Abstract: LHRH analogs and LHRH antagonists for use in the treatment or prophylaxis of hormone-dependent cancers, in particular prostate cancer, prostate carcinoma and/or advanced prostate carcinoma, by administering an initial dose of an LHRH analog over a first period sufficient to effect hormonal castration, then administering a maintenance dose of an LHRH antagonist over a second period, the dose being insufficient to achieve and/or maintain hormonal castration.

Abstract: The present invention relates to radiation detector (2) comprising a radiation sensitive semiconductor element (10) generating electron-hole pairs in response to an irradiation with radiation (3), an anode electrode(20) arranged on a first surface (11) of the semiconductor element (10) facing away from the radiation, said anode electrode (20) being segmented into anode segments (21) representing anode pixels, wherein anode gaps (22) are arranged between said anode segments (21), a cathode electrode (30) arranged on a second surface (12) of the semiconductor element (10) opposite the first surface (11) and facing the radiation (3), said cathode electrode (30) being segmented into first and second cathode segments (31, 32), wherein said first cathode segments (31) are substantially arranged opposite said anode segments (21) and said second cathode segments (32) are substantially arranged opposite said anode gaps (22), and a cathode terminal (41, 42) providing electrical connections to said first cathode segment

Abstract: The present invention generally refers to a correction method for grating-based X-ray differential phase contrast imaging (DPCI) as well as to an apparatus which can advantageously be applied in X-ray radiography and tomography for hard X-ray DPCI of a sample object or an anatomical region of interest to be scanned. More precisely, the proposed invention provides a suitable approach that helps to enhance the image quality of an acquired X-ray image which is affected by phase wrapping, e.g. in the resulting Moiré interference pattern of an emitted X-ray beam in the detector plane of a Talbot-Lau type interferometer after diffracting said X-ray beam at a phase-shifting beam splitter grating.

Abstract: In radiation-sensitive detector devices, such as direct conversion detectors, charges are drifting within an externally applied electric field towards collecting electrodes (4), which are segmented (e.g. representing a pixel array). At the gaps between segments, electrical field lines can leave the detector, and charges drifting along those field lines can be trapped within the gap. This can be avoided by external electrodes (8) which push electric field lines back into the direct conversion material.

Abstract: The present invention relates to processing electronics (18) for a detector (12) of an X-ray imaging device (14), the processing electronics (18) with a pulse counter section (22) having at least one count output (30) and with an integrator section (24) having an intensity output (32), wherein the processing electronics (18) is adapted to be connected to a sensor (16) in such a manner that X-ray photons (58) arriving at the sensor (16) can be processed by the pulse counter section (22), by the integrator section (24), or both, and wherein the processing electronics (18) comprises a processor (34) adapted to be connected to the count output (30) and to the intensity output (32) and adapted to output a count result (K) that takes into account both count information (N) obtained at the count output (30) and intensity information (I) obtained at the intensity output (32), so that the count result (K) contains information (N) obtained from the pulse counter section (22) and information (M) obtained from the integr

Abstract: The invention relates to a radiation detector (200), particularly an X-ray detector, which comprises at least one sensitive layer (212) for the conversion of incident photons (X) into electrical signals. A two-dimensional array of electrodes (213) is located on the front side of the sensitive layer (212), while its back side carries a counter-electrode (211). The size of the electrodes (213) may vary in radiation direction (y) for adapting the counting workload of the electrodes. Moreover, the position of the electrodes (213) with respect to the radiation direction (y) provides information about the energy of the detected photons (X).

Abstract: The invention relates to an X-ray detector (30) that comprises an array of sensitive elements (Pi?1,b, Pia, Pib, Pi+1,a, Pi+1,b) and at least two analyzer gratings (G2a, G2b) disposed with different phase and/or periodicity in front of two different sensitive elements. Preferably, the sensitive elements are organized in macro-pixels (IIi) of e.g. four adjacent sensitive elements, where analyzer gratings with mutually different phases are disposed in front said sensitive elements. The detector (30) can particularly be applied in an X-ray device (100) for generating phase contrast images because it allows to sample an intensity pattern (I) generated by such a device simultaneously at different positions.

Abstract: The invention relates to a radiation detector (10), comprising an array of pixels (1), wherein each pixel (1) comprises a conversion layer of a semiconductor material (4) for converting incident radiation into electrical signals and wherein each pixel (1) is surrounded by a trench (3) that is at least partly filled with a barrier material that absorbs at least a part of photons generated by the incident radiation. The invention also relates to a method of manufacturing such a radiation detector (10).

Abstract: Scattered radiation has non-intuitive properties. A signalling system (28) is presented which provides a perceptible signal (34) being indicative of a predicted or measured spatial distribution of scattered radiation. An embodiment provides for easy assessment of the individual risk of scattered radiation exposure for personnel working in an environment exposed to scattered radiation. A method for predicting a distribution of scattered radiation takes into account at least one object related parameter (18) and at least one radiation related parameter (22) and, in response hereto, predicts a distribution of scattered radiation.

Abstract: The invention relates to a method and an imaging system (100) for generating X-ray 101a 101b 101c 101d images. The system (100) comprises at least one X-ray source, preferably an array of X-ray sources (101a-101d), and an X-ray detector (103) with an array of sensitive pixels (103a-103e). A collimator (102) is arranged between the X-ray source and the detector such that two openings (P) of the collimator (102) allow the passage of X-rays towards two neighboring pixels (103a-103e) while the region between said pixels is substantially shielded. This shielding of the usually insensitive regions between pixels reduces unnecessary X-ray exposure. A sufficiently large X-ray intensity can be achieved by using a plurality of small X-ray sources (101a-101d).

Abstract: The invention relates to the use of alkylphosphocholines in combination with antitumor medicaments for the treatment of benign and malignant oncoses in humans and animals. It is possible in this connection for the alkylphosphocholines to be employed in a combination according to the invention with one or a combination of various approved cytostatics. Preferred alkylphosphocholines are described by the Formula II.

Abstract: The invention relates to the use of alkylphosphocholines in combination with antimetabolites for the treatment of multiple myeloma, colon cancer or renal cancer. Preferred alkylphosphocholines are described by the Formula II. A particularly effective treatment includes administering a combination of perifosine and capecitabine.

Abstract: The present invention relates to X-ray image acquisition technology in general. Employing phase-contrast imaging for X-ray image acquisition may significantly enhance the quality and information content of images acquired. However, phase-contrast information may only be obtainable in a small detector region, possibly being too small for a sufficient field of rotation view for specialized X-ray imaging applications. Accordingly, an apparatus for phase-contrast imaging is provided that may allow the acquisition of an enlarged field of view. According to the present invention an apparatus (1) for phase-contrast imaging is provided, comprising an X-ray source (2), an X-ray detector (12) element having a detector size, a beam splitter grating (8) and an analyzer grating (10). An object (6) is arrangeable between the X-ray source (2) and the X-ray detector (12). The beam splitter grating (8) and the analyzer grating (10) are arrangeable between the X-ray source (2) and the X-ray detector (12).

Abstract: The present invention relates to an X-ray imaging system and a method for differential phase—contrast imaging of an object. To improve calibration of differential phase—contrast imaging systems and the alignment of the gratings an X-ray imaging system is provided that comprises an X-ray emitting arrangement providing at least partially coherent X-ray radiation and an X-ray detection arrangement comprising a phase-shift diffraction grating, a phase analyzer grating, and an X-ray image detector, all arranged along an optical axis. For stepping, the gratings and/or the X-ray emitting arrangement are provided with at least two actuators arranged opposite to each other with reference to the optical axis. For calibration, calibration projections are acquired without an object, wherein, the emitted X-ray radiation or one of the gratings is stepwise displaced with a calibration displacement value.

Abstract: X-ray devices for Phase Contrast Imaging (PCI) are often built up with the help of gratings. For large field-of-views (FOV), production cost and complexity of these gratings could increase significantly as they need to have a focused geometry. Instead of a pure PCI with a large FOV, this invention suggests to combine a traditional absorption X-ray-imaging system with large-FOV with an insertable low-cost PCI system with small-FOV, The invention supports the user to direct the PCI system with reduced FOV to a region that he regards as most interesting for performing a PCI scan thus eliminating X-ray dose exposure for scanning regions not interesting for a radiologist. The PCI scan may be generated on the basis of local tomography.

Abstract: The invention relates to methods of treatment or prophylaxis of physiological and/or pathological conditions with at least one LHRH antagonist, in particular at least one peptidomimetic LHRH antagonist such that the at least one LHRH antagonist is administered in a dose, which does not cause chemical (hormonal) castration.

Abstract: The invention relates to the field of X-ray differential phase contrast imaging. For scanning large objects and for an improved contrast to noise ration, an X-ray device (10) for imaging an object (18) is provided. The X-ray device (10) comprises an X-ray emitter arrangement (12) and an X-ray detector arrangement (14), wherein the X-ray emitter arrangement (14) is adapted to emit an X-ray beam (16) through the object (18) onto the X-ray detector arrangement (14). The X-ray beam (16) is at least partial spatial coherent and fan-shaped. The X-ray detector arrangement (14) comprises a phase grating (50) and an absorber grating (52). The X-ray detector arrangement (14) comprises an area detector (54) for detecting X-rays, wherein the X-ray device is adapted to generate image data from the detected X-rays and to extract phase information from the X-ray image data, the phase information relating to a phase shift of X-rays caused by the object (18).

Abstract: The invention relates to a method and a data processing device for evaluating measurement signals provided by a layered, pixelated radiation detector. A generalized detector response function is provided that describes the energy-related crosstalk caused by radiation incident in the d-th neighboring pixel. With the help of this GDR-function, crosstalk effects can be taken into account to achieve a more accurate determination of imaging parameters related to an imaged object. The approach can particularly be used in spectrally resolved, photon counting CT detectors with small, layered pixels.

Abstract: The present invention generally refers to a correction method for grating-based X-ray differential phase contrast imaging (DPCI) as well as to an apparatus which can advantageously be applied in X-ray radiography and tomography for hard X-ray DPCI of a sample object or an anatomical region of interest to be scanned. More precisely, the proposed invention provides a suitable approach that helps to enhance the image quality of an acquired X-ray image which is affected by phase wrapping, e.g. in the resulting Moiré interference pattern of an emitted X-ray beam in the detector plane of a Talbot-Lau type interferometer after diffracting said X-ray beam at a phase-shifting beam splitter grating.

Abstract: The present invention relates to processing electronics (18) for a detector (12) of an X-ray imaging device (14), the processing electronics (18) with a pulse counter section (22) having at least one count output (30) and with an integrator section (24) having an intensity output (32), wherein the processing electronics (18) is adapted to be connected to a sensor (16) in such a manner that X-ray photons (58) arriving at the sensor (16) can be processed by the pulse counter section (22), by the integrator section (24), or both, and wherein the processing electronics (18) comprises a processor (34) adapted to be connected to the count output (30) and to the intensity output (32) and adapted to output a count result (K) that takes into account both count information (N) obtained at the count output (30) and intensity information (I) obtained at the intensity output (32), so that the count result (K) contains information (N) obtained from the pulse counter section (22) and information (M) obtained from the integr