Abstract: The present invention relates to phase-contrast imaging which visualizes the phase information of coherent radiation passing a scanned object. Focused gratings are used which reduce the creation of trapezoid profile in a projection with a particular angle to the optical axis. A laser supported method is used in combination with a dedicating etching process for creating such focused grating structures.

Abstract: A method of treating infertility disorders by 1) administering an LH-RH antagonist, preferably Cetrorelix, in amounts to selectively suppress endogenous LH but not FSH secretion and 2) inducing follicle growth by administration of exogenous gonadotropin. The selective suppression OF LH allows FSH secretion to be at natural level S thereby not affecting individual estrogen development. The LH-RH antagonist can be given as a single or dual subcutaneous dose in the range of 1 mg to 10 mg, preferably 2 mg-6 mg. In multiple dosing posology, LH-RH antagonist can be administered subcutaneously in an amount in the range of 0.1 to 0.5 mg of LH-RH antagonist/day . LH-RH antagonist is applied starting cycle day 1 to 10, preferably on day 4 to 8, and ovulation can be induced between day 9 and 20 of the menstruation cycle by administering rec. LH, native LH-RH, LH-RH agonist or by HCG. In addition rec.

Abstract: The invention relates to converter element (100) for a radiation detector, particularly for a Spectral CT scanner. The converter element (100) comprises at least two conversion cells (131) that are at least partially separated from each other by intermediate separation walls (135) which affect the spreading of electrical signals generated by incident radiation (X). The conversion cells (131) may particularly consist of a crystal of CdTe and/or CdZnTe. Said crystal is preferably grown by e.g. vapor deposition between preformed separation walls.

Abstract: The invention relates to a radiation detector (10), comprising an array of pixels (1), wherein each pixel (1) comprises a conversion layer of a semiconductor material (4) for converting incident radiation into electrical signals and wherein each pixel (1) is surrounded by a trench (3) that is at least partly filled with a barrier material that absorbs at least a part of photons generated by the incident radiation. The invention also relates to a method of manufacturing such a radiation detector (10).

Abstract: The invention provides sterile suspensions and sterile lyophilizates of slightly soluble basic peptide complexes, and pharmaceutical formulations comprising them. The provided sterile suspensions, sterile lyophilizates and pharmaceutical formulations comprising them are particularly suitable for use in a parenteral dosage form as medicaments for the treatment and prophylaxis of diseases and pathological states in mammals, especially in humans.

Abstract: A process for preventing a protozoal disease by the administration of an alkyl phosphocholine to a human being.

Abstract: The invention relates to the use of alkylphosphocholines in combination with antimetabolites for the treatment of multiple myeloma, colon cancer or renal cancer. Preferred alkylphosphocholines are described by the Formula II. A particularly effective treatment includes administering a combination of perifosine and capecitabine.

Abstract: The present invention provides a novel process for producing sterile suspensions of slightly soluble basic peptide complexes. The present invention further provides a novel process for producing sterile lyophilizates of slightly soluble basic peptide complexes. In addition, a novel process for producing sterile suspensions suitable for the parenteral administration of slightly soluble basic peptide complexes is provided. The invention moreover provides sterile suspensions and sterile lyophilizates of slightly soluble basic peptide complexes, and pharmaceutical formulations comprising them. The provided sterile suspensions, sterile lyophilizates and pharmaceutical formulations comprising them are particularly suitable for use in a parenteral dosage form as medicaments for the treatment and prophylaxis of diseases and pathological states in mammals, especially in humans.

Abstract: The invention relates to an X-ray detector (30) that comprises an array of sensitive elements (Pi?1,b, Pia, Pib, Pi+1,a, Pi+1,b) and at least two analyzer gratings (G2a, G2b) disposed with different phase and/or periodicity in front of two different sensitive elements. Preferably, the sensitive elements are organized in macro-pixels (IIi) of e.g. four adjacent sensitive elements, where analyzer gratings with mutually different phases are disposed in front said sensitive elements. The detector (30) can particularly be applied in an X-ray device (100) for generating phase contrast images because it allows to sample an intensity pattern (I) generated by such a device simultaneously at different positions.

Abstract: An apparatus is described for deburring with planing tools a metal strand cut to length by gas cutting, which planing tools are adjustably held each for themselves transversally to the metal strand in a support, and with a drive for the relative advancing movement of the planing tools relative to the metal strand which is cut to length. The annular support includes at least two sets of planing tools which are radially adjustable to the metal strand cut to length, which sets are arranged behind one another in the longitudinal direction of the metal strand cut to length and which are staggered against each other set by set.

Abstract: The invention relates to a radiation detector that comprises a converter element and a plurality of electrode systems arranged on said element, wherein each electrode system comprises a primary electrode and a supplementary electrode, which are connected to a readout circuitry. The primary and the supplementary electrodes may particularly be realized by planar, parallel stripes extending in a common plane, wherein said stripes are electrically connected above said plane.

Abstract: An aqueous injectable solution of an LHRH antagonist, such as Cetrorelix, in an organic, pharmaceutically acceptable acid, such as gluconic acid.

Abstract: The invention relates to the use of alkylphosphocholines in combination with antimetabolite antitumor substances for the treatment of benign and malignant oncoses in humans and animals. It is possible in this connection for the alkylphosphocholines to be employed in a combination according to the invention with one or more antimetabolite antitumor substances. Preferred alkylphosphocholines are described by the Formula II. One such preferred alkylphosphocholine is perifosine.

Abstract: The invention relates to pharmaceutical compositions comprising alkylphosphocholines and antimetabolite antitumor substances. The pharmaceutical compositions of the invention are useful for the treatment of benign and malignant oncoses in humans and animals. Preferred alkylphosphocholines are described by the Formula II. One such preferred alkylphosphocholine is perifosine.

Abstract: Scattered radiation has non-intuitive properties. A signalling system (28) is presented which provides a perceptible signal (34) being indicative of a predicted or measured spatial distribution of scattered radiation. An embodiment provides for easy assessment of the individual risk of scattered radiation exposure for personnel working in an environment exposed to scattered radiation. A method for predicting a distribution of scattered radiation takes into account at least one object related parameter (18) and at least one radiation related parameter (22) and, in response hereto, predicts a distribution of scattered radiation.

Abstract: A method is for production of a moulded skin. The method includes a) inserting a film into a clamping frame; b) moving a positive mould relative to the clamping frame for pre-shaping of the film; c) impressing an insert on a side of the film which is orientated away from the positive mould; d) moving the positive mould into a negative mould which corresponds at least in regions; and e) applying a low pressure from the negative mould in order to emboss at least one of a shape and a surface structure of the negative mould onto the film fitted with the insert.

Abstract: A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the solution is transferred to water and freeze dried.

Abstract: The invention relates to an Anti-Scatter-Grid (ASG) with lamellae (2) that absorb incident radiation (1, 8) and that produce an electrical signal proportional to the amount of absorbed radiation. The lamellae (2) may particularly consist of a semiconductor material in which photons produce electron-hole pairs that can be detected with the help of electrodes (3, 4, 6) on the sidewalls of the lamellae (2). The amount of absorbed scattered (8) or primary (1) radiation may thus be determined in a spatially resolved way, allowing to correct the image generated by an array (5) of sensor units (9).

Abstract: The invention relates to methods of treatment or prophylaxis of physiological and/or pathological conditions with at least one LHRH antagonist, in particular at least one peptidomimetic LHRH antagonistsuch that the at least one LHRH antagonist is administered in a dose, which does not cause chemical (hormonal) castration.

Abstract: The invention relates to a novel combination of a soft steroid, in particular loteprednol, and at least one ?2 adrenoceptor agonist for the simultaneous, sequential or separate treatment of allergies and/or airway disorders, medicaments comprising the combination, processes for the production of such medicaments and the use of the novel combination for the production of medicaments for the simultaneous, sequential or separate treatment of allergies and/or airway disorders.