrays
    Patent number: 6600031
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Grant
    Filed: April 21, 1998
    Date of Patent: July 29, 2003
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Lubert Stryer, J. Leighton Read, Michael C. Pirrung
  • Nucleotides and analogs having photoremovable protecting groups
    Publication number: 20030119008
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Application
    Filed: December 28, 2001
    Publication date: June 26, 2003
    Applicant: Affymetrix, Inc.
    Inventors: Stephen P.A. Fodor, Lubert Stryer, J. Leighton Read, Michael C. Pirrung
  • Very large scale immobilized polymer synthesis
    Publication number: 20030108899
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Application
    Filed: July 8, 2002
    Publication date: June 12, 2003
    Applicant: Affymetrix, INC.
    Inventors: Stephen P.A. Fodor, Lubert Stryer, Michael C. Pirrung, J. Leighton Read
  • Very large scale immobilized polymer synthesis
    Patent number: 6566495
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: May 20, 2003
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Lubert Stryer, J. Leighton Read, Michael C. Pirrung
  • Apparatus for polymer synthesis
    Publication number: 20030064391
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Application
    Filed: May 20, 2002
    Publication date: April 3, 2003
    Applicant: Affymetrix, Inc.
    Inventors: Michael C. Pirrung, J. Leighton Read, Stephen P. A. Fodor, Lubert Stryer
  • Nucleic acid reading and analysis system
    Publication number: 20030013100
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Application
    Filed: March 15, 2002
    Publication date: January 16, 2003
    Applicant: Affymetrix, INC.
    Inventors: Stephen P.A. Fodor, J. Leighton Read, Lubert Stryer, Michael C. Pirrung
  • Very large scale immobilized polymer synthesis
    Patent number: 6506558
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Grant
    Filed: November 29, 1995
    Date of Patent: January 14, 2003
    Assignee: Affymetrix Inc.
    Inventors: Stephen P. A. Fodor, Lubert Stryer, Michael C. Pirrung, J. Leighton Read, Paul D. Hoeprich, Jr.
  • Apparatus for polymer synthesis
    Publication number: 20020192693
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Application
    Filed: May 15, 2002
    Publication date: December 19, 2002
    Applicant: Affymetrix, Inc.
    Inventors: Michael C. Pirrung, J. Leighton Read, Stephen P.A. Fodor, Lubert Stryer
  • Very large scale immobilized polymer synthesis
    Publication number: 20020155588
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Application
    Filed: September 5, 2001
    Publication date: October 24, 2002
    Applicant: Affymetrix, Inc.
    Inventors: Stephen P.A. Fodor, Lubert Stryer, Michael C. Pirrung, J. Leighton Read
  • Apparatus comprising polymers
    Publication number: 20020137096
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Application
    Filed: December 14, 2001
    Publication date: September 26, 2002
    Applicant: Affymetrix, Inc.
    Inventors: Stephen P.A. Fodor, Lubert Stryer, Michael C. Pirrung, J. Leighton Read, Paul D. Hoeprich