Abstract: A method for treatment of degenerative disc disease using capacitively coupled electrical stimulation. In one embodiment, a subject diagnosed as having degenerative disc disease is treated by placing first and second electrodes on the subject's body at the site of an identified disc in a state of degenerative disc disease, and applying an electric field to the identified disc via the first and second electrodes with the intent to treat the degenerative disc disease. The electric field is created with an electrical signal having a frequency within a range of 20 to 100 kHz and having a symmetrical waveform with an amplitude within a range of 0.1 to 20 volts peak-to-peak, preferably a frequency of approximately 60 kHz and an amplitude of approximately 5 volts peak-to-peak.

Abstract: Monoclonal antibodies that specifically bind to ?v??. Also included are methods of using these antibodies to treat mammals having or at risk of having ?v?6-mediated diseases, or to diagnose ?V?6-mediated diseases.

Abstract: A system and method for uniquely identifying an SIP device extends the SIP communications protocol with an end point identifier, carried for example in the header of an SIP transmission. The end point identifier is useful for routing, registration, subscription, and authentication. The end point (device) of a given user epid can be uniquely identified by creating a key from an epid and a user's address-of-record (URI). This in turn enables improved connection management and security association management when the connections/IP addresses are transient, such as when HTTPS tunneling is used.

Abstract: Methods and devices for treatment of osteonecrosis of the femoral head with core decompression include a dowel adapted for placement into a core decompression channel of a femoral head. A cathode at the distal end of the dowel provides electrical stimulation of bone growth in the femoral head. A method of treating osteonecrosis of the femoral head involves placing a dowel having a cathode thereon into a core decompression channel of a femoral head in a state of osteonecrosis. Electrical current is supplied to the cathode for electrical stimulation of bone growth in the femoral head.

Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: 2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and their salts are kinase inhibitors, useful in the treatment of cancer.

Abstract: A method for treatment of degenerative disc disease using capacitively coupled electrical stimulation. In one embodiment, a subject diagnosed as having degenerative disc disease is treated by placing first and second electrodes on the subject's body at the site of an identified disc in a state of degenerative disc disease, and applying an electric field to the identified disc via the first and second electrodes with the intent to treat the degenerative disc disease. The electric field is created with an electrical signal having a frequency within a range of 20 to 100 kHz and having a symmetrical waveform with an amplitude within a range of 0.1 to 20 volts peak-to-peak, preferably a frequency of approximately 60 kHz and an amplitude of approximately 5 volts peak-to-peak.

Abstract: Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.

Abstract: Systems and methods for monitoring the condition of equipment in a manufacturing plant or other facility. A computing node is attached to each piece of equipment under consideration. Each node gathers relevant information from the machine using sensors and is capable of determining the condition of the machine from a preexisting set of possible conditions, using only the information obtained from the sensors. Each node is thus entirely self-sufficient, in that it requires no interaction with a global controller or with other nodes in order to make a decision about the condition of the equipment, and does not necessarily require any information about the past history of the equipment. The nodes are capable of communicating the condition of their corresponding equipment to key maintenance or other personnel, potentially via a wireless network to a convenient wireless-capable device such as a cellular phone or laptop.

Abstract: Devices, systems and instructing methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease. The instructing method for treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.

Abstract: A method for treatment of degenerative disc disease using capacitively coupled electrical stimulation. In one embodiment, a subject diagnosed as having degenerative disc disease is treated by placing first and second electrodes on the subject's body at the site of an identified disc in a state of degenerative disc disease, and applying an electric field to the identified disc via the first and second electrodes with the intent to treat the degenerative disc disease. The electric field is created with an electrical signal having a frequency within a range of 20 to 100 kHz and having a symmetrical waveform with an amplitude within a range of 0.1 to 20 volts peak-to-peak, preferably a frequency of approximately 60 kHz and an amplitude of approximately 5 volts peak-to-peak.

Abstract: The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize ?v?6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-?v?6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin ?v?6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin ?v?6.

Abstract: A printing system using multiple printheads maintains color consistency between the printheads by printing a first color patch (102) with a first color with a plurality of printheads (30) at a first pressure and with a first pixel fill coverage. A second color patch (104) is printed with the first color with the plurality of printheads at a second pressure with the first pixel fill coverage. The print density of the first patch and the second patch is measured for each of the plurality of printheads and the print density for each of the plurality of printheads is compared. A pressure for each of the plurality of printheads is adjusted to compensate for differences in density between the first patch and the second patch for each of the printheads.

Abstract: An application displays a user interface (UI) component. A client can apply customizations to this UI component. After the client applies customizations to the UI component, the client modifies a solution set containing solutions that modify the UI component. After the client modifies the solution set, the application displays a new version of the UI component. Modifications provided by the solutions in the solution set are applied to the new version of the UI component. In addition, the customizations remain applied to the UI component without the client manually re-applying the customizations to the UI component.

Abstract: A printing system using multiple printheads maintains color consistency between the printheads by printing a first color patch (102) with a first color with a plurality of printheads (30) at a first pressure and with a first pixel fill coverage. A second color patch (104) is printed with the first color with the plurality of printheads at a second pressure with the first pixel fill coverage. The print density of the first patch and the second patch is measured for each of the plurality of printheads and the print density for each of the plurality of printheads is compared. A pressure for each of the plurality of printheads is adjusted to compensate for differences in density between the first patch and the second patch for each of the printheads.

Abstract: A modular accessory system is supportable on a vertical surface such as a wall, an office divider, or the like and includes a support member or base that supports decorative panels and/or functional panels to provide a desired appearance and/or functions for use in an area. The panels are repositionable, and some may be oriented in two or more different orientations on the support base. Engaging members are provided at spaced intervals along each panel, with additional engaging members provided at spaced intervals along the support base. The engaging members along the support base releasably engage the engaging members on the panels to support them on the support base.

Abstract: A method and system for aggregating presence information generated by multiple devices associated with a single user is presented. A server acting as a presence agent on behalf of a first user and the first user's computing device receives and responds to a subscription request generated by a computing device operated by a second user that wishes to be permitted as a watcher of the first user. If the server is not capable of acting as a presence agent, then the first user's computing device assumes the role of a presence agent.

Abstract: Chemical permeation enhancers (CPEs) improve access of local anesthetics to the nerve, thereby improving their performance. Surfactants, representing three CPE sub-groups: anionic, cationic, and nonionic surfactants, were co-injected with tetrodotoxin (TTX) or bupivacaine at the sciatic nerve of Sprague-Dawley rats. All enhancers produced marked concentration-dependent improvements in the frequency and duration of block with TTX but not bupivacaine. An in vitro toxicity assay showed a wide range of CPE myotoxicity, but in vivo histological assessment showed no signs of muscle or nerve damage at concentrations of CPEs that produced a half-maximal increase in the duration of block of TTX. There was no systematic relationship between the enhancers' charge or hydrophobicity and their enhancement of block duration or potency.

Abstract: Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.

Abstract: A system and method for uniquely identifying an SIP device extends the SIP communications protocol with an end point identifier, carried for example in the header of an SIP transmission. The end point identifier is useful for routing, registration, subscription, and authentication. The end point (device) of a given user epid can be uniquely identified by creating a key from an epid and a user's address-of-record (URI). This in turn enables improved connection management and security association management when the connections/IP addresses are transient, such as when HTTPS tunneling is used.