Abstract: A camshaft assembly includes an actuator and an axially moveable structure mounted to a base shaft wherein the axially moveable structure includes a plurality of lobe packs and a cam barrel. The axially movable structure moves along the base shaft in the axial direction along a longitudinal axis of the base shaft, but is rotationally fixed to the base shaft. The barrel cam includes an inner wall and an outer wall which defines a control groove therebetween. The control groove further defines first and second regions wherein the first region includes a fixed narrow control groove width and the second region includes a progressively decreasing control groove width. The actuator shifts the axially moveable structure relative to the base shaft between a first position and a second position. A recess is defined in the outer wall such that the recess is disposed adjacent to the first region.

Abstract: Provided herein are macromolecular structures comprising charged macromolecules. In particular, provided herein are synthetic neutrophil extracellular traps and uses thereof.

Abstract: The present invention relates to polymers associated with (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) bio macromolecule agents (e.g., peptides, neo-antigens, adjuvant molecules, nucleic acids, etc.) configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising polymer moieties (e.g., poly(L-glutamic acid moieties)) associated with biomacromolecule agents, methods for synthesizing such polymer conjugates, as well as systems and methods utilizing such polymer conjugates.

Abstract: A system and method for sensing a camshaft barrel position of a sliding camshaft includes at least one sliding camshaft having at least one camshaft barrel and at least one position shifting slot disposed in the at least one camshaft barrel. At least one actuator is provided for engaging the at least one position shifting slot on the rotating sliding camshaft and shifting position of the at least one camshaft barrel and at least one sensor is provided for detecting the shifted position of the at least one camshaft barrel wherein the camshaft barrel includes position identifying features.

Abstract: Systems, methods, apparatus, and computer program products are provided for processing medication requests. In one embodiment, a user may define an operational mode that can be initiated by one or more triggers. A user may also define one or more workflows for processing medication requests. The one or more workflows can be associated with the operational mode. In response to the occurrence of the appropriate triggers, the operational mode can automatically, semi-automatically, and/or manually be initiated. When the operational mode is initiated, the associated workflows are used for processing medication requests.

Abstract: A camshaft assembly for a vehicle engine includes a camshaft member, a cam phaser and a cam nose. The camshaft member includes a front end and a rear end. The camshaft member may be configured to actuate at least one intake valve of a combustion chamber. The cam phaser affixed to the front end of the camshaft member while the cam nose may be disposed at the front end of the camshaft. The cam nose further includes a cam nose face with a curvilinear groove surrounding a central axis region of the cam nose. The curvilinear groove may be configured to engage with the cam phaser to prevent oil leakage out from the central axis region and/or to rotationally lock the cam phaser to the camshaft member.

Abstract: A system and method for sensing a camshaft barrel position of a sliding camshaft includes at least one sliding camshaft having at least one camshaft barrel and at least one position shifting slot disposed in the at least one camshaft barrel. At least one actuator is provided for engaging the at least one position shifting slot on the rotating sliding camshaft and shifting position of the at least one camshaft barrel and at least one sensor is provided for detecting the shifted position of the at least one camshaft barrel wherein the camshaft barrel includes position identifying features.

Abstract: A method is provided for forming a substantially uniaxially-oriented, high content cellulose nanocrystal film. The method includes providing a plant-biomass-based suspension of cellulose nanocrystals and altering the pH of the cellulose nanocrystals to a substantially neutral pH. The suspension is sheared at a shearing rate. The method further includes orienting the cellulose nanocrystals in a substantially axial direction and removing water from the sheared cellulose nanocrystal suspension. As a result, a substantially uniaxially-oriented cellulose nanocrystal film is formed.

Abstract: An engine control module includes at least one high side driver connected to at least one intake camshaft actuator and at least one exhaust camshaft actuator. A plurality of low side drivers is connected to the at least one intake camshaft actuator and the at least one exhaust camshaft actuator. A sliding camshaft control module selectively actuates the at least one high side driver and the plurality of low side drivers based on a status associated with the at least one intake camshaft actuator and/or the at least one exhaust camshaft actuator.

Abstract: A variable camshaft includes a base shaft, an axially movable structure, and an actuator. The axially movable structure includes a plurality of lobe packs and at least one barrel cam defining a control groove having an engagement region, a first shift region, a balancing region, a second shift region and a disengagement region. The actuator includes at least one pin operatively configured to move relative to the actuator body between a retracted position and an extended position into the control groove. The axially movable structure moves axially relative to the base shaft the pin is in the extended position and is at least partially disposed in one of the first or second shift regions of the control groove.

Abstract: The present invention relates to nanoparticles complexed with biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) carrying biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).

Abstract: A system according to the principles of the present disclosure includes a switching period module and at least one of a valve lift control module and a start-stop control module. The switching period module determines a switching period that elapses as a valve lift actuator of an engine switches between a first valve lift position and a second valve lift position that is different than the first lift position. The switching period begins when a measured position of the valve lift actuator corresponds to the first lift position and the switching period ends when the measured position of the valve lift actuator corresponds to the second lift position. The valve lift control module controls the valve lift actuator based on the switching period. The start-stop control module determines whether to automatically stop the engine based on the switching period.

Abstract: A rib is disclosed for use in a torque box of a wing structure provided on an aircraft. The wing structure has a skin panel and a stringer coupled to the skin panel. The rib includes a web defining at least one stringer hole sized to receive the stringer, a shear tie coupled to the web and configured to engage the skin panel, and a clip positioned adjacent the at least one stringer hole. The clip has a base coupled to and aligned with the web, a head extending at an angle relative to the base and configured to engage the stringer, and a transition portion extending between the base and the head.

Abstract: A camshaft assembly includes a base shaft including at least one lobe pack axially movably mounted on the base shaft, the lobe pack including a control groove therein. An actuator device includes a pin movably mounted to the actuator between a retracted position and an extended position for engaging with the control groove to cause axial movement of the lobe pack. The control groove includes a pin engagement region, a shifting region and an ejection region. The pin engagement region of the control groove has a first pair of sidewalls. The shifting region extends from the pin engagement region and has a second pair of sidewalls angled relative to the first pair of sidewalls and having a first portion with a varying groove width that varies relative to a groove width of the pin engagement region.

Abstract: A camshaft assembly includes a base shaft including at least one lobe pack axially movably mounted on the base shaft, the lobe pack including a control groove therein. An actuator device includes a pin movably mounted to the actuator between a retracted position and an extended position for engaging with the control groove to cause axial movement of the lobe pack. The control groove includes a pin engagement region, a shifting region and an ejection region. The pin engagement region of the control groove has a first pair of sidewalls. The shifting region extends from the pin engagement region and has a second pair of sidewalls angled relative to the first pair of sidewalls and having a first portion with a varying groove width that varies relative to a groove width of the pin engagement region.

Abstract: An engine control module includes at least one high side driver connected to at least one intake camshaft actuator and at least one exhaust camshaft actuator. A plurality of low side drivers is connected to the at least one intake camshaft actuator and the at least one exhaust camshaft actuator. A sliding camshaft control module selectively actuates the at least one high side driver and the plurality of low side drivers based on a status associated with the at least one intake camshaft actuator and/or the at least one exhaust camshaft actuator.

Abstract: An engine assembly includes a camshaft having an exhaust cam lobe defining an exhaust lift region and an exhaust base circle region and an EGR cam lobe defining an EGR lift region and an EGR base circle region. The EGR lift region is rotationally offset from the exhaust lift region and the EGR base circle region is rotationally aligned with the exhaust lift region. An exhaust valve lift mechanism is engaged with an exhaust valve, the exhaust cam lobe and the EGR cam lobe and is operable in first and second modes. The exhaust valve remains closed when the EGR lift region engages the exhaust valve lift mechanism during the second mode and the exhaust valve is opened when the EGR lift region engages the exhaust valve lift mechanism during the first mode to provide exhaust gas flow into the combustion chamber during an intake stroke of the combustion chamber.

Abstract: A system according to the principles of the present disclosure includes a switching period module and at least one of a valve lift control module and a start-stop control module. The switching period module determines a switching period that elapses as a valve lift actuator of an engine switches between a first valve lift position and a second valve lift position that is different than the first lift position. The switching period begins when a measured position of the valve lift actuator corresponds to the first lift position and the switching period ends when the measured position of the valve lift actuator corresponds to the second lift position. The valve lift control module controls the valve lift actuator based on the switching period. The start-stop control module determines whether to automatically stop the engine based on the switching period.

Abstract: A detent assembly and a method of assembling the detent assembly are disclosed. The detent assembly includes a first shaft rotatable about a longitudinal axis and has an outer surface. The first shaft defines a cavity having an opening defined by the outer surface. The detent assembly further includes a camshaft defining an aperture along the longitudinal axis to present an inner wall of the camshaft that circumscribes the longitudinal axis. The inner wall defines a plurality of recesses spaced from each other. The detent assembly also includes a self-contained plunger unit that is secured to the first shaft in the cavity as a unit. A plunger of the self-contained plunger unit engages the inner wall as the camshaft is disposed over the self-contained plunger unit so that the plunger rests in one of the recesses of the camshaft to selectively secure together the first shaft and the camshaft.

Abstract: A rib is disclosed for use in a torque box of a wing structure provided on an aircraft. The wing structure has a skin panel and a stringer coupled to the skin panel. The rib includes a web defining at least one stringer hole sized to receive the stringer, a shear tie coupled to the web and configured to engage the skin panel, and a clip positioned adjacent the at least one stringer hole. The clip has a base coupled to and aligned with the web, a head extending at an angle relative to the base and configured to engage the stringer, and a transition portion extending between the base and the head.