Abstract: The invention relates to compound of the formula (I), in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.

Abstract: The invention relates to a piston pump for conveying fluids. The piston pump includes a piston, and a pressure chamber located between an intake valve and a discharge valve. The intake valve is arranged between the pressure chamber and a low-pressure zone of the piston pump. The intake valve has a valve body, a closing element, a device for preloading the closing element, and a device for fastening the intake valve to the piston. The fastening device encompasses at least two fastening elements which protrude from the valve body toward the piston. The fastening elements are positioned at a distance from one another, and are fitted with inlets therebetween for supplying fluid. The invention further relates to a piston pump having an intake valve without a spring-biased element.

Abstract: The present invention relates to a bearing device for a wind turbine, wherein the bearing arrangement has two bearing partners, which are pivoted arranged relative to each other over a common axis. A gliding pad acting in an axial direction is provided between the bearing partners. The object of the invention is to provide a bearing arrangement for a wind turbine, which among others avoids the disadvantages of the prior art. In particular, a maintenance-friendly and force flow-optimized arrangement of the gliding pads is to be enabled. The replaceability of the gliding pads is to be improved in a simple and cost-effective manner by disposing the individual gliding pads in pockets between the two bearing partners, wherein the pockets are provided in the material of the machine frame. Additionally, the option exists to use the bearing arrangement at the same time as an active brake.

Abstract: A compound of formula (I) wherein R denotes another heterocyclic residue and wherein Ra, Rb, Rc, Rd and Re, are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.

Abstract: The invention relates to compounds of the formula I A-D-C(R1)2—B??(I), in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.

Abstract: A lubricant-tight vane rotary vacuum pump, includes a pump stage (17) having a pump stage housing (10) with a gas inlet, compression chamber (11), and a gas outlet (51), a channel (50) connecting the compression chamber (11) with the gas outlet (51), and a groove (54) at least partially surrounding a mouth of the connecting channel (50) that opens into the gas outlet (51), so that lubricant, which is tossed out of the compression chamber, is collected in the groove (54) and re-entry of the lubricant back into the compression chamber (11) is prevented.

Abstract: The invention relates to a magnetic field sensor comprising a housing which includes a plug and encloses sensor electronics. According to the invention, the housing comprises a two-pieced housing composed of a housing top part, which has a single opening, and a housing base which closes the opening, and out of which the contact pins of the plug extend, and which carries the sensor electronics.

Abstract: The present invention pertains “to the use of a PKC inhibitor in the manufacture of a medicament in the treatment or prevention of diabetic complications, where in the PKC inhibitor is one of 3-(1.H.-indol-3-yl)-4-[2-(4-methyl-piperazin-1-yl)-quinazolin-4-yl]-pyrrole-2,5-dione, 3-(1.H.-indol-3-yl)-4-[2-(piperazin-1-yl)-quinazolin-4-yl]-pyrrole-2,5-dione, 3-[3-(4,7-Diaza-spiro [2.5]oct-7-yl)-isoquinolin-1-yl]-4-(7-methyl-1H-indol-3-yl)-pyrrole-2,5-dione or a pharmaceutically acceptable salt thereof.

Abstract: A lubricant-tight vane rotary vacuum pump includes at least one pump stage (17, 18) having a safety valve (3) for controlling gas flow to the pump stage, a lubricant pump, a lubricant reservoir (30) at least partially surrounding the pump stage housing (10, 40), and a hydraulic conduit (31) connecting the lubricant pump outlet (22) with the safety valve (3), with a pressurized lubricant flow through the hydraulic conduit (31) opening the safety valve (3), and a channel (32) branching from the hydraulic conduit (31) for delivering a pressurized lubricant into the lubricant reservoir (30).

Abstract: The invention relates to a linear sensor, comprising a sleeve (5), a pin (7) which comprises a permanent magnet (1) and is linearly displaceably supported in the sleeve (5), and a magnetic field sensor (3) which is fastened to the sleeve (5) and used to detect a displacement of the permanent magnet (1), characterized in that the pin (7) is guided by way of a substantially cylindrical guide (8) and has a magnet or pin holder (6).

Abstract: A compound of formula I wherein R, Ra and Rb are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.

Abstract: A linear sensor is described with a casing (5), with a pin (7) which contains a permanent magnet (1) and which is mounted in the casing (5) in a linearly displaceable manner against the force of a spring (6), and with a magnetic field sensor (3) attached to said casing (5) for detecting of a displacement of the permanent magnet (1). The invention provides that the pin (7) is controlled by a first cylindrical guide (8) and a second cylindrical guide (8).

Abstract: Method of performing condensation reactions, acylations or of preparing heterocycles comprising forming cyclic phosphonic anhydride of the formula (III) by a) reacting phosphonic acid derivatives of formula (I) with acetic anhydride at a temperature ranging between 30 and 150° C. while separating a mixture of ethanoic acid and acetic anhydride by means of distillation, b) then reactively distilling the oligomeric phosphonic acid anhydrides of formula (II) obtained in step a) and transforming the same into the corresponding cyclic trimeric phosphonic acid anhydrides of formula (III), wherein n represents a number between 0 and 300 while R represents allyl, aryl, or open-chain, cyclic, or branched C1 to C8 alkyl radicals, aryloxy, allyloxy, or alkoxy comprising open-chain, cyclic, or branched C1 to C8 alkyl radicals. Preferably the cyclic trimeric phosphonic acid anhydrides formed in step b) are immediately dissolved in an organic solvent that exhibits an inert behavior relative thereto.

Abstract: A compound of formula (I), wherein R, R1, R2, ring A, which ring contains one or two nitrogen atoms, and ring B are as defined in the Specification, pharmaceutical compositions containing these compounds, and uses for these compounds and compositions, in particular, in transplantation.

Abstract: The compounds are indolylmaleimide derivatives comprising either a substituted pyridyl or indolyl residue. The compounds have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, or acute or chronic transplant rejection.

Abstract: The invention relates to compound of the formula I in which the substituents are as defined in the specification; in free form or in salt form; to its preparation, to its use as medicament and to medicaments comprising it.

Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.

Abstract: The present invention relates to a fluid separation device (10) for separating fluid, oil and oil spray from a gas. This fluid separation device (10) comprises a base carrier (21) in which fluid separator elements (20) in the form of flow-through tubes with worm-like segments (23) arranged therein, are integrated. The worm-like segments (23) at the same time form spiral flow paths (25) for the gas. They have a maximal length of half a pitch of the worm-like segment (23) so that the base carrier (21) together with the associated fluid separator elements (20) may be formed as one piece. Several base carriers may be arranged one after the other in a manner such that individual fluid separator elements of various base carriers form a common flow path for the gas.