Abstract: This invention is in the field of medicinal chemistry and relates to a new class of cyclic dinucleotide conjugates (e.g., Formula I) which function as tumor-targeted imaging agents, and their use in diagnostic and therapeutic intervention for disorders (e.g., cancer).

Abstract: A connection assembly for securing a support member to a work surface (e.g., a table leg to a table top) that includes an attachment plate, a retainer, and a fitting. The attachment plate connects to a bottom surface of the table top, the fitting connects to an upper end of the table leg, and the retainer exerts a force on the fitting that helps absorb or take up tolerances within the connection assembly so that the support member is securely connected to the work surface. In one example, the retainer is a resilient component that is compressed between the fitting and a receiving portion of the attachment plate to help take up tolerances within the connection assembly, whereas in another example the retainer is a rotatable component that exerts a force against the fitting to address tolerances and the like. A method for providing a connection assembly is also disclosed.

Abstract: Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4-position via N(H), C(O) or O moieties.

Abstract: The present invention relates to nanoparticles complexed with biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) carrying biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).

Abstract: Methods, systems, apparatuses, and computer program products are described for providing content recommendations to a requestor. In implementations, user event records associated with media items and content types may be stored, for instance, in an event catalog. A set of user scores may be generated based on a user-content score model and the user event records, where each generated user score represents an affinity between a user and a corresponding content type of the plurality of content types. A set of title scores may also be generated for a media item based on a title-content score model, where each generated title score represents an affinity between the media item and a corresponding content type. In response to a request, the sets of scores may be combined to generate a set of content recommendations to provide to the requestor.

Abstract: The present invention relates to nanoparticles complexed with biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) carrying biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).

Abstract: This invention relates generally to compositions comprising a gel-based inulin formulation associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) one or more therapeutic agents (e.g., immunomodulatory agent, immunosuppressant, allergen) and related methods for the treatment of autoimmune disorders (e.g., colitis) (e.g, allergy, such as food allergy). Also provided herein are compositions and methods for modulating an immune response associated with an autoimmune disorder (e.g., allergy) and/or inducing immune tolerance or desensitization to an autoimmune disorder (e.g., allergy, such as a food allergy).

Abstract: The present invention relates to compositions comprising nanoparticles associated with a plurality of tolerogenic antigens (e.g., between 1-30 tolerogenic 5 antigens per nanoparticle) in such a manner that facilitates strong immune tolerance upon administration to a subject (e.g., a human subject suffering from or at risk of suffering from an autoimmune disorder e.g., MS or celiac disease). The present invention further relates to methods for utilizing such nanoparticles to treat autoimmune disorders (e.g., MS or celiac disease).

Abstract: A method implemented by a computing system that facilitates formation of an object from a material comprises receiving an object model that specifies a top surface and a side surface connected to an edge of the top surface via a fillet that extends along the edge. At a particular region along the edge, adjacent planar regions of the side surface define an obtuse angle therebetween. The fillet is adjusted along the edge to have a first radius at a particular distance from the particular region and to have a second radius, smaller than the first radius, proximate the particular region. Output data associated with an adjusted model is communicated to equipment configured to form a mandrel that facilitates formation of the object. Adjusting the fillet to have a smaller radius proximate the particular region facilitates elimination of wrinkles in the material when draped over the mandrel to form the object.

Abstract: This invention relates generally to compositions and methods for increasing the efficacy of immunotherapies and vaccines. In particular, the present invention relates to elevating the richness and diversity of a subject's gut microbiome through administration of an agent (e.g., fiber containing prebiotic agent (e.g., epigallocatechin gallate (EGCG), fucoidan, potato starch, oligofructose and inulin)) (e.g., melatonin) with an immunotherapy or vaccine. Such compositions and methods are useful for treating cancer, infectious pathogens, autoimmune diseases, neurological disorders, and/or obesity.

Abstract: A method performed by a computing system that facilitates formation of an object comprises receiving manufacturing process data associated with an object to be formed via a drape-forming operation. The computing system receives a parametric model of the object. The parametric model facilitates specification of a radius of a fillet within a region associated with the object. The computing system determines, based on the parametric model of the object, a unit vector field associated with a surface of the object and the manufacturing process data. The computing system adjusts the radius of the fillet of the parametric model within the region to reduce an average divergence of the vector field to a minimum amount, and communicates output data associated with an adjusted parametric model to equipment configured to form a mandrel that facilitates formation of the object.

Abstract: This disclosure provides compositions and methods for stimulating the innate immune response in a subject with agents capable of stimulating an innate immune response in a subject upon administration to the subject (e.g., damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs)). In particular, the present invention is directed to compositions of DAMPs/PAMPs and metals ions, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).

Abstract: The present invention relates to nanoparticles complexed with biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) carrying biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).

Abstract: The present invention relates to nanoparticles complexed with biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) carrying biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).

Abstract: The present invention relates to nanoparticles associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).

Abstract: Provided herein are synthetic vesicles carrying a payload of one or more suppressors of cytokine signaling (SOCS) proteins. In particular, liposomes encapsulating SOCS1 and/or SOCS3, and methods of delivery and use for the treatment of lung disease and conditions, are provided.

Abstract: A camshaft assembly includes an actuator and an axially moveable structure mounted to a base shaft wherein the axially moveable structure includes a plurality of lobe packs and a cam barrel. The axially movable structure moves along the base shaft in the axial direction along a longitudinal axis of the base shaft, but is rotationally fixed to the base shaft. The barrel cam includes an inner wall and an outer wall which defines a control groove therebetween. The control groove further defines first and second regions wherein the first region includes a fixed narrow control groove width and the second region includes a progressively decreasing control groove width. The actuator shifts the axially moveable structure relative to the base shaft between a first position and a second position. A recess is defined in the outer wall such that the recess is disposed adjacent to the first region.

Abstract: Provided herein are macromolecular structures comprising charged macromolecules. In particular, provided herein are synthetic neutrophil extracellular traps and uses thereof.

Abstract: The present invention relates to polymers associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) bio macromolecule agents (e.g., peptides, neo-antigens, adjuvant molecules, nucleic acids, etc.) configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising polymer moieties (e.g., poly(L-glutamic acid moieties)) associated with biomacromolecule agents, methods for synthesizing such polymer conjugates, as well as systems and methods utilizing such polymer conjugates.

Abstract: A system and method for sensing a camshaft barrel position of a sliding camshaft includes at least one sliding camshaft having at least one camshaft barrel and at least one position shifting slot disposed in the at least one camshaft barrel. At least one actuator is provided for engaging the at least one position shifting slot on the rotating sliding camshaft and shifting position of the at least one camshaft barrel and at least one sensor is provided for detecting the shifted position of the at least one camshaft barrel wherein the camshaft barrel includes position identifying features.